Chinese General Practice ›› 2023, Vol. 26 ›› Issue (15): 1804-1810.DOI: 10.12114/j.issn.1007-9572.2022.0354
• Monographic Research of Inpatient Glucose Menitoring • Previous Articles Next Articles
Received:
2022-03-12
Revised:
2022-05-12
Published:
2023-05-20
Online:
2022-05-19
Contact:
LI Sheyu
通讯作者:
李舍予
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0354
项目 | 数据 |
---|---|
性别(男/女,人次) | 88 233/57 195 |
年龄( | 62.9±13.7 |
手术科室〔n(%)〕 | 48 962(33.7) |
高血压史〔n(%)〕 | 70 015(48.1) |
缺血性心脏病史〔n(%)〕 | 24 824(17.1) |
脑卒中史〔n(%)〕 | 18 730(12.9) |
CCI( | 3.8±3.4 |
使用糖皮质激素〔n(%)〕 | 61 880(42.6) |
HbA1c( | 7.4±1.8 |
血糖( | 8.7±6.1 |
HDL-C( | 1.1±0.5 |
LDL-C( | 2.3±1.0 |
TG( | 1.8±1.9 |
eGFR〔n(%)〕 | |
≥90 ml·min-1·(1.73 m2)-1 | 62 224(47.1) |
60~89 ml·min-1·(1.73 m2)-1 | 42 328(32.0) |
30~59 ml·min-1·(1.73 m2)-1 | 16 327(12.4) |
15~29 ml·min-1·(1.73 m2)-1 | 4 302(3.3) |
0~14 ml·min-1·(1.73 m2)-1 | 6 908(5.2) |
Table 1 Baseline characteristics and laboratory findings of the included hospitalized patients
项目 | 数据 |
---|---|
性别(男/女,人次) | 88 233/57 195 |
年龄( | 62.9±13.7 |
手术科室〔n(%)〕 | 48 962(33.7) |
高血压史〔n(%)〕 | 70 015(48.1) |
缺血性心脏病史〔n(%)〕 | 24 824(17.1) |
脑卒中史〔n(%)〕 | 18 730(12.9) |
CCI( | 3.8±3.4 |
使用糖皮质激素〔n(%)〕 | 61 880(42.6) |
HbA1c( | 7.4±1.8 |
血糖( | 8.7±6.1 |
HDL-C( | 1.1±0.5 |
LDL-C( | 2.3±1.0 |
TG( | 1.8±1.9 |
eGFR〔n(%)〕 | |
≥90 ml·min-1·(1.73 m2)-1 | 62 224(47.1) |
60~89 ml·min-1·(1.73 m2)-1 | 42 328(32.0) |
30~59 ml·min-1·(1.73 m2)-1 | 16 327(12.4) |
15~29 ml·min-1·(1.73 m2)-1 | 4 302(3.3) |
0~14 ml·min-1·(1.73 m2)-1 | 6 908(5.2) |
变量 | 有血糖管理会诊患者(n=20 486) | 无血糖管理会诊患者(n=124 942) | χ2(t)值 | P值 |
---|---|---|---|---|
性别(男/女,人次) | 12 331/8 155 | 75 902/49 040 | 2.29 | 0.130 |
年龄( | 62.1±12.9 | 63.0±13.9 | 8.08a | <0.001 |
手术科室〔n(%)〕 | 5 817(28.4) | 43 145(34.5) | 296.55 | <0.001 |
高血压史〔n(%)〕 | 9 996(48.8) | 60 019(48.0) | 4.04 | 0.046 |
缺血性心脏病史〔n(%)〕 | 3 026(14.8) | 21 798(17.4) | 88.81 | <0.001 |
脑卒中史〔n(%)〕 | 2 937(14.3) | 15 793(12.6) | 45.00 | <0.001 |
CCI( | 3.5±3.0 | 3.8±3.4 | 12.03a | <0.001 |
使用糖皮质激素〔n(%)〕 | 7 947(38.8) | 53 933(43.2) | 38.84 | <0.001 |
HbA1c( | 8.1±1.9 | 7.2±1.7 | 47.89a | <0.001 |
血糖( | 10.1±5.2 | 8.4±6.2 | 35.14a | <0.001 |
HDL-C( | 1.1±0.5 | 1.1±0.5 | 3.44a | <0.001 |
LDL-C( | 2.4±1.0 | 2.2±1.0 | 17.62a | <0.001 |
TG( | 2.0±2.2 | 1.8±1.9 | 14.11a | <0.001 |
eGFR〔n(%)〕 | 139.16 | <0.001 | ||
≥90 ml·min-1·(1.73 m2)-1 | 9 685(48.6) | 52 539(46.8) | ||
60~89 ml·min-1·(1.73 m2)-1 | 6 217(31.2) | 36 111(32.2) | ||
30~59 ml·min-1·(1.73 m2)-1 | 2 545(12.8) | 13 782(12.3) | ||
15~29 ml·min-1·(1.73 m2)-1 | 731(3.7) | 3 571(3.2) | ||
0~14 ml·min-1·(1.73 m2)-1 | 734(3.7) | 6 174(5.5) |
Table 2 Baseline characteristics and laboratory findings in hospitalized patients with and without consultation for glucose management
