Chinese General Practice ›› 2023, Vol. 26 ›› Issue (20): 2482-2487.DOI: 10.12114/j.issn.1007-9572.2022.0877
Special Issue: 心肌梗死最新文章合集
• Original Research • Previous Articles Next Articles
Received:
2022-12-14
Revised:
2023-02-26
Published:
2023-07-15
Online:
2023-03-30
Contact:
ZHAO Xin
About author:
通讯作者:
赵昕
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0877
变量 | 匹配前 | 匹配后 | ||||||
---|---|---|---|---|---|---|---|---|
死亡组(n=115) | 非死亡组(n=3 131) | 检验统计量值 | P值 | 死亡组(n=115) | 非死亡组(n=115) | 检验统计量值 | P值 | |
男性〔n(%)〕 | 64(55.65) | 2 116(67.60) | 7.158a | 0.007 | 64(55.65) | 63(54.80) | 0.018a | 0.895 |
年龄(岁) | 77.5±11.5 | 66.1±12.4 | -9.648b | <0.001 | 77.5±11.5 | 77.4±9.2 | -0.051b | 0.960 |
体质指数(kg/m2) | 23.95±3.10 | 25.51±3.55 | 5.261b | <0.001 | 23.95±3.10 | 24.23±3.85 | 0.594b | 0.553 |
教育水平〔n(%)〕 | 3.024a | 0.220 | 1.674a | 0.433 | ||||
义务教育 | 14(12.20) | 273(8.70) | 14(12.20) | 9(7.80) | ||||
中学 | 28(24.30) | 647(20.70) | 28(24.30) | 34(29.60) | ||||
大学 | 73(63.50) | 2 211(70.60) | 73(63.50) | 72(62.60) | ||||
退休〔n(%)〕 | 103(89.60) | 2 361(75.40) | 12.159a | <0.001 | 103(89.60) | 103(89.60) | 0a | 1.000 |
血压等级〔n(%)〕 | 2.137a | 0.544 | 3.144a | 0.370 | ||||
正常 | 37(32.20) | 923(29.50) | 37(32.20) | 27(23.50) | ||||
1级 | 17(14.80) | 578(18.50) | 17(14.80) | 25(21.70) | ||||
2级 | 10(8.70) | 355(11.30) | 10(8.70) | 11(9.60) | ||||
3级 | 51(44.30) | 1 275(40.70) | 51(44.30) | 52(45.20) | ||||
心力衰竭〔n(%)〕 | 107(93.00) | 1 725(55.10) | 64.977a | <0.001 | 107(93.00) | 102(88.70) | 1.310a | 0.252 |
糖尿病〔n(%)〕 | 59(51.30) | 1 309(41.80) | 4.103a | 0.044 | 59(51.30) | 62(53.9) | 0.157a | 0.690 |
糖化血红蛋白(%) | 6.79±1.55 | 6.88±1.64 | 0.541b | 0.580 | 6.79±1.55 | 7.01±1.66 | 1.023b | 0.300 |
急性心肌梗死类型〔n(%)〕 | 3.801a | 0.051 | 0.898a | 0.343 | ||||
NSTEMI | 74(64.30) | 2 274(72.60) | 74(64.30) | 67(58.30) | ||||
STEMI | 41(35.70) | 857(27.40) | 41(35.70) | 48(41.70) | ||||
血钠(mmol/L) | 138.26±5.78 | 139.86±3.14 | 2.955b | <0.005 | 138.26±5.78 | 137.50±4.46 | -1.113b | 0.260 |
血钾(mmol/L) | 4.15±0.67 | 3.92±0.46 | -3.584b | <0.001 | 4.15±0.67 | 4.12±0.54 | -0.403b | 0.680 |
血小板计数(×109/L) | 215.15±85.03 | 214.13±60.52 | -0.128b | 0.890 | 215.15±85.03 | 208.46±64.22 | -0.674b | 0.500 |
中性粒细胞计数(×109/L) | 9.10±4.01 | 5.63±2.54 | -9.241b | <0.001 | 9.10±4.01 | 6.03±2.62 | -6.891b | <0.001 |
淋巴细胞计数(×109/L) | 1.23±0.58 | 1.64±0.61 | 6.969b | <0.001 | 1.23±0.58 | 1.38±0.56 | 1.913b | 0.057 |
