Chinese General Practice ›› 2023, Vol. 26 ›› Issue (20): 2459-2468.DOI: 10.12114/j.issn.1007-9572.2023.0068
Special Issue: 睡眠问题专题研究; 高血压最新文章合集
• Original Research • Previous Articles Next Articles
Received:
2022-12-04
Revised:
2023-03-03
Published:
2023-07-15
Online:
2023-03-21
Contact:
ZHANG Hui, LUO Yingquan
About author:
通讯作者:
张慧, 罗荧荃
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2023.0068
组别 | 例数 | 一般资料 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
年龄( | 性别〔n(%)〕 | BMI ( | 空腹血糖( | 肌酐( | 总胆固醇( | 三酰甘油( | LDL-C( | HDL-C( | 高血压病程( | 服用降压药物种类( | |||
男 | 女 | ||||||||||||
单纯高血压组 | 114 | 60.6±12.8 | 78(68.4) | 36(31.6) | 23.5±5.0 | 4.9±0.7 | 71.4±19.3 | 4.3±1.1 | 2.1±1.3 | 2.8±1.1 | 1.1±0.3 | 9.6±9.1 | 1.4±0.6 |
高血压合并OSAHS组 | 114 | 57.4±12.9 | 90(78.9) | 24(21.1) | 26.8±3.9 | 5.1±1.2 | 73.9±18.8 | 4.1±1.2 | 2.4±1.2 | 2.8±1.0 | 1.0±0.2 | 10.2±7.5 | 1.5±0.7 |
t(χ2)值 | 1.880 | 1.805a | 5.556 | 1.537 | 0.992 | 1.312 | 1.811 | 0 | 1.376 | 0.543 | 1.158 | ||
P值 | 0.061 | 0.071 | <0.001 | 0.126 | 0.318 | 0.191 | 0.072 | 0.996 | 0.173 | 0.570 | 0.269 | ||
组别 | 平均血压水平( | BPV相关指标( | |||||||||||
24 hSBP | 24 hDBP | dSBP | dDBP | nSBP | nDBP | 24 hSSD | 24 hDSD | dSSD | dDSD | nSSD | nDSD | ||
单纯高血压组 | 132±8 | 68±4 | 133±13 | 77±8 | 121±8 | 66±6 | 11±3 | 8±2 | 11±5 | 10±3 | 10±5 | 9±4 | |
高血压合并OSAHS组 | 139±8 | 72+6 | 136±12 | 78±14 | 134±9 | 70±8 | 14±3 | 11+2 | 12±5 | 10±4 | 12±5 | 13±6 | |
t(χ2)值 | 6.428 | 7.327 | 1.884 | 0.889 | 11.260 | 4.631 | 7.300 | 10.860 | 1.963 | 1.224 | 4.130 | 5.841 | |
P值 | <0.001 | <0.001 | 0.069 | 0.336 | <0.001 | <0.001 | <0.001 | <0.001 | 0.056 | 0.280 | <0.001 | <0.001 | |
组别 | 血压昼夜节律〔n(%)〕 | HRV相关指标 | |||||||||||
时域指标( | 频域指标( | ||||||||||||
杓型 | 非杓型 | ||||||||||||
SDNN | SDANN | RMSSD | LF | HF | LF/HF | ||||||||
单纯高血压组 | 72(63.2) | 42(36.8) | 119.6±12.6 | 124.8±15.7 | 29.1±8.6 | 463.2±174.8 | 254.9±63.7 | 1.97±0.27 | |||||
高血压合并OSAHS组 | 34(29.8) | 80(70.2) | 91.1±20.5 | 90.0±20.3 | 22.5±10.0 | 360.2±58.3 | 231.6±47.9 | 2.08±0.50 | |||||
t(χ2)值 | 5.046a | 12.650 | 14.480 | 5.343 | 5.968 | 3.121 | 2.067 | ||||||
P值 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.002 | 0.039 |
Table 1 Comparison of clinical data between hypertension patients with and without OSAHS
