Chinese General Practice ›› 2023, Vol. 26 ›› Issue (11): 1318-1324.DOI: 10.12114/j.issn.1007-9572.2022.0779
Special Issue: 男性健康最新文章合集; 全科质控专项研究
• Original Research • Previous Articles Next Articles
Received:
2022-10-27
Revised:
2022-12-13
Published:
2023-04-15
Online:
2022-12-30
Contact:
WANG Anhui, QIN Weijun
About author:
通讯作者:
王安辉, 秦卫军
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0779
结果 | 氧化应激组(n=67) | 能量代谢组(n=42) | |
---|---|---|---|
基本特征 | |||
年龄( | 30.0±4.3 | 32.3±5.2 | |
体质指数( | 24.0±3.1 | 23.7±2.8 | |
受教育程度〔n(%)〕 | |||
高中及以下 | 41(61.2) | 27(64.3) | |
大专及以上 | 26(38.8) | 15(35.7) | |
吸烟状况〔n(%)〕 | |||
吸烟 | 26(38.8) | 10(23.8) | |
不吸烟 | 41(61.2) | 32(76.2) | |
饮酒状况〔n(%)〕 | |||
饮酒 | 24(35.8) | 12(28.6) | |
不饮酒 | 43(64.2) | 30(71.4) | |
精液量〔M(QR),ml〕 | 3.50(0.30) | 3.35(1.05) | |
精子密度参数〔M(QR),×106/ml〕 | |||
精子密度 | 58.58(104.14) | 41.16(63.84) | |
直线运动精子密度 | 15.59(24.13) | 8.66(16.92) | |
精子活动力参数(%) | |||
前向运动率 | 39.77±19.89 | 33.55(38.19) | |
非前向运动率 | 12.20±6.03 | 10.03(6.87) | |
精子总活力 | 51.97±23.24 | 40.90(47.86) | |
运动速度参数〔M(QR),μm/s〕 | |||
曲线速度 | 36.02(25.54) | 26.55(26.95) | |
直线速度 | 15.55(11.27) | 13.12(16.21) | |
平均路径速度 | 19.87(10.69) | 15.65(17.69) | |
运动轨迹参数 | |||
平均侧摆幅值( | 2.30±0.27 | 2.58±0.47 | |
平均鞭打频率〔M(QR),Hz〕 | 9.93(7.19) | 7.97(8.84) | |
平均移动角度( | 14.28°±4.35° | 13.26°±5.12° | |
运动的直线性( | 39.99±7.76 | 26.33±19.06 | |
运动的摆动性( | 51.99±6.21 | 58.29±11.22 | |
运动的前向性〔M(QR),%〕 | 77.02(7.03) | 80.96(13.35) |
Table 1 Statistical description of basic demographics,oxidative stress,energy metabolism and sperm quality parameters in subjects
结果 | 氧化应激组(n=67) | 能量代谢组(n=42) | |
---|---|---|---|
基本特征 | |||
年龄( | 30.0±4.3 | 32.3±5.2 | |
体质指数( | 24.0±3.1 | 23.7±2.8 | |
受教育程度〔n(%)〕 | |||
高中及以下 | 41(61.2) | 27(64.3) | |
大专及以上 | 26(38.8) | 15(35.7) | |
吸烟状况〔n(%)〕 | |||
吸烟 | 26(38.8) | 10(23.8) | |
不吸烟 | 41(61.2) | 32(76.2) | |
饮酒状况〔n(%)〕 | |||
饮酒 | 24(35.8) | 12(28.6) | |
不饮酒 | 43(64.2) | 30(71.4) | |
精液量〔M(QR),ml〕 | 3.50(0.30) | 3.35(1.05) | |
精子密度参数〔M(QR),×106/ml〕 | |||
精子密度 | 58.58(104.14) | 41.16(63.84) | |
直线运动精子密度 | 15.59(24.13) | 8.66(16.92) | |
精子活动力参数(%) | |||
前向运动率 | 39.77±19.89 | 33.55(38.19) | |
非前向运动率 | 12.20±6.03 | 10.03(6.87) | |
精子总活力 | 51.97±23.24 | 40.90(47.86) | |
运动速度参数〔M(QR),μm/s〕 | |||
曲线速度 | 36.02(25.54) | 26.55(26.95) | |
直线速度 | 15.55(11.27) | 13.12(16.21) | |
平均路径速度 | 19.87(10.69) | 15.65(17.69) | |