估算肾小球滤过率〔n(%)〕 | 93.961a | <0.001 | 0.505a | 0.777 | ||||
>60 mL·min-1·(1.73 m2)-1 | 40(34.80) | 2 291(73.20) | 40(34.80) | 43(37.40) | ||||
30~60 mL·min-1·(1.73 m2)-1 | 39(33.90) | 316(10.10) | 39(33.90) | 34(29.60) | ||||
<30 mL·min-1·(1.73 m2)-1 | 36(31.30) | 524(16.70) | 36(31.30) | 38(33.00) | ||||
血生化 | ||||||||
三酰甘油〔M(P25,P75),mmol/L〕 | 1.17(0.92,1.69) | 1.43(1.04,2.05) | -3.765 | <0.001 | 1.17(0.92,1.69) | 1.31(1.02,1.79) | -1.780 | 0.075 |
低密度脂蛋白胆固醇〔M(P25,P75),mmol/L〕 | 2.27(1.79,3.09) | 2.45(1.87,3.04) | -0.989 | 0.323 | 2.27(1.79,3.09) | 2.49(2.03,2.98) | -1.024 | 0.306 |
载脂蛋白比值〔M(P25,P75) | 1.37(1.04,1.67) | 1.37(1.13,1.71) | -1.351 | 0.177 | 1.37(1.04,1.67) | 1.28(1.05,1.59) | -0.920 | 0.358 |
住院药物治疗 | ||||||||
阿司匹林〔n(%)〕 | 98(85.20) | 2 971(94.90) | 20.129a | <0.001 | 98(85.20) | 102(88.70) | 0.613a | 0.434 |
他汀类药物〔n(%)〕 | 105(91.30) | 3 084(98.50) | 33.282a | <0.001 | 105(91.30) | 105(91.30) | 0a | 1.000 |
血管紧张素转换酶抑制剂〔n(%)〕 | 28(24.30) | 1 556(49.70) | 28.527a | <0.001 | 28(24.30) | 34(29.60) | 0.795a | 0.373 |
NLR〔M(P25,P75)〕 | 7.36(4.71,12.18) | 3.19(2.29,4.78) | -11.819 | <0.001 | 7.36(4.71,12.18) | 4.19(2.79,6.74) | -6.056 | <0.001 |
PLR〔M(P25,P75)〕 | 170.83 (122.32,258.82) | 132.06 (103.39,170.72) | -6.354 | <0.001 | 170.83 (122.32,258.82) | 156.52 (118.94,197.31) | -2.029 | 0.420 |
Table 1 Baseline characteristics of subjects before and after matching
变量 | 匹配前 | 匹配后 | ||||||
---|---|---|---|---|---|---|---|---|
死亡组(n=115) | 非死亡组(n=3 131) | 检验统计量值 | P值 | 死亡组(n=115) | 非死亡组(n=115) | 检验统计量值 | P值 | |
男性〔n(%)〕 | 64(55.65) | 2 116(67.60) | 7.158a | 0.007 | 64(55.65) | 63(54.80) | 0.018a | 0.895 |
年龄(岁) | 77.5±11.5 | 66.1±12.4 | -9.648b | <0.001 | 77.5±11.5 | 77.4±9.2 | -0.051b | 0.960 |
体质指数(kg/m2) | 23.95±3.10 | 25.51±3.55 | 5.261b | <0.001 | 23.95±3.10 | 24.23±3.85 | 0.594b | 0.553 |
教育水平〔n(%)〕 | 3.024a | 0.220 | 1.674a | 0.433 | ||||
义务教育 | 14(12.20) | 273(8.70) | 14(12.20) | 9(7.80) | ||||
中学 | 28(24.30) | 647(20.70) | 28(24.30) | 34(29.60) | ||||
大学 | 73(63.50) | 2 211(70.60) | 73(63.50) | 72(62.60) | ||||
退休〔n(%)〕 | 103(89.60) | 2 361(75.40) | 12.159a | <0.001 | 103(89.60) | 103(89.60) | 0a | 1.000 |
血压等级〔n(%)〕 | 2.137a | 0.544 | 3.144a | 0.370 | ||||
正常 | 37(32.20) | 923(29.50) | 37(32.20) | 27(23.50) | ||||
1级 | 17(14.80) | 578(18.50) | 17(14.80) | 25(21.70) | ||||
2级 | 10(8.70) | 355(11.30) | 10(8.70) | 11(9.60) | ||||
3级 | 51(44.30) | 1 275(40.70) | 51(44.30) | 52(45.20) | ||||