组别 | 例数 | 一般资料 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
年龄( | 性别〔n(%)〕 | BMI ( | 空腹血糖( | 肌酐( | 总胆固醇( | 三酰甘油( | LDL-C( | HDL-C( | 高血压病程( | 服用降压药物种类( | |||
男 | 女 | ||||||||||||
单纯高血压组 | 114 | 60.6±12.8 | 78(68.4) | 36(31.6) | 23.5±5.0 | 4.9±0.7 | 71.4±19.3 | 4.3±1.1 | 2.1±1.3 | 2.8±1.1 | 1.1±0.3 | 9.6±9.1 | 1.4±0.6 |
高血压合并OSAHS组 | 114 | 57.4±12.9 | 90(78.9) | 24(21.1) | 26.8±3.9 | 5.1±1.2 | 73.9±18.8 | 4.1±1.2 | 2.4±1.2 | 2.8±1.0 | 1.0±0.2 | 10.2±7.5 | 1.5±0.7 |
t(χ2)值 | 1.880 | 1.805a | 5.556 | 1.537 | 0.992 | 1.312 | 1.811 | 0 | 1.376 | 0.543 | 1.158 | ||
P值 | 0.061 | 0.071 | <0.001 | 0.126 | 0.318 | 0.191 | 0.072 | 0.996 | 0.173 | 0.570 | 0.269 | ||
组别 | 平均血压水平( | BPV相关指标( | |||||||||||
24 hSBP | 24 hDBP | dSBP | dDBP | nSBP | nDBP | 24 hSSD | 24 hDSD | dSSD | dDSD | nSSD | nDSD | ||
单纯高血压组 | 132±8 | 68±4 | 133±13 | 77±8 | 121±8 | 66±6 | 11±3 | 8±2 | 11±5 | 10±3 | 10±5 | 9±4 | |
高血压合并OSAHS组 | 139±8 | 72+6 | 136±12 | 78±14 | 134±9 | 70±8 | 14±3 | 11+2 | 12±5 | 10±4 | 12±5 | 13±6 | |
t(χ2)值 | 6.428 | 7.327 | 1.884 | 0.889 | 11.260 | 4.631 | 7.300 | 10.860 | 1.963 | 1.224 | 4.130 | 5.841 | |
P值 | <0.001 | <0.001 | 0.069 | 0.336 | <0.001 | <0.001 | <0.001 | <0.001 | 0.056 | 0.280 | <0.001 | <0.001 | |
组别 | 血压昼夜节律〔n(%)〕 | HRV相关指标 | |||||||||||
时域指标( | 频域指标( | ||||||||||||
杓型 | 非杓型 | ||||||||||||
SDNN | SDANN | RMSSD | LF | HF | LF/HF | ||||||||
单纯高血压组 | 72(63.2) | 42(36.8) | 119.6±12.6 | 124.8±15.7 | 29.1±8.6 | 463.2±174.8 | 254.9±63.7 | 1.97±0.27 | |||||
高血压合并OSAHS组 | 34(29.8) | 80(70.2) | 91.1±20.5 | 90.0±20.3 | 22.5±10.0 | 360.2±58.3 | 231.6±47.9 | 2.08±0.50 | |||||
t(χ2)值 | 5.046a | 12.650 | 14.480 | 5.343 | 5.968 | 3.121 | 2.067 | ||||||
P值 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.002 | 0.039 |
组别 | 例数 | 年龄(岁) | BMI (kg/m2) | nSBP (mmHg) | nDBP (mmHg) | dSBP (mmHg) | dDBP (mmHg) | 24 hSBP (mmHg) | 24 hDBP (mmHg) | nSSD (mmHg) | nDSD (mmHg) |
---|---|---|---|---|---|---|---|---|---|---|---|
轻度亚组 | 30 | 55.8±13.2 | 23.5±2.8 | 133±7 | 65±5 | 138±17 | 76±13 | 137±9 | 72±5 | 8±2 | 9±1 |
中度亚组 | 37 | 56.9±11.6 | 27.3±3.8 | 135±9 | 72±8 | 141±21 | 76±13 | 138±12 | 73±6 | 10±2a | 11±4a |
