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·论著·
原发性甲状腺淋巴瘤的超声特征研究
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欧阳向柳 ,高蓓 ,王艳滨 ,刘丽云 ,顾程 ,郑立春 3* 扫描二维码
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【摘要】 背景 原发性甲状腺淋巴瘤(PTL)是较为罕见的结外型淋巴瘤类型,临床特征不典型,超声特征不
明显,经常被误诊和漏诊。目的 总结分析 PTL 的二维超声及超声造影声像图特征表现。方法 回顾性分析 2012 年
12 月至 2020 年 12 月唐山市工人医院收治的 16 例经病理证实的 PTL 患者(PTL 组)的超声声像图特征,并与同期收
治的 16 例甲状腺癌患者(甲状腺癌组)的超声声像图进行对比分析。结果 PTL 组病理结果:10 例为弥漫性大 B 细
胞淋巴瘤、4 例为黏膜相关淋巴组织结外边缘区 B 细胞淋巴瘤、1 例为滤泡性淋巴瘤、1 例为伯基特淋巴瘤。甲状腺癌
组病理结果:11 例为乳头状癌、4 例为滤泡癌、1 例为髓样癌。PTL 组甲状腺体积增大率(13/16)高于甲状腺癌组(5/16)
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(χ =8.127,P<0.05),病灶后方回声增强率(14/16)高于甲状腺癌组(3/16)(χ =15.184,P<0.05),钙化率(0 例)
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低于甲状腺癌组(10/16)(χ =14.545,P<0.05)。PTL 组患者中 13 例病灶形态较规则、边界清晰,甲状腺癌组中 12
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例病灶形态不规则、边界不清晰,两组的病灶形态和边界特征比较,差异有统计学意义(χ =10.165,P<0.05)。PTL
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组(7/16)和甲状腺癌组(3/16)病灶血流信号增多率比较,差异无统计学意义(χ =3.327,P>0.05)。PTL 组(8/16)
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和甲状腺癌组(11/16)颈部淋巴结转移率比较,差异无统计学意义(χ =1.166,P>0.05)。超声造影 PTL 动脉期及
静脉期多呈高增强,甲状腺癌动脉期及静脉期多呈低增强。结论 PTL 的超声表现有一定的特征性,甲状腺体积增大,
伴弥漫性极低回声病灶,无钙化,病灶形态规则、边界清晰,后方回声增强,造影动脉期及静脉期呈高增强时应考虑
为 PTL。
【关键词】 甲状腺;淋巴瘤;超声检查;超声造影;甲状腺肿瘤
【中图分类号】 R 581 【文献标识码】 A DOI:10.12114/j.issn.1007-9572.2022.02.004
欧阳向柳,高蓓,王艳滨,等 . 原发性甲状腺淋巴瘤的超声特征研究[J]. 中国全科医学,2022,25(15):
1869-1874. [www.chinagp.net]
OUYANG X L,GAO B,WANG Y B,et al. Ultrasonographic analysis of primary thyroid lymphoma[J]. Chinese
General Practice,2022,25(15):1869-1874.
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Ultrasonographic Analysis of Primary Thyroid Lymphoma OUYANG Xiangliu ,GAO Bei ,WANG Yanbin ,LIU
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Liyun ,GU Cheng ,ZHENG Lichun 3*
1.Department of Ultrasound,Tangshan Gongren Hospital,Tangshan 063000,China
2.Department of Pathology,Tangshan Gongren Hospital,Tangshan 063000,China
3.Department of Nuclear Medicine,Tangshan Gongren Hospital,Tangshan 063000,China
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Corresponding author:ZHENG Lichun,Chief physician;E-mail:nmzhenglch@163.com
【Abstract】 Background Primary thyroid lymphoma (PTL) is a rare type of extranodal lymphoma,which is prone
to misdiagnosis and missed diagnosis due to atypical clinical and ultrasonic features. Objective To summarize and analyze the
features of 2-D ultrasonography and contrast-enhanced ultrasonography in PTL. Methods A retrospective,comparative analysis
was conducted on ultrasonographic features of 16 patients with pathologically confirmed PTL (PTL group) and 16 thyroid cancer
patients (thyroid cancer group) recruited from Tangshan Gongren Hospital during December 2012 to December 2020. Results
Pathological results of PTL group:10 cases were diffuse large B-cell lymphoma,4 cases were mucous-associated lymphoid
tissue extranodular marginal zone B-cell lymphoma,1 case was follicular lymphoma,and 1 case was Burkitt lymphoma.
Pathological results of thyroid cancer group:11 cases were papillary carcinoma,4 cases were follicular carcinoma and 1 case
was medullary carcinoma. The rate of thyroid enlargement in PTL group was higher than that in thyroid cancer group(13/16 vs
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5/16)(χ =8.127,P<0.05). PTL group also had higher rate of posterior echo enhancement (14/16 vs 3/16)(χ =15.184,
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P<0.05). Besides that,PTL group had lower calcification rate(0) than thyroid cancer group did (10/16)(χ =14.545,
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P<0.05). PTL and thyroid cancer groups had statistically differences in lesion morphology and margins(χ =10.165,P<0.05)
基金项目:河北省省级科技计划基金资助项目(182777145);河北省医学科学研究课题计划基金资助项目(20201517)
1.063000 河北省唐山市工人医院超声科 2.063000 河北省唐山市工人医院病理科 3.063000 河北省唐山市工人医院核医学科
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通信作者:郑立春,主任医师;E-mail:nmzhenglch@163.com
本文数字出版日期:2022-03-17