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    05 April 2020, Volume 23 Issue 10
    Monographic Research
    Developing Strategies for Primary Healthcare in Times of Epidemic of COVID-19 
    FU Wei,QIN Jiangmei,HUANG Erdan,MIAO Yanqing,ZHANG Yanchun,ZHANG Lifang
    2020, 23(10):  1199-1201.  DOI: 10.12114/j.issn.1007-9572.2020.00.324
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    Primary healthcare settings are the control and prevention network basis of COVID-19 epidemic.So improving COVID-19 control and prevention,service delivery and response levels of these institutions is crucial to the national epidemic control and prevention.Based on the analysis of related field survey results as well as information from national and local official websites,we summed up the important role of primary healthcare in dealing with the epidemic.Moreover,we proposed the following priorities for primary healthcare settings in combating the complex epidemic and delivering daily healthcare services:strengthening community-based control and prevention of COVID-19,providing assistance for other institutions in combating COVID-19,implementing daily healthcare and essential public health services,ensuring medical safety and strengthening the control and prevention of nosocomial infections,and adequately playing the role in county-based healthcare network.Furthermore,developing strategies targeting the weaknesses in combating the epidemic and inadequacies in delivering daily healthcare services of primary healthcare were also put forward:strengthening the development of general practitioner system and hierarchical medical system;improving early warning sensitivity,awareness of timely report of major epidemic,and emergency response level in primary healthcare workers;enhancing the informatization construction and application in primary care using artificial intelligence and cutting-edge technologies;promoting the development of regional medical consortiums and local healthcare networks,and exploring patterns for efficiently integrating medical and prevention services;vigorously carrying out patriotic public health campaigns,strengthening the mechanism of group-based control and prevention of communicable diseases,and facilitating the construction of healthy communities and villages.
    Key points of clinical diagnosis and treatment of special types of hypertension
    Hypertension Specialist Committee of Expert Committee on Prevention and Rehabilitation of Cardiovascular Diseases
    2020, 23(10):  1202-1228.  DOI: 10.12114/j.issn.1007-9572.2020.00.221
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    Research Hotspots and Evolution on Hierarchical Diagnosis and Treatment System in China 
    WU Qinde
    2020, 23(10):  1229-1238.  DOI: 10.12114/j.issn.1007-9572.2020.00.171
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    Abstract Background The hierarchical diagnosis and treatment system has become the top priority of deepening medical reform at present, and it is particularly important to understand its research hotspots and evolution.ObjectiveTo systematically summarize the development trend and evolution process of hierarchical diagnosis and treatment system in China and grasp its knowledge base, research hotspots and development trends, in order to provide scientific reference for subsequent research.Methods China National Knowledge Infrastructure(CNKI) database was used as the data source and "hierarchical diagnosis" "hierarchical treatment" "ladder network of medical prevention" "hierarchical medical system and division of labor in blocks" "hierarchical medical and service system and division of labor in blocks" "hierarchical medical system and division of labor" "initial diagnosis in community" "initial diagnosis at grassroots level" "treating acute and chronic diseases separately" "two-way referral" "cooperation between superior and subordinate medical institutions" "different division of labor in diagnosis" "different division of labor in treatment" "orderly medical diagnosis" "orderly medical treatment" "health service system+integration" "health service system+hierarchical" and "health service system+collaboration and division of labor" were used as key words to retrieve the documents related to the hierarchical diagnosis and treatment system in China from January to July in 2019.The retrieval time was from January 1, 1949 to July 31, 2019.Excel was used to retain and analyze the data, and descriptive statistical analysis was made on the authors, titles, document sources, publishing institutions, and volume of publications of the included documents.CiteSpace was used to obtain published journals, institutional cooperation and author distribution of the research results of China's hierarchical medical system.Through the analysis of high-frequency keywords, research hotspots were identified.Through time zone maps, clustering words and emergent words, the frontiers and development trends of the research were determined.Results In the end, 1233 articles were included, and the journal with the largest number of publications were Chinese General Practice〔287(23.28%)〕.The top five journals with the most published articles were all from the core database of Peking University Library(a total of 729 articles) with more than half of the total published articles.The institutions with high yield of research results were mainly centered around Huazhong University of Science and Technology, Capital Medical University, National Health Commission, Fudan University and Peking University.There were 68 core authors with a total of 457 articles, accounting for 37.28% of the total literature."Community health service" "medical alliance" "influencing factor" and "general practitioner" had always been hot topics in the research field of hierarchical diagnosis and treatment.The clustering labels of "patriotic health movement" "hospital bed" and "outpatient", and key words of "effect evaluation" "influencing factors" and "medical treatment" appeared from 1949 to 1978.The clustering labels of "medical treatment" and "medical insurance system", and key words of "community health service" "two-way referral" and "community health service institution" appeared from 1979 to 2008.The clustering labels of "grassroots medical and health institution" "combination of medical and nursing care" "medical service system" and "medical insurance", and key words of "medical service system" and "hierarchical diagnosis and treatment" appeared from 2009 to 2018.Conclusion The increase rate of literature of China's hierarchical diagnosis and treatment system is accelerated, but the quality of research results need to be further improved.There are a lot of cooperation among institutions, but the cooperation and communication among authors are limited, and no stable core author group has been formed.The research hotspots are gradually diversified and the research directions are continuously refined. How to find a new way of innovation from the institutional level through closer communication and collaboration is worthy of further study.

    Key wordsHierarchical diagnosis and treatment;Research hotspots;Research evolution;Bibliometrics

     

    The hierarchical diagnosis and treatment system refers to the hierarchical of diseases according to the severity of diseases and the difficulty of treatment. Medical institutions of different levels undertake the treatment of different diseases, forming a diagnosis and treatment order of "primary treatment at the grassroots level, two-way referral, separation of urgent treatment and slow treatment, and linkage of upper and lower levels". Under the hierarchical diagnosis and treatment system, the general outpatient services, rehabilitation and nursing services undertaken by large and medium-sized hospitals are transferred to primary medical and health institutions, resulting in the decline of medical resources[1]. The hierarchical diagnosis and treatment system is an important issue in deepening the medical reform in China. The implementation of this system is conducive to the maximum efficiency of the use of health resources, the refinement of patient services and the guarantee of everyone's access to basic medical services.

    The system of hierarchical diagnosis and treatment has long been formed in foreign countries. The United Kingdom is one of the early representatives who strictly practiced the system of hierarchical diagnosis and treatment. The National Health Service Act was enacted in 1948 and the National Health Service (NHS) was established[2]. The United States is the world's typical representative of medical marketization, effectively forming a hierarchical medical treatment model through the medical insurance system[3]. Canada implements strict hierarchical diagnosis and treatment, and patients cannot go to secondary medical service institutions without the recommendation of family doctors[4]. Chinese scholar Yang et al.[5-6] published a series of literature on China's medical reform in the Lancet, pointing out that the disease spectrum in China has changed significantly in the past 30 years, from the former infectious diseases and perinatal diseases to chronic non-infectious diseases. The effective strategy to deal with the current situation is to establish a good hierarchical diagnosis and treatment system. Combined with the research results of many scholars, the General Office of the State Council issued the Guiding Opinions on Promoting the Construction of the Hierarchical Diagnosis and Treatment System in 2015 (Guo Ban Fa [2015] No. 70), which marked that the hierarchical diagnosis and treatment system officially became the most important starting point for deepening the medical reform and became the key to the success or failure of the new medical reform. Therefore, it is necessary to comprehensively grasp the past, present and future of the research on hierarchical medical system. Based on this, this paper, from the perspective of bibliometrics knowledge map, sorted out the journals and literatures in the research field of hierarchical diagnosis and treatment system, clarified the development trend and evolution process of the research, analyzed the research hot spots and cutting-edge research results in this field, and provided scientific reference for future research.

    1       Materials and methods

    1.1  Literature search

    From January to July 2019, CNKI database will be used as the data source. The concept of the hierarchical system in the early call "ladder network of medical treatment, prevention and health care", 1954 years later changed to "blocks hierarchical division of medical service system", the eighteenth big used to call it the "community first option" first option "base layer" "two-way referral" “hierarchical health", after the new reform according to connotation points level diagnosis system is called" the first option at the grass-roots level, two-way referral, acute slow partition, the upper and lower linkage ", through literature reading, found "division of diagnosis and treatment" "division of medical" orderly "medical" orderly "diagnosis" "integration of medical service system" "medical treatment organization collaboration" similar to "hierarchical diagnosis and treatment". To sum up, in order to ensure the accuracy and comprehensiveness of literature retrieval, with "hierarchical diagnosis" "points level medical" "ladder medical prevention network" "blocks hierarchical division of medical system" "row area hierarchical division of medical service system" "hierarchical division of medical system" first option "community" "first option at the grass-roots level", "urgent slow divide and conquer" the "two-way referral" "the upper and lower linkage" "division of diagnosis and treatment" "division of medical" orderly "medical" "orderly clinical therapy" "health service + integrated" "+ hierarchical of health service system" "the medical treatment organization + collaboration" as the keyword search, retrieve the entry for "main topic", The retrieval time is set to 1949-01-01 to 2019-07-31.

    1.2  Inclusion and exclusion criteria

    Inclusion criteria :(1) literature related to hierarchical treatment system; (2) Literature is in Chinese; (3) Literature types are journal papers. In order to ensure the quality of research, journal sources are Science Citation Index (SCI), Engineering Index (EI), Chinese Core Keys General of Peking University, and Chinese Social Sciences Citation Index. CSSCI) and Chinese Science Citation Database (CSCD). Exclusion criteria: excluded newspapers, conference abstract literature, newspaper and periodical report literature, diagnosis and treatment guidelines, thematic discussion, exclusive interviews and abstract irregularities, invalid institutions, lack of authors, and literature unrelated to the research topic.

    1.3 Literature screening, data extraction and quality assessment

    Data were stored in RefWorks and Excel format, and literature was manually sorted and screened. During literature screening, the papers with the same name, author, journal and publication time were defined as repeated papers, which were combined into one included study. Replicative screening was performed by the investigator and checked two weeks later. After the articles are checked, literature screening is strictly carried out according to the inclusion criteria and exclusion criteria.For the controversial literatures, whether to be included or not is determined after discussion with relevant personnel.For the literature included in the study, the researchers extracted the article information and made further econometric analysis.