重度亚组 | 47 | 58.3±13.8 | 27.5±3.9ab | 134±10 | 71±8ab | 156±24ab | 88±13ab | 146±15ab | 74±8 | 16±5a | 16±7a |
F值 | 1.076 | 46.340 | 1.666 | 28.520 | 23.290 | 32.200 | 17.300 | 2.886 | 165.000 | 85.540 | |
P值 | 0.342 | <0.001 | 0.191 | <0.001 | <0.001 | <0.001 | <0.001 | 0.057 | <0.001 | <0.001 | |
组别 | dSSD (mmHg) | dDSD (mmHg) | 24 hSSD (mmHg) | 24 hDSD (mmHg) | SDNN (ms) | SDANN (ms) | RMSSD (ms) | LF (ms2) | HF (ms2) | LF/HF (ms2) | |
轻度亚组 | 12±5 | 9±3 | 13±1 | 11±2 | 114.4±38.0 | 106.3±30.8 | 19.5±6.1 | 390.2±63.1 | 322.1±44.3 | 1.7±0.1 | |
中度亚组 | 12±4 | 10±3 | 14±3 | 11±2 | 93.7±8.8a | 87.9±20.2 | 23.9±9.7a | 340.2±29.3a | 267.1±44.3a | 1.8±0.1a | |
重度亚组 | 13±5 | 12±5a | 15±4a | 11±2 | 82.1±11.3ab | 86.6±13.4ab | 25.9±8.3a | 307.9±33.5ab | 176.1±61.4ab | 1.9±0.1a | |
F值 | 1.638 | 8.581 | 14.840 | 0.103 | 55.520 | 27.020 | 18.310 | 98.630 | 241.600 | 114.000 | |
P值 | 0.196 | <0.001 | <0.001 | 0.902 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
Table 2 Comparison of age,BMI,mean blood pressure,BPV and HRV related indices in hypertension patients with mild,moderate and severe OSAHS stratified by the level of AHI
组别 | 例数 | 年龄(岁) | BMI (kg/m2) | nSBP (mmHg) | nDBP (mmHg) | dSBP (mmHg) | dDBP (mmHg) | 24 hSBP (mmHg) | 24 hDBP (mmHg) | nSSD (mmHg) | nDSD (mmHg) |
---|---|---|---|---|---|---|---|---|---|---|---|
轻度亚组 | 30 | 55.8±13.2 | 23.5±2.8 | 133±7 | 65±5 | 138±17 | 76±13 | 137±9 | 72±5 | 8±2 | 9±1 |
中度亚组 | 37 | 56.9±11.6 | 27.3±3.8 | 135±9 | 72±8 | 141±21 | 76±13 | 138±12 | 73±6 | 10±2a | 11±4a |
重度亚组 | 47 | 58.3±13.8 | 27.5±3.9ab | 134±10 | 71±8ab | 156±24ab | 88±13ab | 146±15ab | 74±8 | 16±5a | 16±7a |
F值 | 1.076 | 46.340 | 1.666 | 28.520 | 23.290 | 32.200 | 17.300 | 2.886 | 165.000 | 85.540 | |
P值 | 0.342 | <0.001 | 0.191 | <0.001 | <0.001 | <0.001 | <0.001 | 0.057 | <0.001 | <0.001 | |
组别 | dSSD (mmHg) | dDSD (mmHg) | 24 hSSD (mmHg) | 24 hDSD (mmHg) | SDNN (ms) | SDANN (ms) | RMSSD (ms) | LF (ms2) | HF (ms2) | LF/HF (ms2) | |
轻度亚组 | 12±5 | 9±3 | 13±1 | 11±2 | 114.4±38.0 | 106.3±30.8 | 19.5±6.1 | 390.2±63.1 | 322.1±44.3 | 1.7±0.1 | |
中度亚组 | 12±4 | 10±3 | 14±3 | 11±2 | 93.7±8.8a | 87.9±20.2 | 23.9±9.7a | 340.2±29.3a | 267.1±44.3a | 1.8±0.1a | |
