Mechanism of Action of 10-week Aerobic Exercise versus Combined Aerobic and Resistance Exercise in Improving the Microcirculation in Obese College Students

doi:10.12114/j.issn.1007-9572.2022.0118

Chinese General Practice ›› 2022, Vol. 25 ›› Issue (19): 2349-2355.DOI: 10.12114/j.issn.1007-9572.2022.0118

Special Issue: 运动相关研究最新文章合集；肥胖最新文章合集

• Original Research·Clinical Quality Improvement • Previous Articles Next Articles

Mechanism of Action of 10-week Aerobic Exercise versus Combined Aerobic and Resistance Exercise in Improving the Microcirculation in Obese College Students

1. School of Physical Education, Hubei Minzu University, Enshi 445000, China
2. School of Physical Education, Guangxi Normal University for Nationalities, Chongzuo 532200, China
3. School of Music and Physical Education, Hubei Enshi College, Enshi 445000, China

Received:2022-02-25 Revised:2022-05-24 Published:2022-07-05 Online:2022-06-02
Contact: Huan ZHU
About author:
XIAO Z, ZHU H, HU J P, et al. Mechanism of action of 10-week aerobic exercise versus combined aerobic and resistance exercise in improving the microcirculation in obese college students[J]. Chinese General Practice, 2022, 25 (19) : 2349-2355, 2362.

10周有氧运动和有氧结合抗阻运动对肥胖大学生微循环功能的影响及机制研究

1．445000　湖北省恩施市，湖北民族大学体育学院
2．532200　广西壮族自治区崇左市，广西民族师范学院体育学院
3．445000　湖北省恩施市，湖北恩施学院音乐与体育学院

通讯作者: 朱欢
作者简介:
肖哲，朱欢，胡江平，等. 10周有氧运动和有氧结合抗阻运动对肥胖大学生微循环功能的影响及机制研究[J].中国全科医学，2022，25（19）：2349-2355，2362. [www.chinagp.net] 作者贡献：肖哲是本研究试验的执行者，负责试验实施、数据整理分析及论文撰写；朱欢、胡江平负责试验设计，并提出修改意见；杨梅、彭永、周慧敏参与试验的运动干预。
基金资助:
2020年湖北省高等学校省级教学研究项目(2020550); 2021年国家民委高等教育教学改革项目(21064); 2020年湖北省教育厅科学研究计划项目(Q20201905); 2021年湖北省教育厅科学研究计划项目(B2021445)

Abstract

Abstract:

Background

Microcirculation dysfunction is closely associated with the development of obesity. Exercise intervention could effectively improve the microcirculation in obese people, but the intensity of an exercise intervention schemes often lacks of individualization and precision. FATmax is a precise and individualized exercise intensity determined on the basis of individual fat oxidation rate.

Objective

To compare the effects of aerobic exercise and combined aerobic and resistance exercise at FATmax intensity on improving the microcirculation in obese college students, and to explore the mechanism of action by analyzing the changes in nitric oxide (NO) , endogenous NO synthase (eNOS) , endothelin-1 (ET-1) and endothelial growth factor (VEGF) .

Methods

In March, 2021, Sixty-six obese college students were recruited from Hubei University for Nationalities, and equally randomized into sex-matched three groups with different 10-week interventions: aerobic exercise group (performing aerobic exercise at the FATmax intensity, 4 times a week, 60 minutes each time) , combined aerobic and resistance exercise group〔performing combined aerobic and resistance exercise at FATmax intensity, 4 times a week, 60 minutes each time (40 minutes for aerobic exercise and 20 minutes for resistance exercise) 〕, and control group (maintaining their normal living habits) . Body weight, body fat percentage, BMI, microvascular reactivity, transcutaneous oxygen pressure (TcPO₂) , muscle oxygen saturation (SmO₂) , NO, eNOS, ET-1, VEGF and HOMA-IR were tested on March 18 and June 2, 2021, respectively.

