Abstract: Abnormal fat metabolism is one of the culprit causing and aggravating cardiovascular disease，and even causing MACE.A large number of studies have shown that statins，the major guideline-recommended Western medicines for regulating lipid metabolism，may often cause a series of adverse effects such as liver and kidney dysfunction and myotoxicity in the case of high intensity，large dose，and unreasonable application.It has become a cardiovascular problem that needs to be solved in recent years.Meanwhile，studies about regulating lipid metabolism using Chinese medicine are increasing.For example，Wenxin Granules regulate myocardial fatification and prevents MACE such as ventricular tachycardia after myocardial infarction.We reviewed the pathogenesis of abnormal lipid metabolism，and advances in the research on preventing MACE by regulating lipid metabolism using Wenxin Granules and other proprietary Chinese medicines with astragalus mongholicus and pseudo-ginseng as the main active ingredients，and used network pharmacology to explore the potential mechanisms of astragalus mongholicus and pseudo-ginseng in Wenxin Granules in preventing MACE by regulating lipid metabolism.This may be used as a reference for further exploration and research.

Key words: Lipid metabolism, Cardiovascular diseases, Astragalus membranaceus, Panax notoginseng, Pharmacology, Major adverse cardiovascular events

摘要： 脂质代谢异常是引起及加重心血管疾病，乃至引发主要不良心血管事件（MACE）的罪魁之一。大量的研究表明，调节脂质代谢的主要西药他汀类药物，在高强度、大剂量、不合理应用的情况下，常会引起肝肾功能损害、肌毒性等一系列不良后果，其已成为近年来亟待解决的心血管领域问题。近年来，中医药在调节脂质代谢方面的研究愈来愈多，如稳心颗粒调节心肌内脂肪化生预防心肌梗死后室性心动过速发生等MACE。本文就中医药调节脂质代谢的原理和稳心颗粒中主要组分黄芪、三七活性成分及其含两者的中成药调节脂质代谢预防MACE的研究进展做一综述，并运用网络药理学探究稳心颗粒中黄芪-三七药对通过调节脂质代谢预防MACE的潜在分子作用机制，为将来进一步探索研究提供参考。

关键词: 脂类代谢, 心血管疾病, 黄芪, 三七, 药理学, 主要不良心血管事件