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骨质疏松与认知障碍关系的研究进展

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任昀 1，2 ，陶立元 ，范东伟 4，5，6* 扫描二维码
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【摘要】 近年研究显示，在老年共病患者中，骨质疏松与认知障碍共病的发病率逐年上升，表现为跌倒发生率
高，骨折风险增加，从而引起致残、致死率升高，严重危害共病患者的健康和生活质量，同时也给家庭和社会带来沉
重的经济负担，成为目前社区慢性病管理中较为棘手的问题。本文对骨质疏松与认知障碍关系的进展进行综述。重点
讨论骨质疏松与认知障碍的共病机制、共病临床危险因素及共病临床特征。发现骨质疏松与认知障碍关系密切，并严
重危害老年人群健康。希望本文能为探索骨质疏松与认知障碍共病新的风险因素提供思路，为有效预防和管理骨质疏
松与认知障碍共病提供帮助。
【关键词】 骨质疏松；认知障碍；认知功能障碍；骨质疏松性骨折；慢性病共病；骨 - 脑轴

【中图分类号】 R 681 R 741 【文献标识码】 A DOI：10.12114/j.issn.1007-9572.2021.01.314
任昀，陶立元，范东伟 . 骨质疏松与认知障碍关系的研究进展［J］. 中国全科医学，2022，25（11）：1406-1410. ［www.
chinagp.net］
REN Y，TAO L Y，FAN D W. Research progress on the relationship between osteoporosis and cognitive impairment［J］.
Chinese General Practice，2022，25（11）：1406-1410.

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Research Progress on the Relationship between Osteoporosis and Cognitive Impairment REN Yun 1，2 ，TAO Liyuan ，
FAN Dongwei 4，5，6*
1.Department of Obstetrics and Gynecology，Peking University Third Hospital，Beijing 100191，China
2.Center for Reproductive Medicine，Peking University Third Hospital，Beijing 100191，China
3.Research Center of Clinical Epidemiology，Peking University Third Hospital，Beijing 100191，China
4.Department of Orthopaedics，Peking University Third Hospital，Beijing 100191，China
5.Beijing Key Laboratory of Spinal Disease Research，Beijing 100191，China
6.Engineering Research Center of Bone and Joint Precision Medicine，Ministry of Education，Beijing 100191，China
*
Corresponding author：FAN Dongwei，Attending physician；E-mail：fdw@bjmu.edu.cn
【Abstract】 In recent years，studies have shown that among elderly comorbidities，the incidence of comorbidity
between osteoporosis and cognitive impairment is increasing year by year，which is manifested as a high incidence of falls and
an increased risk of fractures，which leads to disability，increased mortality，and serious harm to health and quality of life of
patients with comorbidities also bring a heavy economic burden to the family and society，which has become a more difficult
problem in the management of chronic diseases in the community. This article reviews the progress of the relationship between
osteoporosis and cognitive impairment. The focus is on the co-morbidity mechanism，clinical risk factors and clinical features of
co-morbidity between osteoporosis and cognitive impairment. It is found that osteoporosis is closely related to cognitive impairment
and seriously endangers the health of the elderly. It is hoped that this article can provide ideas for exploring new risk factors for
comorbidity of osteoporosis and cognitive impairment，and provide help for the effective prevention and management of patients
with comorbidity of osteoporosis and cognitive impairment.
【Key words】 Osteoporosis；Cognition Disorders；Cognitive Dysfunction；Osteoporotic fractures；Multiple chronic
conditions；Bone-brain axis

基金项目：国家自然科学基金资助项目（30801156，41931291）
1.100191 北京市，北京大学第三医院妇产科 2.100191 北京市，北京大学第三医院生殖医学中心 3.100191 北京市，北京大学
第三医院临床流行病学研究中心 4.100191 北京市，北京大学第三医院骨科 5.100191 北京市，脊柱疾病研究北京市重点实验室
6.100191 北京市，北京大学“骨与关节精准医学教育部工程中心”
* 通信作者：范东伟，主治医师；E-mail：fdw@bjmu.edu.cn
本文数字出版日期：2022-03-04