    1.4Statistical Methods

    Excel was used to retain and analyze the data, and descriptive statistical analysis was conducted on the information of the included literature, such as author, title, literature source, publication organization, publication volume, etc. Scientific knowledge map in literature metrology, information metrology and metrology is widely used in fields such as, not only can through the visual way to show a certain source of scientific knowledge in the field of research, development, knowledge architecture and research frontier of literature can be effectively mining hidden characteristics, patterns and trends, as the research in the field of a scientific knowledge to provide a unique perspective[7].CiteSpace was prepared for America's Drexel University computing machines and information science beauty professor Chen information of visual software developed by using Java language, as the world's emerging scientific knowledge map drawing tools, in acquiring knowledge in the field of research foundation, research frontier and hot spots, analysis and research fields of scientific knowledge structure, insight into the evolution process, etc., have the computing power and force[8]. Therefore, in this paper, RefWorks format data were imported into CiteSpace(version :5.3.R4.8.31.2018) for analysis to obtain the journals, institutional collaborations and author distribution of the research results of China's hierarchical medical system. Through the analysis of high-frequency keywords, the hot research areas are determined. Through time zone diagram, cluster words and emergent words, the research frontiers and development trends were determined.

    2       Results

    2.1 Literature retrieval results

    At first, 1685 records were retrieved from the database, and 452 literatures were removed by the literature de-merging and inclusion and exclusion criteria, finally 1233 valid literatures were obtained.

    2.2 Publication time and quantity distribution of included literatures

    After sorting out 1233 literatures, the detailed number and growth trend of literatures on the research of China's hierarchical medical system from 1949 to 2019 were obtained, and the cumulative number of literatures increased in the form of approximate exponents over time. Among them, the number of published articles from 1949 to 1978 was less, with a total of 19. From 1979 to 2008, the number of papers published showed an increasing trend (from 1 to 30), and 142 papers were published in total. From 2009 to 2018, the number of papers published increased rapidly (from 48 to 233), with a total of 992 papers published (Figure 1).

    2.3 Distribution of published journals, cooperative institutions and authors on the research of China's hierarchical medical system

    2.3.1 Distribution of published journals on the research of China's hierarchical medical system

    The top 5 journals in the list of published articles were: Chinese General Practice (287 articles, 23.28%), Chinese Hospital Management (137 articles, 11.11%), Chinese Health Economy (126 articles, 10.22%), Chinese Health Service Management (98 articles, 7.95%), and Health Economy Research (81 articles, 6.57%). Among the top 15 published journals, 9 journals belong to the source journals of Peking University's Chinese Core Periodical Contents, 4 journals are from CSCD, 2 journals are from the database of Japan Agency for the Promotion of Science and Technology (JST), and no CSSCI. The top 5 journals were all from the General Catalogue of Chinese Core Journals of Peking University, with a total of 729 articles published, more than half of the total (Table 1).

     

    Table 1 Distribution of source journals on hierarchical diagnosis and treatment system in China from 1949 to 2019(top 15)

    Ranking

    Journals

    Number

    Percentage

    Source

    1

    Chinese General Practice

    287

    23.28

    Core of Peking University

    2

    Chinese Hospital Management

    137

    11.11

    Core of Peking University

    3

    Chinese Health Economics

    126

    10.22

    Core of Peking University

    4

    Chinese Health Service Management

    98

    7.95

    Core of Peking University

    5

    Health Economics Research

    81

    6.57

    Core of Peking University

    6

    Chinese Journal of Health Policy

    60

    4.87

    CSCD

    7

    Medicineand Philosophy

    37

    3.00

    JST

    8

    Modern Preventive Medicine

    27

    2.19

    Core of Peking University

    9

    Medicine and Society

    24

    1.95

    Core of Peking University

    10

     Chongqing Medicine

    24

    1.95

    JST

    11

    Chinese Health Resources

    24

    1.95

    Core of Peking University

    12

    Chinese Journal of Public Health

    15

    1.22

    CSCD

    13

    Chinese Nursing Management

    13

    1.05

    CSCD

    14

    Chinese Journal of Health Statistics

    9

    0.73

    CSCD

    15

    Population and Family Planning

    8

    0.65

    Core of Peking University

    Note: Core of Peking University=General Overview of Chinese Core Keys of Peking University, CSCD=Chinese Science Citation Database, JST=Japan Science Technology Corportion

     

    2.3.2 Distribution of cooperation institutions in China's hierarchical medical system research

    The refining statistics of 1233 literatures were carried out according to the sources of research institutions, and the data was imported into CiteSpace software. Institutions in Node Types were selected, Pathfinder algorithm was selected, and other options were set as the default. In the output results, the circular coverage area (represented by the font size of the research institution) represents the occurrence frequency of the author's signature institution. The larger the area, the higher the occurrence frequency. The lines between the circles represent the cooperation between institutions. The lines are directly proportional to the frequency of cooperation, and the line nodes are the cooperation centers.

    The hierarchical system in the country study the distribution of productive organizations, mainly including Agencies group 1: Huazhong university of science and technology, Tongji medical college medical institute of medicine health management as the core, and has cooperation withthe humanities and social science in Hubei province key research base of rural health services research center, Nanjing institute of major medical study medicine administration, according to the righteous medical school, school of management, Hubei university of political science and law and public management institute, China university of science and technology in school of economics, Huazhong university of science and health policy and management research institute (think-tank), Shenzhen Guangming New District Gongming Hospital, School of International Medicine, China Pharmaceutical University, etc..Agencies group 2:School of Health Management and Education, Capital Medical University and Health Development Research Center of the former National Health and Family Planning Commission as the core, and has cooperation withthe National health committee, the original Beijing Municipal Commission of Health and Family Planning, the original Health and Family Planning Commission of Heilongjiang Province, the original Health and Family Planning Commission of Heilongjiang Province, School of Public Administration, RenMinUniversity of China, Beijing DitanHospital, Beijing Children's Hospital, Capital Medical Universit, Beijing Xicheng District Community Health Service Management Center, Weifang Medical UniversitySchoolOf Public Health, YouJiangMedical UniversityforNationalities, Chinese Academy of Medical Sciences Institute of Medical Information, andsoon. Institutional Cooperation Group 3: With School of Social Development and Public Policy of Fudan University as the core, cooperated with School of Public Health of Fudan University and former Health and Family Planning Commission of Changning District, Shanghai, etc. Institutional Cooperation Group 4: China Health Development Research Center of Peking University asthe core, and has cooperated with School of Public Health of Peking University, etc. (Figure 2).

    2.3.3 Distribution of authors in the study of China's hierarchical medical system

    The refining statistics of 1233 literatures were conducted according to the core authors and the cooperation between authors. Data was imported into CiteSpace software, Author in Node Types was selected, Pathfinder was selected by the algorithm, and other options were set as the default. The results of the core authors (the first 22) are shown in Table 2, and the cooperation among authors is shown in Figure 3.

    Due to the limitation of software function, the published statistics of authors cannot be identified as the corresponding author or the first author for the time being. Therefore, there may be cumulative studies in the research field of the hierarchical diagnosis and treatment system in which the author has published articles other than the corresponding author or the first author. Statistical analysis showed that the cumulative number of papers published by the most scholars was 26. According to the "square root law" proposed by Price, the number of core authors in a research field can be determined. The formula is:N=0.749×nmax

    Table 2 Distribution of core authors of the study on hierarchical diagnosis and treatment system in China from 1949 to 2019(top 22)

    Ranking

    Author

    Frequency

    Organization

    Ranking

    Author

    Frequency

    Organization

    1

    Zhang L

    26

    Huazhong University of Science and Technology

    12

    Miao C X

    9

    Xuzhou Medical University

    2

    Fang P Q

    19

    Huazhong University of Science and Technology

    13

    Wang C X

    9

    Tongji University

    3

    Zhang Y

    18

    Huazhong University of Science and Technology

    14

    Zhen J

    8

    Xuzhou Medical University

    4

    Feng Z Y

    13

    Chongqing Medical University

    15

    Liang H

    8

    Fudan University

    5

    Qian D F

    11

    Nanjing Medical University

    16

    Li H H

    8

    Xuzhou Medical University

    6

    Gan X Q

    11

    Jiujiang University

    17

    Lei G H

    7

    Guangdong Medical University

    7

    Kuang L

    10

    Sun YAT-SEN University

    18

    Tao H B

    7

    Huazhong University of Science and Technology

    8

    Zhuo L

    9

    Xuzhou Medical University

    19

    Du X P

    7

    Fuxing Hospital

    9

    Zhao S H

    9

    Xuzhou Medical University

    20

    Luo L

    7

    Fudan University

    10

    Jiang J X

    9

    Xuzhou Medical University

    21

    Zhang T T

    7

    Fudan University

    11

    Lu Z X

    9

    Huazhong University of Science and Technology

    22

    Dai R M

    7

    Fudan University

     

    2.4 Research hotspots of China's hierarchical medical system

    The research hotspot is usually the common concern of the closely related and numerous literatures in a certain period of time. Key words are the author's highly condensed research content, which can well reflect the core content of the article. Therefore, through the statistical analysis of the frequency of the occurrence of key words, we can well grasp the research hot spots in this field.[10]Review found that couplet of "medical" and "medical association", "impact factor" and "factor analysis" as a concept, the number of high frequency can be stacked, so, after finishing the data import CiteSpace software, select the Node type (Node Types) of keyword (Key word), algorithm selection Pathfinder and Pruning sliced networks, and other options in accordance with the default Settings. The hot point knowledge map of China's hierarchical diagnosis and treatment system was obtained. The larger the font in the map, the higher the frequency of the keyword.The results showed that the top five keywords were community health service (364 times), influencing factors (337 times), medical confederation (243 times), general practitioner (185 times), and effect evaluation (152 times).In terms of centrality value, the top five centrality were "community health services" (0.24), "medical confederacy" (0.22), "influencing factors" (0.19), "medical insurance" (0.13) and "general practitioner" (0.12), besides "hierarchical diagnosis and treatment" and "two-way referral", which were the strongest research topics.In terms of outbreak points, the top five hot spots were "influencing factors" (69.59), "community health services" (42.28), "effect evaluation" (37.29), "general practitioners"(28.58), and"medical association" (10.15).Thus, "community health services", "medical confederacy", "influencing factors" and "general practitioners" have always been hot terms in the research field of hierarchical diagnosis and treatment (Figure 4).

    It is important to note that the sequence and the sequence of the centricity can be found by comparing the keywords, the sequence of the part of the word frequency is not high but the sequence of the centricity is higher, mainly for: "medical service system", "diabetes" "medical resources" "primary health care, " "family doctor service contract", "healthy China" shows that a lot of research around the health under the background of China, the family doctor to sign, chronic diseases, between the hospital and community medical institution reform research.

