Chinese General Practice ›› 2022, Vol. 25 ›› Issue (14): 1700-1706.DOI: 10.12114/j.issn.1007-9572.2022.0031
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Received:
2021-12-05
Revised:
2022-02-10
Published:
2022-03-31
Online:
2022-04-07
Contact:
Minghang WANG
About author:
通讯作者:
王明航
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0031
组别 | 例数 | 性别〔n(%)〕 | 年龄〔M(Q25,Q75),岁〕 | |
---|---|---|---|---|
男 | 女 | |||
急性发作期组 | 155 | 62(40.0) | 93(60.0) | 48.0(36.0,56.0) |
非急性发作期组 | 138 | 52(37.7) | 86(62.3) | 46.0(34.0,59.0) |
健康志愿者组 | 39 | 19(48.7) | 20(51.3) | 48.0(30.0,58.0) |
χ2(H)值 | 1.543 | 0.843a | ||
P值 | 0.462 | 0.656 |
Table 1 Comparison of gender ratio and mean age between acute and non-acute attack asthma patients and healthy physical examinees
组别 | 例数 | 性别〔n(%)〕 | 年龄〔M(Q25,Q75),岁〕 | |
---|---|---|---|---|
男 | 女 | |||
急性发作期组 | 155 | 62(40.0) | 93(60.0) | 48.0(36.0,56.0) |
非急性发作期组 | 138 | 52(37.7) | 86(62.3) | 46.0(34.0,59.0) |
健康志愿者组 | 39 | 19(48.7) | 20(51.3) | 48.0(30.0,58.0) |
χ2(H)值 | 1.543 | 0.843a | ||
P值 | 0.462 | 0.656 |
组别 | 例数 | 细胞因子(pg/ml) | ||||||
---|---|---|---|---|---|---|---|---|
IL-4 | IL-6 | IL-8 | IL-17 | IFN-γ | TGF-β2 | TNF-α | ||
急性发作期组 | 155 | 15.41(12.33,24.94)a | 6.57(4.90,10.62)a | 9.14(7.65,10.57)a | 12.19(9.46,21.00)a | 8.05(4.55,13.95)a | 1 952.70(1 720.43,2 476.61)a | 73.20(46.20,327.28)a |
非急性发作期组 | 138 | 15.35(11.62,23.38)a | 6.38(4.90,10.62)a | 8.38(7.03,9.72)a | 11.60(9.30,19.52)a | 8.16(5.98,14.21)a | 1 892.21(1 665.35,2 412.73)a | 71.74(45.53,166.26)a |
健康志愿者组 | 39 | 5.75(5.11,7.54) | 2.94(2.31,3.76) | 2.26(1.53,3.03) | 3.25(2.15,7.46) | 25.26(16.26,41.58) | 1 354.11(1 298.97,1 509.81) | 29.03(22.37,48.00) |
H值 | 68.827 | 49.632 | 103.821 | 69.078 | 54.705 | 66.968 | 33.975 | |
P值 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | |
组别 | 免疫球蛋白(μg/L) | 嗜酸粒细胞型炎症 | 血清炎性递质(μg/L) | |||||
TIgE | SIgE | Eotaxin(ng/L) | ECP(μg/L) | Periostin | LTD4 | HMGB1 | YKL-40 | |
急性发作期组 | 152.55(50.48,429.48)a | 98.68(28.37,137.95)a | 28.27(19.82,46.80)ab | 14.68(10.72,20.26) | 2 035.64(1 789.30,2 267.86) | 5.05(1.85,13.21) | 13.51(8.09,21.03)a | 248.33(161.81,334.84)ab |
非急性发作期组 | 107.44(38.57,323.19)a | 92.51(27.30,135.24)a | 22.78(16.04,32.45)a | 13.60(10.71,21.19) | 2 014.64(1 744.65,2 316.86)a | 5.63(1.59,14.21) | 11.20(6.78,17.10)a | 191.61(133.99,294.98)a |
健康志愿者组 | 14.62(10.33,23.25) | 12.94(4.94,19.12) | 14.53(7.08,23.10) | 11.64(9.23,17.83) | 2 216.04(1 842.18,2 964.45) | 3.53(2.69,5.44) | 7.07(5.89,10.10) | 132.02(88.53,178.99) |
H值 | 79.905 | 53.784 | 26.823 | 4.253 | 6.596 | 2.468 | 24.052 | 36.617 |
P值 | <0.001 | <0.001 | <0.001 | 0.119 | 0.037 | 0.291 | <0.001 | <0.001 |
Table 2 Comparison of serum biomarkers between acute and non-acute attack asthma patients and healthy physical examinees
组别 | 例数 | 细胞因子(pg/ml) | ||||||
---|---|---|---|---|---|---|---|---|
IL-4 | IL-6 | IL-8 | IL-17 | IFN-γ | TGF-β2 | TNF-α | ||
急性发作期组 | 155 | 15.41(12.33,24.94)a | 6.57(4.90,10.62)a | 9.14(7.65,10.57)a | 12.19(9.46,21.00)a | 8.05(4.55,13.95)a | 1 952.70(1 720.43,2 476.61)a | 73.20(46.20,327.28)a |
非急性发作期组 | 138 | 15.35(11.62,23.38)a | 6.38(4.90,10.62)a | 8.38(7.03,9.72)a | 11.60(9.30,19.52)a | 8.16(5.98,14.21)a | 1 892.21(1 665.35,2 412.73)a | 71.74(45.53,166.26)a |
健康志愿者组 | 39 | 5.75(5.11,7.54) | 2.94(2.31,3.76) | 2.26(1.53,3.03) | 3.25(2.15,7.46) | 25.26(16.26,41.58) | 1 354.11(1 298.97,1 509.81) | 29.03(22.37,48.00) |
H值 | 68.827 | 49.632 | 103.821 | 69.078 | 54.705 | 66.968 | 33.975 | |
P值 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | |
组别 | 免疫球蛋白(μg/L) | 嗜酸粒细胞型炎症 | 血清炎性递质(μg/L) | |||||
TIgE | SIgE | Eotaxin(ng/L) | ECP(μg/L) | Periostin | LTD4 | HMGB1 | YKL-40 | |
急性发作期组 | 152.55(50.48,429.48)a | 98.68(28.37,137.95)a | 28.27(19.82,46.80)ab | 14.68(10.72,20.26) | 2 035.64(1 789.30,2 267.86) | 5.05(1.85,13.21) | 13.51(8.09,21.03)a | 248.33(161.81,334.84)ab |
非急性发作期组 | 107.44(38.57,323.19)a | 92.51(27.30,135.24)a | 22.78(16.04,32.45)a | 13.60(10.71,21.19) | 2 014.64(1 744.65,2 316.86)a | 5.63(1.59,14.21) | 11.20(6.78,17.10)a | 191.61(133.99,294.98)a |
健康志愿者组 | 14.62(10.33,23.25) | 12.94(4.94,19.12) | 14.53(7.08,23.10) | 11.64(9.23,17.83) | 2 216.04(1 842.18,2 964.45) | 3.53(2.69,5.44) | 7.07(5.89,10.10) | 132.02(88.53,178.99) |
H值 | 79.905 | 53.784 | 26.823 | 4.253 | 6.596 | 2.468 | 24.052 | 36.617 |
P值 | <0.001 | <0.001 | <0.001 | 0.119 | 0.037 | 0.291 | <0.001 | <0.001 |
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