Results

The intervention modality and duration had significant interactive effects on body weight, BMI and body fat percentage of three groups (P<0.05) . In particular, the average body weight, BMI and body fat percentage decreased significantly in both aerobic exercise group and combined aerobic and resistance exercise group after the intervention (P<0.05) . What's more, the average post-intervention levels of the above-mentioned three indicators in the two groups were significantly lower than those of the control group (P<0.05) . The intervention modality and duration had significant interactive effects on microvascular reactivity, TcPO₂ and SmO₂ of three groups (P<0.05) . In particular, the average microvascular reactivity, TcPO₂ and SmO₂ increased significantly in both aerobic exercise group and combined aerobic and resistance exercise group after the intervention (P<0.05) . In addition, the average post-intervention levels of the average microvascular reactivity and TcPO₂ in the two groups were significantly higher than those of the control group (P<0.05) . The intervention modality and duration produced obvious interactive effects on NO, eNOS, VEGF and HOMA-IR of three groups (P<0.05) . In particular, the average NO, eNOS, and VEGF increased significantly and HOMA-IR decreased significantly in both aerobic exercise group and combined aerobic and resistance exercise group after the intervention (P<0.05) . Moreover, these two groups showed higher average post-intervention levels of NO and lower average post-intervention level of HOMA-IR than the control group (P<0.05) .

Conclusion

Both 10-week aerobic exercise and combined aerobic and resistance exercise at FATmax intensity could reduce body weight, body fat percentage, BMI and HOMA-IR in obese college students, and the latter may be more effective in improving microvascular reactivity and HOMA-IR. These two modalities of exercise improved microcirculation may be by improving the levels of NO, ET-1, VEGF and other factors.

Key words: Obesity, Obesity management, Aerobic exercise, Resistance exercise, Maximum fat oxidation intensity, Microcirculation function

摘要：

背景

微循环功能障碍与肥胖的发生、发展都有密切关系。运动干预是改善肥胖人群微循环功能的有效方式，但运动强度的制定存在缺乏个体差异性及精度不够等问题。FATmax基于个体化的脂肪氧化速率而定，能实现运动强度的精准化、个体化。

目的

比较FATmax下的有氧运动和有氧结合抗阻运动对肥胖大学生微循环功能的影响，并从一氧化氮（NO）、内源性一氧化氮合酶（eNOS）、内皮素-1（ET-1）、内皮细胞生长因子（VEGF）角度探讨运动改善微循环功能的机制。

方法

2021年3月，从湖北民族大学招募66例符合标准的肥胖大学生为研究对象。在性别比例一致的情况下，随机将66例受试者分成对照组、有氧运动组及有氧结合抗阻运动组。有氧运动组进行4次/周、60 min/次的有氧运动，有氧结合抗阻运动组进行4次/周有氧结合抗阻运动，其中有氧运动和抗阻运动强度均维持在FATmax；对照组受试者维持正常的生活习惯。分别在试验前1 d和试验后1 d测试三组受试者体质量、体脂率、体质指数（BMI）、微血管反应性、经皮氧分压（TcPO₂）、肌氧饱和度（SmO₂）及NO、eNOS、ET-1、VEGF、胰岛素抵抗指数（HOMA-IR）等指标。

结果

试验前后，三组受试者体质量、BMI和体脂率治疗与时间的交互作用具有统计学意义（P<0.05），其中有氧运动组和有氧结合抗阻运动组体质量、BMI和体脂率均低于试验前及对照组，差异有统计学意义（P<0.05）；三组受试者微血管反应性、TcPO₂、SmO₂治疗与时间的交互作用具有统计学意义（P<0.05），有氧运动组和有氧结合抗阻运动组微血管反应性、TcPO₂高于试验前及对照组，SmO₂高于试验前，差异有统计学意义（P<0.05）；三组受试者NO、eNOS、VEGF、HOMA-IR治疗与时间的交互作用具有统计学意义（P<0.05），有氧运动组和有氧结合抗阻运动组NO高于试验前及对照组，eNOS、VEGF高于试验前，HOMA-IR低于试验前及对照组，差异有统计学意义（P<0.05）。

结论

10周基于FATmax的有氧运动和有氧结合抗阻运动均能降低肥胖大学生体质量、体脂率、BMI及HOMA-IR，且有氧结合抗阻运动在改善微血管反应性、胰岛素抵抗方面效果更佳。另外，运动可能通过改善NO、ET-1、VEGF等因子水平提高肥胖大学生微循环功能。

关键词: 肥胖症, 肥胖管理, 有氧运动, 抗阻运动, 最大脂肪氧化强度, 微循环功能

Zhe XIAO,Huan ZHU,Jiangping HU, et al. Mechanism of Action of 10-week Aerobic Exercise versus Combined Aerobic and Resistance Exercise in Improving the Microcirculation in Obese College Students[J]. Chinese General Practice, 2022, 25(19): 2349-2355. DOI: 10.12114/j.issn.1007-9572.2022.0118.
肖哲,朱欢,胡江平等. 10周有氧运动和有氧结合抗阻运动对肥胖大学生微循环功能的影响及机制研究[J]. 中国全科医学, 2022, 25(19): 2349-2355. DOI: 10.12114/j.issn.1007-9572.2022.0118.

