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2023年1月 第26卷 第2期 http: //www.chinagp.net E-mail: zgqkyx@chinagp.net.cn ·135·

children published from January 1，2010 to January 31，2022 were searched in databases of CNKI，Wanfang Data，VIP，
CBM，and PubMed（with searching databases of MedLive，WHO and NICE as a supplement）. The AGREE Ⅱ and RIGHT
checklists were used to evaluate the methodological and reporting quality of included studies. According to the AGREE Ⅱ，the
recommended grade of each guideline/consensus was rated as "recommended （A）"，"recommended after update（B）"，
and "not recommended （C）". The intra-class correlation coefficient（ICC） was used for the consistency test. Results
Altogether，eight guidelines and five consensuses were included，which provide 185 recommendations，including 44 for
diagnosis and evaluation，140 for treatment，and one for follow-up. By the AGREE Ⅱ checklist，these 13 studies were assessed
with average scores of （66.99%±16.73%），（46.26%±21.56%），（34.42%±26.73%），（60.36% ±32.13%），
（39.82%±20.14%） and （45.35%±37.93%） for scope and purpose，stakeholder involvement，rigour of development，
clarity of presentation，applicability，and editorial independence，respectively. None of the studies were with recommendation
grade A，eight were with recommendation grade B，and five were with grade C. The reporting rates of the studies in accordance
with seven domains of basic information，background，evidence，recommendations，review and quality assurance，funding
and declaration and management of interests and other information were （60.58%±12.19%），（50.72%±20.18%），
（30.77%±26.88%），（32.97%±27.53%），25.00%（40.63%），（25.96%±24.00%） and 16.67%（33.33%），
respectively. The guidelines had higher score in terms of the scope and purpose domain of AGREE Ⅱ than consensuses （P<0.05）.
The guidelines and consensuses had no significant differences in assessment results by each of the seven domains of RIGHT
（P>0.05）. The ICC for the reliability of each of the domains of the AGREE Ⅱ checklist in assessment was greater than 0.750，
showing a high consistency. The ICC for the reliability of each of the domains of the RIGHT checklist was 0.736，which showed
a good consistency. Conclusion The overall methodological and reporting quality of the included guidelines and consensuses
needs to be improved. The recommended grades of the included literature consist of B and C without A，suggesting that high-
quality guidelines should be referred first when making clinical decisions. Currently，there is no guideline for the diagnosis and
treatment of enuresis in children in primary care in China，and the quality of existing guideline on Traditional Chinese Medicine
management of enuresis in children needs to be improved. It is suggested to develop relevant guidelines according to the AGREE
Ⅱ and RIGHT checklists to guide the clinical management of enuresis in children.
【Key words】 Nocturnal enuresis；Child；Guidebook；Consensus；AGREE Ⅱ；RIGHT；Evaluation study；
Research report

小儿遗尿症（NE）是小儿常见病之一，以 5 岁以 Excellence，NICE）等数据库。临床实践指南具有明显
上儿童出现夜间尿床为主要临床表现，常导致儿童出现 的时效性，部分临床实践指南约 1/5 的推荐意见将在 3
严重的心理压力，同时给家庭带来极大的负担 ［1-2］ 。 年后失效，约 50% 的指南将在发布后的 5.8 年内过时 ［5］ ，
AGREE Ⅱ（Appraisal of Guidelines Research and 因此本研究设置的检索时限为 2010-01-01 至 2022-01-
Evaluation Ⅱ ） 和 RIGHT（Reporting Items for Practice 31。指南语种限制为中、英文。采用主题词与自由词结
Guidelines in Healthcare）是国际公认的评价指南方法学 合的检索方式，并根据具体数据库进行适当调整，具体
和报告质量的工具 ［3-4］ 。高质量的临床实践指南或专家 检索词包括：尿床，儿童遗尿症，遗尿，夜尿症，遗尿
共识是指导 NE 规范化管理的重要参考，然而目前尚无 症，小儿遗尿症，小儿遗尿，青少年遗尿，指南，共识，
研究对国内外 NE 指南及专家共识质量进行规范性评价， 规 范，Enuresis，Wetting，Incontinence，Bedwetting，
现存指南的质量如何仍不得而知。鉴于此，本研究运用 children，young people，guideline，consensus，code，
AGREE Ⅱ和 RIGHT 工具对 2010 年以来公开发布的 NE norm。
指南的方法学和报告质量进行评价和系统性分析，旨在 1.2 文献纳入与排除标准 纳入标准：（1）研究类型
为未来 NE 指南的制定提供参考，以更好地提高指南的 为公开发表的临床实践指南、共识、规范；（2）研究
质量和报告规范性。 对象为小儿 NE 患者；（3）同一系列指南仅纳入最新
1 资料与方法 发表的一版；（4）重复发表的指南仅纳入最早发表的
1.1 检索策略 计算机检索以下数据库：中国知网， 一版。排除标准：（1）指南摘要；（2）解读版或翻译
万方数据知识服务平台，维普网，中国生物医学文献 版指南；（3）指南草案、试行版和会议纪要；（4）技
数据库和 PubMed，同时补充检索医脉通、世界卫生 术规范；（5）指南语种非中、英文。
组 织（World Health Organization，WHO） 以 及 英 国 国 1.3 文献筛选及资料提取 由 2 名研究者独立进行文
家 临 床 示 范 研 究 所（National Institute Health and Care 献筛选，剔除重复文献后阅读标题和摘要，排除明显不