    2.5 Evolution of China's hierarchical medical system

    To overall analysis our country the hierarchical system research in the field of knowledge base structure and the evolution process, in this paper, the Time in a 1233 documentary by CiteSpace software - zone view, select 10 years as a Time section display keywords network node the structural relationships change over Time, and according to the automatic clustering graph clustering algorithm, using the logarithmic likelihood ratio algorithm to extract clustering tags, and the top 10 emergence nouns.

    The results show that "patriotic health movement", "bed" and "outpatient" cluster labels appeared from 1949 to 1978. From 1979 to 2008, "medical treatment" and "medical insurance system" cluster labels appeared. From 2009 to 2018, "primary medical and health institutions", "combination of medical and nursing care", "medical service system" and "medical insurance" cluster labels appeared (Figure 5). From 1949 to 1978, the key words "effect evaluation", "influencing factors" and "medical treatment" appeared. From 1979 to 2008, "patient", "community health service", "two-way referral" and "community health service institution" appeared. From 2009 to 2018, "hierarchical medical care", "medical service system" and "hierarchical diagnosis and treatment" appeared (Figure 6).

    3 Discuss

    3.1 Research literature characteristics analysis of China's hierarchical medical system

    Combined with the changes of China's social and economic system, medical service system and the implementation of relevant policies, it can be divided into three stages. (1) Initial exploration stage (1949-1978): This stage was the planned economy period at the beginning of the founding of the People's Republic of China. The country implemented the "medical service system based on regional division of labor" and initially formed the hierarchical diagnosis and treatment pattern. However, there were few relevant literatures, with an average of no more than one paper per year. (2) Stable rise stage (1979-2008): This stage was from the early stage of China's reform and opening up to the early stage of the new medical reform. China's hierarchical diagnosis and treatment experienced a process from becoming loose to re-exploring and returning. Therefore, the number of relevant research literatures increased year by year and showed a steady rise trend, reaching a peak of 30 in 2008. (3)Rapid development stage (2009-present): After the new medical reform in 2009, the government put forward the importance of hierarchical diagnosis and treatment again, and took it as an important push to deepen medical reform in 2015. Therefore, the number of literatures at this stage showed a rapid rise. Especially after 2015, the number of articles published each year was basically maintained at more than 100, and the annual average number of articles was 185.

    3.2 Analysis of high-yield journals, institutional cooperation and author distribution in China's hierarchical medical system

    In terms of the distribution of high-yield journals, although the journals in their research fields have disadvantages in academic circles, it also reflects to some extent that the research results of hierarchical diagnosis and treatment in China need to be further strengthened and improved.

    Look from distribution agencies, the health administrative organization (government actors) and government research institutions, medical institutions, schoolsresearch institution, interest groups (health services organizations, such as hospitals, community health service centers) actively involved in the hierarchical system research, and constitute the main body of research in colleges and universities, academic cooperation broke the traditional disciplinary boundaries, to promote the progress and development of the hierarchical system research.

    Core author refers to a scholar who has great influence and plays an important role in a certain research field. Scientific research is often a team activity, and most articles are completed through collaboration among authors. Authors learn from each other's strengths to improve the depth and breadth of research.[11] Therefore, it is very important to analyze the distribution of cooperation between the core authors of the literature.According to the statistical results, the total number of core authors is less than half of the total number of papers, it can be concluded that China has not formed a stable core group of authors in the research field of the hierarchical diagnosis and treatment system.

    From the perspective of the distribution of cooperation among authors, the cooperation and communication among the authors of the research on the system of hierarchical diagnosis and treatment is relatively limited, and the cooperative groups formed are more frequent within the group and less among the groups, which is not conducive to the improvement of the research level of hierarchical diagnosis and treatment, which may be related to the different research points of different authors. At present, a group of authors with Zhang Liang, Fang Pengqian, Lu Zuxun, Wang Chaoxin, Zhuo Lang and Liang Hong as the core has been formed in domestic research. Zhang Liang's team from the School of Health Management, Tongji Medical College of Huazhong University of Science and Technology mostly studies the hierarchical diagnosis and treatment system from the perspective of township and county medical institutions. Fang Pengqian's team from the Institute of Health Policy and Management of Huazhong University of Science and Technology mainly studied the hierarchical diagnosis and treatment system from the perspective of medical association, "three-medical linkage" and public hospitals. Lu Zu Xun's team from the School of Public Health, Tongji Medical College, Huazhong University of Science and Technology (HUST) mainly discusses from the perspective of "community first diagnosis".

    Wang ChaoxinfromTongji university school of medicinehas cooperation with both research network, one is with Luoli, Baige and Zhang tian-tian from Fudan university school of public health, focused on clinics, rehabilitation and long-term care shunt hierarchical diagnosis and related studies.

    The other is the cooperation with the affiliated hospital of Tongji University, mainly studying the status quo of bidirectional referral criteria for hypertension, the systematic evaluation of the status quo ofhierarchicaldiagnosis and treatment in Shanghai and explore the three-dimensional collaborative mode of regional health based on hierarchical diagnosis and treatment.Zhuo Lang from Xuzhou Medical University and other researchers mainly studied hierarchical diagnosis and treatment from the awareness rate and willingness of residents (demanders) in Xuzhou. Liang Hong's team from the School of Social Development and Public Policy of Fudan University conducted research from the perspectives of "medical association" and "contract system of family doctors".

    3.3 Evolution analysis of China's hierarchical medical system

    According to the above three development stages (initial exploration stage, steady rise stage, and rapid development stage), and the analysis of the key node literature, influential literature, published authors and other information in each stage, the research evolution and development trend of this research field in the past 70 years can be revealed.

    3.3.1 Initial Exploration Stage (1949-1978)

    In the early days after the founding of the People's Republic of China, the state put forward the "ladder medical prevention network", which was later the "medical service system based on district division and division of labor", which was adopted at the National Health Conference in 1956 after being tested in some provinces and cities.This system is mainly for the convenience of the masses to go to a doctor nearby, to overcome the crowded and busy phenomenon of large hospitals and improve the quality of medical treatment, through the unified layout planning, the province, city, county (district) three level hospitals and grass-roots medical and health institutions organically constitute the medical and health network, according to the regional hierarchical division of labor and business guidance contact. Countries in this time period also released the measures for the implementation of the national worker medical treatment to prevent (1952), the Ministry of Finance, the ministry of health on consolidation and strengthening medical treatment management work notice (1978), the articles of association of rural cooperative medical care system (1979), such as file requirements shall, first of all, in the patients with medical institutions, adhere to strict referral program, without approval and referral referrals, unable to get the reimbursement. The government has set up a three-tier medical system in urban and rural areas. The health care system is centered on "primary health care". The health care system is fully funded by the government, and the government implements the public health care system for government organs and public institutions, the enterprise labor insurance medical system, and the rural cooperative medical system. [12] During this period, "blocks hierarchical division of medical service system" and the planned economy system, under the condition of the weak economy, through three more strict control of medical treatment insurance, under the condition of ensure the basic medical services a "specified type to see a doctor", promote the vaccine to eliminate pests, in order to control the disease such as smallpox, malaria, schistosomiasis, quickly improve the health level of the masses, form a pattern of essentially the hierarchical of diagnosis and treatment, known by the world health organization (who) as the model of medical and health system.[13]

    Stage of the academics around the effect of "blocks hierarchical division of medical service system", solve the problem of outpatient crowded, how to do a good job of prevention and management under the system of "socialized medicine" to save medical resources, avoid the waste of medical insurance funds aspects are studied, thus the dash forward show the noun "influencing factors", "performance evaluation" clustering words "patriotic health campaign" "bed" "outpatients.The Cai Hengfang[14] is introduced using scribing point of Beijing, reorganization of medical institutions, to set up similar couplet of the medical model of medical institutions between the superior and the subordinate business leadership, we must adjust the relationship between health and propaganda education way to carry out the hierarchical division of medical treatment, can solve the problem of uneven hospital busy idle, to facilitate the masses to go to a doctor, improving medical technology level, promote the purpose of prevention work.LiuShao-zhu[15]put forward "three long and one short" problem should be deal with hospital executive blocks hierarchical division of the medical system to improve the medical order, and to all levels of different kinds of tasks should be different and collaboration with each other, form an organic whole, help grassroots health institutions will assume the task of common frequently-occurring disease, convenient to the masses, to the nearest according to undergo, alleviate the problem of large hospital outpatient medical consultations.Sun Jiaxian[16]consider that in Heilongjiang province after the implementation of "blocks hierarchical division of medical service system", is beneficial to improve the level of hospital management and medical quality, to give full play to the potential factory enterprise systems such as hospital, to establish policy of medical order and step by step business technical guidance, to mobilize the enthusiasm of the grassroots health institutions, put forward the system can be implemented in the country and shall establish the national medical college center, establish the national urban and rural medical and health web.In order to solve the problem of overspending on public health care, Huang Yun[17] believed that the main reason is that there are deficiencies in management, such as lax control of treatment, referral and reimbursement procedures, and that medical institutions do not grasp the principles of treatment, leading to the occurrence of more prescriptions and more inspections.Liu Ruiqing[18] believes that the "partition package, classification of responsibility", which not only ensures the treatment and can overcome the problem of medical institutions just treatment regardless of saving, strict implementation of hospitalization, hospital transfer, hospitalization system to reduce unnecessary medical costs, strict investigation of the side and financial accounts, etc.Hua Ying[19] pointed out that preventive health care is the most effective way to save medical costs, and management, treatment and health care should be combined. Patients who need to be referred should go to a designated hospital for treatment, and patients who need to be referred should have a letter of referral before reimbursing medical expenses.From 1949 to 1978, the practice of medical confederacy had been established, and some scholars proposed to establish several specialized medical centers throughout the country. However, in general, there were not many research achievements in this field during this period, and it has not been widely concerned by researchers.