重度亚组 | 13±5 | 12±5a | 15±4a | 11±2 | 82.1±11.3ab | 86.6±13.4ab | 25.9±8.3a | 307.9±33.5ab | 176.1±61.4ab | 1.9±0.1a | |
F值 | 1.638 | 8.581 | 14.840 | 0.103 | 55.520 | 27.020 | 18.310 | 98.630 | 241.600 | 114.000 | |
P值 | 0.196 | <0.001 | <0.001 | 0.902 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
组别 | 例数 | 年龄(岁) | BMI (kg/m2) | nSBP (mmHg) | nDBP (mmHg) | dSBP (mmHg) | dDBP (mmHg) | 24 hSBP (mmHg) | 24 hDBP (mmHg) | nSSD (mmHg) | nDSD (mmHg) |
---|---|---|---|---|---|---|---|---|---|---|---|
轻度亚组 | 28 | 56.7±12.8 | 26.3±4.7 | 132±9 | 70±7 | 143±21 | 79±13 | 139±12 | 74±13 | 9±2 | 10±4 |
中度亚组 | 35 | 56.4±12.2 | 26.6±3.9 | 134±9 | 70±7 | 148±17 | 82±12 | 134±12 | 72±12 | 9±2 | 9±3 |
重度亚组 | 51 | 60.0±13.7 | 26.7±3.7 | 138±12 | 71±9 | 141±21 | 77±14 | 138±11 | 72±5 | 14±5ab | 14±6ab |
F值 | 2.727 | 0.291 | 1.152 | 0.170 | 0.982 | 0.691 | 0.134 | 1.197 | 81.540 | 41.970 | |
P值 | 0.067 | 0.748 | 0.317 | 0.844 | 0.375 | 0.502 | 0.874 | 0.303 | <0.001 | <0.001 | |
组别 | dSSD (mmHg) | dDSD (mmHg) | 24 hSSD (mmHg) | 24 hDSD (mmHg) | SDNN (ms) | SDANN (ms) | RMSSD (ms) | LF (ms2) | HF (ms2) | LF/HF (ms2) | |
轻度亚组 | 11±5 | 11±3 | 16±4 | 11±2 | 102.7±18.6 | 93.9±29.0 | 24.0±5.5 | 372.8±62.9 | 282.6±40.8 | 1.9±0.1 | |
中度亚组 | 12±6 | 10±1 | 14±3 | 11±2 | 101.5±29.7 | 97.1±13.8 | 25.4±8.0 | 330.0±34.7a | 225.3±45.5a | 1.7±0.1 | |
重度亚组 | 13±5 | 10±4 | 14±3a | 11±2 | 86.5±18.1ab | 88.1±17.6 | 21.8±11.2 | 327.8±25.1a | 209.1±78.8a | 2.1±0.1a | |
F值 | 4.298 | 0.928 | 12.510 | 0.267 | 17.910 | 4.307 | 2.632 | 235.800 | 57.304 | 456.000 | |
P值 | 0.061 | 0.396 | <0.001 | 0.766 | <0.001 | 0.064 | 0.073 | <0.001 | <0.001 | <0.001 |
Table 3 Comparison of age,BMI,mean blood pressure,BPV and HRV related indices in hypertension patients with mild,moderate and severe OSAHS stratified by the level of MinSpO2
组别 | 例数 | 年龄(岁) | BMI (kg/m2) | nSBP (mmHg) | nDBP (mmHg) | dSBP (mmHg) | dDBP (mmHg) | 24 hSBP (mmHg) | 24 hDBP (mmHg) | nSSD (mmHg) | nDSD (mmHg) |
---|---|---|---|---|---|---|---|---|---|---|---|
轻度亚组 | 28 | 56.7±12.8 | 26.3±4.7 | 132±9 | 70±7 | 143±21 | 79±13 | 139±12 | 74±13 | 9±2 | 10±4 |
中度亚组 | 35 | 56.4±12.2 | 26.6±3.9 | 134±9 | 70±7 | 148±17 | 82±12 | 134±12 | 72±12 | 9±2 | 9±3 |
