Chinese General Practice ›› 2021, Vol. 24 ›› Issue (24): 3137-3140.DOI: 10.12114/j.issn.1007-9572.2021.00.484

Special Issue: 泌尿系统疾病最新文章合集

• Monographic Research • Previous Articles    

Adrenal Crisis Provoked by Levothyroxine in Autoimmune Polyglandular Syndrome TypeⅡ:a Case Report and Literature Review 

  

  1. 1.School of Medicine,Wuhan University of Science and Technology,Wuhan 430081,China
    2.Department of Endocrinology,Puren Hospital of Wuhan University of Science and Technology,Wuhan 430081,China
    *Corresponding author:ZHOU Feng,Associate chief physician,Associate professor,Master supervisor;E-mail:przhoufeng@sina.com
  • Published:2021-08-20 Online:2021-08-20

自身免疫性多内分泌腺病综合征Ⅱ型患者因左甲状腺素治疗引起肾上腺危象一例报道并文献复习

  

  1. 1.430081湖北省武汉市,武汉科技大学医学院
    2.430081湖北省武汉市,武汉科技大学附属普仁医院内分泌科
    *通信作者:周锋,副主任医师,副教授,硕士生导师; E-mail:przhoufeng@sina.com
  • 基金资助:
    湖北省卫生健康科研基金资助项目(WJ2019H222)

Abstract: Adrenal crisis is a life-threatening state of adrenal insufficiency that requires immediate treatment. Adrenal insufficiency is usually dividen into primary,secondary and tertiary. Addison's disease is the commonest cause of primary adrenal insufficiency,and is an important component of autoimmune polyglandular syndrome(APS). APS is a rare endocrine disease with presence of autoimmune damage of more than one endocrine glands,which includes APS typeⅠ and APS type Ⅱ. This article reported a APS type Ⅱ patient with levothyroxine-induced adrenal crisis,with detailed analysis of the causes,hoping to offer more information for clinical practice.

Key words: Polyendocrinopathies, autoimmune;Thyroxine;Adrenal crisis;Adrenal insufficiency;Case reports

摘要: 肾上腺危象是肾上腺皮质功能不全的一种危急状态,严重威胁患者的生命安全。肾上腺皮质功能不全分为原发性、继发性及三发性。Addison病是引起原发性肾上腺皮质功能不全最常见的原因,也是自身免疫性多内分泌腺病综合征(APS)的重要组成部分。APS是一种罕见的内分泌系统疾病,其特点为出现一个以上内分泌腺体自身免疫性损伤。APS主要分为APS Ⅰ型和APS Ⅱ型。本文报道了1例因左甲状腺素治疗而诱发肾上腺危象的APS Ⅱ型病例,并对引发肾上腺危象的原因进行了分析、讨论,旨在为临床提供更多资料。

关键词: 多内分泌腺疾病, 自身免疫性;甲状腺素;肾上腺危象;肾上腺皮质功能不全 ;病例报告