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·论著·
儿童期不良经历与中老年抑郁状态的相关性研究
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陆伟伟 ,朱睿 ,陈君 ,付腾飞 ,张键 ,林岳军 1 扫描二维码
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【摘要】 背景 中老年抑郁状态和儿童期不良经历(ACEs)的研究在国际上愈受重视,但以中国人群为样本
的研究仍然较少报道,需要进一步探索。目的 探索我国当前成年人群的 ACEs 发生率,研究 ACEs 对中老年抑郁状
态的影响,提供基于我国人群样本的抑郁与 ACEs 的精准画像。方法 2021 年 7—8 月,利用北京大学社会科学调查
中心主办的中国健康与养老追踪调查数据库(CHARLS)2015 年和 2018 年的截面数据,选取符合研究要求的 7 035 例
≥ 45 岁的中老年人为研究对象。根据抑郁评估量表、ACEs(虐待、忽视、不良家庭)和个体特征,从数据库中筛选
出相关问题,生成新的虚拟变量并重新赋值。以零ACEs经历的研究对象为控制组,以有ACEs经历的研究对象为处理组,
将所有协变量纳入倾向得分匹配模型,采用稳健标准误形式的多因素 Logistic 回归模型预估所有协变量的倾向得分,
按最近邻 1∶1 方法匹配控制组和处理组样本,同时进行平衡性检验和共同支持检验,评估处理组 ACEs 对中老年抑郁
状态的平均处理效应。结果 7 035 例调查对象中,6 529 例(92.81%)经历过 ACEs,1 802 例(25.61%)经历≥ 4 种
ACEs,1 003 例(14.26%)为抑郁状态。多因素 Logistic 回归模型结果显示,年龄、性别、自评健康与 ACEs 相关(P<0.05);
接下来通过倾向得分匹配模型达到控制组和处理组的个体特征无统计学差异(P>0.05),通过平衡性检验和共同支持
检验。倾向得分匹配模型结果显示,有 ACEs 比零 ACEs 导致的中老年抑郁状态发生率高出 6.9%,差异有统计学意义
(P<0.001)。结论 当前中老年群体的 ACEs 发生率居于高位水平,ACEs 可明显提升抑郁发生率,亟须建立 ACEs
筛查干预机制,提升该类人群的健康服务和福祉水平。
【关键词】 抑郁;童年不良经历;倾向得分匹配
【中图分类号】 R 749.42 R 197 【文献标识码】 A DOI:10.12114/j.issn.1007-9572.2022.0144
陆伟伟,朱睿,陈君,等 . 儿童期不良经历与中老年抑郁状态的相关性研究[J]. 中国全科医学,2022,25(10):
1191-1196.[www.chinagp.net]
LU W W,ZHU R,CHEN J,et al. Association between depression prevalence and adverse childhood experiences in
middle-aged and older people[J]. Chinese General Practice,2022,25(10):1191-1196.
Association between Depression Prevalence and Adverse Childhood Experiences in Middle-aged and Older People LU
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Weiwei ,ZHU Rui ,CHEN Jun ,FU Tengfei ,ZHANG Jian ,LIN Yuejun 1
1.Department of Rehabilitation Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China
2.Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education,School of Medicine Tongji
University,Shanghai 200092,China
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Corresponding author:ZHANG Jian,Chief physician,Professor,Doctoral supervisor;E-mail:zhang.jian@zs-hospital.sh.cn
【Abstract】 Background Depression prevalence and adverse childhood experiences(ACEs) in middle-aged and
older people has become an increasingly concerned issue,yet it in Chinese population has been less reported,and needs to be
further explored. Objective To investigate the epidemiology of ACEs among middle-aged and elderly Chinese people,and to
analyze its association with depression prevalence,providing an accurate delineation of ACEs and depression prevalence in this
group of Chinese people. Methods Information of 7 035 middle-aged and elderly people ≥ 45 years old who met the research
requirements were selected during July to August,2021 from the database of China Health and Retirement Longitudinal Study
held by Institute of Social Science Survey,Peking University,in which the questions in the Center for Epidemiologic Studies
Depression Scale used in the CHARLS,ACEs(including abuse,neglect,dysfunctional family) and individual characteristics
were screened and generated into new dummy variables with the weight reassigned. Covariates of those with ACEs(treatment
基金项目:2020 年国家重点研发计划(2020YFC2008700)——主动健康和老龄化科技应对重点专项;上海市临床重点专科项
目(shslczdzk02703)
1.200032 上海市,复旦大学附属中山医院康复医学科
2.200092 上海市,同济大学医学院脊柱脊髓损伤再生修复教育部重点实验室
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通信作者:张键,主任医师,教授,博士生导师;E-mail:zhang.jian@zs-hospital.sh.cn
本文数字出版日期:2022-03-17