Chinese General Practice ›› 2024, Vol. 27 ›› Issue (03): 348-356.DOI: 10.12114/j.issn.1007-9572.2023.0328
• Original Research • Previous Articles Next Articles
Received:
2023-04-18
Revised:
2023-07-18
Published:
2024-01-20
Online:
2023-10-23
Contact:
CHEN Yunzhi
通讯作者:
陈云志
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2023.0328
组别 | 只数 | 第0天 | 第7天 | 第14天 | 第21天 | 第28天 |
---|---|---|---|---|---|---|
Control组 | 10 | 237.80±16.75 | 249.00±17.41 | 270.40±16.75 | 272.20±17.01 | 276.60±20.17 |
Model组 | 10 | 240.70±16.26 | 237.70±18.34 | 241.70±19.09a | 242.60±20.73a | 243.30±23.33a |
MTX组 | 10 | 240.10±15.92 | 243.40±13.83 | 259.10±11.40b | 267.50±11.73b | 273.60±11.63b |
VD组 | 10 | 232.30±8.93 | 256.50±12.51b | 267.50±12.47b | 266.00±11.52b | 271.30±7.68b |
SMT-L组 | 10 | 236.10±17.62 | 253.80±20.86b | 262.30±22.31b | 270.60±20.17b | 268.80±21.06b |
SMT-M组 | 10 | 236.40±12.08 | 251.40±12.97 | 255.00±11.84 | 263.00±13.10b | 266.60±14.39b |
SMT-H组 | 10 | 239.80±14.82 | 257.90±16.15b | 265.30±16.73b | 271.90±13.83b | 272.70±15.81b |
F值 | 0.39 | 1.99 | 3.52 | 4.27 | 4.27 | |
P值 | 0.88 | 0.08 | <0.05 | <0.05 | <0.05 |
Table 1 Comparison of weight change result of rats in the seven groups
组别 | 只数 | 第0天 | 第7天 | 第14天 | 第21天 | 第28天 |
---|---|---|---|---|---|---|
Control组 | 10 | 237.80±16.75 | 249.00±17.41 | 270.40±16.75 | 272.20±17.01 | 276.60±20.17 |
Model组 | 10 | 240.70±16.26 | 237.70±18.34 | 241.70±19.09a | 242.60±20.73a | 243.30±23.33a |
MTX组 | 10 | 240.10±15.92 | 243.40±13.83 | 259.10±11.40b | 267.50±11.73b | 273.60±11.63b |
VD组 | 10 | 232.30±8.93 | 256.50±12.51b | 267.50±12.47b | 266.00±11.52b | 271.30±7.68b |
SMT-L组 | 10 | 236.10±17.62 | 253.80±20.86b | 262.30±22.31b | 270.60±20.17b | 268.80±21.06b |
SMT-M组 | 10 | 236.40±12.08 | 251.40±12.97 | 255.00±11.84 | 263.00±13.10b | 266.60±14.39b |
SMT-H组 | 10 | 239.80±14.82 | 257.90±16.15b | 265.30±16.73b | 271.90±13.83b | 272.70±15.81b |
F值 | 0.39 | 1.99 | 3.52 | 4.27 | 4.27 | |
P值 | 0.88 | 0.08 | <0.05 | <0.05 | <0.05 |
组别 | 只数 | 第0天 | 第7天 | 第14天 | 第21天 | 第28天 |
---|---|---|---|---|---|---|
Control组 | 10 | 0.51±0.07 | 0.44±0.03 | 0.52±0.04 | 0.62±0.05 | 0.87±0.04 |
Model组 | 10 | 2.19±0.10a | 3.02±0.09a | 3.13±0.32a | 3.45±0.23a | 3.98±0.07a |
MTX组 | 10 | 2.22±0.09a | 2.80±0.05b | 3.08±0.05 | 2.52±0.20b | 1.60±0.18b |
VD组 | 10 | 2.41±0.13a | 2.81±0.23b | 3.11±0.09 | 3.68±0.08b | 2.16±0.17b |
SMT-L组 | 10 | 2.31±0.11a | 2.66±0.19b | 3.21±0.07 | 3.79±0.11b | 2.72±0.12b |
SMT-M组 | 10 | 2.24±0.16a | 2.55±0.16b | 3.33±0.05b | 3.75±0.06b | 2.42±0.19b |
SMT-H组 | 10 | 2.39±0.10a | 2.63±0.14b | 3.16±0.03 | 3.62±0.05b | 2.11±0.03b |
F值 | 35.66 | 35.02 | 54.72 | 75.96 | 50.69 | |
P值 | <0.05 | <0.05 | <0.05 | <0.05 | <0.05 |
Table 2 Comparison of the swelling degree of rats in the seven groups
