Chinese General Practice ›› 2021, Vol. 24 ›› Issue (36): 4599-4606.DOI: 10.12114/j.issn.1007-9572.2021.02.037
Special Issue: 衰弱最新文章合集; 老年问题最新文章合集
• Monographic Research • Previous Articles Next Articles
Published:
2021-12-20
Online:
2022-03-01
基金资助:
DAI Jingrong, LI Jie, HE Xu, LI Yang, LI Yan. Relationship of 25-Hydroxyvitamin D and Interleukin-6 with Frailty in Hospitalized Elderly Patients with Chronic Disease in the Stable Phase [J]. Chinese General Practice, 2021, 24(36): 4599-4606.
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2021.02.037
序号 | 条目 | 内容 |
---|---|---|
1 | 自觉疲乏 | 过去1周内疲乏>3 d |
2 | 肌力下降 | 握力:男<23 kg,女<14 kg |
3 | 功能下降 | 步速(6 m步行试验)用时≥7 s或速度<0.65 m/s |
4 | 体质量减轻 | 无意识的1年内体质量减轻>3 kg或总体质量的5% |
5 | 活动减少 | 每周活动量<600 MET-min/W(通过IPAQ得到) |
Table 1 Contents of the Chinese version of Fried
序号 | 条目 | 内容 |
---|---|---|
1 | 自觉疲乏 | 过去1周内疲乏>3 d |
2 | 肌力下降 | 握力:男<23 kg,女<14 kg |
3 | 功能下降 | 步速(6 m步行试验)用时≥7 s或速度<0.65 m/s |
4 | 体质量减轻 | 无意识的1年内体质量减轻>3 kg或总体质量的5% |
5 | 活动减少 | 每周活动量<600 MET-min/W(通过IPAQ得到) |
衰弱程度 | 例数 | 年龄(![]() | 性别〔n(%)〕 | 身高(![]() | 体质量(![]() | BMI (![]() | 文化程度〔n(%)〕 | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
男性 | 女性 | 文盲 | 小学 | 初中 | 高中 | 大专及以上 | ||||||
无衰弱 | 47 | 74.4±8.0 | 25(53.2) | 22(46.8) | 1.60±0.88 | 59.6±11.2 | 24.5±2.7 | 0 | 17(36.2) | 20(42.6) | 5(10.6) | 5(10.6) |
衰弱前期 | 51 | 80.3±8.8 | 32(62.7) | 19(37.3) | 1.61±0.06 | 58.5±10.6 | 24.2±1.9 | 2(3.9) | 13(25.5) | 13(25.5) | 15(29.4) | 8(15.7) |
衰弱期 | 54 | 85.2±7.1 | 34(63.0) | 20(37.0) | 1.62±0.08 | 60.6±10.3 | 23.8±2.2 | 4(7.4) | 18(33.3) | 13(24.1) | 9(16.7) | 10(18.5) |
χ2(F)值 | 22.678a | 1.263 | 0.815a | 0.494a | 0.959a | 13.692 | ||||||
P值 | <0.001 | 0.532 | 0.444 | 0.611 | 0.385 | 0.090 |
Table 2 Comparison of clinical data and geriatric syndromes in participants by level of frailty
衰弱程度 | 例数 | 年龄(![]() | 性别〔n(%)〕 | 身高(![]() | 体质量(![]() | BMI (![]() | 文化程度〔n(%)〕 | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
男性 | 女性 | 文盲 | 小学 | 初中 | 高中 | 大专及以上 | ||||||
无衰弱 | 47 | 74.4±8.0 | 25(53.2) | 22(46.8) | 1.60±0.88 | 59.6±11.2 | 24.5±2.7 | 0 | 17(36.2) | 20(42.6) | 5(10.6) | 5(10.6) |
衰弱前期 | 51 | 80.3±8.8 | 32(62.7) | 19(37.3) | 1.61±0.06 | 58.5±10.6 | 24.2±1.9 | 2(3.9) | 13(25.5) | 13(25.5) | 15(29.4) | 8(15.7) |
衰弱期 | 54 | 85.2±7.1 | 34(63.0) | 20(37.0) | 1.62±0.08 | 60.6±10.3 | 23.8±2.2 | 4(7.4) | 18(33.3) | 13(24.1) | 9(16.7) | 10(18.5) |