    3.3.2 Stable rising stage (1979-2008)

    During this period, from China's reform and opening up to the early stage of the implementation of the new medical reform, the hierarchical diagnosis and treatment system experienced a process from loosening to being reexplored. The market-oriented transformation of China's social and economic system has promoted the market-oriented transformation of the medical and health system, and the hierarchical diagnosis and treatment model has been impacted. Under the competition mode, hospitals are getting stronger and stronger due to the more resources they occupy, the function orientation is gradually blurred, and the service ability of primary medical and health institutions is gradually reduced. The economic recovery has released people's demand for medical services, and the reconstruction of the three major medical insurance systems has increased patients' choice of medical treatment, prompting patients to flock to large hospitals, forming a "free choice" medical treatment mode. The hierarchical diagnosis and treatment pattern has been completely broken, and the flow of medical treatment presents an "inverted pyramid" pattern. With the increasingly prominent problems of difficult and expensive access to medical services, the poor performance of the market-oriented reform of the medical system and the serious problems of disordered medical treatment, the state began to pay attention to the construction of primary medical care. In 1999, the former Ministry of Health issued Several Opinions on the Development of Urban Community Health Services (Weiji Women [1999] No. 326), which put forward the guideline of strengthening the capacity building of primary medical services. In 2006, the State Council promulgated the Guiding Opinions of the State Council on the Development of Urban Community Health Services (Guo Fa [2006] No. 10), which proposed for the first time in the state document to "establish a system of hierarchical medical treatment and two-way referral, and explore the pilot of community first-visit system". In 2007, as the former Ministry of Health launched the two-way referral hierarchical diagnosis and treatment system to alleviate the problem of difficult and expensive medical treatment, the idea of hierarchical diagnosis and treatment became clear [12-13].

    At this stage, the number of research results began to increase gradually, reaching 30 by 2008, and the research in this field began to become active. At this stage, scholars mainly focus on the research on whether the "medical service system of zoning and grading division of labor" is in line with the current stage of development, the hierarchical management and evaluation of hospitals, the construction of medical confederacy, the new three major medical insurance, and the research on community medical institutions and two-way referral after re-exploration. Because of this, the key node of "two-way referral" and the cluster words of "community health service" and "medical insurance system" appear. In terms of research methods, they mainly focus on theoretical discussion, questionnaire survey, interview, empirical analysis and descriptive statistics.

    With the convening of the Third Plenary Session of the Eleventh Central Committee in December 1978, China established the development direction of economic construction as the center, and the medical and health field also moved toward marketization, and the "medical service system of zoning and grading division of labor" had some contradictions with the current development. In 1984, Zhou Shouqi[20] published the article "Question on Medical Service in Zoned Areas", which affirmed the positive role of the zoned medical service system with hierarchical division of labor, but also pointed out its existing contradictions: with the improvement of people's living standards, the demand for preferential medical treatment increases; Competitive pressure is beneficial to the improvement of medical level of medical institutions, so the autonomy of medical treatment units should be opened up. Nearby medical treatment rather than zoned medical treatment can be more convenient for people to see a doctor; With the increase of specialized demand, many patients cannot be covered "systematically and comprehensively" by zoned hospitals. The basic reason is that the "medical service system based on division of labor by district and level" does not adapt to the development of social demand at the present stage, so necessary adjustment and reform should be carried out. The author believes that a more flexible hierarchical form of "selective medical treatment" can be realized from the aspects of public opinion survey, developing its own technical characteristics, and carrying out two-way referral. During this period, all kinds of medical couplet body construction began to flourish, LiuTie-jun[21]use"xiao cui find diagnosis" as a guide, put forward implementation steps, the medical care system is the necessity of couplet of "medical" construction, through the large hospital and small and medium-sized hospital established cooperation relations, not only will bypass patients, alleviate the pressure of the large hospital beds tight, also make the small and medium-sized hospital doctors medical technology level, incalculable to the promotion of social benefit.HuaZu-xing[22] pointed out such as Shenyang in 1984 created the first "consortium", becausethe medical association has the advantages of voluntary combination, flexible cooperation mode and so on,  by the year 1988 has developed 238 (including 35 and other provinces and cities). While " medical treatment alliance " has brought benefits in various aspects, some problems such as blind association, simple pursuit of economic benefits and disguised charge for improper examination have also appeared.At the same time, he believed that the existing loose type of medical confederations with technical cooperation as the main body will transition and develop into intensive medical groups, from technical cooperation to entity joint management.In June 1989, Zhou Qi[23] published "On the Implementation of Hospital Evaluation and Hierarchical Management System" in Management World. He proposed that, based on the experience of foreign advanced developed countries and China's national conditions, hospitals should implement a hierarchical management system, which could be divided into three levels corresponding to the corresponding institutions, functions and tasks.In November the same year the ministry of health issued "hospital classification management method (trial draft), the hospital according to the function, task, facilities, technology and medical quality integrated level is divided into three ten hierarchical management etc., the ministry of health issued"planning and guiding principles of the establishment of medical institutions"in 1994, put forward to set up the levels clear, structure is reasonable, function in three level hospitals, set up suitable for the situation of medical and two-way referral framework.During this period, a large number of articles on hospital hierarchical management and evaluation have also emerged. Since 1998, China's medical security system has undergone great reform. The basic medical insurance system for urban employees (1998), the new rural cooperative medical system (2003) and the basic medical insurance system for urban residents (2007) have been established successively.Tan Shen-sheng[24] believes that with the deepening of the reform of the urban medical insurance system, the autonomy of the masses in medical treatment is released, which leads to the flow of patients to large hospitals, leading to overcrowding in large hospitals while small hospitals are deserted. Community health services should be vigorously developed to provide convenient, continuous, comprehensive, coordinated and cheap health services.Analysis from the perspective of literature cited frequency, the highest amount of the citedwas Li Xiaoxiao[25] from Renaissance hospital affiliated to the capital university of medical sciences, published in the Chinese General Practiceof "The problems and countermeasures of dual referral system in China", in contrast to foreign two-way referral implementation present situation, proposed our country two-way referral is the easy to the difficult, lack of referral standards, incentive and constraint mechanism, market economic system under the conflict of economic interests, community hospital service ability is weak, the information sharing between the difficult problems, such as medical institutions.Followed by Qi Xiaolin[26]from health management and policy research center of Shandong university published "On obstacle and countermeasure of community health services in China". She believed that China's community health services were still in the primary stage, and there were still some problems, such as the uncoordinated technical level of general practitioners, the incomplete "six-in-one" function, and the imperfect two-way referral system, compensation mechanism and medical insurance system.

    3.3.3 Rapid development stage (2009 to present)

    In April 2009, the CPC Central Committee and the State Council issued the Opinions on Deepening the Reform of the Medical and Health System (Zhongfa [2009] No. 6) to start a new round of medical reform, which defined the policy framework of hierarchical diagnosis and treatment. In 2014, Premier Li Keqiang proposed to improve the hierarchical diagnosis and treatment system, strengthen the training of general practitioners, promote the practice of doctors in multiple locations, so that the public can enjoy quality medical services nearby. However, due to the impact of two lines of income and expenditure, unreasonable performance-based pay, drug allocation restrictions and other factors, the implementation of the hierarchical diagnosis and treatment system has little effect.[12-13] In September 2015, the State Council general office issued the guidelines on promoting the construction of the hierarchical system "(Issued by the State Council Office [2015] NO.70), points out that to establish the hierarchical system is deepening medical and health system reform, to establish an important content of basic medical and health care system with Chinese characteristics, has been clear about the evaluation standard and the 2020 goals in 2017.In 2016, the National Health and Family Planning Commission issued the Notice on the Pilot Work of the Hierarchical Diagnosis and Treatment of Hypertension and Diabetes (No. 1026 [2015] of the National Health Office), which defined the key tasks of the hierarchical diagnosis and treatment of hypertension and diabetes, and regarded its prevention and management as the breakthrough point to promote the establishment of a new hierarchical diagnosis and treatment mode.In August 2016, the CPC Central Committee and the State Council held the first National Conference on Health and Health since the 21st century, and the hierarchical diagnosis and treatment system ranked first among the five basic medical and health systems.In April 2017, the General Office of the State Council issued the Guiding Opinions on Promoting the Construction and Development of Medical Consortium (Issued by the State Council Office [2017] No. 32), making it clear that by the end of 2017, all tertiary hospitals in China will participate in the construction of medical consortium. By the end of 2020, all secondary hospitals and government-run primary medical and health institutions will participate in the medical association.[12-13]

    At this stage, the academic community has increasingly in-depth research on the system of hierarchical diagnosis and treatment. The number of journals published has increased from 48 in 2009 to 233 in 2018, with a nearly five-fold increase. Especially after 2015, the annual research results have exceeded 100, which is related to the fact that the hierarchical diagnosis and treatment has become the key to the success or failure of the new medical reform and has been attached great importance to at the national level."Combination of medical care", "basic health care mechanism" and "medical service system" are cluster words in this stage. A medical and health service system with clear functional orientation and good cooperative relationship among institutions is the basis for realizing hierarchical diagnosis and treatment.In order to effectively deal with the aging problem, the combination of medical care and nursing care must be supported by the hierarchical diagnosis and treatment. One of the key points of the success of the hierarchical diagnosis and treatment is whether the grassroots health service institutions can be revitalized.Have sprung up in this stage, from the planned behavior theory, signal theory, system theory, grounded theory, the social division of labor theory, stakeholder theory, game theory and the theory of incentive compatibility, integration theory, bilateral matching theory, platform, the Angle of theory, the expectancy theory of couplet of hierarchical diagnosis and treatment of medical doctor two-way referral behavior, family doctor contract mechanism, and two-way referral factors such as research.Look from the research content, main from the supplier (medical institutions), the buyer (patients, the masses) satisfaction, recognition and its influencing factors, couplet of implementation path exploration, especially in medical, family doctors to sign pattern more in-depth research, comparison of diagnosis and treatment system at home and abroad, discusses hierarchical diagnosis and to study the related system and mechanism to build relationship;In terms of research methods, it is no longer limited to using questionnaire survey, interview, empirical analysis, descriptive statistics and other methods, but also adds operational research, econometrics and other management engineering methods. In general, this period is more diversified in terms of research theory, research content and research methods.

    From the perspective of the literature cited frequency, cited the highest amount is FuQiang[27] at the National institutes of health committee of the hospital management in 2016, published in the Chinese Health Economics titled “Strategic choice for promoting hierarchical treatment model”, the paper published since the end of July 2019 were cited 178 times, the inductive hierarchical system in foreign countries mainly in a strict legal restriction, health service system that can meet the needs of relying on, clear family and specialist professional orientation, strict controls of diagnosis and treatment cost measures four characteristics of strong, proposed our country establish hierarchical diagnosis system is developed with focus on "at the grass-roots level to" "can health care expenses" "patients really benefit" three key issues, namely solve the problem of better medical services, especially basic medical service supply and perfect related health insurance and medical management policy to effectively guide and promote medical service;

    The second is Huang Bei[28], from the outpatient department of Wuxi Second People's Hospital, whosepaper“Practice and consideration on three types of medical alliance modes” published in Chinese Hospital Management in 2015, which was cited for 147 times. Among the six regional medical confederations in Wuxi City, the medical confederations of Wuxi Second Hospital developed the earliest (from 2009 to 2014, it was a loose regional medical confederations, and from 2015 to now, it has been exploring a tight medical confederations), with relatively mature operation.