组别 | 只数 | 第0天 | 第7天 | 第14天 | 第21天 | 第28天 |
---|---|---|---|---|---|---|
Control组 | 10 | 0.51±0.07 | 0.44±0.03 | 0.52±0.04 | 0.62±0.05 | 0.87±0.04 |
Model组 | 10 | 2.19±0.10a | 3.02±0.09a | 3.13±0.32a | 3.45±0.23a | 3.98±0.07a |
MTX组 | 10 | 2.22±0.09a | 2.80±0.05b | 3.08±0.05 | 2.52±0.20b | 1.60±0.18b |
VD组 | 10 | 2.41±0.13a | 2.81±0.23b | 3.11±0.09 | 3.68±0.08b | 2.16±0.17b |
SMT-L组 | 10 | 2.31±0.11a | 2.66±0.19b | 3.21±0.07 | 3.79±0.11b | 2.72±0.12b |
SMT-M组 | 10 | 2.24±0.16a | 2.55±0.16b | 3.33±0.05b | 3.75±0.06b | 2.42±0.19b |
SMT-H组 | 10 | 2.39±0.10a | 2.63±0.14b | 3.16±0.03 | 3.62±0.05b | 2.11±0.03b |
F值 | 35.66 | 35.02 | 54.72 | 75.96 | 50.69 | |
P值 | <0.05 | <0.05 | <0.05 | <0.05 | <0.05 |
组别 | 只数 | 第0天 | 第7天 | 第14天 | 第21天 | 第28天 |
---|---|---|---|---|---|---|
Control组 | 10 | 0 | 0 | 0 | 0 | 0 |
Model组 | 10 | 12.30±1.05 | 12.10±0.87 | 11.90±0.87 | 11.70±1.16 | 11.40±1.07 |
MTX组 | 10 | 12.60±1.83 | 11.90±1.85 | 10.50±2.06a | 7.80±1.87a | 5.70±1.41a |
VD组 | 10 | 11.90±1.79 | 11.60±1.71 | 10.90±1.91 | 9.70±2.16a | 8.20±1.75a |
SMT-L组 | 10 | 12.40±1.17 | 12.30±1.16 | 11.10±0.87 | 10.20±1.13a | 8.50±1.84a |
SMT-M组 | 10 | 12.20±1.54 | 11.70±1.82 | 11.30±1.33 | 10.60±1.26 | 8.90±1.79a |
SMT-H组 | 10 | 11.60±2.27 | 10.90±1.52 | 9.70±1.70a | 8.30±1.76a | 6.40±2.54a |
F值 | 89.39 | 98.59 | 86.20 | 68.71 | 46.92 | |
P值 | <0.05 | <0.05 | <0.05 | <0.05 | <0.05 |
Table 3 Comparison of AI scores of rats in the seven groups
组别 | 只数 | 第0天 | 第7天 | 第14天 | 第21天 | 第28天 |
---|---|---|---|---|---|---|
Control组 | 10 | 0 | 0 | 0 | 0 | 0 |
Model组 | 10 | 12.30±1.05 | 12.10±0.87 | 11.90±0.87 | 11.70±1.16 | 11.40±1.07 |
MTX组 | 10 | 12.60±1.83 | 11.90±1.85 | 10.50±2.06a | 7.80±1.87a | 5.70±1.41a |
VD组 | 10 | 11.90±1.79 | 11.60±1.71 | 10.90±1.91 | 9.70±2.16a | 8.20±1.75a |
SMT-L组 | 10 | 12.40±1.17 | 12.30±1.16 | 11.10±0.87 | 10.20±1.13a | 8.50±1.84a |
SMT-M组 | 10 | 12.20±1.54 | 11.70±1.82 | 11.30±1.33 | 10.60±1.26 | 8.90±1.79a |
SMT-H组 | 10 | 11.60±2.27 | 10.90±1.52 | 9.70±1.70a | 8.30±1.76a | 6.40±2.54a |
F值 | 89.39 | 98.59 | 86.20 | 68.71 | 46.92 | |
P值 | <0.05 | <0.05 | <0.05 | <0.05 | <0.05 |
组别 | 只数 | MPO | TNF-α |
---|---|---|---|
Control组 | 6 | 5.38±1.50 | 4.06±2.42 |
Model组 | 6 | 21.57±4.71a | 24.46±4.67a |
MTX组 | 6 | 7.95±5.11b | 9.83±2.58b |
VD组 | 6 | 9.30±5.15b | 8.05±3.78b |
SMT-L组 | 6 | 20.82±5.33 | 23.53±1.42 |
SMT-M组 | 6 | 17.70±1.34 | 17.29±6.16b |
SMT-H组 | 6 | 7.15±5.42b | 5.00±2.72b |
F值 | 7.36 | 15.97 | |
P值 | <0.05 | <0.05 |
Table 4 Comparison of MPO and TNF-α expression levels in synovial tissue of 7 groups of rats
组别 | 只数 | MPO | TNF-α |
---|---|---|---|
Control组 | 6 | 5.38±1.50 | 4.06±2.42 |
Model组 | 6 | 21.57±4.71a | 24.46±4.67a |
MTX组 | 6 | 7.95±5.11b | 9.83±2.58b |
VD组 | 6 | 9.30±5.15b | 8.05±3.78b |
SMT-L组 | 6 | 20.82±5.33 | 23.53±1.42 |