Figures/Tables 5

References 41

[1]	LEVY B I，AMBROSIO G，PRIES A R，et al. Microcirculation in hypertension：a new target for treatment[J]. Circulation，2001，104（6）：735-740. DOI：10.1161/hc3101.091158.
[2]	王成科，朱欢，董徽徽，等.运动对高血压患者微血管反应性的干预效应及可能机制研究进展[J].中国预防医学杂志，2021，22（9）：726-731. DOI：10.16506/j.1009-6639.2021.09.013.
[3]	VIRDIS A，MASI S，COLUCCI R，et al. Microvascular endothelial dysfunction in patients with obesity[J]. Curr Hypertens Rep，2019，21（4）：32-38. DOI：10.1007/s11906-019-0930-2.
[4]	BRINKMANN C，BLOCH W，BRIXIUS K. Exercise during short-term exposure to hypoxia or hyperoxia-novel treatment strategies for type 2 diabetic patients[J]. Scand J Med Sci Sports，2018，28（2）：549-564. DOI：10.1111/sms.12937.
[5]	SOUSA-Sá E，ZHANG Z，PEREIRA J R，et al. Systematic review on retinal microvasculature，physical activity，sedentary behaviour and adiposity in children and adolescents[J]. Acta Paediatr，2020，109（10）：1956-1973. DOI：10.1111/apa.15204.
[6]	LAMPRECHT M，OBERMAYER G，STEINBAUER K，et al. Supplementation with a juice powder concentrate and exercise decrease oxidation and inflammation，and improve the microcirculation in obese women：randomized controlled trial data[J]. Br J Nutr，2013，110（9）：1685-1695. DOI：10.1017/S0007114513001001.
[7]	PASQUALINI L，SCHILLACI G，INNOCENTE S，et al. Lifestyle intervention improves microvascular reactivity and increases serum adiponectin in overweight hypertensive patients[J]. Nutr Metab Cardiovasc Dis，2010，20（2）：87-92.
[8]	DIAS I，FARINATTI P，DE SOUZA M G，et al. Effects of resistance training on obese adolescents[J]. Med Sci Sports Exerc，2015，47（12）：2636-2644.
[9]	齐玉刚，王津，徐冬青. 有氧抗阻结合与单纯有氧运动减重干预的对比研究[J]. 天津体育学院学报，2020，35（5）：541-544. DOI：10.13297/j.cnki.issn1005-0000.2020.05.008.
[10]	朱欢，胡庆华，彭爱萍，等.长期太极拳运动对中老年人膝关节皮肤微血管反应性、经皮氧分压的影响[J].中国应用生理学杂志，2020，36（4）：321-323，384. DOI：10.12047/j.cjap.5957.2020.069.
[11]	胡庆华，乾佑玲，刘晓丽，等. 12周太极拳运动对中老年轻度高血压患者微血管反应性的影响及机制[J].中国应用生理学杂志，2021，37（6）：683-687. DOI：10.12047/j.cjap.6164.2021.080.
[12]	杨梅，朱欢，彭永，等. 12周FATmax强度运动对肥胖大学生外周动脉硬化的影响及机制研究[J].中国细胞生物学学报，2021，43（4）：781-788. DOI：10.11844/cjcb.2021.04.0010.
[13]	彭永，朱欢，杨梅，等. 12周FATmax强度运动对肥胖型非酒精性脂肪肝患者血糖血脂及肝功能的影响[J].基因组学与应用生物学，2021. [Epub ahead of print].
[14]	FOSTER C，FLORHAUG J A，FRANKLIN J，et al. A new approach to monitoring exercise training[J]. J Strength Cond Res，2001，15（1）：109-115.
[15]	LA FAVOR J D，DUBIS G S，YAN H，et al. Microvascular endothelial dysfunction in sedentary，obese humans is mediated by NADPH oxidase：influence of exercise training[J]. Arterioscler Thromb Vasc Biol，2016，36（12）：2412-2420. DOI：10.1161/ATVBAHA.116.308339.
[16]	RAMSAY J E，FERRELL W R，CRAWFORD L，et al. Maternal obesity is associated with dysregulation of metabolic，vascular，and inflammatory pathways[J]. J Clin Endocrinol Metab，2002，87（9）：4231-4237. DOI：10.1210/jc.2002-020311.
[17]	BUSS C，MARANHO P A，DE SOUZA M D G C，et al. Obesity blunts cephalic-phase microvascular responses to food[J]. Physiol Behav，2020，225：113087-113091. DOI：10.1016/j.physbeh.2020.113087.
[18]	WESELER A R，BAST A. Oxidative stress and vascular function：implications for pharmacologic treatments[J]. Curr Hypertens Rep，2010，12（3）：154-161. DOI：10.1007/s11906-010-0103-9.
[19]	ANDERSON T J，CHARBONNEAU F，TITLE L M，et al. Microvascular function predicts cardiovascular events in primary prevention：long-term results from the Firefighters and Their Endothelium（FATE） study[J]. Circulation，2011，23（2）：163-169. DOI：10.1161/CIRCULATIONAHA.110.953653.
