Chinese General Practice ›› 2022, Vol. 25 ›› Issue (26): 3281-3289.DOI: 10.12114/j.issn.1007-9572.2022.0217
• Original Research • Previous Articles Next Articles
Received:
2022-02-25
Revised:
2022-05-10
Published:
2022-09-15
Online:
2022-05-19
Contact:
Fei LIU, Bin GUO
About author:
通讯作者:
刘飞, 郭斌
作者简介:
基金资助:
组别 | 只数 | 第0周 | 第2周 | 第4周 | 第6周 | 第8周 |
---|---|---|---|---|---|---|
正常对照小鼠 | 10 | 25.06±0.58 | 35.07±0.63 | 42.58±0.53 | 46.84±1.10 | 48.96±0.78 |
糖尿病模型小鼠 | 60 | 26.63±0.51 | 25.72±0.83 | 25.67±0.58 | 25.57±0.80 | 24.82±0.90 |
t值 | 2.04 | 8.96 | 21.54 | 15.59 | 20.29 | |
P值 | >0.05 | <0.01 | <0.01 | <0.01 | <0.01 |
Table 1 Comparison of weight level between two groups of mice at different time
组别 | 只数 | 第0周 | 第2周 | 第4周 | 第6周 | 第8周 |
---|---|---|---|---|---|---|
正常对照小鼠 | 10 | 25.06±0.58 | 35.07±0.63 | 42.58±0.53 | 46.84±1.10 | 48.96±0.78 |
糖尿病模型小鼠 | 60 | 26.63±0.51 | 25.72±0.83 | 25.67±0.58 | 25.57±0.80 | 24.82±0.90 |
t值 | 2.04 | 8.96 | 21.54 | 15.59 | 20.29 | |
P值 | >0.05 | <0.01 | <0.01 | <0.01 | <0.01 |
组别 | 只数 | 第0周 | 第2周 | 第4周 | 第6周 | 第8周 |
---|---|---|---|---|---|---|
正常对照小鼠 | 10 | 7.69±0.24 | 10.71±0.56 | 8.16±0.28 | 8.77±0.38 | 8.61±0.36 |
糖尿病模型小鼠 | 60 | 7.24±0.22 | 28.15±0.71 | 30.75±0.36 | 30.08±0.64 | 29.57±0.89 |
t值 | 1.36 | 19.23 | 49.10 | 28.59 | 21.70 | |
P值 | >0.05 | <0.01 | <0.01 | <0.01 | <0.01 |
Table 2 Comparison of fasting blood glucose level between two groups of mice at different time
组别 | 只数 | 第0周 | 第2周 | 第4周 | 第6周 | 第8周 |
---|---|---|---|---|---|---|
正常对照小鼠 | 10 | 7.69±0.24 | 10.71±0.56 | 8.16±0.28 | 8.77±0.38 | 8.61±0.36 |
糖尿病模型小鼠 | 60 | 7.24±0.22 | 28.15±0.71 | 30.75±0.36 | 30.08±0.64 | 29.57±0.89 |
t值 | 1.36 | 19.23 | 49.10 | 28.59 | 21.70 | |
P值 | >0.05 | <0.01 | <0.01 | <0.01 | <0.01 |
组别 | 只数 | 第7天 | 第14天 |
---|---|---|---|
NC组 | 10 | 56.52±1.55 | 93.57±3.15 |
DM组 | 10 | 29.89±5.27a | 75.56±5.12a |
rhEGF组 | 10 | 55.91±0.83b | 90.17±1.12b |
matrix组 | 10 | 36.92±0.53a | 82.91±0.98a |
0.5% o-HA组 | 10 | 43.92±0.86ab | 88.02±1.60b |
1% o-HA组 | 10 | 51.79±1.48b | 92.92±1.39b |
2% o-HA组 | 10 | 47.50±2.64ab | 88.17±1.08b |
F值 | 16.81 | 6.29 | |
P值 | <0.01 | <0.05 |
Table 3 Comparison of wound healing rate in each group of mice at different time points after trauma
组别 | 只数 | 第7天 | 第14天 |
---|---|---|---|
NC组 | 10 | 56.52±1.55 | 93.57±3.15 |