    The article described the author through to the Wuhan Fifth Hospital, Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital, Wuxi Second People's Hospitalmedical treatment alliance field interview and questionnaire survey, respectively from the aspects of management system, running mechanism, and the results of three different types of couplet of medical mode, found the three hospitals all believed that community first treatment and two-way referral should be carried out. It was pointed out that the appropriate type should be selected according to the specific situation. The tight type direct regulation should be the first choice if the relationship is relatively simple in the medical association, and the loose type should be tried first if the relationship is complex.

    From the perspective of the number of papers published by authors, the top three were Zhang Liang (24 papers, Huazhong University of Science and Technology), Fang Peng-qian (15 papers, Huazhong University of Science and Technology), and Feng Ze-yong (13 papers, Chongqing Medical University).This stage Zhang Liang mainly focus in the counties and townships on the two levels of medical service system, by using the theory of integration, system thinking, collaborative division of labor theory and stakeholder theory of interaction between the levels of medical institutions, hierarchical diagnosis and "joining together of two insurance" policy, classifying medical connotation and essential elements, the key role of collaboration between counties and townships, counties and townships medical service integration mechanism is studied.

    Fang Peng-qian mainly focus in public hospitals, using game theory and stakeholder theory to analyze the construction of hierarchical diagnosis and treatment service system and the first diagnosis at the grassroots level.It is the first time to build a comprehensive hierarchical diagnosis and treatment evaluation system, to discuss the construction of China's medical service system from the perspective of foreign experience and China's county classification, and to consider the relationship between "Medical care, medicine and medical insurance are interconnected", hierarchical diagnosis and treatmentand medical confederation.Feng Ze-yong mainly studies the relationship, influence and effect between two-way referral, community first diagnosis and the multi-site practice of doctors, essential medicine system, medical insurance system and other related systems.

    4 Conclusion

    4.1 The increase speed of the number of literatures is accelerated, but the research results need to be further improved

    1949-2019, our country the hierarchical system overall present a trend of increasing number of research in the field of literature, presents the blowout growth since 2015, the main and countries since 2015 to the hierarchical system as an important driving force of deepening reform and intensify efforts to promote, as the "healthy China 2030" plan is put forward, and the hierarchical system will be the key reform direction in the future, is also much starker choices-and graver consequences-in planning a system comprehensive strategic deployment, the hierarchical system of related research number will be showed a trend of sustained and rapid growth in the next ten years.Among SCI sources, EI sources, Peking University Chinese core journals, CSSCI and CSCD journals, more than half of the research results are from Peking University Chinese core journals, which to some extent reflects the need to further strengthen and improve the authority and influence of the research results of China's hierarchical medical system.

    4.2 There is a lot of cooperation among institutions, but the cooperation and communication among authors is limited, and no stable core group of authors has been formed

    The hierarchical system research field in our country Formed the four major institutions of cooperation, although less communication between agencies group, but in college as the main body, cross-regional and health administrative organization (government actors) and the government research institutes, medical research institutions such as the cooperation and communication of broke the traditional disciplinary boundaries, benefit to the progress of the hierarchical system research and development; At present, a group of authors with Zhang Liang, Fang Pengqian, Lu Zuxun, Wang Chaoxin, Zhuo Lang and Liang Hong as the core is basically formed in the domestic research. The cooperation within the group is mostly in the mode of tutor-guided cooperation. The cooperation and communication among the authors is relatively loose, and the region is limited to Hubei Province, Shanghai and Xuzhou City, with less cross-regional cooperation. The total number of published papers by core authors calculated by Price's law accounts for less than half of the total number of literatures, indicating that a stable core group of authors has not been formed in the research field of hierarchical diagnosis and treatment in China.

    4.3 Research hotspots are gradually diversified and research directions are continuously refined

    From the point of the evolution, hierarchical system of diagnosis and treatment of research in China has experienced the planned economy period in the three major health care under the control of "blocks hierarchical division of medical service system", appeared in the early years of the reform and opening up loose and new exploration period, the new health care reform is put forward with the period a total of three stages, after a "community health service" couplet of "medical" "impact factor" "all-around doctor" "effect appraisal" hot word "medical service system" and so on and highlight the key words, the research direction is more diverse, refining, there are a lot of groundbreaking research.

