Page 93 - 2022-12-中国全科医学
P. 93

·1498· http://www.chinagp.net   E-mail:zgqkyx@chinagp.net.cn


               lowering drugs:the CVD-REAL 2 study[J]. J Am Coll Cardiol,  [44]LEE T M,CHANG N C,LIN S Z. Dapagliflozin,a selective
               2018,71(23):2628-2639. DOI:10.1016/j.jacc.2018.03.009.   SGLT2 Inhibitor,attenuated cardiac fibrosis by regulating the
           [35]QUAN N H,LI X,ZHANG J W,et al. Substrate metabolism   macrophage polarization via STAT3 signaling in infarcted rat
               regulated by Sestrin2-mTORC1 alleviates pressure overload-induced   hearts[J]. Free Radic Biol Med,2017,104:298-310. DOI:
               cardiac hypertrophy in aged heart[J]. Redox Biol,2020,36:  10.1016/j.freeradbiomed.2017.01.035.
               101637. DOI:10.1016/j.redox.2020.101637.        [45]YE Y M,JIA X M,BAJAJ M,et al. Dapagliflozin attenuates
                                                                       +
                                                                     +
           [36]JAIKUMKAO  K,PROMSAN  S,THONGNAK  L,et  al.          Na /H  exchanger-1 in cardiofibroblasts via AMPK activation[J].
               Dapagliflozin ameliorates pancreatic injury and activates kidney   Cardiovasc Drugs Ther,2018,32(6):553-558. DOI:
               autophagy by modulating the AMPK/mTOR signaling pathway in   10.1007/s10557-018-6837-3.
               obese rats[J]. J Cell Physiol,2021,236(9):6424-6440.   [46]BAARTSCHEER A,SCHUMACHER C A,WÜST R C,et al.
                                                                                                         +
               DOI:10.1002/jcp.30316.                               Empagliflozin decreases myocardial cytoplasmic Na  through
                                                                                     +
                                                                                       +
           [37]FERRANNINI  E,MARK  M,MAYOUX  E.  CV  protection     inhibition of the cardiac Na /H  exchanger in rats and rabbits[J].
               in the EMPA-REG OUTCOME trial:a “thrifty substrate”   Diabetologia,2017,60(3):568-573. DOI:10.1007/s00125-
               hypothesis[J]. Diabetes Care,2016,39(7):1108-1114.   016-4134-x.
               DOI:10.2337/dc16-0330.                          [47]UTHMAN L,BAARTSCHEER A,BLEIJLEVENS B,et al.
           [38]SANTOS-GALLEGO C G,IBANEZ J A R,ANTONIO R S,et al.    Class effects of SGLT2 inhibitors in mouse cardiomyocytes and
                                                                                   +
                                                                                                              +
                                                                                      +
               Empagliflozin induces a myocardial metabolic shift from glucose   hearts:inhibition of Na /H  exchanger,lowering of cytosolic Na
               consumption to ketone metabolism that mitigates adverse cardiac   and vasodilation[J]. Diabetologia,2018,61(3):722-726.
               remodeling and improves myocardial contractility[J]. J Am Coll   DOI:10.1007/s00125-017-4509-7.
               Cardiol,2018,71(11):A674. DOI:10.1016/S0735-1097(18)  [48]ZHOU H,HU S Y,JIN Q H,et al. Mff-dependent mitochondrial
               31215-4.                                             fission contributes to the pathogenesis of cardiac microvasculature
           [39]SANTOS-GALLEGO C G,REQUENA-IBANEZ J A,SAN            ischemia/reperfusion injury via induction of mROS-mediated
               ANTONIO R,et al. Empagliflozin ameliorates adverse left   cardiolipin oxidation and HK2/VDAC1 disassociation-involved
               ventricular remodeling in nondiabetic heart failure by enhancing   mPTP opening[J]. J Am Heart Assoc,2017,6(3):e005328.
               myocardial energetics[J]. J Am Coll Cardiol,2019,73(15):  DOI:10.1161/JAHA.116.005328.
               1931-1944. DOI:10.1016/j.jacc.2019.01.056.      [49]SAWADA N,JIANG A H,TAKIZAWA F,et al. Endothelial
           [40]梁志山,许志盟,吉庆伟 . 钠 - 葡萄糖共转运蛋白 2 抑制剂                     PGC-1α  mediates  vascular  dysfunction  in  diabetes[J].
