Recent Advances in Parenteral Nutrition-associated Metabolic Bone Disease

doi:10.12114/j.issn.1007-9572.2020.00.242

Abstract

Abstract: Chinese Academy of Medical Science /Peking Union Medical College/Department of Endocrinology，Peking Union Medical College Hospital/Key Laboratory of Metabolic bone diseases are quite common in patients receiving long-term parenteral nutrition （PN），which significantly impair their life quality.Many risk factors are correlated with PN-associated metabolic bone disease，such as micronutrient deficiencies，vitamin D deficiency，secondary hyperparathyroidism，imbalanced bone turnover and underlying diseases.Because most of the patients are asymptomatic in the early stage，it is essential to regularly monitor bone biochemical markers and evaluate bone mineral density.For those with higher risk of metabolic bone diseases，primary interventions consist in removing risk factors and improving nutrition，and initiating pharmacological therapies if necessary，should be delivered early.

Key words: Parenteral nutrition, Metabolic bone disease, Bone biochemical markers, Bone density

摘要： 长期接受肠外营养患者代谢性骨病的发生率高，严重影响患者的生活质量，其与骨骼营养元素缺乏、维生素D缺乏、继发甲状旁腺功能亢进、骨转换失衡、基础疾病等多重因素相关。由于大多数患者早期缺乏代谢性临床表现，定期监测患者骨代谢生化指标、骨密度至关重要。对于有代谢性骨病高危风险的患者，应早期预防，去除危险因素，加强营养，必要时予以药物治疗。

关键词: 肠外营养, 代谢性骨病, 骨代谢生化指标, 骨密度

HU Jing,LI Mei. Recent Advances in Parenteral Nutrition-associated Metabolic Bone Disease　[J]. Chinese General Practice, 2020, 23(27): 3488-3491. DOI: 10.12114/j.issn.1007-9572.2020.00.242.
胡静,李梅. 肠外营养相关代谢性骨病的研究进展[J]. 中国全科医学, 2020, 23(27): 3488-3491. DOI: 10.12114/j.issn.1007-9572.2020.00.242.

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