[20]	FLAMMER A J，ANDERSON T，CELERMAJER D S，et al. The assessment of endothelial function：from research into clinical practice[J]. Circulation，2012，126（6）：753-767. DOI：10.1161/CIRCULATIONAHA.112.093245.
[21]	FRANCO R L，FALLOW B A，HUANG C J，et al. Forearm blood flow response to acute exercise in obese and non-obese males[J].Eur J Appl Physiol，2013，113（8）：2015-2023. DOI：10.1007/s00421-013-2626-7.
[22]	KARPOFF L，VINET A，SCHUSTER I，et al. Abnormal vascular reactivity at rest and exercise in obese boys[J]. Eur J Clin Invest，2009，39（2）：94-102. DOI：10.1111/j.1365-2362.2008.02068.x.
[23]	周术锋，肖哲，朱欢，等. 12周有氧运动对习惯久坐大学生微循环功能的影响[J]. 中国学校卫生，2021，42（9）：1332-1335，1339. DOI：10.16835/j.cnki.1000-9817.2021.09.013.
[24]	LUCOTTI P，MONTI L D，SETOLA E，et al. Aerobic and resistance training effects compared to aerobic training alone in obese type 2 diabetic patients on diet treatment[J]. Diabetes Res Clin Pract，2011，94（3）：395-403. DOI：10.1016/j.diabres.2011.08.002.
[25]	唐东辉，侯玉洁，杨东升，等. 有氧运动结合抗阻训练对肥胖青少年微血管内皮功能的影响：第四届（2016）全国运动生理与生物化学学术会议论文集[C]. 无锡：中国体育科学学会，2016.
[26]	赵军，梁晋裕.有氧运动结合抗阻训练对肥胖男性大学生身体成分、心血管功能及血清C反应蛋白水平的改善作用[J].吉林大学学报（医学版），2019，45（5）：1134-1140.
[27]	刘晓丽，刘超能，王人卫，等.心肺功能在健康风险预测中的应用[J].中国运动医学杂志，2018，37（2）：158-165. DOI：10.16038/j.1000-6710.2018.02.012.
[28]	杨梅，朱欢，肖杰文，等.长期有氧运动对大学生下肢微循环功能及最大摄氧量的影响[J].中国学校卫生，2021，42（7）：1000-1004. DOI：10.16835/j.cnki.1000-9817.2021.07.010.
[29]	蔡前鑫，魏文哲，赵之光，等.肌氧饱和度与全身耐力的关联性[J].山东体育科技，2016，38（2）：56-59.
[30]	蔡前鑫. 肌氧饱和度评定肌肉耐力和全身耐力的实验研究[D].苏州：苏州大学，2016.
[31]	徐坤，刘永.股四头肌肌肉氧饱和度与Wingate test无氧功率相关性分析[EB/OL].（2022-03-25）[2022-05-10].
[32]	SAADON N，HAMZAID N A，HASNAN N，et al. Electrically evoked wrist extensor muscle fatigue throughout repetitive motion as measured by mechanomyography and near-infrared spectroscopy[J]. Biomed Tech（Berl），2019，64（4）：439-448. DOI：10.1515/bmt-2018-0058.
[33]	FLAMMER A J，ANDERSON T，CELERMAJER D S，et al. The assessment of endothelial function：from research into clinical practice[J]. Circulation，2012，126（6）：753-767. DOI：10.1161/CIRCULATIONAHA.112.093245.
[34]	VIRDIS A，GHIADONI L，VERSARI D，et al. Endothelial function assessment in complicated hypertension[J]. Curr Pharm Des，2008，14（18）：1761-1770.
[35]	KERSHAW E E，FLIER J S. Adipose tissue as an endocrine organ[J]. J Clin Endocrinol Metab，2004，89（6）：2548-2556. DOI：10.1210/jc.2004-0395.
[36]	KIM J A，MONTAGNANI M，KOH K K，et al. Reciprocal relationships between insulin resistance and endothelial dysfunction：molecular and pathophysiological mechanisms[J]. Circulation，2006，113（15）：1888-1904. DOI：10.1161/CIRCULATIONAHA.105.563213.
[37]	HE Z，OPLAND D M，WAY K J，et al. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia[J]. Arterioscler Thromb Vasc Biol，2006，26（4）：787-793.
[38]	DONGHUI T，SHUANG B，XULONG L，et al. Improvement of microvascular endothelial dysfunction induced by exercise and diet is associated with microRNA-126 in obese adolescents[J]. Microvasc Res，2019，123：86-91. DOI：10.1016/j.mvr.2018.10.009.
[39]	BOA B C，SOUZA M D，LEITE R D，et al. Chronic aerobic exercise associated to dietary modification improve endothelial function and eNOS expression in high fat fed hamsters[J]. PLoS One，2014，9（7）：e102554-102563.
[40]	罗曦娟，王正珍，李博文，等.抗阻和有氧运动对糖尿病前期人群胰岛素抵抗的影响[J]. 成都体育学院学报，2018，44（5）：66-72. DOI：10.15942/j.jcsu.2018.05.011.
[41]	魏建翔，何玉秀，刘阳. 有氧联合抗阻运动与单纯有氧运动改善不同人群血糖与胰岛素抵抗效果的差异比较：meta分析[J]. 中国康复医学杂志，2021，36（8）：984-991. DOI：10.3969/j.issn.1001-1242.2021.08.015.

