Abstract: Background　Metformin is an important anti-diabetic drug for type 2 diabetes mellitus（T2DM）. Metformin hydrochloride sustained release tablets（XR）shows similar efficacy and safety with normal preparation of metformin （metformin IR），but simpler administration（once-daily use）. Objective　To investigate the knowledge，attitude and practice of metformin XR in outpatient adults with T2DM. Methods　We recruited outpatient adults with T2DM from the Department of Endocrinology and Metabolism，West China Hospital，Sichuan University using simple sampling from January 1 to July 31，2020. A single investigator interviewed each participant using a self-designed questionnaire of the knowledge，attitude and practice of metformin XR in a face-to-face manner. Results　Altogether，151 cases attended the survey，and 149 of them gave an effective response，with a response rate of 98.7%（149/151）. Among the 149 included participants，14（9.4%）knew the correct dosing range of metformin XR，43（28.9%）knew the correct dosing frequency，and 7（4.7%）knew the right time to take the drug. Forty patients（26.8%）preferred metformin XR to metformin IR. A toal of 121 patients（81.2%）believed in the priority of metformin XR in safety. Fifteen patients（10.1%）felt confident to change their treatment regimen without consulting the doctor. Fifty-one（34.2%）and 29（19.5%）patients thought that once or at least twice daily does and does not affect the efficacy，respectively. The numbers of taking metformin XR once daily，twice daily，and thrice daily were 36（24.2%），80（53.7%），and 27（18.1%），respectively. Forty-five patients（30.2%）reported adverse events during the use of metformin XR.According to the subgroup analyses，patients older than 60 years old were less likely to answer the correct dosing frequency but more likely to answer the correct time to take the drug（P<0.05）. Patients receiving 12-year education and more were more likely to believe the priority of metformin XR and the impact of dosing frequency（P<0.05）. Conclusion　Our study suggested that the knowledge，attitude，and practice of outpatient adults with T2DM need improving. Most patients did not know the correct usage or understand the advantage of metformin XR.

Key words: Diabetes mellitus, type 2, Outpatients, Metformin hydrochloride sustained release tablets, Drug utilization, Pharmacoepidemiology, Rational drug use

摘要： 背景　二甲双胍是临床治疗2型糖尿病的重要药物，其缓释剂型相对于普通剂型疗效和安全性相当，但给药方式相对简单（每天仅需服用1次）。目的　了解门诊2型糖尿病患者应用二甲双胍缓释片的知识、态度及实践。方法　采取简单抽样方法对2020-01-01至2020-07-31在四川大学华西医院内分泌代谢科就诊的门诊2型糖尿病患者，通过自制调查问卷由同一研究员在门诊诊间进行一对一、面对面调查，分析其应用二甲双胍缓释片的知识、态度与实践。结果　共发放自制调查问卷151份，回收有效问卷149份，有效问卷回收率为98.7%（149/151）。最终共纳入149例患者，其中14例（9.4%）知道二甲双胍缓释片的正确剂量范围，43例（28.9%）知道二甲双胍缓释片的正确服用频率，7例（4.7%）知道二甲双胍缓释片的正确服用时间。40例（26.8%）患者认为二甲双胍缓释片优于二甲双胍普通片，121例（81.2%）表示对二甲双胍缓释片的安全性更有信心。15例（10.1%）患者认为血糖控制不佳时可自行停药或换药，51例（34.2%）患者认为1次/d或≥2次/d给药对治疗有影响，29例（19.5%）患者认为无影响。二甲双胍缓释片服药频率为1次/d（推荐用药频次）的患者为36例（24.2%），2次/d者为80例（53.7%），3次/d者为27例（18.1%）；45例（30.2%）患者在使用二甲双胍缓释片后曾出现不良反应。亚组分析提示，60岁以上患者知道二甲双胍缓释片的正确服用频率比例更低，而知道正确服用时间的比例更高；高中及以上教育程度的患者中认为二甲双胍缓释片优于二甲双胍普通片者和认为1次/d或≥2 次/d给药对治疗有影响者的比例更高（P<0.05）。结论　门诊2型糖尿病患者二甲双胍缓释片应用知识、态度与实践尚存在较大的提高空间，多数患者对二甲双胍缓释片的用法和优势存在误解。

关键词: 糖尿病，2型, 门诊病人, 二甲双胍缓释片, 药物利用, 药物流行病学, 合理用药