Heart rate variability (HRV) is commonly used to evaluate the short-term prognosis of coronary artery diseaseas a well-known non-invasive indicator of cardiac autonomic function. Percutaneous coronary intervention (PCI) is a commonly usedsuigical treatment of coronary artery disease, however, major adverse cardiac event (MACE) such as malignant arrhythmias and recurrent myocardial infarction are common after suigical treatment. Although dual antiplatelet therapy (DAPT) can reduce the occurrence of MACE to a certain extent, it is prone to be complicated with gastrointestinal bleeding, and unable to consistently improve the prognosis of PCI. Ocular acupuncture can effectively reduce the duration and frequency of chest pain, and exercise therapy can enhance the function of heart and blood vessels. The application of ocular acupuncture and exercise combination therapy (OAECT) after PCI remains to be explored.

To investigate the effect of OAECT on postoperative heart rate variability and prognosis of patients treated with PCI.

A total of 32 CHD patients after PCI with moderate and low risk attending Hospital of Chengdu University of Traditional Chinese Medicine were selected and randomly divided into the OAECT group and drug treatment group in a 1∶1 allocation ratio. Patients in the OAECT group received OAECT in addition to DAPT, patients in the drug treatment group received DAPT alone, patients in both 2 groups completed the 2-week intervention. The data of patients was collectedas follows: (1) Baseline indicators: gender, age, height, weight, blood pressure, respiratory rate, interval between onset and intervention, education level, occupation, severity of coronary artery disease, and number of underlying diseases. (2) Main indicators: HRV within 24 h after PCI and on the day of the end of 2-week intervention, including the standard deviation of all normal to normal RR intervals (SDNN) , standard deviation of all 5-minute RR intervals (SDANN) , mean of the standard deviation of all NN intervals for all 5-min segment of 24 hours (SDNN index) , root mean square of difference between adjacent NN intervals (rMSSD) , percent of NN50 in the total number of NN intervals (PNN50) , high frequency (HF) , low frequency (LF) low frequency/high frequency (LF/HF) values. Prognosis at 2, 4, and 8 weeks after the intervention assessed by MACE, including cardiac or all-cause deaths, malignant arrhythmias such as ventricular tachycardia and ventricular fibrillation, severe heart failure, recurrent myocardial infarction, repeat PCI and chest pain recorded by telephone and outpatient consultations. (3) Secondary indicators: C-reactive protein (CRP) , N-terminal pro B type natriuretic peptide (NT-proBNP) , creatine kinase isoenzyme (CK-MB) , high-sensitivity troponin I (hs-TnI) . (4) Safety indicators: the occurrence of complications after PCI such as subcutaneous hematoma, skin lesions, muscle soreness, respiratory abnormalities and stroke, all the outcome indicators were measured within 24 hours after PCI and on the day of the end of 2-week intervention.

There was no significant difference in LF/HF, SDNN, SDANN, SDNN index, LF, HF, RMSSD and PNN50 between the 2 groups (P>0.05) . There were significant differences in LF/HF, SDNN and SDANN (P<0.05) .CRP was higher in the drug treatment group than OAECT group after 2 weeks (P<0.05) ; there was no significant difference in NT-proBNP, CK-MB and hs-TnI between the 2 groups (P>0.05) . The incidence rates of MACE and adverse reactions in the OAECT group were lower than DAPT group (P<0.05) .

OAECT is more effective than drug treatment in improving HRV with a lower incidence rate of MACE and better prognosis for patients after PCI.

已知心率变异性（HRV）是评价心脏自主神经功能的非侵入性指标，常用于评估冠状动脉病变短期预后。经皮冠状动脉介入治疗（PCI）是一种常用的冠状动脉病变手术方式，但术后常见恶性心律失常、复发性心肌梗死等主要不良心血管事件（MACE），双联抗血小板治疗（DAPT）虽可在一定程度上减少MACE发生，但易合并消化道出血，不能持续有效地改善PCI预后。而眼针可有效减少胸痛持续时间和频率，运动疗法可增强心脏和血管功能，二者相结合的眼针带针运动在PCI术后的应用有待探索。

探讨眼针带针运动对冠心病（CHD）患者PCI后HRV及预后的影响。

选取2021年9月—2022年8月在成都中医药大学附属医院就诊的32例PCI后中、低危的CHD患者为研究对象。按1∶1的分配比例随机分为眼针带针运动组或药物治疗组。眼针带针运动组在双联抗血小板治疗的基础上加以眼针带针运动，药物治疗组仅接受双联抗血小板治疗，两组受试者均完成了2周干预。收集患者以下资料：（1）基线指标：包括性别、年龄、身高、体质量、血压、呼吸频率、介入治疗的时间间隔、教育水平、职业、冠状动脉病变严重程度、患基础疾病数量。（2）主要指标：采用24 h动态心电图评价PCI后24 h内和2周干预结束当天HRV。记录全部正常窦性心搏RR间期的标准差（SDNN）、24 h内每5 min RR间期平均值的标准差（SDANN）、24 h内每5 min内RR间期标准差的平均值（SDNN index）、相邻RR间期差值均方的平方根（rMSSD）、相邻RR间期相差>50 ms的个数占总心跳次数的百分比（PNN50）、高频（HF）、低频（LF）、低频/高频比值（LF/HF）。采用MACE评估干预后2、4、8周的预后。通过电话和门诊会诊记录心源性或全因死亡、恶性心律失常如室性心动过速和心室颤动、重度心力衰竭、复发性心肌梗死、再次PCI、胸痛等情况。（3）次要指标：C反应蛋白（CRP）、N末端脑钠肽前体（NT-proBNP）、肌酸激酶同工酶（CK-MB）、高敏肌钙蛋白I（hs-TnI）。（4）安全性指标：PCI后皮下血肿、皮肤病变、肌肉酸痛、呼吸异常、脑卒中等并发症发生情况。结局指标均在PCI后24 h内和2周干预结束当天测量。

治疗2周后，两组LF/HF、SDNN、SDANN、SDNN index、LF、HF、RMSSD、PNN50比较，差异无统计学意义（P>0.05）。两组LF/HF、SDNN、SDANN水平比较，差异有统计学意义（P<0.05）。2周后药物治疗组CRP高于眼针带针运动组（P<0.05）；两组NT-proBNP、CK-MB和hs-TnI比较，差异无统计学意义（P>0.05）。眼针带针运动组MACE发生率和不良反应率低于药物治疗组（P<0.05）。

眼针带针运动在改善PCI后CHD患者的HRV方面比药物治疗更有效，MACE发生率更低，术后短期预后更好。