组别		最大脂肪氧化速率（g/min）	FATmax对应的摄氧量		功率（W）	心率（次/min）
组别		最大脂肪氧化速率（g/min）	绝对值（ml/min）	相对值（ml·kg^-1·min^-1）	功率（W）	心率（次/min）
试验前
	有氧运动组	0.39±0.32	1 468±456	20.26±5.45	77±18	130±18
	联合运动组	0.40±0.25	1 492±346	20.42±4.21	78±21	128±16
第5周
	有氧运动组	0.51±0.21	1 508±311	21.88±4.15	85±14	135±20
	联合运动组	0.53±0.19	1 539±401	22.22±3.82	88±20	134±23

组别		最大脂肪氧化速率（g/min）	FATmax对应的摄氧量		功率（W）	心率（次/min）
组别		最大脂肪氧化速率（g/min）	绝对值（ml/min）	相对值（ml·kg^-1·min^-1）	功率（W）	心率（次/min）
试验前
	有氧运动组	0.39±0.32	1 468±456	20.26±5.45	77±18	130±18
	联合运动组	0.40±0.25	1 492±346	20.42±4.21	78±21	128±16
第5周
	有氧运动组	0.51±0.21	1 508±311	21.88±4.15	85±14	135±20
	联合运动组	0.53±0.19	1 539±401	22.22±3.82	88±20	134±23

组别	例数	男/女	年龄（±s，岁）	身高（±s，m）	体质量（±s，kg）	体脂率（±s，%）	BMI（±s，kg/m²）
对照组	22	8/14	20.9±1.7	1.63±0.08	73.67±8.92	33.08±3.72	27.70±2.04
有氧运动组	22	8/14	20.8±1.1	1.64±0.08	72.47±7.73	32.47±4.30	26.94±2.14
联合运动组	22	8/14	20.8±1.8	1.63±0.09	73.03±9.13	32.98±4.70	27.32±2.29
F值		-	0.034	0.073	0.066	0.543	0.496
P值		-	0.967	0.930	0.937	0.585	0.613