变量 | 有血糖管理会诊患者(n=20 486) | 无血糖管理会诊患者(n=124 942) | χ2(t)值 | P值 |
---|---|---|---|---|
性别(男/女,人次) | 12 331/8 155 | 75 902/49 040 | 2.29 | 0.130 |
年龄( | 62.1±12.9 | 63.0±13.9 | 8.08a | <0.001 |
手术科室〔n(%)〕 | 5 817(28.4) | 43 145(34.5) | 296.55 | <0.001 |
高血压史〔n(%)〕 | 9 996(48.8) | 60 019(48.0) | 4.04 | 0.046 |
缺血性心脏病史〔n(%)〕 | 3 026(14.8) | 21 798(17.4) | 88.81 | <0.001 |
脑卒中史〔n(%)〕 | 2 937(14.3) | 15 793(12.6) | 45.00 | <0.001 |
CCI( | 3.5±3.0 | 3.8±3.4 | 12.03a | <0.001 |
使用糖皮质激素〔n(%)〕 | 7 947(38.8) | 53 933(43.2) | 38.84 | <0.001 |
HbA1c( | 8.1±1.9 | 7.2±1.7 | 47.89a | <0.001 |
血糖( | 10.1±5.2 | 8.4±6.2 | 35.14a | <0.001 |
HDL-C( | 1.1±0.5 | 1.1±0.5 | 3.44a | <0.001 |
LDL-C( | 2.4±1.0 | 2.2±1.0 | 17.62a | <0.001 |
TG( | 2.0±2.2 | 1.8±1.9 | 14.11a | <0.001 |
eGFR〔n(%)〕 | 139.16 | <0.001 | ||
≥90 ml·min-1·(1.73 m2)-1 | 9 685(48.6) | 52 539(46.8) | ||
60~89 ml·min-1·(1.73 m2)-1 | 6 217(31.2) | 36 111(32.2) | ||
30~59 ml·min-1·(1.73 m2)-1 | 2 545(12.8) | 13 782(12.3) | ||
15~29 ml·min-1·(1.73 m2)-1 | 731(3.7) | 3 571(3.2) | ||
0~14 ml·min-1·(1.73 m2)-1 | 734(3.7) | 6 174(5.5) |
建议降糖方案 | 诊次 | 构成比(%) |
---|---|---|
餐时胰岛素联合基础胰岛素 | 5 921 | 32.34 |
仅生活方式干预 | 2 191 | 11.97 |
仅餐时胰岛素 | 1 470 | 8.03 |
α-葡萄糖苷酶抑制剂单药 | 1 138 | 6.22 |
二甲双胍单药 | 1 118 | 6.11 |
仅基础胰岛素 | 1 001 | 5.47 |
仅静脉胰岛素 | 972 | 5.31 |
仅预混胰岛素 | 485 | 2.65 |
基础胰岛素联合α-葡萄糖苷酶抑制剂 | 472 | 2.58 |
二甲双胍联合α-葡萄糖苷酶抑制剂 | 403 | 2.20 |
其他 | 3 135 | 17.13 |
Table 3 The therapeutic regimens for diabetes in consultations for glucose management
建议降糖方案 | 诊次 | 构成比(%) |
---|---|---|
餐时胰岛素联合基础胰岛素 | 5 921 | 32.34 |
仅生活方式干预 | 2 191 | 11.97 |
仅餐时胰岛素 | 1 470 | 8.03 |
α-葡萄糖苷酶抑制剂单药 | 1 138 | 6.22 |
二甲双胍单药 | 1 118 | 6.11 |
仅基础胰岛素 | 1 001 | 5.47 |
仅静脉胰岛素 | 972 | 5.31 |
仅预混胰岛素 | 485 | 2.65 |
基础胰岛素联合α-葡萄糖苷酶抑制剂 | 472 | 2.58 |
二甲双胍联合α-葡萄糖苷酶抑制剂 | 403 | 2.20 |
其他 | 3 135 | 17.13 |
药物种类 | 总建议数 | 肾功能 | 肝功能 | ||
---|---|---|---|---|---|
禁忌数〔n(%)〕 | 禁忌判断标准 | 禁忌数〔n(%)〕 | 禁忌判断标准 | ||
二甲双胍 | 3 051 | 37(1.21) | eGFR<45 ml·min-1·(1.73 m2)-1 | 28(0.92) | AST或ALT>3倍ULN |
α-葡萄糖苷酶抑制剂 | 3 449 | 71(2.06) | 阿卡波糖、米格列醇:eGFR<25 ml·min-1·(1.73 m2)-1 | 63(1.83) | 阿卡波糖:ALT>8倍ULN,或ALT>3倍ULN且TBiL>2倍ULN,或诊断肝硬化 |
磺脲类药物 | 1 113 | 22(1.98) | 格列美脲:eGFR<45 ml·min-1·(1.73 m2)-1;格列齐特:eGFR<30 ml·min-1·(1.73 m2)-1 | — | — |
Table 4 Contraindication of suggested drugs in consultation for glucose management
药物种类 | 总建议数 | 肾功能 | 肝功能 | ||
---|---|---|---|---|---|
禁忌数〔n(%)〕 | 禁忌判断标准 | 禁忌数〔n(%)〕 | 禁忌判断标准 | ||
二甲双胍 | 3 051 | 37(1.21) | eGFR<45 ml·min-1·(1.73 m2)-1 | 28(0.92) | AST或ALT>3倍ULN |
α-葡萄糖苷酶抑制剂 | 3 449 | 71(2.06) | 阿卡波糖、米格列醇:eGFR<25 ml·min-1·(1.73 m2)-1 | 63(1.83) | 阿卡波糖:ALT>8倍ULN,或ALT>3倍ULN且TBiL>2倍ULN,或诊断肝硬化 |
磺脲类药物 | 1 113 | 22(1.98) | 格列美脲:eGFR<45 ml·min-1·(1.73 m2)-1;格列齐特:eGFR<30 ml·min-1·(1.73 m2)-1 | — | — |
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