    4.4 Future Prospects

    In general, the hierarchical diagnosis and treatment system has experienced nearly 70 years of evolution and has attracted great attention since 2015, which is closely related to the importance of the country, the doctor-patient problems facing China today, and the people's livelihood issues. In terms of research results, from the perspective of theoretical research, some scholars put forward integration theory, synergistic effect, stakeholders, Pareto efficiency, game theory, halo effect and so on to explain and improve the system, but there is still a lack of deeper research and innovation in the management concept. From the perspective of the practice research of scholars around the study paths, supply and demand both sides will, recognition of investigation and study, from lack of practice deepening the research on to more specific aspects of the system, and clarifying the hierarchical system and basic medical insurance system, the basic drug system, relevant relations between system problems such as reform of public hospitals. The concept of hierarchical diagnosis and treatment has been advocated since the early days of the founding of the People's Republic of China. It has been nearly 70 years since then. How to find a new innovation path from the system level through closer communication and cooperation is a problem worth studying.
    Different Models of Social Workers Participating in Mental Health Services:a Comparative Study 
    WANG Xun,YAN Fang,LUO Jianjun,LI Changhong,XUE Lili,MA Ning
    2020, 23(10):  1239-1242.  DOI: 10.12114/j.issn.1007-9572.2019.00.703
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    This article attempts to compare similarities,differences and application prospects of three typical modes in which social workers participate in mental health services.These are specialized social worker training,governmental purchases,and setting up social worker departments in mental hospitals.Beijing,Chongqing and Shanghai were selected as representative sites.The first two modes are guided by government administrative departments,while the third mode is dominated by mental hospitals.In the aspect of future development of social worker team,specialized social worker training can expand the workforce in a short time.Governmental purchases can fully tap into the potential of existing social work organizations.Setting up social worker departments in mental hospitals makes the team more stable.In terms of service orientation,the government pays more attention to continuous service provision in the community,while social workers in mental hospitals provide services within hospitals as well as take on leadership roles in community work.The three models are neither isolated nor exclusive.All localities should make comprehensive explorations in accordance with its own economic level,social work resources and capability of mental hospitals,so as to promote the development of social work in mental health services.
    Effects of Quality Control Circle on Enhancing the Adhesion between Community Elderly People and Contracted Family Doctors 
    WANG Daoqiong,BAI Yan
    2020, 23(10):  1243-1247.  DOI: 10.12114/j.issn.1007-9572.2019.00.694
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    Background The elderly are the key groups of contracted family doctor services.However,due to the insufficient number of family doctors,the lack of health awareness of the elderly,and the attention paid by community health service institutions to the number of services,there is a phenomenon of "signing but not signing".Objective To explore the role of quality control circle(QCC) activities in improving the adhesion between community elderly people and contracted family doctors.Methods A QCC of family doctors was established with the theme "improving the adhesion between the elderly and contracted family doctors" and its activities according to the steps of QCC were implemented.A total of 100 contracted elderly people received the contracted family doctor services were surveyed via telephone survey before and after the QCC activities about telephone consultation,outpatient treatment,hospitalization,physical examination and door-to-door service,so as to reflect the cohesion between the elderly and contracted family doctors by the proportion of the elderly who had received any services among all the elderly people.Results The adhesion degree after the implementation of QCC activities(67.0%) between the elderly people and contracted family doctors was significantly higher than that before the activities(35.0%)(P<0.05).The target compliance rate was 87.2% and the progress rate was 49.2%.Conclusion QCC activities can significantly improve the adhesion between community elderly people and contracted family doctors,improve the awareness and utilization rate of contracted family doctor services,and promote the relationship between community elderly people and family doctors,which could lay the foundation for hierarchical diagnosis and treatment.
    Implementation of Appointment Services in Community Health Centers in Downtown Shanghai 
    WU Shuyao,XU Hongxia,HE Ming,CHEN Liping,WU Pengliang
    2020, 23(10):  1248-1253.  DOI: 10.12114/j.issn.1007-9572.2019.00.604
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    Background Opinions on the Implementation of Appointment Services in Public Hospitals〔WYGF(2009)No.95〕 issued by the original Ministry of Health put forward that public hospitals should be scheduled for appointments,and primary health care institutions are also within the scope of implementation.So analyzing the implementation of appointment services is of great significance for optimizing the diagnosis and treatment model of primary health care institutions.Objective To explore the implementation status of appointment services in community health centers(CHCs) in downtown Shanghai,providing suggestions for optimizing the primary healthcare system.Methods The survey was conducted across all the 10 CHCs located in Huangpu District,Shanghai through August 27th to September 11th,2018,with the method of focus group discussion.Participants were directors,and representatives of information department workers,and first-line clinicians and nurses recruited from the CHCs(4-6 cases from each).Information about current implementation of appointment services,including implementation plans,practice and evaluation were collected.Description was formed after coding,classification and condensing with content analysis.Results A total of 44 medical professionals attended.The survey that appointment services had been carried out in 9 CHCs.There were 3 major types of making appointments:making an appointment without medical record(3 CHCs),making an appointment with medical record,and consulting on the appointment date(7 CHCs),making an appointment with medical record,and having priority in consulting during the appointment period(5 CHCs).Multiple CHCs implement different appointment modes in different departments.But only a small percentage of patients made appointments,accounting for less than 10% of the total outpatient visits.The majority of patients who frequently used the appointment system were elderly adults,mainly for regular revisits or prescriptions.Those making an general-specialty appointment were mainly for obtaining specialty treatments.Patients preferred making an appointment during their visits,and the no-show rate was relatively low.Reducing the waiting time for consultation or improving the treatment environment,could alleviate patients' anxiety during consultation.However,all the types of making an appointment helped little in terms of balancing the number of patients in peak hours and off-peak hours.Neither would doctors lengthen the time of treatment for patients with an appointment.Conclusion The three types of making an appointment used in the CHCs,making an appointment without medical record,making an appointment with medical record,and having the priority in consulting during the appointment period if making an appointment with medical record,shows that the precise treatment time distribution and binding force for both patients and healthcare providers shave been gradually enhanced.Also,from the perspective of further upgrading the allocation of medical resources,the implementation of precise specialty appointment services is more mature than that of general appointment services.Overall,delivering appointment services for featured outpatient care that is different from general services,for example,home-based health management,would be the development direction of the general appointment services in the community.
    Changes in Medication Attitudes and Behaviors among Community-dwelling Residents after Comprehensive Medical Reform of Separating Drug Sales from Medical Treatment in Beijing 
    CAO Ne,GUAN Lizheng,XU Jian,FU Xiaobo,LI Peng,SHI Yumeng,PU Yuying
    2020, 23(10):  1254-1260.  DOI: 10.12114/j.issn.1007-9572.2020.00.082
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    Background The comprehensive reform of separating drug sales from medical treatment was launched in an all-round way in Beijing in 2017.It would inevitably have a significant impact on community-dwelling residents' healthcare-seeking behaviors,but few studies have evaluated the impact from patients' perspective.This study provides empirical basis for deepening the comprehensive reform by evaluating changes of residents' utilization of health services after the reform.Objective To assess the changes in medication attitudes and behaviors of community-dwelling residents of Beijing since the comprehensive medical reform of separating drug sales from medical treatment has been launched in 2017 to evaluate the effect of the policy reform,and to provide solutions and advice based on key findings.Methods This questionnaire survey was conducted in 1 005 participants with an experience of seeking healthcare or purchasing medicines in medical institutions in the past 6 months,recruited from 8 community health centers in Xicheng District(at least 125 from each center) by convenience and voluntary sampling in January 2018.The survey collected residents' knowledge level of zero-profit drug policy,and medication attitudes and behaviors,and preferred institutions and flow in seeking healthcare/purchasing medicines(the latter two are evaluation indicators for the effect of the policy reform).Results A total of 969(96.42%) valid questionnaires were collected.After the reform,80.2%(777/969) of the residents were more likely to seek healthcare or purchase medicines in community health centers.Multivariate Logistic regression analysis found that those covered by free medical care were less likely to seek healthcare or purchase medicines in a community health center compared with those with basic medical insurance for urban residents〔OR(95%CI)=0.420(0.210,0.839),P<0.05〕.For the population flow of healthcare-seeking or purchasing medicines,55.7%(540/969) of the residents continued to see a doctor or purchase medicines in the community health center after the reform,and 27.2%(264/969) switched to the community health center from secondary and tertiary hospitals.Multivariate Logistic regression analysis showed that,higher possibility of changing health institutions,from a community health center to a higher level hospital,for seeking healthcare or purchasing medicines was found in residents with high education level rather than those with low education level〔OR(95%CI)=0.721(0.529,0.983),P<0.05〕,and in residents with free medical care rather than those with basic medical insurance for urban residents〔OR(95%CI)=0.383(0.194,0.757),P<0.05〕,and in residents with perceptions of drug cost reduction after the reform rather than those without such perceptions〔OR(95%CI)=0.475(0.227,0.993),P<0.05〕.Conclusion Since the comprehensive medical reform of separating drug sales from medical treatment has been launched in Beijing,a series of community-oriented measures,such as canceling drug markups and expanding the variety of drugs in the community,have effectively promoted the flow of residents to community health institutions to see a doctor or purchase drugs.It is necessary to further inform residents of drug policies,advocate zero-profit drugs and reduce medication costs,so as to encourage residents to change medication behaviors.
    Establishment and Verification of a Diabetes Risk Assessment Model Based on TCM Constitution 
    ZHANG Ying,ZHANG Yiying,YANG Ruiwen,JIN Minglan,JI Conghua,HUANG Qi
    2020, 23(10):  1261-1266.  DOI: 10.12114/j.issn.1007-9572.2019.00.593
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    Background Physical constitution is supposed to play an important role in the occurrence and development of diabetes mellitus in traditional Chinese medicine(TCM).However,current models for predicting and warning diabetes only cover general demographic data,objective inspection indicators,lifestyle and so on.It is of great significance to incorporate TCM constitution into the diabetes risk assessment model for the prevention and treatment of diabetes.Objective To establish and verify a TCM constitution-based diabetes risk assessment model using the health check-up data.Methods Health checkup data during 2014 to 2017 were obtained from the physical examination center of a provincial hospital from January 2016 to December 2018.In particular,the data of those(n=30 951) undergoing health checkup during 2014 to 2015 were used as the training data.Univariate and multivariate logistic regression were adopted to explore factors associated with diabetes in this group.Then a diabetes risk assessment model was developed with the identified risk factors for diabetes incorporated,and was verified using the data of those(test data,n=24 061) undergoing health check up during 2016 to 2017.ROC curve of the model in predicting diabetes was plotted and analyzed.Results Of those undergoing health checkup during 2014 to 2015,1 315 were found with diabetes(4.25%),and 29 636(95.75%) without.Multivariate Logistic regression analysis showed that Logit(P)(prevalence of diabetes mellitus)=-4.632-0.198
