Clinical Characteristic of Anti-Caspr 2 Antibody Autoimmune-associated Encephalitis in Adults
Department of Neurology,the Second Affiliated Hospital of Nanchang University,Nanchang 330000,China
*Corresponding author:WU Wei,Chief physician;E-mail:13807038803@163.com
[1]BASTIAANSEN A E M,VAN SONDEREN A,TITULAER M J. Autoimmune encephalitis with anti-leucine-rich glioma-inactivated 1 or anti-contactin-associated protein-like 2 antibodies (formerly called voltage-gated potassium channel-complex antibodies)[J]. Curr Opin Neurol,2017,30(3):302-309. DOI:10.1097/wco.0000000000000444.
[2]GADOTH A,PITTOCK S J,DUBEY D,et al. Expanded phenotypes and outcomes among 256 LGI1/Caspr 2-IgG-positive patients[J]. Ann Neurol,2017,82(1):79-92. DOI:10.1002/ana.24979.
[3]中华医学会神经病学分会. 中国自身免疫性脑炎诊治专家共识[J]. 中华神经科杂志,2017,50(2):91-98. DOI:10.3760/cma.j.issn.1006-7876.2017.02.004.
[4]GRAUS F,TITULAER M J,BALU R,et al. A clinical approach to diagnosis of autoimmune encephalitis[J]. Lancet Neurol,2016,15(4):391-404. DOI:10.1016/S1474-4422(15)00401-9.
[5]VAN SONDEREN A,ARI?O H,PETIT-PEDROL M,et al. The clinical spectrum of Caspr2 antibody-associated disease[J]. Neurology,2016,87(5):521-528. DOI:10.1212/WNL.0000000000002917.
[6]GILLESPIE L E,DAVE A,GOLDSTEIN A. A tale of two brothers:familial voltage-gated potassium channel autoimmune encephalitis[J]. Cureus,2020,12(6):e8723. DOI:10.7759/cureus.8723.
[7]IRANI S R,PETTINGILL P,KLEOPA K A,et al. Morvan syndrome:clinical and serological observations in 29 cases[J]. Ann Neurol,2012,72(2):241-255. DOI:10.1002/ana.23577.
[8]LINNOILA J J,BINNICKER M J,MAJED M,et al. CSF Herpes virus and autoantibody profiles in the evaluation of encephalitis[J]. Neurol Neuroimmunol Neuroinflamm,2016,3(4):e245. DOI:10.1212/nxi.0000000000000245.
[9]NOSADINI M,MOHAMMAD S S,CORAZZA F,et al. Herpes simplex virus-induced anti-N-methyl-d-aspartate receptor encephalitis:a systematic literature review with analysis of 43 cases[J]. Dev Med Child Neurol,2017,59(8):796-805. DOI:10.1111/dmcn.13448.
[10]DENG S,QIU K,LIU H,et al. Clinical characteristics and short-term prognosis of autoimmune encephalitis:a single-center cohort study in Changsha,China[J]. Front Neurol,2019,10:539. DOI:10.3389/fneur.2019.00539.
[11]GREGOIRE S M,VAN PESCH V,GOFFETTE S,et al. Polymerase chain reaction analysis and oligoclonal antibody in the cerebrospinal fluid from 34 patients with varicella-zoster virus infection of the nervous system[J]. J Neurol Neurosurg Psychiatry,2006,77(8):938-942. DOI:10.1136/jnnp.2006.090316.
[12]NAGEL M A,GILDEN D. Neurological complications of varicella zoster virus reactivation[J]. Curr Opin Neurol,2014,27(3):356-360. DOI:10.1097/WCO.0000000000000092.
[13]PRAKASH P A,JIN J X,MATHARU K,et al. Anti-NMDAR encephalitis with concomitant varicella zoster virus detection and nonteratomatous malignancy[J]. Neurol Neuroimmunol Neuroinflamm,2019,6(2):e537. DOI:10.1212/NXI.0000000000000537.
[14]ALVAREZ J C,ALVAREZ J,TINOCO J,et al. Varicella-zoster virus meningitis and encephalitis:an understated cause of central nervous system infections[J]. Cureus,2020,12(11):e11583. DOI:10.7759/cureus.11583.
[15]OSTERMAN A,RUF V C,DOMINGO C,et al. Travel-associated neurological disease terminated in a postmortem diagnosed atypical HSV-1 encephalitis after high-dose steroid therapy——a case report[J]. BMC Infect Dis,2020,20(1):150. DOI:10.1186/s12879-020-4859-5.
[16]SAKIYAMA Y,MATSUURA E,SHIGEHISA A,et al. Cryptococcus meningitis can co-occur with anti-NMDA receptor encephalitis[J]. Intern Med,2020,59(18):2301-2306. DOI:10.2169/internalmedicine.4629-20.
[17]陈丹,张昀,周宝桐,等. 结核性脑膜炎继发抗N-甲基-D-天冬氨酸受体脑炎一例报道及诊治思路分析[J]. 中国全科医学,2019,22(32):4006-4010. DOI:10.12114/j.issn.1007-9572.2019.00.267.