重度亚组 | 51 | 60.0±13.7 | 26.7±3.7 | 138±12 | 71±9 | 141±21 | 77±14 | 138±11 | 72±5 | 14±5ab | 14±6ab |
F值 | 2.727 | 0.291 | 1.152 | 0.170 | 0.982 | 0.691 | 0.134 | 1.197 | 81.540 | 41.970 | |
P值 | 0.067 | 0.748 | 0.317 | 0.844 | 0.375 | 0.502 | 0.874 | 0.303 | <0.001 | <0.001 | |
组别 | dSSD (mmHg) | dDSD (mmHg) | 24 hSSD (mmHg) | 24 hDSD (mmHg) | SDNN (ms) | SDANN (ms) | RMSSD (ms) | LF (ms2) | HF (ms2) | LF/HF (ms2) | |
轻度亚组 | 11±5 | 11±3 | 16±4 | 11±2 | 102.7±18.6 | 93.9±29.0 | 24.0±5.5 | 372.8±62.9 | 282.6±40.8 | 1.9±0.1 | |
中度亚组 | 12±6 | 10±1 | 14±3 | 11±2 | 101.5±29.7 | 97.1±13.8 | 25.4±8.0 | 330.0±34.7a | 225.3±45.5a | 1.7±0.1 | |
重度亚组 | 13±5 | 10±4 | 14±3a | 11±2 | 86.5±18.1ab | 88.1±17.6 | 21.8±11.2 | 327.8±25.1a | 209.1±78.8a | 2.1±0.1a | |
F值 | 4.298 | 0.928 | 12.510 | 0.267 | 17.910 | 4.307 | 2.632 | 235.800 | 57.304 | 456.000 | |
P值 | 0.061 | 0.396 | <0.001 | 0.766 | <0.001 | 0.064 | 0.073 | <0.001 | <0.001 | <0.001 |
项目 | nSSD | nDSD | dSSD | dDSD | 24 hSSD | 24 hDSD |
---|---|---|---|---|---|---|
年龄 | -0.063 | -0.103 | -0.179 | -0.180 | 0.157 | -0.047 |
BMI | 0.470a | 0.507a | -0.107 | 0.029 | 0.179 | 0.015 |
AHI | 0.568a | 0.457a | 0.032 | 0.113 | 0.074 | 0.074 |
ODI | 0.962a | 0.797a | -0.056 | 0.057 | 0.082 | 0.092 |
MinSpO2 | -0.833a | -0.703a | -0.015 | -0.051 | -0.013 | 0.009 |
MeanSpO2 | -0.116 | -0.139 | -0.071 | -0.132 | 0.095 | -0.183 |
总呼吸紊乱时间 | 0.019 | 0.029 | 0.016 | 0.148 | -0.007 | -0.059 |
平均暂停时间 | -0.002 | 0.092 | -0.125 | 0.016 | 0.184 | -0.091 |
最长呼吸暂停时间 | 0.018 | 0.048 | -0.010 | 0.071 | 0.101 | -0.115 |
总呼吸暂停时间 | 0.038 | 0.046 | 0.016 | 0.125 | -0.004 | -0.067 |
总低通气时间 | -0.146 | -0.145 | -0.007 | 0.139 | -0.032 | 0.079 |
呼吸紊乱时长所占百分比 | 0.054 | 0.086 | -0.007 | 0.092 | -0.034 | -0.093 |
Table 4 Correlation analysis of BPV related indices with age,BMI and PSG parameters in hypertension patients with OSAHS
项目 | nSSD | nDSD | dSSD | dDSD | 24 hSSD | 24 hDSD |
---|---|---|---|---|---|---|
年龄 | -0.063 | -0.103 | -0.179 | -0.180 | 0.157 | -0.047 |
BMI | 0.470a | 0.507a | -0.107 | 0.029 | 0.179 | 0.015 |
AHI | 0.568a | 0.457a | 0.032 | 0.113 | 0.074 | 0.074 |
ODI | 0.962a | 0.797a | -0.056 | 0.057 | 0.082 | 0.092 |
MinSpO2 | -0.833a | -0.703a | -0.015 | -0.051 | -0.013 | 0.009 |