组别	例数	男/女	年龄（±s，岁）	身高（±s，m）	体质量（±s，kg）	体脂率（±s，%）	BMI（±s，kg/m²）
对照组	22	8/14	20.9±1.7	1.63±0.08	73.67±8.92	33.08±3.72	27.70±2.04
有氧运动组	22	8/14	20.8±1.1	1.64±0.08	72.47±7.73	32.47±4.30	26.94±2.14
联合运动组	22	8/14	20.8±1.8	1.63±0.09	73.03±9.13	32.98±4.70	27.32±2.29
F值		-	0.034	0.073	0.066	0.543	0.496
P值		-	0.967	0.930	0.937	0.585	0.613

组别	例数	体质量（kg）		BMI（kg/m²）		体脂率（%）
组别	例数	试验前	试验后	试验前	试验后	试验前	试验后
对照组	22	73.67±8.92	74.41±8.40	27.70±2.04	28.01±1.72	33.08±3.72	33.73±4.72
有氧运动组	22	72.47±7.73	68.52±7.53^ab	26.94±2.14	25.52±2.03^ab	32.47±4.30	29.91±3.60^ab
联合运动组	22	73.03±9.13	67.92±11.76^ab	27.32±2.29	25.44±2.30^ab	32.98±4.70	29.63±3.92^ab
F值		F_组间=5.764，F_交互=4.763，F_时间=5.104		F_组间=4.280，F_交互=4.320，F_时间=5.940		F_组间=4.771，F_交互=5.764，F_时间=4.075
P值		P_组间=0.013，P_交互=0.030，P_时间=0.026		P_组间=0.042，P_交互=0.041，P_时间=0.017		P_组间=0.031，P_交互=0.013，P_时间=0.046

Mechanism of Action of 10-week Aerobic Exercise versus Combined Aerobic and Resistance Exercise in Improving the Microcirculation in Obese College Students