SMT-M组 | 6 | 17.70±1.34 | 17.29±6.16b |
SMT-H组 | 6 | 7.15±5.42b | 5.00±2.72b |
F值 | 7.36 | 15.97 | |
P值 | <0.05 | <0.05 |
组别 | 只数 | IL-6(pg/mL) | 25(OH)D3(ng/mL) | NETs(ng/mL) |
---|---|---|---|---|
Control组 | 6 | 41.85±10.53 | 32.19±5.24 | 23.80±3.01 |
Model组 | 6 | 90.50±17.57a | 19.54±3.93a | 39.38±5.62a |
MTX组 | 6 | 37.63±7.33b | 28.22±5.07b | 26.78±4.95b |
VD组 | 6 | 46.14±14.97b | 27.07±5.01b | 29.49±4.90b |
SMT-L组 | 6 | 86.39±13.80 | 19.73±4.32 | 37.16±4.64 |
SMT-M组 | 6 | 74.29±15.08 | 21.44±2.31 | 30.95±3.21b |
SMT-H组 | 6 | 53.73±17.74b | 25.33±1.33b | 31.33±5.89b |
F值 | 14.06 | 7.97 | 8.06 | |
P值 | <0.05 | <0.05 | <0.05 |
Table 5 Comparison of serum levels of IL-6,25(OH)D3 and NETs in 7 groups
组别 | 只数 | IL-6(pg/mL) | 25(OH)D3(ng/mL) | NETs(ng/mL) |
---|---|---|---|---|
Control组 | 6 | 41.85±10.53 | 32.19±5.24 | 23.80±3.01 |
Model组 | 6 | 90.50±17.57a | 19.54±3.93a | 39.38±5.62a |
MTX组 | 6 | 37.63±7.33b | 28.22±5.07b | 26.78±4.95b |
VD组 | 6 | 46.14±14.97b | 27.07±5.01b | 29.49±4.90b |
SMT-L组 | 6 | 86.39±13.80 | 19.73±4.32 | 37.16±4.64 |
SMT-M组 | 6 | 74.29±15.08 | 21.44±2.31 | 30.95±3.21b |
SMT-H组 | 6 | 53.73±17.74b | 25.33±1.33b | 31.33±5.89b |
F值 | 14.06 | 7.97 | 8.06 | |
P值 | <0.05 | <0.05 | <0.05 |
组别 | 只数 | CYP24A1 | CYP27B1 | MPO | VDR | NE |
---|---|---|---|---|---|---|
Control组 | 6 | 0.24±0.11 | 0.64±0.07 | 0.25±0.02 | 0.68±0.08 | 0.27±0.05 |
Model组 | 6 | 0.76±0.15a | 0.19±0.03a | 0.78±0.06a | 0.20±0.08a | 0.73±0.10a |
MTX组 | 6 | 0.42±0.09b | 0.36±0.06b | 0.54±0.05b | 0.43±0.03b | 0.57±0.14 |
VD组 | 6 | 0.41±0.16b | 0.41±0.09b | 0.36±0.12b | 0.49±0.05b | 0.43±0.05b |
SMT-L组 | 6 | 0.61±0.13 | 0.23±0.04 | 0.59±0.08b | 0.26±0.06 | 0.64±0.06 |
SMT-M组 | 6 | 0.47±0.20b | 0.39±0.05b | 0.52±0.08b | 0.40±0.07b | 0.50±0.09b |
SMT-H组 | 6 | 0.32±0.14b | 0.47±0.07b | 0.36±0.04b | 0.52±0.06b | 0.44±0.12b |
F值 | 4.24 | 16.17 | 16.89 | 17.96 | 7.05 | |
P值 | <0.05 | <0.01 | <0.05 | <0.05 | <0.05 |
Table 6 Comparative expression of CYP24A1,CYP27B1,MPO,VDR and NE in synovial tissue of 7 groups of rats
组别 | 只数 | CYP24A1 | CYP27B1 | MPO | VDR | NE |
---|---|---|---|---|---|---|
Control组 | 6 | 0.24±0.11 | 0.64±0.07 | 0.25±0.02 | 0.68±0.08 | 0.27±0.05 |
Model组 | 6 | 0.76±0.15a | 0.19±0.03a | 0.78±0.06a | 0.20±0.08a | 0.73±0.10a |
MTX组 | 6 | 0.42±0.09b | 0.36±0.06b | 0.54±0.05b | 0.43±0.03b | 0.57±0.14 |
VD组 | 6 | 0.41±0.16b | 0.41±0.09b | 0.36±0.12b | 0.49±0.05b | 0.43±0.05b |
SMT-L组 | 6 | 0.61±0.13 | 0.23±0.04 | 0.59±0.08b | 0.26±0.06 | 0.64±0.06 |
SMT-M组 | 6 | 0.47±0.20b | 0.39±0.05b | 0.52±0.08b | 0.40±0.07b | 0.50±0.09b |
SMT-H组 | 6 | 0.32±0.14b | 0.47±0.07b | 0.36±0.04b | 0.52±0.06b | 0.44±0.12b |
F值 | 4.24 | 16.17 | 16.89 | 17.96 | 7.05 | |
P值 | <0.05 | <0.01 | <0.05 | <0.05 | <0.05 |
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