MeanSpO2 | -0.116 | -0.139 | -0.071 | -0.132 | 0.095 | -0.183 |
总呼吸紊乱时间 | 0.019 | 0.029 | 0.016 | 0.148 | -0.007 | -0.059 |
平均暂停时间 | -0.002 | 0.092 | -0.125 | 0.016 | 0.184 | -0.091 |
最长呼吸暂停时间 | 0.018 | 0.048 | -0.010 | 0.071 | 0.101 | -0.115 |
总呼吸暂停时间 | 0.038 | 0.046 | 0.016 | 0.125 | -0.004 | -0.067 |
总低通气时间 | -0.146 | -0.145 | -0.007 | 0.139 | -0.032 | 0.079 |
呼吸紊乱时长所占百分比 | 0.054 | 0.086 | -0.007 | 0.092 | -0.034 | -0.093 |
因变量 | 自变量 | B(95%CI) | SE | β | t值 | P值 |
---|---|---|---|---|---|---|
nSSD | BMI | 0.387(0.338,0.436) | 0.025 | 0.119 | 15.480 | <0.001 |
ODI | 0.582(0.333,0.831) | 0.127 | 0.364 | 4.583 | <0.001 | |
MinSpO2 | -0.934(-1.030,-0.838) | 0.049 | -0.627 | -19.061 | <0.001 | |
nDSD | BMI | 0.529(0.460,0.598) | 0.035 | 0.147 | 15.114 | <0.001 |
ODI | 0.653(0.416,0.890) | 0.121 | 0.482 | 5.397 | <0.001 | |
MinSpO2 | -0.793(-0.911,-0.675) | 0.060 | -0.659 | -13.217 | <0.001 |
Table 5 Multiple linear regression analysis of the factors associated with the levels of nSSD and nDSD in hypertension patients with OSAHS
因变量 | 自变量 | B(95%CI) | SE | β | t值 | P值 |
---|---|---|---|---|---|---|
nSSD | BMI | 0.387(0.338,0.436) | 0.025 | 0.119 | 15.480 | <0.001 |
ODI | 0.582(0.333,0.831) | 0.127 | 0.364 | 4.583 | <0.001 | |
MinSpO2 | -0.934(-1.030,-0.838) | 0.049 | -0.627 | -19.061 | <0.001 | |
nDSD | BMI | 0.529(0.460,0.598) | 0.035 | 0.147 | 15.114 | <0.001 |
ODI | 0.653(0.416,0.890) | 0.121 | 0.482 | 5.397 | <0.001 | |
MinSpO2 | -0.793(-0.911,-0.675) | 0.060 | -0.659 | -13.217 | <0.001 |
项目 | SDNN | SDANN | RMSSD | LF | HF | LF/HF |
---|---|---|---|---|---|---|
年龄 | -0.105 | -0.073 | 0.093 | 0.090 | 0.038 | 0.025 |
BMI | -0.324a | -0.382a | -0.229a | -0.384a | -0.419a | 0.241a |
AHI | -0.371a | -0.349a | -0.299a | -0.433a | -0.495a | 0.300a |
ODI | -0.489a | -0.296a | -0.427a | -0.515a | -0.809a | 0.473a |
MinSpO2 | 0.519a | 0.168 | 0.409a | 0.503a | 0.736a | -0.415a |
MeanSpO2 | -0.163 | -0.065 | 0.011 | -0.018 | 0.023 | 0.071 |
总呼吸紊乱时间 | 0.042 | -0.045 | 0.154 | 0.115 | 0.023 | 0.013 |
平均暂停时间 | -0.084 | -0.111 | 0.066 | 0.068 | 0.006 | -0.061 |
最长呼吸暂停时间 | -0.055 | 0.038 | 0.098 | 0.051 | -0.042 | 0.103 |
总呼吸暂停时间 | 0.037 | -0.057 | 0.144 | 0.018 | 0.012 | 0.013 |