χ2(F)值 | 22.678a | 1.263 | 0.815a | 0.494a | 0.959a | 13.692 | ||||||
P值 | <0.001 | 0.532 | 0.444 | 0.611 | 0.385 | 0.090 |
衰弱程度 | 例数 | WBC 〔M(P25,P75),×109/L〕 | RBC 〔M(P25,P75),×1012/L〕 | Hb (g/L) | PLT 〔M(P25,P75),×109/L〕 | NEUT 〔M(P25,P75),×109/L〕 | CRP 〔M(P25,P75),mg/L〕 | AST 〔M(P25,P75),U/L〕 |
---|---|---|---|---|---|---|---|---|
无衰弱 | 47 | 6.82(5.26,7.76) | 4.34(3.99,4.64) | 132.43±24.84 | 210.00(168.00,248.00) | 4.54(2.74,5.35) | 2.35(0.50,20.75) | 20.00(15.00,27.00) |
衰弱前期 | 51 | 6.16(4.89,7.22) | 4.39(4.07,4.71) | 137.43±17.65 | 194.00(151.00,235.00) | 3.81(2.95,4.71) | 3.04(1.31,11.42) | 19.00(15.00,24.00) |
衰弱期 | 54 | 5.93(5.07,7.26) | 4.10(3.44,4.59) | 121.44±27.33 | 180.50(137.00,224.25) | 4.09(2.95,4.96) | 11.17(2.67,28.05) | 18.50(15.00,26.00) |
Z(F)值 | 1.520 | 8.158 | 6.276a | 4.028 | 1.487 | 8.650 | 0.419 | |
P值 | 0.285 | 0.077 | 0.002 | 0.329 | 0.084 | 0.056 | 0.770 |
Table 3 Comparison of laboratory indicators in in participants by level of frailty
衰弱程度 | 例数 | WBC 〔M(P25,P75),×109/L〕 | RBC 〔M(P25,P75),×1012/L〕 | Hb (g/L) | PLT 〔M(P25,P75),×109/L〕 | NEUT 〔M(P25,P75),×109/L〕 | CRP 〔M(P25,P75),mg/L〕 | AST 〔M(P25,P75),U/L〕 |
---|---|---|---|---|---|---|---|---|
无衰弱 | 47 | 6.82(5.26,7.76) | 4.34(3.99,4.64) | 132.43±24.84 | 210.00(168.00,248.00) | 4.54(2.74,5.35) | 2.35(0.50,20.75) | 20.00(15.00,27.00) |
衰弱前期 | 51 | 6.16(4.89,7.22) | 4.39(4.07,4.71) | 137.43±17.65 | 194.00(151.00,235.00) | 3.81(2.95,4.71) | 3.04(1.31,11.42) | 19.00(15.00,24.00) |
衰弱期 | 54 | 5.93(5.07,7.26) | 4.10(3.44,4.59) | 121.44±27.33 | 180.50(137.00,224.25) | 4.09(2.95,4.96) | 11.17(2.67,28.05) | 18.50(15.00,26.00) |
Z(F)值 | 1.520 | 8.158 | 6.276a | 4.028 | 1.487 | 8.650 | 0.419 | |
P值 | 0.285 | 0.077 | 0.002 | 0.329 | 0.084 | 0.056 | 0.770 |
变量 | β | SE | Wald χ2值 | P值 | OR(95%CI) |
---|---|---|---|---|---|
失能 | 1.818 | 0.883 | 4.240 | 0.039 | 6.162(1.091,34.789) |
25(OH)D | -0.104 | 0.045 | 5.238 | 0.022 | 0.901(0.825,0.985) |
IL-6 | 0.098 | 0.044 | 5.008 | 0.025 | 1.103(1.012,1.201) |
Table 4 Binary Logistic regression analysis of frailty in elderly chronic disease inpatients
变量 | β | SE | Wald χ2值 | P值 | OR(95%CI) |
---|---|---|---|---|---|
失能 | 1.818 | 0.883 | 4.240 | 0.039 | 6.162(1.091,34.789) |
25(OH)D | -0.104 | 0.045 | 5.238 | 0.022 | 0.901(0.825,0.985) |
IL-6 | 0.098 | 0.044 | 5.008 | 0.025 | 1.103(1.012,1.201) |
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