10周有氧运动和有氧结合抗阻运动对肥胖大学生微循环功能的影响及机制研究

RichHTML

PDF

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 5

References 41

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	LI Jixin, QIU Linjie, REN Yan, WANG Wenru, LI Meijie, ZHANG Jin. The Correlation of Dietary Inflammatory Index with Overweight, Obesity and Abdominal Obesity: a Meta-analysis [J]. Chinese General Practice, 2023, 26(32): 4089-4097.
[2]	PAN Yaojia, WANG Weiqiang, YI Weizhuo, GAO Bing, FU Fanglin, HAN Zheng, SUN Meng, DONG Yaqin, GU Huaicong. Relationship between Triglyceride-glucose Index and Risk of Cardiovascular Diseases in Middle-aged Obese Residents of Different Genders [J]. Chinese General Practice, 2023, 26(29): 3628-3635.
[3]	WANG Qianqian, WANG Xiaohang, ZHOU Xiaoying, QIU Shanhu, SUN Zilin. Exercise is the Foundation of Weight Loss [J]. Chinese General Practice, 2023, 26(28): 3471-3476.
[4]	JIANG Qiuhui, LI Xuejun. Exercise is Not the Foundation of Weight Loss [J]. Chinese General Practice, 2023, 26(28): 3477-3481.
[5]	ZHANG Li, ZHENG Wei, WANG Jia, YUAN Xianxian, HAN Weiling, HUANG Junhua, TIAN Zhihong, LI Guanghui. Comparison of Gestational Weight Gain and Pregnancy Outcomes in Chinese Women with Singleton Pregnancy Using Standard of Recommendation for Weight Gain during Pregnancy Period and Guidelines by the Institute of Medicine [J]. Chinese General Practice, 2023, 26(24): 2959-2967.
[6]	YIN Cong, DIAO He, SHENG Wei, CAO Yan, BAI Wenpei. Influence of Daily Self-weighing Supported by Online Supervision on Body Composition and Emotions in Overweight/Obese Women with Anxiety and Depression [J]. Chinese General Practice, 2023, 26(24): 2992-2996.
[7]	HE Rong, ZHANG Li, LI Peng, ZHANG Xiaoling, ZHANG Guo, ZANG Yiran, WU Shouling, SUN Lixia. Immediate Effects of Aerobic Exercise on Arterial Stiffness in a Male Population with Different Blood Glucose Levels [J]. Chinese General Practice, 2023, 26(24): 2997-3004.
[8]	ZHANG Lina, WANG Yan, ZHANG Kanghuai, LI Youjia. Clinical Research Progress of Tirzepatide: a New Hypoglycemic Agent [J]. Chinese General Practice, 2023, 26(15): 1902-1908.
[9]	LIU Yanhui, CHEN Shuchun. Interpretation and Clinical Significance of the Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement [J]. Chinese General Practice, 2023, 26(12): 1422-1428.
[10]	WANG Junwei, LIN Lingjun, SONG Linling, CHENG Xiaocui, NIE Xiuling. Association between Serum Potassium and Metabolic-associated Fatty Liver Disease in Patients with Primary Gout [J]. Chinese General Practice, 2023, 26(12): 1479-1484.
[11]	CAI Ming, WANG Liyan, YANG Ruoyu, LIANG Leichao, YANG Yuanyuan, JIA Shihao, CHEN Ruiyi, REN Yu, LIU Qianle, HU Jingyun. Short-term High-intensity Interval Training Reduces the Accumulation of Advanced Glycation End Products and the Risk of Cardiovascular Disease in Normal Weight Obese Female University Students: a Randomized Controlled Trial [J]. Chinese General Practice, 2023, 26(12): 1472-1478.
[12]	YUAN Lijun, WEI Wenjing, ZHANG Xia, FU Ruiyuan, CHEN Qiu. Bariatric Surgery Increases the Risk of Fracture: a Meta-analysis [J]. Chinese General Practice, 2023, 26(11): 1382-1388.
[13]	WANG Yide, LI Zheng, LI Fengsen. Role of Endocrine Function of Adipose Tissue in the Development of Chronic Obstructive Pulmonary Disease: a Review of Recent Advances [J]. Chinese General Practice, 2023, 26(06): 754-759.
[14]	ZHAO Kang, XU Xinyi, ZHU Hanfei, LIANG Hui, YANG Ningli, LIN Rui, XU Qin. Association of Therapeutic Effects on Psychological Status of Post-bariatric Patients One Year after Surgery [J]. Chinese General Practice, 2022, 25(36): 4528-4536.
[15]	YANG Tao, ZHANG Yongjun, ZHENG Liang, GE Xuhua. Diagnostic Efficacy of New ECG Criteria for Left Ventricular Hypertrophy in Overweight and Obese Patients with Hypertension [J]. Chinese General Practice, 2022, 25(36): 4502-4508.

组别	例数	MBP基础值（PU）		MBP加热值（PU）		TcPO₂（mm Hg）		SmO₂（%）
组别	例数	试验前	试验后	试验前	试验后	试验前	试验后	试验前	试验后
对照组	22	8.45±4.01	8.43±2.36	90.15±19.60	86.95±18.12	59.87±7.34	58.81±7.26	61.60±5.67	60.09±6.25
有氧运动组	22	7.78±2.00	7.93±2.56	89.94±20.11	105.25±19.38^ab	59.02±6.98	65.92±7.28^ab	61.56±6.99	64.93±5.41^a
联合运动组	22	7.83±2.58	8.32±2.46	89.10±20.32	123.32±26.11^abc	59.13±7.13	67.49±7.50^ab	59.82±6.23	65.11±4.95^a
F值		F_组间=0.444，F_交互=0.081，F_时间=0.155		F_组间=6.888，F_交互=7.704，F_时间=16.931		F_组间=3.117，F_交互=4.598，F_时间=11.935		F_组间=1.598，F_交互=3.229，F_时间=4.496
P值		P_组间=0.642，P_交互=0.922，P_时间=0.694		P_组间=0.002，P_交互=0.001，P_时间<0.001		P_组间=0.048，P_交互=0.012，P_时间=0.001		P_组间=0.207，P_交互=0.044，P_时间=0.036

