Benign prostatic hyperplasia (BPH) is a major cause of lower urinary tract symptoms in middle-aged and elderly men, while abnormal blood glucose can also lead to functional and organic changes in urinary system. However, there is still a lack of relevant research on the effect of abnormal blood glucose on urodynamic parameters of BPH patients.

To explore the impact of elevated fasting blood glucose (FBG) on urodynamic parameters of BPH patients.

The clinical data of 95 older male patients with BPH who were hospitalized in Department of Urology, Second Affiliated Hospital of Dalian Medical University from January to December, 2021 were analyzed retrospectively. They were divided into hyperglycemic group (n=11) and normal FBG group (n=84) according to the admission FBG level to compare clinical indicators.

We found that the two groups had no statistically significant differences in average age, BMI, total prostate-specific antigen (tPSA), the volume, length, width and height of the prostate, and glycosylated hemoglobin (P>0.05). It was noticed that the mean course of diabetes in the hyperglycemic group was longer〔2 (0, 10) years vs 0 (0, 0) years, u=705.500, P=0.025〕. The average FBG level of the hyperglycemic group was significantly higher than that of the normal FBG group 〔 (8.9±2.1) mmol/L vs (5.4±0.7) mmol/L, t=-11.263, P<0.001〕. As for urodynamic parameters, the International Prostate Symptom Score (IPSS), IPSS voiding (IPSS-V), quality life (Qol) score, post-voiding residual volume (PVRV), maximum urine flow rate and detrusor pressure at Q-max were similar between the groups (P>0.05). However, the average scores on IPSS-storage〔 (13.7±1.4) scores vs (11.4±3.3) scores, t=-2.316, P=0.023〕 and bladder first sensation volume〔 (147.8±76.9) ml vs (100.2±48.0) ml, t=-2.532, P=0.014〕in the hyperglycemic group were significantly higher.

We demonstrated that elevated FBG has significant adverse effects on subjective and objective urodynamic parameters of BPH patients, which may lead to impaired first sensation volume of bladder and more severe storage symptoms. These patients often have a long course of diabetes, so more clinical attention should be given to their blood glucose control. It is of prominent significance to take active comprehensive intervention for symptomatic management of BPH.

良性前列腺增生症（BPH）是引起中老年男性下尿路症状的重要原因之一，而血糖异常也可以引起泌尿系统的功能性和器质性改变，但目前关于血糖对BPH患者排尿参数的影响效应仍缺乏相关的研究。

探索空腹血糖对BPH患者排尿参数的影响。

回顾性分析2021年于大连医科大学附属第二医院泌尿外科住院的95例老年男性BPH患者的临床资料，依据患者入院时是否存在空腹血糖升高分为高血糖组（n=11）和正常血糖组（n=84），对比两组间临床指标。

两组患者年龄，体质指数（BMI），总前列腺特异性抗原（tPSA），前列腺体积，前列腺长、宽、高，糖化血红蛋白比较，差异均无统计学意义（P>0.05）。高血糖组患者糖尿病病程长于正常血糖组〔2（0，10）年与0（0，0）年，u=705.500，P=0.025〕，高血糖组患者空腹血糖高于正常血糖组〔（8.9±2.1） mmol/L与（5.4±0.7） mmol/L，t=-11.263，P<0.001〕。两组患者国际前列腺症状评分（IPSS）、排尿期症状评分（IPSS-V）、生活质量评分（Qol）、排尿后残余尿量（PVRV）、最大尿流率、最大流率逼尿肌压力比较，差异均无统计学意义（P>0.05）；高血糖组国际前列腺评分储尿期症状评分（IPSS-S）〔（13.7±1.4）分与（11.4±3.3）分，t=-2.316，P=0.023〕和膀胱初始尿意容量〔（147.8±76.9） ml与（100.2±48.0） ml，t=-2.532，P=0.014〕大于正常血糖组。

空腹血糖升高对BPH患者的主观排尿参数中的IPSS-S及客观排尿参数中的膀胱初始尿意容量有不良影响，更易使BPH患者合并膀胱初始尿意容量受损，具有更严重的储尿期症状，且高血糖BPH患者常伴有较长的糖尿病病程。针对空腹血糖升高的BPH患者，临床应更加关注患者的血糖情况，进行积极的综合性干预对于BPH的症状管理具有重要意义。