[18]VAN SONDEREN A,PETIT-PEDROL M,DALMAU J,et al. The value of LGI1,Caspr2 and voltage-gated potassium channel antibodies in encephalitis[J]. Nat Rev Neurol,2017,13(5):290-301. DOI:10.1038/nrneurol.2017.43.
[19]VALE T C,PEDROSO J L,DUTRA L A,et al. Morvan syndrome as a paraneoplastic disorder of thymoma with anti-Caspr 2 antibodies[J]. Lancet,2017,389(10076):1367-1368. DOI:10.1016/s0140-6736(16)31459-3.
[20]DAWES J M,WEIR G A,MIDDLETON S J,et al. Immune or genetic-mediated disruption of Caspr 2 causes pain hypersensitivity due to enhanced primary afferent excitability[J]. Neuron,2018,97(4):806-822.e10. DOI:10.1016/j.neuron.2018.01.033.
[21]LIU Q,MA J,HUANG Y,et al. High prevalence of electrocardiac abnormalities in anti-Caspr 2 antibody-associated disease[J]. J Neurol Neurosurg Psychiatry,2019,90(1):117-118. DOI:10.1136/jnnp-2017-317527.
[22]JOUBERT B,GOBERT F,THOMAS L,et al. Autoimmune episodic ataxia in patients with anti-Caspr 2 antibody-associated encephalitis[J]. Neurol Neuroimmunol Neuroinflamm,2017,4(4):e371. DOI:10.1212/NXI.0000000000000371.
[23]RODENAS-CUADRADO P,PIETRAFUSA N,FRANCAVILLA T,et al. Characterisation of Caspr 2 deficiency disorder——a syndrome involving autism,epilepsy and language impairment[J]. BMC Med Genet,2016,17:8. DOI:10.1186/s12881-016-0272-8.
[24]BIEN C G,MIRZADJANOVA Z,BAUMGARTNER C,et al. Anti-contactin-associated protein-2 encephalitis:relevance of antibody titres,presentation and outcome[J]. Eur J Neurol,2017,24(1):175-186. DOI:10.1111/ene.13180.
[25]VINCENT A,IRANI S R. Caspr2 antibodies in patients with thymomas[J]. J Thorac Oncol,2010,5(10 suppl 4):S277-280. DOI:10.1097/jto.0b013e3181f23f04.
[26]任海涛,杨洵哲,关鸿志,等. 多重抗神经元抗体阳性的自身免疫性脑炎临床分析[J]. 中华神经科杂志,2016,49(1):21-25. DOI:10.3760/cma.j.issn.1006-7876.2016.01.005.
[27]LIU P,BAI M,YAN X,et al. Possible coexistence of MOG-IgG-associated disease and anti-Caspr2 antibody-associated autoimmune encephalitis:a first case report[J]. Ther Adv Neurol Disord,2020,13:1756286420969462. DOI:10.1177/1756286420969462.
[28]SINMAZ N,NGUYEN T,TEA F,et al. Mapping autoantigen epitopes:molecular insights into autoantibody-associated disorders of the nervous system[J]. J Neuroinflammation,2016,13(1):219. DOI:10.1186/s12974-016-0678-4.
[29]CAMDESSANCHé J P,STREICHENBERGER N,CAVILLON G,et al. Brain immunohistopathological study in a patient with anti-NMDAR encephalitis[J]. Eur J Neurol,2011,18(6):929-931. DOI:10.1111/j.1468-1331.2010.03180.x.
[30]PATTERSON K R,DALMAU J,LANCASTER E. Mechanisms of Caspr2 antibodies in autoimmune encephalitis and neuromyotonia[J]. Ann Neurol,2018,83(1):40-51. DOI:10.1002/ana.25120.
[31]VAN SONDEREN A,SCHREURS M W,WIRTZ P W,et al. From VGKC to LGI1 and Caspr2 encephalitis:the evolution of a disease entity over time[J]. Autoimmun Rev,2016,15(10):970-974. DOI:10.1016/j.autrev.2016.07.018.
[32]ZAENKER P,GRAY E S,ZIMAN M R. Autoantibody production in cancer——the humoral immune response toward autologous antigens in cancer patients[J]. Autoimmun Rev,2016,15(5):477-483. DOI:10.1016/j.autrev.2016.01.017.
[33]BINKS S N M,KLEIN C J,WATERS P,et al. LGI1,Caspr 2 and related antibodies:a molecular evolution of the phenotypes[J]. J Neurol Neurosurg Psychiatry,2018,89(5):526-534. DOI:10.1136/jnnp-2017-315720.
[34]HUIJBERS M G,QUEROL L A,NIKS E H,et al. The expanding field of IgG4-mediated neurological autoimmune disorders[J]. Eur J Neurol,2015,22(8):1151-1161. DOI:10.1111/ene.12758.