组别	例数	MBP基础值（PU）		MBP加热值（PU）		TcPO₂（mm Hg）		SmO₂（%）
组别	例数	试验前	试验后	试验前	试验后	试验前	试验后	试验前	试验后
对照组	22	8.45±4.01	8.43±2.36	90.15±19.60	86.95±18.12	59.87±7.34	58.81±7.26	61.60±5.67	60.09±6.25
有氧运动组	22	7.78±2.00	7.93±2.56	89.94±20.11	105.25±19.38^ab	59.02±6.98	65.92±7.28^ab	61.56±6.99	64.93±5.41^a
联合运动组	22	7.83±2.58	8.32±2.46	89.10±20.32	123.32±26.11^abc	59.13±7.13	67.49±7.50^ab	59.82±6.23	65.11±4.95^a
F值		F_组间=0.444，F_交互=0.081，F_时间=0.155		F_组间=6.888，F_交互=7.704，F_时间=16.931		F_组间=3.117，F_交互=4.598，F_时间=11.935		F_组间=1.598，F_交互=3.229，F_时间=4.496
P值		P_组间=0.642，P_交互=0.922，P_时间=0.694		P_组间=0.002，P_交互=0.001，P_时间<0.001		P_组间=0.048，P_交互=0.012，P_时间=0.001		P_组间=0.207，P_交互=0.044，P_时间=0.036

组别	例数	NO（μmol/L）		eNOS（U/mL）		ET-1（ng/L）		VEGF（ng/L）		HOMA-IR
组别	例数	试验前	试验后	试验前	试验后	试验前	试验后	试验前	试验后	试验前	试验后
对照组	22	39.49±4.88	37.91±5.10	7.98±0.84	7.73±0.90	49.80±6.84	50.91±7.09	160.65±14.58	157.41±15.34	2.76±0.25	2.80±0.47
有氧运动组	22	39.85±4.18	44.78±4.38^ab	7.54±1.14	8.45±1.40^a	51.38±6.34	46.84±5.92^a	159.01±14.15	177.37±16.45^a	2.68±0.41	2.45±0.34^ab
联合运动组	22	39.03±5.89	45.20±6.14^ab	7.59±0.89	9.08±1.01^a	51.16±7.07	44.68±6.53^a	160.95±15.09	173.99±16.40^a	2.73±0.21	2.27±0.26^abc
F值		F_组间=3.743，F_交互=3.929，F_时间=6.833		F_组间=1.308，F_交互=4.255，F_时间=8.353		F_组间=0.805，F_交互=2.113，F_时间=4.451		F_组间=2.640，F_交互=3.222，F_时间=6.723		F_组间=4.430，F_交互=3.196，F_时间=7.420
P值		P_组间=0.029，P_交互=0.024，P_时间=0.011		P_组间=0.227，P_交互=0.018，P_时间=0.005		P_组间=0.451，P_交互=0.129，P_时间=0.039		P_组间=0.079，P_交互=0.046，P_时间=0.012		P_组间=0.016，P_交互=0.047，P_时间=0.008

组别	例数	NO（μmol/L）		eNOS（U/mL）		ET-1（ng/L）		VEGF（ng/L）		HOMA-IR
组别	例数	试验前	试验后	试验前	试验后	试验前	试验后	试验前	试验后	试验前	试验后
对照组	22	39.49±4.88	37.91±5.10	7.98±0.84	7.73±0.90	49.80±6.84	50.91±7.09	160.65±14.58	157.41±15.34	2.76±0.25	2.80±0.47
有氧运动组	22	39.85±4.18	44.78±4.38^ab	7.54±1.14	8.45±1.40^a	51.38±6.34	46.84±5.92^a	159.01±14.15	177.37±16.45^a	2.68±0.41	2.45±0.34^ab
联合运动组	22	39.03±5.89	45.20±6.14^ab	7.59±0.89	9.08±1.01^a	51.16±7.07	44.68±6.53^a	160.95±15.09	173.99±16.40^a	2.73±0.21	2.27±0.26^abc
F值		F_组间=3.743，F_交互=3.929，F_时间=6.833		F_组间=1.308，F_交互=4.255，F_时间=8.353		F_组间=0.805，F_交互=2.113，F_时间=4.451		F_组间=2.640，F_交互=3.222，F_时间=6.723		F_组间=4.430，F_交互=3.196，F_时间=7.420
P值		P_组间=0.029，P_交互=0.024，P_时间=0.011		P_组间=0.227，P_交互=0.018，P_时间=0.005		P_组间=0.451，P_交互=0.129，P_时间=0.039		P_组间=0.079，P_交互=0.046，P_时间=0.012		P_组间=0.016，P_交互=0.047，P_时间=0.008