Research Progress on Reversion of Mild Cognitive Impairment to Normal Cognition

doi:10.12114/j.issn.1007-9572.2021.00.500

Abstract

Abstract: Mild cognitive impairment（MCI） is generally deemed to be a high-risk population and therapeutic target for Alzheimer's disease（AD）. Although older adults with MCI have a 10%-15% annual risk of converting to probable AD，most MCIs remain stable，and partially reverse to normal cognition （NC）. So far，the significance of the reversion of MCI to NC remains extremely inconclusive and controversial，and systematic research at home and abroad is still limited. This article systematically sorts out the reversal rate of MCI，various reasons and influential factors，and proposes the significance of the reversion of MCI to NC and the problems to be solved.

Key words: Mild cognitive impairment, Alzheimer disease, Reversion, Normal cognition, Review

摘要： 轻度认知障碍（MCI）通常被认为是阿尔茨海默病（AD）的高风险人群和治疗靶点。尽管每年有近10%~15%的MCI患者进展为AD，但MCI的认知轨迹高度可变，多数MCI患者并没有随着时间的推移而进展为AD，部分逆转为认知正常（NC）。迄今为止，关于MCI逆转为NC的意义尚无定论，且国内外MCI逆转为NC的系统研究仍然有限。本文系统梳理了MCI的逆转率、逆转原因、逆转的潜在影响因素及逆转的研究意义，提出了此类研究亟待解决的问题及展望。

关键词: 轻度认知障碍, 阿尔茨海默病, 逆转, 认知正常, 综述

QIN Yao,ZHANG Jiajia,WU Yan, et al. Research Progress on Reversion of Mild Cognitive Impairment to Normal Cognition　[J]. Chinese General Practice, 2021, 24(27): 3506-3509. DOI: 10.12114/j.issn.1007-9572.2021.00.500.
秦瑶,张嘉嘉,吴妍等. 轻度认知障碍逆转为认知正常的研究进展[J]. 中国全科医学, 2021, 24(27): 3506-3509. DOI: 10.12114/j.issn.1007-9572.2021.00.500.

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