Chinese General Practice ›› 2022, Vol. 25 ›› Issue (14): 1707-1712.DOI: 10.12114/j.issn.1007-9572.2022.0016
Special Issue: 精神卫生最新文章合集
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Received:
2022-01-06
Revised:
2022-03-16
Published:
2022-03-31
Online:
2022-04-07
Contact:
Qingshan GENG
About author:
通讯作者:
耿庆山
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0016
组别 | 例数 | 年龄( | 性别(男/女) | BMI( | 高血压〔n(%)〕 | 糖尿病〔n(%)〕 | 血脂异常〔n(%)〕 | 急性心肌梗死〔n(%)〕 | hs-CRP〔M(P25,P75),mg/L〕 | hs-cTnT〔M(P25,P75),ng/L〕 | NT-proBNP〔M(P25,P75),ng/L〕 | FT3( | FT4( | TSH( |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
冠心病无抑郁组 | 350 | 62.9±9.9 | 291/59 | 24.53±2.67 | 210(60.0) | 108(30.8) | 274(78.3) | 79(22.6) | 2.25(0.79,7.29) | 13.85(8.80,46.48) | 151.45(55.60,572.34) | 4.85±0.83 | 11.81±2.46 | 1.79±1.56 |
冠心病合并抑郁组 | 211 | 64.9±10.4 | 142 /69 | 24.33±3.57 | 133(63.0) | 87(41.2) | 162(76.8) | 39(18.5) | 3.36(0.98,10.10) | 16.64(9.25,62.30) | 222.15(74.73,848.30) | 4.66±0.92 | 11.67±2.39 | 4.66±0.92 |
检验统计量值 | -2.304a | 18.766b | 0.738a | 0.510b | 6.249b | 0.173b | 1.325b | 0.561 | -0.722 | -1.395 | 2.441a | 0.666a | 0.630a | |
P值 | 0.022 | <0.001 | 0.461 | 0.475 | 0.012 | 0.677 | 0.250 | 0.043 | 0.338 | 0.048 | 0.015 | 0.506 | 0.529 |
Table 1 Comparison of general demographic characteristics and clinical data of depressive state groups of study subjects
组别 | 例数 | 年龄( | 性别(男/女) | BMI( | 高血压〔n(%)〕 | 糖尿病〔n(%)〕 | 血脂异常〔n(%)〕 | 急性心肌梗死〔n(%)〕 | hs-CRP〔M(P25,P75),mg/L〕 | hs-cTnT〔M(P25,P75),ng/L〕 | NT-proBNP〔M(P25,P75),ng/L〕 | FT3( | FT4( | TSH( |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
冠心病无抑郁组 | 350 | 62.9±9.9 | 291/59 | 24.53±2.67 | 210(60.0) | 108(30.8) | 274(78.3) | 79(22.6) | 2.25(0.79,7.29) | 13.85(8.80,46.48) | 151.45(55.60,572.34) | 4.85±0.83 | 11.81±2.46 | 1.79±1.56 |
冠心病合并抑郁组 | 211 | 64.9±10.4 | 142 /69 | 24.33±3.57 | 133(63.0) | 87(41.2) | 162(76.8) | 39(18.5) | 3.36(0.98,10.10) | 16.64(9.25,62.30) | 222.15(74.73,848.30) | 4.66±0.92 | 11.67±2.39 | 4.66±0.92 |
检验统计量值 | -2.304a | 18.766b | 0.738a | 0.510b | 6.249b | 0.173b | 1.325b | 0.561 | -0.722 | -1.395 | 2.441a | 0.666a | 0.630a | |
P值 | 0.022 | <0.001 | 0.461 | 0.475 | 0.012 | 0.677 | 0.250 | 0.043 | 0.338 | 0.048 | 0.015 | 0.506 | 0.529 |
组别 | 例数 | FT3 (pmol/L) | FT4 (pmol/L) | TSH(mU/L) |
---|---|---|---|---|
冠心病无抑郁组 | 350 | 4.85±0.83 | 11.81±2.46 | 1.79±1.56 |
轻度抑郁亚组 | 148 | 4.69±0.89a | 11.60±2.38 | 1.70±1.43 |
中度抑郁亚组 | 46 | 4.68±0.84ab | 11.70±2.47 | 1.78±1.06 |
重度抑郁亚组 | 17 | 4.37±1.29abc | 12.11±2.31 | 1.58±1.06 |
F值 | 2.700 | 0.371 | 0.204 | |
P值 | 0.045 | 0.774 | 0.893 |
Table 2 Thyroid hormone levels in patients with coronary heart disease without depression and in groups with different degrees of depression