    ×(female)+0.864×(age 45-59)+1.684×(age≥60)+0.635×(hypertension)+ 0.149×(overweight)+0.376 ×(obesity)-0.531×(underweight)-0.234×(high lymphocyte percentage)+ 0.279×(low lymphocyte percentage)+0.304 ×(abnormal RBC count)-0.430×(low hematocrit)+0.722×(abnormal mean corpuscular hemoglobin concentration)+ 0.532×(abnormal platelet distribution width)+1.016×(abnormal carcinoembryonic antigen)-0.406×(abnormal uric acid)+1.341×(low creatinine)+0.488×(high blood urea nitrogen)+0.473×(abnormal triglyceride)+ 0.257×(high cholesterol)+0.544×(low HDL)+0.290×(abnormal TP)+ 0.395×(abnormal alanine aminotransferase)+ 0.362×(abnormal glutamyl transpeptidase)+0.993×(Yin deficiency)+ 1.016×(Qi deficiency)+0.601×(Phlegm dampness).The verification results showed that the AUC of the model was 0.792〔95%CI(0.779-0.816,P<0.05)〕,the optimal cut-off value was 0.405 with a sensitivity of 0.771,and a specificity of 0.690.The accuracy of the model in identifying diabetes in the 24 061 physical examinees reached 95.69%,Kappa coefficient=0.636(P<0.001).Conclusion Our diabetes risk assessment model proves to be highly accurate,which may be attributed to the inclusion of TCM constitution,a major factor closely associated with diabetes,providing a basis for early TCM-based prevention and treatment of the disease.
    Effect of Cumulative Total Cholesterol Exposure on the Onset of Stroke:a Prospective Cohort Study 
    HUANGFU Chunmei,SONG Yongjian,YAN Lili,LI Xuemei,YUAN Jianxin,YANG Na,WU Shouling
    2020, 23(10):  1267-1273.  DOI: 10.12114/j.issn.1007-9572.2019.00.690
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    Background Baseline total cholesterol(TC) is an influencing factor of new-onset stroke,but no studies have been conducted on the effect of cumulative total cholesterol exposure(cumTC) on new-onset stroke.Objective To explore the effect of cumTC on new-onset stroke.Methods Using prospective cohort study method,52 427 working and retired employees of Kailuan Group who had physical examination in 11 hospitals including KaiLuan General Hospital from 2006 to 2010 were selected as the study objects.The starting point of the follow-up was when the objects completed the physical examination in 2010,and the end point was when new-onset stroke or deaths happened or the end of the follow-up(2017-12-31).Baseline data and the incidence of new-onset stroke in each group were observed after all objects were grouped according to the cumTC quartile.The cumulative incidence was calculated by Kaplan-Meier method and tested by Log-Rank method.Cox regression model was used to analyze the effect of different cumTC on new-onset stroke.The fitting degree of different models was compared by likelihood ratio test.Results There were significant differences in age,male proportion,systolic blood pressure(SBP),diastolic blood pressure(DBP),BMI,cumTC,TC,high-density lipoprotein cholesterol(HDL-C),fasting blood glucose(FBG),stroke,ischemic stroke,smoking,drinking,hypertension and diabetes detection rates,taking lipid-lowering drugs proportion among groups with different levels of cumTC(P<0.05).During a mean follow-up year of(6.89±0.72),there were 1 611 new cases of stroke(1 415 cases of ischemic stroke and 229 cases of hemorrhagic stroke).The cumulative incidence of stroke was 2.53%(331/13 089),2.92%(384/13 148),4.18%(547/13 085) and 4.36%(571/13 105) in the first to the fourth quartile group,respectively,and the cumulative incidence of ischemic stroke was 2.17%(284/13 089),2.51%(330
    /13 148),3.71%(485/13 085) and 3.99%(523/13 105),respectively.The difference was statistically significant by Log-Rank test(χ2=73.15,P<0.001;χ2=109.13,P<0.001).Cox regression analysis showed that after adjusting age,gender,BMI,hypertension,diabetes,smoking,drinking,physical exercise,HR(95%CI) of stroke and ischemic stroke in the fourth quartile group were 1.27(1.10,1.48) and 1.37(1.16,1.60) and those in the third quartile group were 1.22(1.05,1.41) and 1.27(1.08,1.50) compared with that in the first quartile group of cumTC.Increasing the factors of baseline TC level and taking lipid-lowering drugs,after likelihood ratio test,the fitting degree of the model was not optimized(P>0.05).After adjusting age,gender,BMI,hypertension,diabetes,smoking,drinking,physical exercise,HR(95%CI) of stroke and ischemic stroke in the group with cumulative exposure for more than 4 years were 1.20(1.02,1.40) and 1.28(1.08,1.50),compared with the group with cumulative exposure to hypercholesterolemia for 0 years.Increasing the factors of baseline TC level and taking lipid-lowering drugs,the cumulative exposure of hypercholesterolemia had no statistical correlation with the new-onset stroke,ischemic stroke and hemorrhagic stroke.After the likelihood ratio test,the fitting degree of the model was not optimized(P>0.05).Conclusion High cumTC is a risk factor of new-onset stroke and ischemic stroke.
    The Sleep Quality of Patients with Peptic Ulcer and Its Influencing Factors 
    LIU Mengqi,LI Ying,LIU Xingchen,LIU Dehua,LU Xin,ZHU Xiuli
    2020, 23(10):  1274-1280.  DOI: 10.12114/j.issn.1007-9572.2020.00.083
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    Background The prevalence of peptic ulcer(PU) ranks tenth among the common chronic non-communicable diseases in China.The lengthy course of the disease and the changes in patients' life mode make patients have an urgent need for community/home care.However,the current community/home care management mode for chronic non-communicable diseases such as PU is not completed in China.Objective To understand the sleep quality of PU patients and analyze its influencing factors,so as to provide a theoretical basis for improving the relevant community health service system.Methods Twenty-three PU patients who were treated in four tertiary hospitals in Qingdao were selected from May in 2018 to February in 2019,and 213 PU patients were also included through the social platform from December in 2018 to February in 2019.The patients were investigated online and offline.The questionnaires mainly included General Information Questionnaire,Occupational Stress Analogue Scale,Pittsburgh Sleep Quality Index(PSQI),Social Support Rating Scale(SSRS),Self-rating Anxiety Scale(SAS),Self-rating Depression Scale(SDS),and pain Numerical Rating Scale(NRS).Results A total of 223(94.5%) questionnaires were received effectively.The average PSQI score of PU patients was(8.04±2.77),and 53.8%(120/223) patients had poor sleep quality.There were significant differences in PSQI scores among PU patients with different age,education level,family per capita monthly income,personality type,presence of negative emotions,occupational stress,anxiety level and depression level(P<0.05).Spearman rank correlation analysis showed that there was a negative correlation between the score of use of support in SSRS and the PSQI score among PU patients(P<0.05).The results of multiple linear stepwise regression analysis showed that personality type,negative emotions,the score of use of support in SSRS and anxiety level were the influencing factors of sleep quality in PU patients(P<0.05).Conclusion The sleep quality of PU patients is not good.It is important to pay attention to the sleep quality of PU patients with depressive character,negative emotions,low social support and high anxiety level.Community medical staff should provide more individualized and multi-dimensional nursing interventions for PU patients,such as body-psycho-social nursing including understanding the social support of PU patients in depth,establishing healthy social relations,and conducting psychological guidance.
    Investigation of Pulmonary Function Outcomes  of 146 Patients with Suspected Positive Results in Bronchial Provocation or Dilation Test after 6-month Follow-up 
    XIE Han,CHEN Yuanbin,ZHOU Mingjuan,LIN Lin,WU Lei
    2020, 23(10):  1281-1286.  DOI: 10.12114/j.issn.1007-9572.2020.00.020
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    Background Bronchial asthma is a common disease of respiratory system,and positive results of bronchial provocation or dilation test are important evidence in the diagnosis of bronchial asthma.However,suspected positive bronchial provocation or dilation test results associated with symptoms are often observed in clinical practice.At present,there is no literature report on analyzing the influencing factors of the prognosis outcome of such patients.Objective To investigate the prognostic outcomes of patients with suspected positive results in bronchial provocation or dilation test and its influencing factors.Methods From August 2015 to February 2018,320 patients with suspected positive results in bronchial provocation or dilation test accompanied by at least one symptom of cough,expectoration,itching throat,wheezing,dyspnea and chest tightness were followed up for six months.The pulmonary function was reviewed and the symptoms and TCM syndrome scores were recorded to analyze the outcomes of the patients.Significant difference of clinical symptom proportion and TCM syndrome scores before and after follow-up was considered to be the remission of the disease.A transfer from suspected positive results to negative results in bronchial provocation or dilation test after six months was considered to be the improvement of the disease.Factors influencing the outcome of suspected positive patients with bronchial provocation or dilation test were analyzed by Logistic regression analysis.Results A total of 146 patients completed the 6-month follow-up,of which 49 patients were tested with suspected positive results in bronchial provocation test and 97 patients were tested with suspected positive results in bronchial dilation test.Among those 49 cases with suspected positive results in bronchial provocation test,20(40.8%) patients were tested with negative results;2(4.1%) patients were tested with positive results;4(8.2%) patients remained the same results,and 23(46.9%) patients underwent bronchial dilation test after six months.Among those 97 cases with suspected positive results in bronchial dilation test,44(45.4%) patients were tested with negative results;4(4.1%) patients were tested with positive results;10(10.3%) patients remained the same results,and 39(40.2%) patients underwent bronchial provocation test after six months.After 6-month of follow-up,the patients' TCM syndrome scores decreased(P<0.05).Among the patients enrolled,major symptoms(cough,expectoration,itching throat,wheezing,dyspnea,and chest tightness) were relieved with significant difference after six months(P<0.05).Analysis which was carried out on 84 patients who used bronchial provocation or dilation test before and 6 months after the follow-up showed that,there was a significant difference in the outcome of suspected positive patients in different age groups(P<0.05),and the improvement rates of pulmonary function were higher in patients applying acupoint application of traditional Chinese medicine or without allergic rhinitis and inhaled glucocorticoid(P<0.05).The Logistic regression analysis results showed that under the condition of multiple factors acting at the same time,there was no significant factor affecting the prognosis of patients suspected to be positive in bronchial provocation or dilation test.Conclusion Most patients with suspected positive results in bronchial provocation or dilatation test have reversible airway inflammatory responses.Patients may benefit from acupoint application of Chinese traditional medicine.
    Factors Influencing Hearing Loss of Young People 
    PAN Hongran,YANG Lei,ZHUANG Yizhen,LEI Song
    2020, 23(10):  1287-1291.  DOI: 10.12114/j.issn.1007-9572.2019.00.766
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    Background Hearing loss is the most popular sensory organ disability in the world,and its negative impact ranks at the top of the global disease burden list.Therefore,prevention of deafness and hearing loss has become a public health project with common concern all over the world.Objective To understand the main influencing factors of hearing loss among young people in Hangzhou.Methods From June to September 2017,1 100 young people aged 18-28 from Hangzhou Hospital for the Prevention and Treatment of Occupational Disease were selected by convenient sampling method to conduct questionnaire survey and pure tone hearing test.The questionnaire included general demographic characteristics,family history of hearing loss,ear symptoms,use of mobile phones and earphones,frequency of access to entertainment places,attitude to hearing protection,and self-perceived hearing status.The pure tone hearing test used clinical audiological diagnostic criteria.The influencing factors of hearing loss were analyzed by χ2 test and multivariate Logistic regression analysis.Results A total of 1 100 questionnaires were distributed,and 1 049 effective questionnaires were recovered with an effective recovery rate of 95.4%.And 71(6.8%) cases had low-frequency hearing loss in the left ear; 47(4.4%) cases had medium-frequency hearing loss;and 127(12.2%) cases had high-frequency hearing loss.And 40(3.8%) cases had low-frequency hearing loss in the right ear; 32(3.1%) cases had medium-frequency hearing loss,and 116(11.1%) cases had high-frequency hearing loss.There were statistically significant differences in hearing loss among young people in terms of gender,education level,tinnitus,earache,ear nausea,maximum volume of music release,ways of telephone answering,attitude towards hearing protection,and self-perceived hearing status(P<0.05).The results of multivariate Logistic regression analysis showed that moderate volume〔OR(95%CI)=0.361(0.160,0.816)〕,low volume〔OR(95%CI)=0.418(0.219,0.797)〕,college and above degree〔OR(95%CI)=0.466(0.235,0.924) or 0.323(0.140,0.747)〕,female〔OR(95%CI)=0.478(0.277,0.827)〕,answering telephone with earphone〔OR(95%CI=0.448(0.236,0.852)〕 were the protective factors of hearing loss.The risk factors of hearing loss were poor self-perceived hearing status〔OR(95%CI)=2.050(1.067,3.940)〕,negative attitude towards hearing protection〔OR(95%CI)=3.350(1.782,6.300)〕,and earache〔OR(95%CI)=3.347(1.185,9.449)〕(P<0.05).Conclusion The prevalence of hearing loss among young people in Hangzhou is high.The music volume,education level,gender,ways of telephone answering,self-perceived hearing status,and attitude to hearing protection are the influencing factors of hearing loss.Comprehensive prevention and treatment should be conducted according to the influencing factors of hearing loss.
    Correlation between Serum hs-CRP,Homocysteine and Nocturnal Blood Pressure Variability in Patients with Essential Hypertension 
    LIU Fangfang,ZHANG Qiang,YANG Lihong,SUN Caihong,XU Xiaoting,FANG Shijie,LIU Ying,YAO Fang
    2020, 23(10):  1292-1297.  DOI: 10.12114/j.issn.1007-9572.2019.00.788
