Chinese General Practice ›› 2024, Vol. 27 ›› Issue (28): 3546-3551.DOI: 10.12114/j.issn.1007-9572.2023.0539
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Received:
2023-11-07
Revised:
2024-02-25
Published:
2024-10-05
Online:
2024-07-16
Contact:
YANG Yongfeng
通讯作者:
杨永峰
作者简介:
作者贡献:
胡一帆负责数据收集、数据分析和论文撰写;陈妙洋负责数据收集;熊清芳、钟艳丹、刘杜先、顾爱东负责课题指导;杨永峰提出主要研究目标,负责研究设计和论文修改,对文章整体负责,监督管理。
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2023.0539
变量 | 临床资料结果 |
---|---|
年龄( | 52.7±12.4 |
性别(男/女) | 29/53 |
BMI( | 23.18±3.25 |
SBP( | 121±17 |
DBP( | 76±11 |
FPG[M(P25,P75),mmol/L] | 5(5,6) |
UA[M(P25,P75),μmol/L] | 229(169,284) |
TBA[M(P25,P75),μmol/L] | 24(2,17) |
ALT[M(P25,P75),U/L] | 128(63,362) |
AST[M(P25,P75),U/L] | 98(46,294) |
GGT[M(P25,P75),U/L] | 85(33,205) |
TGa[M(P25,P75),mmol/L] | 1.2(1.0,2.0) |
TCa( | 4.7±1.2 |
HDLa( | 1.2±0.4 |
LDLa( | 2.8±1.0 |
Table 1 Results of inclusion clinical data of patients
变量 | 临床资料结果 |
---|---|
年龄( | 52.7±12.4 |
性别(男/女) | 29/53 |
BMI( | 23.18±3.25 |
SBP( | 121±17 |
DBP( | 76±11 |
FPG[M(P25,P75),mmol/L] | 5(5,6) |
UA[M(P25,P75),μmol/L] | 229(169,284) |
TBA[M(P25,P75),μmol/L] | 24(2,17) |
ALT[M(P25,P75),U/L] | 128(63,362) |
AST[M(P25,P75),U/L] | 98(46,294) |
GGT[M(P25,P75),U/L] | 85(33,205) |
TGa[M(P25,P75),mmol/L] | 1.2(1.0,2.0) |
TCa( | 4.7±1.2 |
HDLa( | 1.2±0.4 |
LDLa( | 2.8±1.0 |
影像学 | 组织学 | 合计 | |
---|---|---|---|
无NAFLD组 | NAFLD组 | ||
无NAFLD组 | 36 | 6 | 42 |
NAFLD组 | 2 | 9 | 11 |
合计 | 38 | 15 | 53 |
Table 2 Consistency test between imaging diagnosis and histological diagnosis
影像学 | 组织学 | 合计 | |
---|---|---|---|
无NAFLD组 | NAFLD组 | ||
无NAFLD组 | 36 | 6 | 42 |
NAFLD组 | 2 | 9 | 11 |
合计 | 38 | 15 | 53 |
组织学评分 | NAFL亚组(n=8) | NASH亚组(n=7) |
---|---|---|
肝细胞脂肪变性分值 | ||
1分 | 7 | 5 |
2分 | 0 | 2 |
3分 | 1 | 0 |
小叶内炎症分值 | ||
0分 | 0 | 0 |
1分 | 4 | 2 |
2分 | 4 | 5 |
肝细胞气球样变性 | ||
0分 | 8 | 0 |
1分 | 0 | 7 |
2分 | 0 | 0 |
纤维化分值 | ||
0分 | 7 | 2 |
1分 | 1 | 4 |
2分 | 0 | 0 |
3分 | 0 | 1 |
影像学诊断阳性 | 4 | 5 |
Table 3 Histological characteristics of NAFLD patients
组织学评分 | NAFL亚组(n=8) | NASH亚组(n=7) |
---|---|---|
肝细胞脂肪变性分值 | ||
1分 | 7 | 5 |
2分 | 0 | 2 |
3分 | 1 | 0 |
小叶内炎症分值 | ||
0分 | 0 | 0 |
1分 | 4 | 2 |
2分 | 4 | 5 |
肝细胞气球样变性 | ||
0分 | 8 | 0 |
1分 | 0 | 7 |
2分 | 0 | 0 |
纤维化分值 | ||
0分 | 7 | 2 |
1分 | 1 | 4 |
2分 | 0 | 0 |
3分 | 0 | 1 |
影像学诊断阳性 | 4 | 5 |
变量 | NAFLD组(n=15) | 无NAFLD组(n=38) | 检验统计量 | P值 |
---|---|---|---|---|
年龄(岁) | 46.4±16.3 | 54.8±10.3 | -1.434b | 0.167 |
男/女 | 8/7 | 21/17 | 0.016c | 0.899 |
BMI( | 25.2±3.5 | 22.5±2.9 | 3.199b | 0.002 |
SBP[M(P25,P75),mmHg] | 129(116,135) | 120(106,127) | -2.222d | 0.026 |
DBP( | 76±10 | 76±10 | 0.308b | 0.759 |
实验室指标 | ||||
FPG( | 7.7±3.6 | 5.2±1.2 | 2.594b | 0.020 |