运动轨迹参数 | |||
平均侧摆幅值( | 2.30±0.27 | 2.58±0.47 | |
平均鞭打频率〔M(QR),Hz〕 | 9.93(7.19) | 7.97(8.84) | |
平均移动角度( | 14.28°±4.35° | 13.26°±5.12° | |
运动的直线性( | 39.99±7.76 | 26.33±19.06 | |
运动的摆动性( | 51.99±6.21 | 58.29±11.22 | |
运动的前向性〔M(QR),%〕 | 77.02(7.03) | 80.96(13.35) |
精子质量参数 | 粗模型 | 调整模型 | |||
---|---|---|---|---|---|
β(95%CI) | P值 | β(95%CI) | P值 | ||
精子密度参数 | |||||
精子密度 | -9.36(-20.63,1.91) | 0.108 | -10.74(-22.94,1.46) | 0.083 | |
直线运动精子密度 | -4.58(-9.12,-0.04) | 0.052 | -5.05(-10.04,-0.06) | 0.047 | |
精子活动力参数 | |||||
前向运动率 | -5.38(-8.33,-2.43) | <0.001 | -5.37(-8.65,-2.08) | 0.002 | |
非前向运动率 | -1.51(-2.42,-0.59) | 0.002 | -1.35(-2.36,-0.35) | 0.009 | |
精子总活力 | -6.89(-10.26,-3.51) | <0.001 | -6.72(-10.50,-2.94) | <0.001 | |
精子运动速度参数 | |||||
曲线速度 | -5.68(-8.33,-3.03) | <0.001 | -5.39(-8.31,-2.47) | <0.001 | |
直线速度 | -2.52(-3.82,-1.21) | <0.001 | -2.38(-3.83,-0.92) | 0.002 | |
平均路径速度 | -3.15(-4.70,-1.59) | <0.001 | -2.98(-4.70,-1.25) | 0.001 | |
精子运动轨迹参数 | |||||
平均侧摆幅值 | -0.05(-0.09,-0.01) | 0.018 | -0.05(-0.09,0) | 0.041 | |
平均鞭打频率 | -1.57(-2.35,-0.80) | <0.001 | -1.49(-2.35,-0.63) | 0.001 | |
平均移动角度 | -1.37(-1.99,-0.74) | <0.001 | -1.34(-2.04,-0.65) | <0.001 | |
运动的直线性 | -1.47(-2.67,-0.28) | 0.018 | -1.34(-2.63,-0.06) | 0.041 | |
运动的摆动性 | -1.18(-2.13,-0.23) | 0.018 | -1.07(-2.10,-0.05) | 0.041 | |
运动的前向性 | -1.65(-2.71,-0.58) | 0.004 | -1.55(-2.69,-0.42) | 0.008 |
Table 2 Correlation of malondialdehyde in seminal plasma with sperm concentration,motility,movement velocity and trajectory
精子质量参数 | 粗模型 | 调整模型 | |||
---|---|---|---|---|---|
β(95%CI) | P值 | β(95%CI) | P值 | ||
精子密度参数 | |||||
精子密度 | -9.36(-20.63,1.91) | 0.108 | -10.74(-22.94,1.46) | 0.083 | |
直线运动精子密度 | -4.58(-9.12,-0.04) | 0.052 | -5.05(-10.04,-0.06) | 0.047 | |
精子活动力参数 | |||||
前向运动率 | -5.38(-8.33,-2.43) | <0.001 | -5.37(-8.65,-2.08) | 0.002 | |
非前向运动率 | -1.51(-2.42,-0.59) | 0.002 | -1.35(-2.36,-0.35) | 0.009 | |
精子总活力 | -6.89(-10.26,-3.51) | <0.001 | -6.72(-10.50,-2.94) | <0.001 | |
精子运动速度参数 | |||||
曲线速度 | -5.68(-8.33,-3.03) | <0.001 | -5.39(-8.31,-2.47) | <0.001 | |
直线速度 | -2.52(-3.82,-1.21) | <0.001 | -2.38(-3.83,-0.92) | 0.002 | |
平均路径速度 | -3.15(-4.70,-1.59) | <0.001 | -2.98(-4.70,-1.25) | 0.001 | |
精子运动轨迹参数 | |||||
平均侧摆幅值 | -0.05(-0.09,-0.01) | 0.018 | -0.05(-0.09,0) | 0.041 | |
平均鞭打频率 | -1.57(-2.35,-0.80) | <0.001 | -1.49(-2.35,-0.63) | 0.001 | |
