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           基于两种评分系统对结直肠癌根治术后并发症

           预测价值的研究

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           杜凯微 ,姜霞       1,2 ,王园园 ,耿燕杰 ,高天 ,兰天昊 ,王桂琦                    1*                     查看原文
               【摘要】 背景 结直肠癌是常见肿瘤,手术仍是其主要治疗手段之一。目前对结直肠癌手术治疗的研究十分成熟,
           却很少有根据术前、术中状态预测其术后并发症的研究。目的 探讨 POSSUM 评分系统和年龄校正查尔森合并症(aCCI)
           指数对结直肠癌根治术术后并发症的预测价值。方法 回顾性分析 2016 年 6 月至 2020 年 9 月在河北医科大学第一医
           院实施结直肠癌根治术的 118 例患者的临床资料,根据术后是否出现并发症分为并发症组(n=42)、无并发症组(n=76)。
           采用 Spearman 秩相关分析探讨结直肠癌根治术术后并发症与临床指标的关系,采用受试者工作特征曲线(ROC 曲线)
           评价两种评分系统对结直肠癌根治术术后并发症的预测价值。结果 并发症组预计死亡率(R1)、预计并发症发生率
          (R2),aCCI水平、术中失血量高于无并发症组,预计十年生存率(Z)、术前血红蛋白(Hb)水平低于无并发症组(P<0.05)。
           两组TNM分期比较,差异有统计学意义(P<0.05)。预测30 d内R1为0.065(0.039,0.131),30 d内R2为0.349(0.220,0.585),
           Z 值为 0.775(0.214,0.901)。实际术后 30 d 内 36.1%(42/118)发生术后并发症,1.7%(2/118)死于吻合口瘘。术
           后有无并发症与 TNM 分期、术中失血量呈正相关,与术前 Hb 呈负相关(P<0.05)。R1、R2、aCCI 指数预测结直肠
           癌根治术术后并发症的 ROC 曲线下面积(AUC)分别为 0.727、0.728、0.638,最佳截断值分别为 0.114、0.516、3.500,
           灵敏度分别为 57.1%、57.1%、52.4%,特异度分别为 81.6%、80.3%、65.8%。结论 POSSUM 评分和 aCCI 指数均对结
           直肠癌根治术术后并发症有预测价值,可用于指导临床决策。
               【关键词】 结直肠肿瘤;POSSUM 系统;aCCI 指数;术后并发症;数据相关性;预测
               【中图分类号】 R 735.34 【文献标识码】 A DOI:10.12114/j.issn.1007-9572.2022.0184
               杜凯微,姜霞,王园园,等 . 基于两种评分系统对结直肠癌根治术后并发症预测价值的研究[J]. 中国全科医学,
           2022,25(27):3390-3394.[www.chinagp.net]
               DU K W,JIANG X,WANG Y Y,et al. Application of two scoring systems in prediction of postoperative complications
           after radical resection of colorectal cancer[J]. Chinese General Practice,2022,25(27):3390-3394.

           Application of Two Scoring Systems in Prediction of Postoperative Complications after Radical Resection of Colorectal
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           Cancer DU Kaiwei ,JIANG Xia 1,2 ,WANG Yuanyuan ,GENG Yanjie ,GAO Tian ,LAN Tianhao ,WANG Guiqi 1*
           1.Department of Gastrointestinal Surgery,the First Hospital of Hebei Medical University,Shijiazhuang 050031,China
           2.Hebei Key Laboratory of Precise Diagnosis and Treatment of Colorectal Cancer,Shijiazhuang 050031,China
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           Corresponding author:WANG Guiqi,Chief physician,Professor;E-mail:wangguiqi2011@126.com
               【Abstract】 Background Colorectal cancer is a common tumor,and surgery is still one of the main treatment
           methods. Nowadays the research on surgical treatment of colorectal cancer is very mature,but that of predicting the possibilities
           of postoperative complications from preoperative and intraoperative status is scarce. Objective To investigate the predictive
           value of POSSUM system and aCCI index in postoperative complications after radical resection of colorectal cancer. Methods
            Retrospective analysis was performed on the clinical data of 118 patients performed colorectal cancer operation in the First
           Hospital of Hebei Medical University from June 2016 to September 2020. They were divided into complication group(n=42)and
           non-complication group(n=76)according to the incidence of postoperative complications. Spearman rank correlation was used
           to explore the relationship between postoperative complications after radical resection of colorectal cancer and clinical indicators.
           ROC curve was used to evaluate the predictive value of POSSUM system and aCCI index. Results R1,R2,aCCI levels and
           blood loss in the complication group were higher than those in the non-complication group,while Z and preoperative Hb levels

               基金项目:河北省政府资助项目(361034)
               1.050031 河北省石家庄市,河北医科大学第一医院胃肠外科 2.050031 河北省石家庄市,河北省大肠癌精准诊断与治疗重点实
           验室
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               通信作者:王桂琦,主任医师,教授;E-mail:wangguiqi2011@126.com
               本文数字出版日期:2022-07-07
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