总低通气时间 | 0.023 | 0.104 | 0.040 | 0.080 | 0.102 | 0.005 |
呼吸紊乱时长所占百分比 | 0.029 | -0.023 | 0.155 | 0.122 | 0.003 | -0.016 |
Table 6 Correlation analysis of HRV related indices with age,BMI and PSG parameters in hypertension patients with OSAHS
项目 | SDNN | SDANN | RMSSD | LF | HF | LF/HF |
---|---|---|---|---|---|---|
年龄 | -0.105 | -0.073 | 0.093 | 0.090 | 0.038 | 0.025 |
BMI | -0.324a | -0.382a | -0.229a | -0.384a | -0.419a | 0.241a |
AHI | -0.371a | -0.349a | -0.299a | -0.433a | -0.495a | 0.300a |
ODI | -0.489a | -0.296a | -0.427a | -0.515a | -0.809a | 0.473a |
MinSpO2 | 0.519a | 0.168 | 0.409a | 0.503a | 0.736a | -0.415a |
MeanSpO2 | -0.163 | -0.065 | 0.011 | -0.018 | 0.023 | 0.071 |
总呼吸紊乱时间 | 0.042 | -0.045 | 0.154 | 0.115 | 0.023 | 0.013 |
平均暂停时间 | -0.084 | -0.111 | 0.066 | 0.068 | 0.006 | -0.061 |
最长呼吸暂停时间 | -0.055 | 0.038 | 0.098 | 0.051 | -0.042 | 0.103 |
总呼吸暂停时间 | 0.037 | -0.057 | 0.144 | 0.018 | 0.012 | 0.013 |
总低通气时间 | 0.023 | 0.104 | 0.040 | 0.080 | 0.102 | 0.005 |
呼吸紊乱时长所占百分比 | 0.029 | -0.023 | 0.155 | 0.122 | 0.003 | -0.016 |
因变量 | 自变量 | B(95%CI) | SE | β | t值 | P值 |
---|---|---|---|---|---|---|
SDNN | BMI | -0.290(-0.449,-0.131) | 0.081 | -0.370 | -3.580 | 0.001 |
ODI | -0.613(-0.846,-0.379) | 0.119 | -0.491 | -5.151 | <0.001 | |
MinSpO2 | 0.539(0.443,0.635) | 0.049 | 0.553 | 11.000 | <0.001 | |
SDANN | BMI | -0.582(-0.737,-0.427) | 0.079 | -0.382 | -7.367 | <0.001 |
ODI | 0.724(0.434,1.014) | 0.148 | 0.503 | 4.892 | <0.001 | |
MinSpO2 | 0.432(0.040,0.824) | 0.036 | 0.489 | 12.000 | <0.001 | |
RMSSD | BMI | 0.159(-0.325,0.643) | 0.247 | 0.022 | 0.644 | 0.521 |
ODI | -0.743(-0.829,-0.657) | 0.044 | -0.438 | -16.886 | <0.001 | |
MinSpO2 | 0.139(-0.057,0.335) | 0.100 | 0.081 | 1.390 | 0.167 | |
LF | BMI | -0.539(-0.802,-0.276) | 1.343 | -0.331 | -0.401 | 0.689 |
ODI | 0.638(-2.067,3.342) | 1.380 | 0.484 | 0.462 | 0.645 | |
MinSpO2 | 0.642(0.349,0.934) | 0.149 | 0.465 | 4.309 | <0.001 | |
HF | BMI | -0.568(-0.789,-0.307) | 0.123 | -0.248 | -4.618 | <0.001 |
ODI | -0.483(-0.548,-0.417) | 0.033 | -0.238 | -14.636 | <0.001 | |
MinSpO2 | 0.647(0.298,0.996) | 0.178 | 0.630 | 3.635 | <0.001 |
Table 7 Multiple linear regression analysis of associated factors of HRV in hypertension patients with OSAHS
