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           PET-CT 诊断以发热待查为表现的

           早期大动脉炎的临床价值研究

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           曾克勤 ,尹玉峰,任田,周二叶,王鸣军,武剑                                                             查看原文

               【摘要】 背景 以发热待查(FUO)为表现的大动脉炎(TAK)临床并不多见,由于早期患者临床症状和体征
           无特异性,且缺乏大动脉狭窄和闭塞的影像学表现,这使得早期诊断非常困难。随着正电子发射计算机断层显像 / 计
           算机断层扫描技术(PET-CT)在 FUO 诊断和鉴别诊断中的广泛应用,其可能有助于早期 TAK 的诊断。目的 探讨
           PET-CT 在以 FUO 为表现的早期 TAK 诊断和病情评估中的应用价值。方法 回顾性分析2013年1月至2021年1月
           就诊于苏州大学附属第一医院风湿免疫科以 FUO 为表现而最终通过 PET-CT 确诊为 TAK 的 7 例患者的临床资料,包
           括临床表现、实验室检查、影像学检查及治疗转归等,并对临床资料进行总结及对近 30 年来的相关文献进行复习。
           结果 7 例患者均为女性,发病年龄 27~58 岁,平均年龄(37.9±10.6)岁;病程 1~6 个月,平均(3.9±2.4)个月。
           患者均以发热待查为表现,可伴有心悸(14.3%)、头晕(28.6%)、头痛(14.3%)、乏力(28.6%)等非特异性临床
           症状;实验室检查可见血白细胞计数(71.4%)、血小板计数(57.1%)、红细胞沉降率(ESR)(100.0%)、C 反应
           蛋白(CRP)(85.7%)、肿瘤坏死因子 α(TNF-α)(42.9%)和白介素 6(IL-6)(85.7%)升高。血管彩色多普
           勒超声、计算机断层血管造影(CTA)和磁共振血管造影(MRA)未见大动脉狭窄和闭塞,而 PET-CT 可见多部位动
           脉管壁炎症性改变,包括升主动脉(28.6%)、主动脉弓(14.3%)、颈总动脉(28.6%)、锁骨下动脉(28.6%)、胸
           主动脉(14.3%)、腹主动脉(14.3%)、肾动脉(14.3%)等大动脉。结论 PET-CT 有助于以 FUO 为表现,而无大
           动脉狭窄和闭塞的早期 TAK 的诊断和病情评估。
               【关键词】 动脉炎;大动脉炎;原因不明发热;体层摄影术,X 线计算机;诊断
               【中图分类号】 R 543.5 【文献标识码】 A DOI:10.12114/j.issn.1007-9572.2021.01.048
               曾克勤,尹玉峰,任田,等 .  PET-CT 诊断以发热待查为表现的早期大动脉炎的临床价值研究[J]. 中国全科医学,
           2022,25(8):918-923. [www.chinagp.net]
               ZENG K Q,YIN Y F,REN T,et al. The clinical value of PET-CT in the diagnosis of pre-pulseless takayasu's arteritis
           presenting as fever of unknown origine[J]. Chinese General Practice,2022,25(8):918-923.

           The Clinical Value of PET-CT in the Diagnosis of Pre-pulseless Takayasu's Arteritis Presenting as Fever of Unknown
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           Origine ZENG Keqin ,YIN Yufeng,REN Tian,ZHOU Erye,WANG Mingjun,WU Jian
           Department of Rheumatology,the First Affiliated Hospital of Soochow University,Suzhou 215006,China
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           Corresponding author:ZENG Keqin,Associate chief physician;E-mail:keqinzeng@163.com
               【Abstract】 Background Takayasu's arteritis (TAK) presenting as fever of unknown origin (FUO) is rare in
           clinic. Diagnosis is difficult in the early stageas the non-specific clinical symptoms and signs,the lack of imaging findings of
           great artery stenosis and occlusionof patients. With the wide application of positron emission computed tomography/computed
           tomography (PET-CT) in the diagnosis and differential diagnosis of FUO,it may contribute to the early diagnosis of TAK.
           Objective To investigate the application value of PET-CT in the diagnosis and condition assessment of early TAK presenting as
           FUO. Methods The clinical presentations,laboratory examinations,PET-CT findings,and treatment outcomes of 7 cases of
           TAK presenting as FUO that eventually diagnosed by PET-CT from January 2013 to January 2021were retrospectively analyzed,
           and the medical literature from 1991 to 2021 was reviewed. Results All the 7 patients were female,the age of onsetranging from
           27 to 58 years old,with an average age of(37.9±10.6) years. The course of disease was from 1 to 6 months,with an average of
          (3.9±2.4)months. FUO was the first symptom of all patients(100.0%),which may be accompanied by palpitation (14.3%),
           dizziness (28.6%),headache (14.3%),fatigue (28.6%) and other non-specific clinical symptoms. Laboratory tests

               基金项目:苏州市民生科技项目(SYSD2018084)
               215006 江苏省苏州市,苏州大学附属第一医院风湿免疫科
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               通信作者:曾克勤,副主任医师;E-mail:keqinzeng@163.com
               本文数字出版日期:2022-01-27
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