DM组 | 10 | 29.89±5.27a | 75.56±5.12a |
rhEGF组 | 10 | 55.91±0.83b | 90.17±1.12b |
matrix组 | 10 | 36.92±0.53a | 82.91±0.98a |
0.5% o-HA组 | 10 | 43.92±0.86ab | 88.02±1.60b |
1% o-HA组 | 10 | 51.79±1.48b | 92.92±1.39b |
2% o-HA组 | 10 | 47.50±2.64ab | 88.17±1.08b |
F值 | 16.81 | 6.29 | |
P值 | <0.01 | <0.05 |
组别 | 只数 | MDA(nmol/ml) | SOD(U/ml) |
---|---|---|---|
NC组 | 10 | 4.13±0.86 | 163.40±2.65 |
DM组 | 10 | 15.00±0.29a | 61.34±1.73a |
rhEGF组 | 10 | 8.85±0.96b | 110.10±1.62ab |
matrix组 | 10 | 12.67±0.38a | 80.51±3.23a |
0.5% o-HA组 | 10 | 10.22±1.19ab | 120.90±8.05b |
1% o-HA组 | 10 | 6.18±0.10b | 136.30±11.15b |
2% o-HA组 | 10 | 10.35±0.65ab | 105.70±2.05ab |
F值 | 34.22 | 37.23 | |
P值 | <0.01 | <0.01 |
Table 4 Comparison of SOD and MDA levels in serum of each group
组别 | 只数 | MDA(nmol/ml) | SOD(U/ml) |
---|---|---|---|
NC组 | 10 | 4.13±0.86 | 163.40±2.65 |
DM组 | 10 | 15.00±0.29a | 61.34±1.73a |
rhEGF组 | 10 | 8.85±0.96b | 110.10±1.62ab |
matrix组 | 10 | 12.67±0.38a | 80.51±3.23a |
0.5% o-HA组 | 10 | 10.22±1.19ab | 120.90±8.05b |
1% o-HA组 | 10 | 6.18±0.10b | 136.30±11.15b |
2% o-HA组 | 10 | 10.35±0.65ab | 105.70±2.05ab |
F值 | 34.22 | 37.23 | |
P值 | <0.01 | <0.01 |
组别 | 只数 | Nrf2 | HO-1 | NQO1 |
---|---|---|---|---|
NC组 | 10 | 1.10±0.11 | 1.06±0.10 | 1.08±0.07 |
DM组 | 10 | 0.81±0.04a | 1.11±0.04 | 0.67±0.03a |
rhEGF组 | 10 | 1.41±0.05ab | 2.47±0.13ab | 2.13±0.05ab |
matrix组 | 10 | 0.88±0.01 | 1.40±0.15 | 0.90±0.05 |
0.5% o-HA组 | 10 | 1.23±0.11b | 1.83±0.02ab | 1.16±0.10b |
1% o-HA组 | 10 | 1.42±0.03ab | 2.49±0.06ab | 1.77±0.09ab |
2% o-HA组 | 10 | 0.89±0.04 | 2.34±0.06ab | 1.20±0.04b |
F值 | 14.32 | 47.61 | 58.30 | |
P值 | <0.01 | <0.01 | <0.01 |
Table 5 The relative expression of Nrf2,HO-1 and NQO1 protein in wound tissue of each group
组别 | 只数 | Nrf2 | HO-1 | NQO1 |
---|---|---|---|---|
NC组 | 10 | 1.10±0.11 | 1.06±0.10 | 1.08±0.07 |
DM组 | 10 | 0.81±0.04a | 1.11±0.04 | 0.67±0.03a |
rhEGF组 | 10 | 1.41±0.05ab | 2.47±0.13ab | 2.13±0.05ab |
matrix组 | 10 | 0.88±0.01 | 1.40±0.15 | 0.90±0.05 |
0.5% o-HA组 | 10 | 1.23±0.11b | 1.83±0.02ab | 1.16±0.10b |
1% o-HA组 | 10 | 1.42±0.03ab | 2.49±0.06ab | 1.77±0.09ab |
2% o-HA组 | 10 | 0.89±0.04 | 2.34±0.06ab | 1.20±0.04b |
F值 | 14.32 | 47.61 | 58.30 | |
P值 | <0.01 | <0.01 | <0.01 |
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