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    Background The 24 h Blood pressure variability(24 hBPV),serum high-sensitivity C-reactive protein(hs-CRP) and homocysteine(Hcy) are independently associated with the target organ damage and increased risk of cardiovascular events in patients with essential hypertension.Several studies have shown that hs-CRP and Hcy are positively correlated with blood pressure variability(BPV) in hypertensives,especially the nocturnal blood pressure variability(nBPV) which is associated with the increased target organ damage and risks of cardiovascular events.However,the relationship between serum hs-CRP,Hcy and nBPV has not been fully identified in patients with essential hypertension.Objective To investigate the correlation between serum hs-CRP,Hcy and nBPV in patients with essential hypertension.Methods A total of 210 hypertensive patients who visited the Second Affiliated Hospital of Zhengzhou University from January 2016 to December 2018 were enrolled in the study and divided into three groups according to the serum hs-CRP tertile value with the cut-off value of 4.217 mg/L and 7.450 mg/L.Similarly,these patients were divided into three groups according to the different levels of Hcy:106 cases with Hcy<15.0 μmol/L(group A),45 cases with 15.0 μmol/L≤Hcy<20.0 μmol/L(group B),and 59 cases with Hcy≥20.0 μmol/L(group C).The 24-hour ambulatory blood pressure monitoring was performed on all patients.The mean and standard deviations(as the index of BPV)of systolic and diastolic blood pressure in the periods of 24 hours and at nighttime were recorded.The correlations between hs-CRP,Hcy and nBPV were analyzed by Pearson correlation analysis and multiple linear regression analysis.Results Grouped by hs-CRP level,24 hBPV and nBPV in the third tertile group were significant higher than those in the first tertile group,24 hBPV in the second tertile group was significant higher than that in the first tertile group(P<0.05).Grouped by Hcy level,24 hBPV and nBPV in group B and group C were significant higher than that in group A,nBPV in group C was significant higher than that in group B(P<0.05).Pearson correlation analysis indicated that the serum hs-CRP and Hcy levels were positively correlated with the standard deviation of systolic blood pressure at nighttime(nSSD) linearly(r valus were 0.564 and 0.501,P<0.05).Multiple linear regression analysis showed that hs-CRP and Hcy were the influence factors of nBPV(P<0.05).Conclusion Serum hs-CRP and Hcy are positively correlated with nBPV independently in patients with essential hypertension,suggesting that they may play a role in the pathogenesis of nBPV,possibly aggravate the abnormality of nBPV,and they may be the mediators between nBPV and the terminal target organ damage and cardiovascular endpoint events of essential hypertension.
    Epidemiological Analysis of the Surveillance Data of Birth Defects among Perinatal Infants in Shanxi Province,2012—2017 
    ZHANG Zhili,HU Xianming,FAN Huixia,ZHANG Juan,LI Yufeng,SONG Zhijiao,LI Rude
    2020, 23(10):  1298-1304.  DOI: 10.12114/j.issn.1007-9572.2019.00.708
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    Background Birth defects have become a major global public health concern.In Shanxi Province,a high-incidence region of birth defects,the quality of birth population is seriously affected by the rate of birth defects.Objective To explore the trend in the incidence of birth defects and associated factors in Shanxi Province from 2012 to 2017,to provide evidence for the development of targeted prevention and control measures.Methods Surveillance data of perinatal birth defects covering 11 cities in Shanxi Province during 2012 to 2017 were collected from 37 monitoring institutions.Analysis was performed on the overall incidence of birth defects,prevalence of birth defects by sex,incidence of birth defects by maternal residential area(rural or urban),and maternal age at delivery,changes in major birth defects and the incidence rank in descending order of them,and the diagnosis and outcome of birth defects.Results In 2012—2017,the overall incidence of perinatal birth defects was 1.39%(6 316/455 374),and the average annual incidence of perinatal birth defects was 138.70/10 000.The annual incidence of perinatal birth defects showed an overall upward trend(χ2trend=97.68,P<0.001).The incidence of birth defects in males(149.56/10 000) was significantly higher than that of females(124.65/10 000)(χ2=51.96,P<0.001).The incidence of birth defects(142.58/10 000) in urban areas was significantly higher than that of rural areas(134.84/10 000)(χ2=51.96,P<0.001).There were differences in the incidence of birth defects in different age groups(χ2=41.12,P<0.001).The incidence of birth defects in the age group >35(172.65/10 000) was higher than that in the 20-, 25-, and 30-year-old(χ2 values were 24.32,39.14,28.02,P<0.001).The top five major birth defects were congenital heart disease(37.31/10 000),polydactyly(19.39/10 000),cleft lip with or without cleft palate(14.05/10 000),neural tube defects(7.71/10 000),and other deformities of the outer ear(7.01/10 000).The incidence of congenital heart disease increased from 13.23/10 000 in 2012 to 58.27/10 000 in 2017,with a significant difference(χ2=404.54,P<0.001).Conclusion The incidence of birth defects in Shanxi Province in 2012—2017 was generally on the rise.In particular,the incidence of congenital heart disease ranked first.The implementation of three-level preventive measures need to be strengthened to reduce birth defects and improve the quality of birth population.
    Maternal-infant Health Information Needs among Pregnant and Postpartum Women:a Correspondence Analysis of the Target Group Index Data 
    CHENG Xiaoyun,ZHANG Zhili,PEI Suyun,YUE Zheyu,GUO Xiaoqin,WANG Qian,ZHANG Juan,HU Xianming
    2020, 23(10):  1305-1310.  DOI: 10.12114/j.issn.1007-9572.2019.00.786
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    Background As an important part of maternal and child health care receiving increased attention,understanding and mastering maternal health information needs is of great significance for improving maternal and child health and safety.Objective The aim of this study was to investigate maternal-infant health information needs,and the association of health information with acquiring methods in pregnant and postpartum women in Taiyuan,providing a reference for effective delivery of maternal-infant health education.Methods A survey was conducted with 1 100 pregnant and postpartum women who sought outpatient care in a provincial maternal and child health hospital,a private hospital and a township hospital in Taiyuan from November 2016 to August 2017 using a self-made questionnaire.Analysis of maternal-infant health information needs by target group index(TGI) and correspondence analysis.1 048(95.27%) of the participants responded effectively.Results Among the respondents,the data about prenatal care(70.90%,743/1 048),nutrition during pregnancy(68.42%,717/1 048) and neonatal care(52.29%,548/1 048) were the most needed,and information concerning maternity insurance(23.85%,250/1 048) and labor analgesia(28.53%,299/1 048) was least needed.It is more difficult for them to get maternal psychological health care(31.77%,333/1 048),labor analgesia(25.19%,264/1 048),common physical discomforts during pregnancy(24.90%,261/1 048) and maternity insurance(24.24%,254/1 048) information.Age(χ2=18.331,P=0.787) and education level(χ2=20.139,P=0.065) were not associated with the differences in needs of maternal-infant health information content in the respondents.However,the respondents had different TGI requirements for various types of information.Place of residence(χ2=23.288,P=0.025) and gestational period(χ2=56.181,P=0.017) were associated with the differences in needs of various types of information content.Conclusion The TGI of various maternal-infant health information needs was different in pregnant and postpartum women with different characteristics.And these women also had different preferences when acquiring maternal-infant health information.Hence,maternal-infant health education should be delivered in accordance with the needs of pregnant and postpartum women,namely,it is should be precisely delivered to them according to their needed contents via their preferred ways.
    Preferences for Acquiring Maternal and Infant Health Information in Pregnant Women and Parturients 
    ZHANG Juan,PEI Suyun,CHENG Xiaoyun,ZHANG Zhili,WANG Qian,ZHANG Chichen,HU Xianming
    2020, 23(10):  1310-1313.  DOI: 10.12114/j.issn.1007-9572.2020.00.077
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    Background  The promotion of maternal and infant health is a priority for National Action Plan to Improve Women and Children' Health Literacy,and is also a measure for achieving Health China goals.Disseminating maternal and infant health information,and developing healthy behaviors and life styles,are specific initiatives for increasing health literacy in pregnant women and parturients.Objective To identify the preferences for acquiring maternal and infant health information in pregnant women and parturients,providing a reference for effective delivery of maternal and infant healthcare services.Methods A cross-sectional study was conducted in 1 100 pregnant women and parturients seeking outpatient healthcare in 3 hospitals in Taiyuan from November 2016 to August 2017 for exploring their preferred ways,forms,time and sites for acquiring maternal and infant health information.Results A total of 1 048 cases returned responsive questionnaires,achieving a response rate of 95.27%.The ways most frequently used to get maternal and infant health information were searching the web from mobile devices(768,73.28%),consulting physicians delivering antepartum care(503,48.00%),and searching the web from computers(474,45.23%).The rates of expected utilization of maternal school,consulting physicians delivering antepartum care,and consulting community healthcare workers were higher than those of actual utilization,while rates of expected utilization of computers and mobile phones to search the web,and interpersonal channels were lower than those of actual utilization.Maternal and infant health information is mainly selected according to levels of reliability(620,59.16%),need(533,50.86%) and access convenience(473,45.13%).Conclusion The information acquisition methods currently used by pregnant women differ from their expectations,and reliability and access convenience of information are the most concerned issues among pregnant women and parturients during acquiring maternal and infant health information.Therefore,the construction of maternal and infant health information system should attach importance to these two aspects.
    Advances in the Effect of Donepezil in Cardiovascular Therapy 
    LONG Jieni,XUE Yazhi,MA Yusheng,RAO Jiahuan,GUO Zhigang
    2020, 23(10):  1314-1317.  DOI: 10.12114/j.issn.1007-9572.2019.00.635
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    Alzheimer's disease(AD)is the main type of dementia,and the reduction of cholinergic neurons in the central nervous system is one of its important pathogenesis.Donepezil,as a highly selective and reversible cholinesterase inhibitor,improves cognitive function of dementia patients by elevating acetylcholine level in cortex through inhibiting cholinesterase,and now is one of the front-line treatment drugs for dementia.A large number of clinical studies have confirmed the effectiveness and safety of the clinical application of donepezil.Many AD patients also suffer from cardiovascular diseases,and current researches have indicated a therapeutic effect of donepezil on cardiovascular diseases.This article aims to review the current clinical use of donepezil and its effects on cardiovascular system,and to explore its mechanism.This article compares the effects of donepezil with galantamine and rivastigmine on cardiovascular diseases in order to provide feedback to guide the further use of donepezil in the clinical practice.
    Impact of Labor Analgesia on Labor Outcomes:Recent Advances 
    FU Qiupeng,HE Yinfang,GAO Lianfeng,ZHANG Yuhong
    2020, 23(10):  1318-1322.  DOI: 10.12114/j.issn.1007-9572.2019.00.606
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    Labor pain is a major cause for increased cesarean section rate and adverse pregnancy outcomes,but it can be controlled by interventions,among which labor analgesia is the most effective.Besides,it can also maintain maternal and infant safety and promote natural childbirth.In various labor analgesic methods,non-pharmacological analgesia produces less adverse reactions,but the analgesic effect remains to be confirmed.Drug-induced analgesia can relieve the labor pain,but with certain adverse reactions.So there are studies recommend the combination use of both drug- and non-drug-induced analgesia.Among different forms of drug-induced analgesia,epidural analgesia has a definite analgesic effect and a more flexible analgesic time,but requiring higher level of technique and costing more,with some controversies about the impact on maternal and neonatal outcomes.At present,the prevalence of domestic labor analgesia is far lower than that in foreign countries,wherefore it is necessary to strengthen the publicity,promotion and development of labor analgesia in China.
    Research Progress on Influencing Factors of Cognitive Management Compliance among People with Mild Cognitive Impairment in the Community 
    ZHEN Xueting,WANG Lina,CHEN Haiqin,ZHAO Xia,LIU Xiaoshen,ZHANG Chen
    2020, 23(10):  1322-1326.  DOI: 10.12114/j.issn.1007-9572.2019.00.500
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    Cognitive management is an important means to delay the disease progress of mild cognitive impairment(MCI).However,the compliance of cognitive management among people with MCI at home and abroad is still at a low level at present,which greatly affects the intervention effect of cognitive management.In this paper,the influencing factors of cognitive management compliance among people with MCI were summarized from three aspects of biology,social psychology and methodology.Gender,marital status,education level,disease awareness,ideation and self-efficacy,social support,cognitive management development form,intervention content and effectiveness,and cognitive management environment were main factors affecting the cognitive management compliance of people with MCI.The relationship between depression and cognitive management compliance was still controversial.Based on the above factors,this paper formulated corresponding improvement strategies so as to provide theoretical guide for community medical staff to target high-risk groups of cognitive management and then carry out the compliance-oriented project of cognitive management.