组别 | 例数 | FT3 (pmol/L) | FT4 (pmol/L) | TSH(mU/L) |
---|---|---|---|---|
冠心病无抑郁组 | 350 | 4.85±0.83 | 11.81±2.46 | 1.79±1.56 |
轻度抑郁亚组 | 148 | 4.69±0.89a | 11.60±2.38 | 1.70±1.43 |
中度抑郁亚组 | 46 | 4.68±0.84ab | 11.70±2.47 | 1.78±1.06 |
重度抑郁亚组 | 17 | 4.37±1.29abc | 12.11±2.31 | 1.58±1.06 |
F值 | 2.700 | 0.371 | 0.204 | |
P值 | 0.045 | 0.774 | 0.893 |
变量 | rs值 | P值 |
---|---|---|
年龄 | 0.093 | 0.028 |
BMI | -0.020 | 0.636 |
hs-CRP | 0.090 | 0.032 |
Hs-cTnT | 0.011 | 0.799 |
NT-proBNP | 0.059 | 0.162 |
FT3 | -0.114 | 0.007 |
FT4 | 0.024 | 0.571 |
TSH | -0.006 | 0.882 |
Table 3 Correlation analysis between depression and clinical continuous variables in CHD patients
变量 | rs值 | P值 |
---|---|---|
年龄 | 0.093 | 0.028 |
BMI | -0.020 | 0.636 |
hs-CRP | 0.090 | 0.032 |
Hs-cTnT | 0.011 | 0.799 |
NT-proBNP | 0.059 | 0.162 |
FT3 | -0.114 | 0.007 |
FT4 | 0.024 | 0.571 |
TSH | -0.006 | 0.882 |
项目 | 未调整 | 调整Ⅰ | 调整Ⅱ | ||||
---|---|---|---|---|---|---|---|
OR(95%CI) | P值 | OR(95%CI) | P值 | OR(95%CI) | P值 | ||
FT3 | 0.78 (0.63,0.95) | 0.016 | 0.83 (0.67,1.02) | 0.078 | 0.78(0.63,0.96) | 0.019 | |
FT3每增加1个SD | 0.80 (0.67,0.96) | 0.016 | 0.82(0.71,1.02) | 0.078 | 0.80 (0.67,0.96) | 0.019 | |
FT3五分组(pmol/L) | |||||||
1.03~4.19 | 1.0 | 1.0 | 1.0 | ||||
4.20~4.56 | 0.83 (0.49,1.43) | 0.505 | 0.85 (0.49,1.48) | 0.576 | 0.89 (0.51,1.54) | 0.668 | |
4.58~4.97 | 0.79 (0.47,1.34) | 0.382 | 0.77 (0.45,1.32) | 0.346 | 0.85 (0.49,1.47) | 0.565 | |
4.98~5.34 | 0.50 (0.29,0.87) | 0.015 | 0.56 (0.31,0.99) | 0.046 | 0.55 (0.31,0.97) | 0.040 | |
5.35~9.11 | 0.63 (0.37,1.08) | 0.095 | 0.75 (0.43,1.30) | 0.300 | 0.71 (0.41,1.24) | 0.226 | |
趋势性检验P值 | 0.027 | 0.139 | 0.087 |
Table 4 Association between FT3 levels,per SD increaseof FT3,FT3 divided in quintiles and depression in patients with coronary heart disease
项目 | 未调整 | 调整Ⅰ | 调整Ⅱ | ||||
---|---|---|---|---|---|---|---|
OR(95%CI) | P值 | OR(95%CI) | P值 | OR(95%CI) | P值 | ||
FT3 | 0.78 (0.63,0.95) | 0.016 | 0.83 (0.67,1.02) | 0.078 | 0.78(0.63,0.96) | 0.019 | |
FT3每增加1个SD | 0.80 (0.67,0.96) | 0.016 | 0.82(0.71,1.02) | 0.078 | 0.80 (0.67,0.96) | 0.019 | |
FT3五分组(pmol/L) | |||||||
1.03~4.19 | 1.0 | 1.0 | 1.0 | ||||
4.20~4.56 | 0.83 (0.49,1.43) | 0.505 | 0.85 (0.49,1.48) | 0.576 | 0.89 (0.51,1.54) | 0.668 | |
4.58~4.97 | 0.79 (0.47,1.34) | 0.382 | 0.77 (0.45,1.32) | 0.346 | 0.85 (0.49,1.47) | 0.565 | |
4.98~5.34 | 0.50 (0.29,0.87) | 0.015 | 0.56 (0.31,0.99) | 0.046 | 0.55 (0.31,0.97) | 0.040 | |
5.35~9.11 | 0.63 (0.37,1.08) | 0.095 | 0.75 (0.43,1.30) | 0.300 | 0.71 (0.41,1.24) | 0.226 | |
趋势性检验P值 | 0.027 | 0.139 | 0.087 |
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