Both neurological paroxysmal disorders and patent foramen ovale (PFO) are characterized by episodic nature, and at present, the relationship between neurological paroxysmal disorders and PFO is not clear.

To investigate the possible relationship between neurological paroxysmal disorders and PFO.

A cross-sectional study method was used. Transthoracic cardiac ultrasound was performed on all patients with neurological paroxysmal disorders from the Third Xiangya Hospital of Central South University, who were classified into groups as migraine (n=266) , epilepsy (n=286) , syncope (n=187) , vertigo (n=68) , transient ischemic attack (TIA) (n=48) , according to the main clinical diagnosis. The PFO positive rate at different ages within and between groups was compared with the overall PFO positive rate of the population.

Transthoracic cardiac ultrasound was completed in a total of 1 030 patients, and a total of 390 patients were PFO with a positive rate of 37.9%. According to RLS grade of 340 PFO positive patients in different groups, 109 cases were RLS 1 grade, accounting for 32.1%; 148 cases were RLS 2 grade, accounting for 43.5%; 83 cases were RLS 3 grade, accounting for 24.4%. There was no significantly difference in RLS grades in different groups (P>0.05) . The PFO positive rates in the migraine, epilepsy, syncope, vertigo and TIA group were 46.2%, 40.6%, 35.8%, 33.8%, 22.9%, respectively. The PFO positive rate of the migraine, epilepsy, and syncope group was higher than the overall PFO positive rate of the population, respectively (P<0.05) ; in the migraine, epilepsy, syncope and vertigo group, the PFO positive rate over 11 years, 21 years and 31 years was higher than the overall PFO positive rate in the population, respectively (P<0.05) .

There might be a clinical association between PFO and migraine, epilepsy and syncope. It may be more meaningful to screen PFO in younger patients, but the mechanism of which needs to be further investigated.

神经系统发作性疾病与卵圆孔未闭（PFO）均具有发作性特点，但目前神经系统发作性疾病与PFO的关系尚不明确。

探讨神经系统发作性疾病与PFO的可能关系。

采用横断面研究，选取中南大学湘雅三医院的神经系统发作性疾病患者为研究对象并行经胸心脏超声检查，依据主要临床诊断分为偏头痛组（n=266）、癫痫组（n=286）、晕厥组（n=187）、眩晕组（n=68）、短暂性脑缺血发作（TIA）组（n=48）。比较各组及组内不同年龄患者PFO阳性率与人群整体PFO阳性率的差异。

共1 030例患者完成经胸心脏超声检查，共检出390例PFO患者，阳性率为37.9%。去除无法归类者，340例PFO阳性患者按右向左分流（RLS）分级：RLS 1级109例，占32.1%；RLS 2级148例，占43.5%；RLS 3级83例，占24.4%。各组RLS分级比较，差异无统计学意义（P>0.05）。偏头痛组、癫痫组、晕厥组、眩晕组、TIA组患者PFO阳性率依次为46.2%、40.6%、35.8%、33.8%、22.9%。偏头痛组、癫痫组与晕厥组患者PFO阳性率高于人群总体PFO阳性率（P<0.05）；偏头痛组、癫痫组、晕厥组、眩晕组11~岁、21~岁、31~岁患者PFO阳性率均高于人群总体PFO阳性率（P<0.05）。

PFO与偏头痛、癫痫及晕厥可能存在临床关联，在年轻患者中进行PFO筛选可能更有意义，但其机制尚待进一步研究。