Pathogenesis of Cognitive Deficits Induced by Hippocampal Mitochondrial Dysfunction in Vascular Dementia: a Review of the Latest Developments

doi:10.12114/j.issn.1007-9572.2022.0213

Chinese General Practice ›› 2022, Vol. 25 ›› Issue (23): 2910-2916.DOI: 10.12114/j.issn.1007-9572.2022.0213

Special Issue: 神经退行性病变最新文章合集

• Research of Brain Health：Cognitive Dysfunction • Previous Articles Next Articles

Pathogenesis of Cognitive Deficits Induced by Hippocampal Mitochondrial Dysfunction in Vascular Dementia: a Review of the Latest Developments

¹School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
²First Department of Encephalopathy Rehabilitation, Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China

Received:2022-01-20 Revised:2022-04-10 Published:2022-08-15 Online:2022-06-02
Contact: Juan LI, Yijing JIANG, Lina XIA
About author:
ZHANG X, LI P, WANG Y H, et al. Pathogenesis of cognitive deficits induced by hippocampal mitochondrial dysfunction in vascular dementia: a review of the latest developments[J]. Chinese General Practice, 2022, 25 (23) : 2910-2916.

血管性痴呆认知功能障碍与海马线粒体功能异常的机制研究进展

¹610075　四川省成都市，成都中医药大学养生康复学院
²350001　福建省福州市，福建中医药大学附属康复医院脑病康复一科

通讯作者: 李涓, 江一静, 夏丽娜
作者简介:
张鑫，黎萍，王钰涵，等.血管性痴呆认知功能障碍与海马线粒体功能异常的机制研究进展[J]. 中国全科医学，2022，25（23）：2910-2916. [www.chinagp.net] 作者贡献：张鑫、黎萍和邓小艳确定文章的主要分析内容，参与文章的构思与设计；王钰涵和郑彩平进行相关文献的收集；齐路明参与论文的修订；张鑫撰写论文；李涓、江一静和夏丽娜负责文章质量和审校。
基金资助:
国家自然科学基金资助项目--基于miR-181b/PKC信号轴介导NVU稳态探讨巨刺法改善MCAO大鼠运动功能的作用机制(81904268); 福建省自然科学基金资助项目--基于AMPK信号通路对话小胶质细胞-线粒体探讨电针改善慢性脑缺血大鼠认知功能的作用机制(2020J01763)

Abstract

Abstract:

Hippocampal mitochondrial dysfunction is closely related to cognitive deficits in vascular dementia. We reviewed the latest developments in the internal associations of hippocampal mitochondrial dysfunction with cognitive deficits in vascular dementia, which mainly encompass seven aspects: abnormal mitochondrial autophagy, abnormal apoptotic pathway, oxidative damage, abnormal biosynthetic function, dynamic imbalance, imbalance of calcium homeostasis and abnormal respiratory function. According to the evidence, hippocampal mitochondrial dysfunction may be a major cause of cognitive impairment in vascular dementia, which provides insights into the development of new ideas and effective ways for clinical prevention and improvement of cognitive function in vascular dementia.

Key words: Dementia, vascular, Hippocampus, Mitochondria, Cognitive dysfunction, Free radicals

摘要：

海马线粒体功能异常与血管性痴呆认知功能密切相关。本文从海马线粒体功能异常，包括线粒体细胞自噬、凋亡途径异常、氧化损伤、生物合成功能异常、动力学失衡、钙稳态失衡、呼吸功能异常7个方面，分别探讨其与血管性痴呆认知功能障碍之间的内在机制。通过分析文献，提示海马线粒体功能异常是造成血管性痴呆认知功能障碍的重要原因之一，为今后临床预防与改善血管性痴呆认知功能障碍的治疗提供新思路和有效途径。

关键词: 痴呆，血管性, 海马, 线粒体, 认知功能障碍, 自由基

Xin ZHANG,Ping LI,Yuhan WANG, et al. Pathogenesis of Cognitive Deficits Induced by Hippocampal Mitochondrial Dysfunction in Vascular Dementia: a Review of the Latest Developments[J]. Chinese General Practice, 2022, 25(23): 2910-2916. DOI: 10.12114/j.issn.1007-9572.2022.0213.
张鑫,黎萍,王钰涵等. 血管性痴呆认知功能障碍与海马线粒体功能异常的机制研究进展[J]. 中国全科医学, 2022, 25(23): 2910-2916. DOI: 10.12114/j.issn.1007-9572.2022.0213.

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Pathogenesis of Cognitive Deficits Induced by Hippocampal Mitochondrial Dysfunction in Vascular Dementia: a Review of the Latest Developments

血管性痴呆认知功能障碍与海马线粒体功能异常的机制研究进展

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