心力衰竭〔n(%)〕 | 107(93.00) | 1 725(55.10) | 64.977a | <0.001 | 107(93.00) | 102(88.70) | 1.310a | 0.252 |
糖尿病〔n(%)〕 | 59(51.30) | 1 309(41.80) | 4.103a | 0.044 | 59(51.30) | 62(53.9) | 0.157a | 0.690 |
糖化血红蛋白(%) | 6.79±1.55 | 6.88±1.64 | 0.541b | 0.580 | 6.79±1.55 | 7.01±1.66 | 1.023b | 0.300 |
急性心肌梗死类型〔n(%)〕 | 3.801a | 0.051 | 0.898a | 0.343 | ||||
NSTEMI | 74(64.30) | 2 274(72.60) | 74(64.30) | 67(58.30) | ||||
STEMI | 41(35.70) | 857(27.40) | 41(35.70) | 48(41.70) | ||||
血钠(mmol/L) | 138.26±5.78 | 139.86±3.14 | 2.955b | <0.005 | 138.26±5.78 | 137.50±4.46 | -1.113b | 0.260 |
血钾(mmol/L) | 4.15±0.67 | 3.92±0.46 | -3.584b | <0.001 | 4.15±0.67 | 4.12±0.54 | -0.403b | 0.680 |
血小板计数(×109/L) | 215.15±85.03 | 214.13±60.52 | -0.128b | 0.890 | 215.15±85.03 | 208.46±64.22 | -0.674b | 0.500 |
中性粒细胞计数(×109/L) | 9.10±4.01 | 5.63±2.54 | -9.241b | <0.001 | 9.10±4.01 | 6.03±2.62 | -6.891b | <0.001 |
淋巴细胞计数(×109/L) | 1.23±0.58 | 1.64±0.61 | 6.969b | <0.001 | 1.23±0.58 | 1.38±0.56 | 1.913b | 0.057 |
估算肾小球滤过率〔n(%)〕 | 93.961a | <0.001 | 0.505a | 0.777 | ||||
>60 mL·min-1·(1.73 m2)-1 | 40(34.80) | 2 291(73.20) | 40(34.80) | 43(37.40) | ||||
30~60 mL·min-1·(1.73 m2)-1 | 39(33.90) | 316(10.10) | 39(33.90) | 34(29.60) | ||||
<30 mL·min-1·(1.73 m2)-1 | 36(31.30) | 524(16.70) | 36(31.30) | 38(33.00) | ||||
血生化 | ||||||||
三酰甘油〔M(P25,P75),mmol/L〕 | 1.17(0.92,1.69) | 1.43(1.04,2.05) | -3.765 | <0.001 | 1.17(0.92,1.69) | 1.31(1.02,1.79) | -1.780 | 0.075 |
低密度脂蛋白胆固醇〔M(P25,P75),mmol/L〕 | 2.27(1.79,3.09) | 2.45(1.87,3.04) | -0.989 | 0.323 | 2.27(1.79,3.09) | 2.49(2.03,2.98) | -1.024 | 0.306 |
载脂蛋白比值〔M(P25,P75) | 1.37(1.04,1.67) | 1.37(1.13,1.71) | -1.351 | 0.177 | 1.37(1.04,1.67) | 1.28(1.05,1.59) | -0.920 | 0.358 |
住院药物治疗 | ||||||||
阿司匹林〔n(%)〕 | 98(85.20) | 2 971(94.90) | 20.129a | <0.001 | 98(85.20) | 102(88.70) | 0.613a | 0.434 |
他汀类药物〔n(%)〕 | 105(91.30) | 3 084(98.50) | 33.282a | <0.001 | 105(91.30) | 105(91.30) | 0a | 1.000 |
血管紧张素转换酶抑制剂〔n(%)〕 | 28(24.30) | 1 556(49.70) | 28.527a | <0.001 | 28(24.30) | 34(29.60) | 0.795a | 0.373 |
NLR〔M(P25,P75)〕 | 7.36(4.71,12.18) | 3.19(2.29,4.78) | -11.819 | <0.001 | 7.36(4.71,12.18) | 4.19(2.79,6.74) | -6.056 | <0.001 |
PLR〔M(P25,P75)〕 | 170.83 (122.32,258.82) | 132.06 (103.39,170.72) | -6.354 | <0.001 | 170.83 (122.32,258.82) | 156.52 (118.94,197.31) | -2.029 | 0.420 |
变量 | AUC | 灵敏度(%) | 特异度(%) | 约登指数 | 临界值 | 95%CI | P值 |
---|---|---|---|---|---|---|---|