平均移动角度 | -1.37(-1.99,-0.74) | <0.001 | -1.34(-2.04,-0.65) | <0.001 | |
运动的直线性 | -1.47(-2.67,-0.28) | 0.018 | -1.34(-2.63,-0.06) | 0.041 | |
运动的摆动性 | -1.18(-2.13,-0.23) | 0.018 | -1.07(-2.10,-0.05) | 0.041 | |
运动的前向性 | -1.65(-2.71,-0.58) | 0.004 | -1.55(-2.69,-0.42) | 0.008 |
精子质量参数 | 粗模型 | 调整模型 | |||
---|---|---|---|---|---|
β(95%CI) | P值 | β(95%CI) | P值 | ||
精子密度参数 | |||||
精子密度 | 3.69(0.39,6.99) | 0.032 | 3.59(-0.13,7.30) | 0.058 | |
直线运动精子密度 | 1.67(0.35,3.00) | 0.016 | 1.77(0.27,3.28) | 0.022 | |
精子活动力参数 | |||||
前向运动率 | 1.34(0.43,2.24) | 0.004 | 1.44(0.42,2.47) | 0.007 | |
非前向运动率 | 0.27(-0.02,0.55) | 0.068 | 0.26(-0.06,0.58) | 0.110 | |
精子总活力 | 1.60(0.55,2.65) | 0.004 | 1.70(0.51,2.90) | 0.006 | |
精子运动速度参数 | |||||
曲线速度 | 0.82(-0.03,1.67) | 0.064 | 0.90(-0.07,1.86) | 0.068 | |
直线速度 | 0.50(0.09,0.91) | 0.021 | 0.53(0.06,0.99) | 0.026 | |
平均路径速度 | 0.54(0.05,1.03) | 0.036 | 0.60(0.04,1.16) | 0.035 | |
精子运动轨迹参数 | |||||
平均侧摆幅值 | 0.02(0.01,0.03) | 0.001 | 0.02(0.01,0.04) | 0.002 | |
平均鞭打频率 | 0.27(0.02,0.51) | 0.036 | 0.30(0.02,0.58) | 0.035 | |
平均移动角度 | 0.29(0.09,0.49) | 0.005 | 0.31(0.08,0.53) | 0.008 | |
运动的直线性 | 0.60(0.25,0.94) | 0.001 | 0.62(0.24,0.99) | 0.002 | |
运动的摆动性 | 0.48(0.20,0.75) | 0.001 | 0.49(0.20,0.79) | 0.002 | |
运动的前向性 | 0.52(0.20,0.84) | 0.002 | 0.53(0.19,0.87) | 0.003 |
Table 3 Correlation of reduced glutathione in seminal plasma with sperm concentration,motility,movement velocity and trajectory
精子质量参数 | 粗模型 | 调整模型 | |||
---|---|---|---|---|---|
β(95%CI) | P值 | β(95%CI) | P值 | ||
精子密度参数 | |||||
精子密度 | 3.69(0.39,6.99) | 0.032 | 3.59(-0.13,7.30) | 0.058 | |
直线运动精子密度 | 1.67(0.35,3.00) | 0.016 | 1.77(0.27,3.28) | 0.022 | |
精子活动力参数 | |||||
前向运动率 | 1.34(0.43,2.24) | 0.004 | 1.44(0.42,2.47) | 0.007 | |
非前向运动率 | 0.27(-0.02,0.55) | 0.068 | 0.26(-0.06,0.58) | 0.110 | |
精子总活力 | 1.60(0.55,2.65) | 0.004 | 1.70(0.51,2.90) | 0.006 | |
精子运动速度参数 | |||||
曲线速度 | 0.82(-0.03,1.67) | 0.064 | 0.90(-0.07,1.86) | 0.068 | |
直线速度 | 0.50(0.09,0.91) | 0.021 | 0.53(0.06,0.99) | 0.026 | |
平均路径速度 | 0.54(0.05,1.03) | 0.036 | 0.60(0.04,1.16) | 0.035 | |
精子运动轨迹参数 | |||||
平均侧摆幅值 | 0.02(0.01,0.03) | 0.001 | 0.02(0.01,0.04) | 0.002 | |
平均鞭打频率 | 0.27(0.02,0.51) | 0.036 | 0.30(0.02,0.58) | 0.035 | |
平均移动角度 | 0.29(0.09,0.49) | 0.005 | 0.31(0.08,0.53) | 0.008 | |
运动的直线性 | 0.60(0.25,0.94) | 0.001 | 0.62(0.24,0.99) | 0.002 | |