               治疗心力衰竭循证证据与机制的研究进展[J]. 中国临床新                         Cell  Metab,2014,19(2):246-258.  DOI:10.1016/j.
               医   学,2021,14(6):554-558. DOI:10.3969/j.issn.1674-   cmet.2013.12.014.
               3806.2021.06.06.                                [50]ZHOU H,WANG S Y,ZHU P J,et al. Empagliflozin rescues
               LIANG Z S,XU Z M,JI Q W. Research progress in evidence-  diabetic myocardial microvascular injury via AMPK-mediated
               based evidence and mechanisms of sodium-glucose cotransporter 2   inhibition of mitochondrial fission[J]. Redox Biol,2018,15:
               inhibitors in treatment of heart failure[J]. Chinese Journal of New   335-346. DOI:10.1016/j.redox.2017.12.019.
               Clinical Medicine,2021,14(6):554-558. DOI:10.3969/j.  [51]HANSSON  G  K,LIBBY  P.  The  immune  response  in
               issn.1674-3806.2021.06.06.                           atherosclerosis:a double-edged sword[J]. Nat Rev Immunol,
           [41]高文君,韩明华 . 急性冠脉综合征预后的预测研究进展[J].                       2006,6(7):508-519. DOI:10.1038/nri1882.
               心血管病学进展,2018,39(4):606-610. DOI:10.16806/j.     [52]NASIRI-ANSARI Ν,DIMITRIADIS G K,AGROGIANNIS G,
               cnki.issn.1004-3934.2018.04.025.                     et al. Canagliflozin attenuates the progression of atherosclerosis and
               GAO W J,HAN M H. Progress in prediction of acute coronary   inflammation process in APOE knockout mice[J]. Cardiovasc
               syndrome[J]. Advances in Cardiovascular Diseases,2018,39(4):  Diabetol,2018,17(1):106. DOI:10.1186/s12933-018-
               606-610. DOI:10.16806/j.cnki.issn.1004-3934.2018.04.025.   0749-1.
           [42]王继航,沈明志,焦阳,等 . SGLT2i 在合并糖尿病动脉粥样                [53]MANCINI S J,BOYD D,KATWAN O J,et al. Canagliflozin
               硬化性心血管疾病中的作用研究进展[J]. 中华老年多器官疾                        inhibits interleukin-1β-stimulated cytokine and chemokine
               病杂志,2021,20(4):300-304. DOI:10.11915/j.issn.1671-    secretion in vascular endothelial cells by AMP-activated protein
               5403.2021.04.062.                                    kinase-dependent and-independent mechanisms[J]. Sci Rep,
               WANG J H,SHEN M Z,JIAO Y,et al. Research progress in role   2018,8(1):5276. DOI:10.1038/s41598-018-23420-4.
               of SGLT2i in atherosclerotic cardiovascular disease with diabetes   [54]NAKATSU Y,KOKUBO H,BUMDELGER B,et al. The SGLT2
               mellitus[J]. Chinese Journal of Multiple Organ Diseases in the   inhibitor luseogliflozin rapidly normalizes aortic mRNA levels of
               Elderly,2021,20(4):300-304. DOI:10.11915/j.issn.1671-  inflammation-related but not lipid-metabolism-related genes and
               5403.2021.04.062.                                    suppresses atherosclerosis in diabetic ApoE KO mice[J]. Int J Mol
           [43]KANG S A,VERMA S,HASSANABAD A F,et al. Direct effects   Sci,2017,18(8):1704. DOI:10.3390/ijms18081704.
               of empagliflozin on extracellular matrix remodelling in human cardiac   [55]LENG W L,OUYANG X S,LEI X T,et al. The SGLT-2 inhibitor
               myofibroblasts:novel translational clues to explain EMPA-REG   dapagliflozin has a therapeutic effect on atherosclerosis in diabetic
               OUTCOME results[J]. Can J Cardiol,2020,36(4):543-    ApoE-/- mice[J]. Mediators Inflamm,2016,2016:6305735.
               553. DOI:10.1016/j.cjca.2019.08.033.                 DOI:10.1155/2016/6305735.
   88   89   90   91   92   93   94   95   96   97   98