NLR+PLR | 0.754 | 55.65 | 85.22 | 0.408 | 0.549 | (0.693,0.809) | <0.001 |
NLR | 0.731 | 61.74 | 74.78 | 0.362 | 6.495 | (0.669,0.787) | <0.001 |
PLR | 0.577 | 49.57 | 68.70 | 0.182 | 178.985 | (0.511,0.642) | 0.040 |
Table 2 Predictive value of NLR+PLR,NLR,and PLR for in-hospital mortality risk in AMI patients
变量 | AUC | 灵敏度(%) | 特异度(%) | 约登指数 | 临界值 | 95%CI | P值 |
---|---|---|---|---|---|---|---|
NLR+PLR | 0.754 | 55.65 | 85.22 | 0.408 | 0.549 | (0.693,0.809) | <0.001 |
NLR | 0.731 | 61.74 | 74.78 | 0.362 | 6.495 | (0.669,0.787) | <0.001 |
PLR | 0.577 | 49.57 | 68.70 | 0.182 | 178.985 | (0.511,0.642) | 0.040 |
变量 | AUC差值 | Z值 | 标准差 | 95%CI | P值 |
---|---|---|---|---|---|
NLR+PLR与NLR | 0.023 | 2.078 | 0.011 | (0.001,0.045) | 0.037 |
NLR+PLR与PLR | 0.177 | 4.412 | 0.040 | (0.098,0.255) | <0.001 |
NLR与PLR | 0.154 | 4.756 | 0.032 | (0.090,0.217) | <0.001 |
Table 3 Comparison of areas under ROC curve of predictive value between combined indicators and independent indicators
变量 | AUC差值 | Z值 | 标准差 | 95%CI | P值 |
---|---|---|---|---|---|
NLR+PLR与NLR | 0.023 | 2.078 | 0.011 | (0.001,0.045) | 0.037 |
NLR+PLR与PLR | 0.177 | 4.412 | 0.040 | (0.098,0.255) | <0.001 |
NLR与PLR | 0.154 | 4.756 | 0.032 | (0.090,0.217) | <0.001 |
变量 | NSTEMI | STEMI | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
AUC | SE | 灵敏度(%) | 特异度(%) | 95%CI | P值 | AUC | SE | 灵敏度(%) | 特异度(%) | 95%CI | P值 | |
NLR+PLR | 0.739 | 0.041 | 71.62 | 65.67 | (0.657,0.820) | <0.001 | 0.797 | 0.047 | 68.29 | 85.42 | (0.705,0.890) | <0.001 |
NLR | 0.720 | 0.043 | 70.15 | 54.95 | (0.636,0.803) | <0.001 | 0.754 | 0.051 | 68.75 | 73.17 | (0.653,0.854) | <0.001 |
PLR | 0.613 | 0.048 | 55.41 | 70.15 | (0.520,0.706) | 0.018 | 0.512 | 0.063 | 63.41 | 25.00 | (0.389,0.636) | 0.847 |
Table 4 Predictive value of NLR+PLR,NLR,and PLR for in-hospital mortality risk in patients with NSTEMI and STEMI
变量 | NSTEMI | STEMI | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
AUC | SE | 灵敏度(%) | 特异度(%) | 95%CI | P值 | AUC | SE | 灵敏度(%) | 特异度(%) | 95%CI | P值 | |
NLR+PLR | 0.739 | 0.041 | 71.62 | 65.67 | (0.657,0.820) | <0.001 | 0.797 | 0.047 | 68.29 | 85.42 | (0.705,0.890) | <0.001 |
NLR | 0.720 | 0.043 | 70.15 | 54.95 | (0.636,0.803) | <0.001 | 0.754 | 0.051 | 68.75 | 73.17 | (0.653,0.854) | <0.001 |
PLR | 0.613 | 0.048 | 55.41 | 70.15 | (0.520,0.706) | 0.018 | 0.512 | 0.063 | 63.41 | 25.00 | (0.389,0.636) | 0.847 |
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