Page 106 - 2023-06-中国全科医学

2023年2月 第26卷 第6期 http: //www.chinagp.net E-mail: zgqkyx@chinagp.net.cn ·747·

2906-2916. DOI：10.1111/liv.14696 low glycemic index Mediterranean diet combined with aerobic
［19］CHEN J，ZHENG M H，LIU J，et al. Ratio of conjugated physical activity rearranges the gut microbiota signature in NAFLD
chenodeoxycholic to muricholic acids is associated with severity patients［J］. Nutrients，2022，14（9）：1773. DOI：
of nonalcoholic steatohepatitis［J］. Obesity （Silver Spring）， 10.3390/nu14091773.
2019，27（12）：2055-2066. DOI：10.1002/oby.22627. ［32］HILL C，GUARNER F，REID G，et al. Expert consensus
［20］JI Y，YIN Y，SUN L J，et al. The molecular and mechanistic document. The International Scientific Association for Probiotics and
insights based on gut-liver axis：nutritional target for non-alcoholic Prebiotics consensus statement on the scope and appropriate use of
fatty liver disease （NAFLD） improvement［J］. Int J Mol Sci， the term probiotic［J］. Nat Rev Gastroenterol Hepatol，2014，11
2020，21（9）：E3066. DOI：10.3390/ijms21093066. （8）：506-514. DOI：10.1038/nrgastro.2014.66.
［21］ZHAO S，JANG C，LIU J，et al. Dietary fructose feeds hepatic ［33］MOHAMAD NOR M H，AYOB N，MOKHTAR N M，et al. The
lipogenesis via microbiota-derived acetate［J］. Nature，2020， effect of probiotics （MCP® BCMC® strains） on hepatic steatosis，
579（7800）：586-591. DOI：10.1038/s41586-020-2101-7. small intestinal mucosal immune function，and intestinal barrier
［22］VIVEIROS K. The role of life style modifications in comprehensive in patients with non-alcoholic fatty liver disease［J］. Nutrients，
non-alcoholic fatty liver disease treatment［J］. Clin Liver Dis 2021，13（9）：3192. DOI：10.3390/nu13093192.
（Hoboken），2021，17（1）：11-14. DOI：10.1002/cld.1007. ［34］LUO M M，YAN J B，WU L Y，et al. Probiotics alleviated
［23］BARTON W，PENNEY N C，CRONIN O，et al. The nonalcoholic fatty liver disease in high-fat diet-fed rats via gut
microbiome of professional athletes differs from that of more microbiota/FXR/FGF15 signaling pathway［J］. J Immunol Res，
sedentary subjects in composition and particularly at the functional 2021，2021：2264737. DOI：10.1155/2021/2264737.
metabolic level［J］. Gut，2018，67（4）：625-633. DOI： ［35］PARK E J，LEE Y S，KIM S M，et al. Beneficial effects of
10.1136/gutjnl-2016-313627. Lactobacillus plantarum strains on non-alcoholic fatty liver disease
［24］VALLIANOU N，DALAMAGA M，STRATIGOU T，et al. Do in high fat/high fructose diet-fed rats［J］. Nutrients，2020，12（2）：
antibiotics cause obesity through long-term alterations in the gut E542. DOI：10.3390/nu12020542.
microbiome? A review of current evidence［J］. Curr Obes Rep， ［36］AHN S B，JUN D W，KANG B K，et al. Randomized，double-
2021，10（3）：244-262. DOI：10.1007/s13679-021-00438-w. blind，placebo-controlled study of a multi species probiotic mixture
［25］CARBAJO-PESCADOR S，PORRAS D，GARCÍA-MEDIAVILLA in nonalcoholic fatty liver disease［J］. Sci Rep，2019，9（1）：
M V，et al. Beneficial effects of exercise on gut microbiota 5688. DOI：10.1038/s41598-019-42059-3.
functionality and barrier integrity，and gut-liver crosstalk in ［37］DUSEJA A，ACHARYA S K，MEHTA M，et al. High potency
an in vivo model of early obesity and non-alcoholic fatty liver multistrain probiotic improves liver histology in non-alcoholic fatty
disease［J］. Dis Model Mech，2019，12（5）：dmm039206. liver disease （NAFLD）：a randomised，double-blind，proof of
DOI：10.1242/dmm.039206. concept study［J］. BMJ Open Gastroenterol，2019，6（1）：
［26］CHENG R T，WANG L，LE S L，et al. A randomized controlled e000315. DOI：10.1136/bmjgast-2019-000315.
trial for response of microbiome network to exercise and diet ［38］LAVEKAR A S，V RAJE D，MANOHAR T，et al. Role of
intervention in patients with nonalcoholic fatty liver disease［J］. probiotics in the treatment of nonalcoholic fatty liver disease：
Nat Commun，2022，13（1）：2555. DOI：10.1038/s41467- a meta-analysis［J］. Euroasian J Hepatogastroenterol，2017，
022-29968-0. 7（2）：130-137. DOI：10.5005/jp-journals-10018-1233.
［27］VILAR-GOMEZ E，MARTINEZ-PEREZ Y，CALZADILLA- ［39］HOLSCHER H D. Dietary fiber and prebiotics and the
BERTOT L，et al. Weight loss through lifestyle modification gastrointestinal microbiota［J］. Gut Microbes，2017，8（2）：
significantly reduces features of nonalcoholic steatohepatitis［J］. 172-184. DOI：10.1080/19490976.2017.1290756.
Gastroenterology，2015，149（2）：367-378.e5；quize14-15. ［40］PLOVIER H，EVERARD A，DRUART C，et al. A purified
DOI：10.1053/j.gastro.2015.04.005. membrane protein from Akkermansia muciniphila or the pasteurized
［28］SAVARD C，TARTAGLIONE E V，KUVER R，et al. Synergistic bacterium improves metabolism in obese and diabetic mice［J］.
interaction of dietary cholesterol and dietary fat in inducing Nat Med，2017，23（1）：107-113. DOI：10.1038/nm.4236.
experimental steatohepatitis［J］. Hepatology，2013，57（1）： ［41］SINGH D P，KHARE P，ZHU J，et al. A novel cobiotic-based
81-92. DOI：10.1002/hep.25789. preventive approach against high-fat diet-induced adiposity，
［29］CHALASANI N，YOUNOSSI Z，LAVINE J E，et al. The diagnosis nonalcoholic fatty liver and gut derangement in mice［J］.
and management of nonalcoholic fatty liver disease：practice Int J Obes （Lond），2016，40（3）：487-496. DOI：
guidance from the American Association for the Study of Liver 10.1038/ijo.2015.197.
Diseases［J］. Hepatology，2018，67（1）：328-357. DOI： ［42］BOMHOF M R，PARNELL J A，RAMAY H R，et al. Histological
10.1002/hep.29367. improvement of non-alcoholic steatohepatitis with a prebiotic：
［30］ALLER R，BURGUEÑO GOMEZ B，SIGÜENZA R，et al. a pilot clinical trial［J］. Eur J Nutr，2019，58（4）：1735-
Comparative study of overweight and obese patients with nonalcoholic 1745. DOI：10.1007/s00394-018-1721-2.
fatty liver disease［J］. Rev Esp Enferm Dig，2019，111（4）： ［43］CHONG P L，LAIGHT D，ASPINALL R J，et al. A randomised
256-263. DOI：10.17235/reed.2019.5926/2018. placebo controlled trial of VSL#3® probiotic on biomarkers of
［31］CALABRESE F M，DISCIGLIO V，FRANCO I，et al. A cardiovascular risk and liver injury in non-alcoholic fatty liver