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·临床诊疗提示·
慢性蝶窦炎致海绵窦血栓性静脉炎伴颈内动脉血栓形成
和多发脑梗死一例报道并文献复习
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董立朋,程金明,楚宝,刘志娟,赵景茹,李俐涛 * 查看原文
【摘要】 海绵窦血栓性静脉炎(CST)是一种罕见且可能危及生命的疾病。随着抗生素的使用,CST 的死亡率
已明显下降,尽管目前 CST 的死亡率有所改善但仍然较高,多数由误诊引起的延误治疗所致。慢性蝶窦炎致 CST 伴颈
内动脉血栓形成和多发脑梗死的病例报告较少见,但伴有颈内动脉血栓形成的 CST 可导致严重的神经系统后遗症,因
此有必要迅速识别、诊断和治疗该疾病。本文报道了 1 例慢性蝶窦炎致 CST 伴颈内动脉血栓形成和多发脑梗死,并应
用高分辨率磁共振成像明确有血管病变患者的诊治过程,结合文献回顾性分析 CST 伴颈内动脉受累的诊治及预后,并
探讨其发病机制,希望为 CST 患者的临床治疗提供更多资料及经验。
【关键词】 血栓性静脉炎;海绵窦血栓性静脉炎;蝶窦炎;颈动脉血栓形成;脑梗死;糖尿病;磁共振成像;
病例报告
【中图分类号】 R 714.625 【文献标识码】 A DOI:10.12114/j.issn.1007-9572.2022.0462
董立朋,程金明,楚宝,等 . 慢性蝶窦炎致海绵窦血栓性静脉炎伴颈内动脉血栓形成和多发脑梗死一例报道并文
献复习[J]. 中国全科医学,2022,25(27):3452-3458.[www.chinagp.net]
DONG L P,CHENG J M,CHU B,et al. Chronic sphenoid sinusitis-associated cavernous sinus thrombophlebitis
complicated with internal carotid artery thrombosis and multiple cerebral infarction:a case report and literature review[J].
Chinese General Practice,2022,25(27):3452-3458.
Chronic Sphenoid Sinusitis-associated Cavernous Sinus Thrombophlebitis Complicated with Internal Carotid Artery
Thrombosis and Multiple Cerebral Infarction:a Case Report and Literature Review DONG Lipeng,CHENG
Jinming,CHU Bao,LIU Zhijuan,ZHAO Jingru,LI Litao *
Department of Neurology,Hebei General Hospital,Shijiazhuang 050051,China
*
Corresponding author:LI Litao,Chief physician;E-mail:dingding51800@163.com
【Abstract】 Cavernous sinus thrombophlebitis(CST)is a rare disease that may be life-threatening. The overall
morbidity and mortality of CST are still high although the introduction of antibiotics has greatly promoted the reduction of them,
which mostly due to delayed treatment caused by misdiagnosis. CST with internal carotid artery thrombosis and multiple cerebral
infarction secondary to chronic sphenoid sinusitis is rare,but it is essential to rapidly identify,diagnose and treat the disease,
since it can lead to serious neurological sequelae. We encountered a patient with chronic sphenoid sinusitis-associated internal
carotid artery thrombosis and multiple cerebral infarction,identified his vascular lesions using high-resolution magnetic resonance
imaging,and discussed relevant diagnosis and treatment for him,his prognosis as well as the pathogenesis based on a literature
review,hoping to inform clinical treatment of CST patients.
【Key words】 Thrombophlebitis;Cavernous sinus thrombophlebitis;Sphenoid sinusitis;Carotid artery thrombosis;
Brain infarction;Diabetes mellitus;Magnetic resonance imaging;Case report
海绵窦血栓性静脉炎(cavernous sinus thrombophlebitis, 引起 [1] 。CST 的临床症状源自眼眶静脉引流受阻和穿过海绵
CST)是一种罕见且可能致命的疾病,通常由急性鼻窦炎感染 窦的相关脑神经受压,表现为眶周水肿、上睑下垂、眼球突
出、球结膜水肿、眼肌麻痹和视力丧失。CST 炎症从海绵窦
基金项目:国家自然科学基金资助项目(82001229);河北省 扩散到蝶鞍可影响垂体供血引起垂体功能不全 [2] 。在抗生素
重点研发计划项目民生科技专项(203777112D);河北省医学科学 之前,CST 死亡率高达 80%~100% [3] 。随着抗生素的使用和
研究重点课题(20170342)
影像学诊断的不断进步,CST 的死亡率已显著下降,尽管有
050051 河北省石家庄市,河北省人民医院神经内科 [4]
* 通信作者:李俐涛,主任医师; 所改善,但目前的死亡率仍为 20%~30% 。同时约 50% 的
E-mail:dingding51800@163.com 患者有神经系统后遗症,突出了对该疾病迅速识别、诊断和
本文数字出版日期:2022-07-14 治疗的必要性 [5] 。也正是由于抗生素的有效使用,已很少有