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           2.4.3.2 NO 共 3 项研究  [10,11,15] 报告 NO,278 例患者。异      P<0.05〕,见图 11。
                                                2
           质性检验显示,各研究异质性较小(P=0.86,I =0%),采用                    2.4.4 临床总有效率 共 8 项研究       [8-15] 报告临床总有效率,
           固定效应模型。结果显示,试验组改善 ET-1 效果优于对照组,                     1 075 例患者。异质性检验显示,各研究异质性较小(P=0.41,
                                                               2
           差异有统计学意义〔MD=-16.74,95%CI(-20.13,-13.35),            I =3%),采用固定效应模型。结果显示,试验组临床总有效
                                                               率优于对照组,差异有统计学意义〔RR=1.22,95%CI(1.16,
                                                               1.29),P<0.05〕,见图 12。







                                                               图 6 试验组对比对照组改善冠心病合并心力衰竭患者 LAEDD 的森
                                                               林图
                                                               Figure 6 Forest plot of the experimental group versus the control groupt for
                                                               improving LAEDD in patients with coronary heart disease with heart failure







                                                               图 7 试验组对比对照组改善冠心病合并心力衰竭患者 LVESD 的森
                                                               林图
                                                               Figure 7 Forest plot of the experimental group versus the control group for
                                                               improving LVESD in patients with coronary heart disease with heart failure




                            图 3 偏倚风险总结
                 Figure 3 Risk of bias summary for each included RCT  图 8 试验组对比对照组改善冠心病合并心力衰竭患者 CO 的森林图
                                                               Figure 8 Forest plot of the experimental group versus the control group for
                                                               improving CO in patients with coronary heart disease with heart failure






                                                               图 9 试验组对比对照组改善冠心病合并心力衰竭患者 NT-proBNP 的
                                                               森林图
                                                               Figure 9 Forest plot of the experimental group versus the control group
                                                               for improving NT-proBNP in patients with coronary heart disease with heart
                                                               failure






           图 4 试验组对比对照组改善冠心病合并心力衰竭患者 LVEF 的森林图
           Figure 4 Forest plot of the experimental group versus the control group for
                                                               图 10 试验组对比对照组改善冠心病合并心力衰竭患者 ET-1 的森林图
           improving LVEF in patients with coronary heart disease with heart failure
                                                               Figure 10 Forest plot of the experimental group versus the control group
                                                               for improving ET-1 in patients with coronary heart disease with heart failure






           图 5 试验组对比对照组改善冠心病、心力衰竭患者 LVEDD 的森林图                 图 11 试验组对比对照组改善冠心病合并心力衰竭患者 NO 的森林图
            Figure 5 Forest plot of the experimental group versus the control group for   Figure 11 Forest plot of the experimental group versus the control group
           improving LVEDD in patients with coronary heart disease with heart failure  for improving NO in patients with coronary heart disease with heart failure
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