运动的摆动性 | 0.48(0.20,0.75) | 0.001 | 0.49(0.20,0.79) | 0.002 | |
运动的前向性 | 0.52(0.20,0.84) | 0.002 | 0.53(0.19,0.87) | 0.003 |
精子质量参数 | 粗模型 | 调整模型 | |||
---|---|---|---|---|---|
β(95%CI) | P值 | β(95%CI) | P值 | ||
精子密度参数 | |||||
精子密度 | 4.34(-2.82,11.49) | 0.242 | 2.16(-5.15,9.46) | 0.553 | |
直线运动精子密度 | 4.62(2.42,6.83) | <0.001 | 4.34(1.99,6.68) | <0.001 | |
精子活动力参数 | |||||
前向运动率 | 4.22(1.07,7.36) | 0.012 | 4.65(1.41,7.88) | 0.006 | |
非前向运动率 | 1.74(0.84,2.64) | <0.001 | 1.62(0.65,2.59) | 0.002 | |
精子总活力 | 5.96(2.28,9.64) | 0.003 | 6.26(2.43,10.10) | 0.002 | |
精子运动速度参数 | |||||
曲线速度 | 4.57(2.23,6.91) | <0.001 | 4.73(2.22,7.25) | <0.001 | |
直线速度 | 2.73(1.21,4.26) | 0.001 | 3.11(1.57,4.65) | <0.001 | |
平均路径速度 | 3.10(1.44,4.76) | <0.001 | 3.44(1.73,5.15) | <0.001 | |
精子运动轨迹参数 | |||||
平均侧摆幅值 | 0.08(0.00,0.15) | 0.049 | 0.09(0.02,0.17) | 0.019 | |
平均鞭打频率 | 1.54(0.71,2.36) | <0.001 | 1.71(0.85,2.56) | <0.001 | |
平均移动角度 | 0.98(0.25,1.70) | 0.012 | 0.99(0.23,1.75) | 0.013 | |
运动的直线性 | 2.10(0.07,4.14) | 0.049 | 2.60(0.45,4.75) | 0.019 | |
运动的摆动性 | 1.69(0.05,3.33) | 0.049 | 2.09(0.35,3.83) | 0.019 | |
运动的前向性 | 1.79(0.11,3.47) | 0.042 | 2.00(0.14,3.86) | 0.036 |
Table 4 Correlation of ATP level in sperm with sperm concentration,motility,movement velocity and trajectory
精子质量参数 | 粗模型 | 调整模型 | |||
---|---|---|---|---|---|
β(95%CI) | P值 | β(95%CI) | P值 | ||
精子密度参数 | |||||
精子密度 | 4.34(-2.82,11.49) | 0.242 | 2.16(-5.15,9.46) | 0.553 | |
直线运动精子密度 | 4.62(2.42,6.83) | <0.001 | 4.34(1.99,6.68) | <0.001 | |
精子活动力参数 | |||||
前向运动率 | 4.22(1.07,7.36) | 0.012 | 4.65(1.41,7.88) | 0.006 | |
非前向运动率 | 1.74(0.84,2.64) | <0.001 | 1.62(0.65,2.59) | 0.002 | |
精子总活力 | 5.96(2.28,9.64) | 0.003 | 6.26(2.43,10.10) | 0.002 | |
精子运动速度参数 | |||||
曲线速度 | 4.57(2.23,6.91) | <0.001 | 4.73(2.22,7.25) | <0.001 | |
直线速度 | 2.73(1.21,4.26) | 0.001 | 3.11(1.57,4.65) | <0.001 | |
平均路径速度 | 3.10(1.44,4.76) | <0.001 | 3.44(1.73,5.15) | <0.001 | |
精子运动轨迹参数 | |||||
平均侧摆幅值 | 0.08(0.00,0.15) | 0.049 | 0.09(0.02,0.17) | 0.019 | |
平均鞭打频率 | 1.54(0.71,2.36) | <0.001 | 1.71(0.85,2.56) | <0.001 | |
平均移动角度 | 0.98(0.25,1.70) | 0.012 | 0.99(0.23,1.75) | 0.013 | |
运动的直线性 | 2.10(0.07,4.14) | 0.049 | 2.60(0.45,4.75) | 0.019 | |
运动的摆动性 | 1.69(0.05,3.33) | 0.049 | 2.09(0.35,3.83) | 0.019 | |
运动的前向性 | 1.79(0.11,3.47) | 0.042 | 2.00(0.14,3.86) | 0.036 |
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