因变量 | 自变量 | B(95%CI) | SE | β | t值 | P值 |
---|---|---|---|---|---|---|
SDNN | BMI | -0.290(-0.449,-0.131) | 0.081 | -0.370 | -3.580 | 0.001 |
ODI | -0.613(-0.846,-0.379) | 0.119 | -0.491 | -5.151 | <0.001 | |
MinSpO2 | 0.539(0.443,0.635) | 0.049 | 0.553 | 11.000 | <0.001 | |
SDANN | BMI | -0.582(-0.737,-0.427) | 0.079 | -0.382 | -7.367 | <0.001 |
ODI | 0.724(0.434,1.014) | 0.148 | 0.503 | 4.892 | <0.001 | |
MinSpO2 | 0.432(0.040,0.824) | 0.036 | 0.489 | 12.000 | <0.001 | |
RMSSD | BMI | 0.159(-0.325,0.643) | 0.247 | 0.022 | 0.644 | 0.521 |
ODI | -0.743(-0.829,-0.657) | 0.044 | -0.438 | -16.886 | <0.001 | |
MinSpO2 | 0.139(-0.057,0.335) | 0.100 | 0.081 | 1.390 | 0.167 | |
LF | BMI | -0.539(-0.802,-0.276) | 1.343 | -0.331 | -0.401 | 0.689 |
ODI | 0.638(-2.067,3.342) | 1.380 | 0.484 | 0.462 | 0.645 | |
MinSpO2 | 0.642(0.349,0.934) | 0.149 | 0.465 | 4.309 | <0.001 | |
HF | BMI | -0.568(-0.789,-0.307) | 0.123 | -0.248 | -4.618 | <0.001 |
ODI | -0.483(-0.548,-0.417) | 0.033 | -0.238 | -14.636 | <0.001 | |
MinSpO2 | 0.647(0.298,0.996) | 0.178 | 0.630 | 3.635 | <0.001 |
变量 | B | SE | Wald χ2值 | P值 | OR(95%CI) |
---|---|---|---|---|---|
年龄 | -0.53 | 0.015 | 4.478 | 0.035 | 1.04(1.01,1.06) |
BMI | 1.722 | 0.082 | 5.824 | 0.014 | 1.13(1.07,1.31) |
nSSD | 1.543 | 0.214 | 9.295 | 0.002 | 1.62(1.20,2.19) |
SDANN | 0.770 | 0.015 | 7.715 | 0.005 | 0.95(0.92,0.98) |
nSBP | 1.542 | 0.061 | 11.243 | <0.001 | 1.22(1.10,1.36) |
24 hDSD | 0.052 | 0.332 | 9.931 | <0.001 | 2.09(1.44,3.05) |
LF | 1.070 | 0.006 | 10.246 | <0.001 | 0.97(0.96,0.99) |
Table 8 Multivariate Logistic regression analysis on the associated factors of OSAHS in hypertensive patients
变量 | B | SE | Wald χ2值 | P值 | OR(95%CI) |
---|---|---|---|---|---|
年龄 | -0.53 | 0.015 | 4.478 | 0.035 | 1.04(1.01,1.06) |
BMI | 1.722 | 0.082 | 5.824 | 0.014 | 1.13(1.07,1.31) |
nSSD | 1.543 | 0.214 | 9.295 | 0.002 | 1.62(1.20,2.19) |
SDANN | 0.770 | 0.015 | 7.715 | 0.005 | 0.95(0.92,0.98) |
nSBP | 1.542 | 0.061 | 11.243 | <0.001 | 1.22(1.10,1.36) |
24 hDSD | 0.052 | 0.332 | 9.931 | <0.001 | 2.09(1.44,3.05) |
LF | 1.070 | 0.006 | 10.246 | <0.001 | 0.97(0.96,0.99) |
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