UA[M(P25,P75),μmol/L] | 239(162.5,412.3) | 228.0(169.0,282.0) | -1.214d | 0.225 |
TBA[M(P25,P75),μmol/L] | 3.0(0.8,9.1) | 7.0(2.1,21.6) | -1.738d | 0.082 |
ALT[M(P25,P75),U/L] | 96.0(41.6,220.2) | 158.0(74.7,412.2) | -1.836d | 0.066 |
AST[M(P25,P75),U/L] | 48.0(27.9,129.5) | 109.0(59.2,326.4) | -2.488d | 0.013 |
GGT[M(P25,P75),U/L] | 49.0(15.3,135.4) | 99.0(36.2,211.0) | -1.758d | 0.079 |
TGa( | 1.7±0.3 | 1.6±1.1 | -0.617b | 0.542 |
TCa( | 4.4±1.3 | 4.2±1.1 | -0.552b | 0.585 |
HDLa( | 0.9±0.2 | 1.1±0.7 | -0.359b | 0.722 |
LDLa( | 2.8±0.8 | 2.3±0.9 | 0.276b | 0.784 |
Table 4 Comparison of clinical data between NAFLD group and non NAFLD group
变量 | NAFLD组(n=15) | 无NAFLD组(n=38) | 检验统计量 | P值 |
---|---|---|---|---|
年龄(岁) | 46.4±16.3 | 54.8±10.3 | -1.434b | 0.167 |
男/女 | 8/7 | 21/17 | 0.016c | 0.899 |
BMI( | 25.2±3.5 | 22.5±2.9 | 3.199b | 0.002 |
SBP[M(P25,P75),mmHg] | 129(116,135) | 120(106,127) | -2.222d | 0.026 |
DBP( | 76±10 | 76±10 | 0.308b | 0.759 |
实验室指标 | ||||
FPG( | 7.7±3.6 | 5.2±1.2 | 2.594b | 0.020 |
UA[M(P25,P75),μmol/L] | 239(162.5,412.3) | 228.0(169.0,282.0) | -1.214d | 0.225 |
TBA[M(P25,P75),μmol/L] | 3.0(0.8,9.1) | 7.0(2.1,21.6) | -1.738d | 0.082 |
ALT[M(P25,P75),U/L] | 96.0(41.6,220.2) | 158.0(74.7,412.2) | -1.836d | 0.066 |
AST[M(P25,P75),U/L] | 48.0(27.9,129.5) | 109.0(59.2,326.4) | -2.488d | 0.013 |
GGT[M(P25,P75),U/L] | 49.0(15.3,135.4) | 99.0(36.2,211.0) | -1.758d | 0.079 |
TGa( | 1.7±0.3 | 1.6±1.1 | -0.617b | 0.542 |
TCa( | 4.4±1.3 | 4.2±1.1 | -0.552b | 0.585 |
HDLa( | 0.9±0.2 | 1.1±0.7 | -0.359b | 0.722 |
LDLa( | 2.8±0.8 | 2.3±0.9 | 0.276b | 0.784 |
变量 | 赋值 |
---|---|
GD患者是否合并NAFLD | 是=1,否=0 |
BMI | 实测值 |
FPG | 实测值 |
SBP | 实测值 |
AST | 实测值 |
Table 5 Multivariate Logistic regression analysis of variable assignment of influencing factors of NAFLD in GD patients
变量 | 赋值 |
---|---|
GD患者是否合并NAFLD | 是=1,否=0 |
BMI | 实测值 |
FPG | 实测值 |
SBP | 实测值 |
AST | 实测值 |
变量 | B | SE | Wald χ2值 | OR值 | 95%CI | P值 |
---|---|---|---|---|---|---|
BMI | 0.405 | 0.166 | 5.993 | 1.500 | 1.084~2.075 | 0.014 |
FPG | 0.772 | 0.282 | 7.509 | 2.163 | 1.246~3.756 | 0.006 |
SBP | 0.005 | 0.025 | 0.046 | 1.005 | 0.957~1.057 | 0.830 |
AST | -0.002 | 0.001 | 2.095 | 0.998 | 0.996~1.001 | 0.148 |
Table 6 Multivariate Logistic regression analysis of influencing factors of NAFLD in GD patients
变量 | B | SE | Wald χ2值 | OR值 | 95%CI | P值 |
---|---|---|---|---|---|---|
BMI | 0.405 | 0.166 | 5.993 | 1.500 | 1.084~2.075 | 0.014 |
FPG | 0.772 | 0.282 | 7.509 | 2.163 | 1.246~3.756 | 0.006 |
SBP | 0.005 | 0.025 | 0.046 | 1.005 | 0.957~1.057 | 0.830 |
AST | -0.002 | 0.001 | 2.095 | 0.998 | 0.996~1.001 | 0.148 |
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