Abstract: Background　Pulmonary infection during hospitalization significantly increases hospitalization costs，length of stay and mortality，and seriously increases the disease burden.Whether the blood test indicators within 24 hours after admission have effects on pulmonary infection in ischemic stroke patients is not well known.Objective　To evaluate the effects of blood test indicators on pulmonary infection in patients with first-ever ischemic stroke.Methods　Clinical data of 6 284 patients with first-ever ischemic stroke admitted to the Second Affiliated Hospital of Nanchang University from January 2009 to July 2017 were retrospectively collected.The patients were divided into two groups according to whether they were complicated by pulmonary infection.The gender，age，current drinking status，current smoking status and blood test indicators within 24 hours after admission were compared between the two groups.Non-conditional Logistic regression were used to analyze the influencing factors.Results　During the observation period，a total of 373（237 males and 136 females）cases out of 6 284 patients were complicated with pulmonary infection with an average age of（72.6±10.1） and the incidence was 5.94%.Logistic regression analysis showed that age，smoking status，platelet count，hemoglobin，absolute neutrophil count，standard deviation of distribution width（RDW-SD），creatinine and lipoprotein（a） were independent influencing factors of pulmonary infection（OR=2.316，2.258，0.998，0.987，1.106，1.029，1.003 and 1.056）（P<0.05）.Conclusion　Blood test indicators have predictive effects on pulmonary infection in patients with first-ever ischemic stroke.Platelet count and elevated hemoglobin are protective factors.Patients with increased neutrophil，RDW-SD，creatinine and lipoprotein（a） are associated with the increased risk of pulmonary infection.

Key words: Stroke, Ischemic stroke, Pulmonary infection, Root causes analysis

摘要： 背景　住院期间并发肺部感染会明显增加住院费用、时间和死亡率，大大加重了疾病负担。入院24 h内血液检测值对肺部感染是否存在影响尚不清楚。目的　分析血液检测值对首发缺血性脑卒中患者并发肺部感染的影响。方法　回顾性收集2009年1月—2017年7月南昌大学第二附属医院收治的6 284例首发缺血性脑卒中患者的临床资料，根据是否并发肺部感染将患者分为两组，比较两组患者性别、年龄、当前饮酒情况、当前吸烟情况等基本信息及入院24 h内的血液检测值，采用非条件Logistic回归分析首发缺血性脑卒中患者并发肺部感染的影响因素。结果　6 284例首发缺血性脑卒中患者中并发肺部感染者373例（5.94%），其中男237例，女136例，平均年龄为（72.6±10.1）岁。Logistic回归分析显示，年龄、当前吸烟情况、血小板计数、血红蛋白、中性粒细胞绝对值、红细胞分布宽度标准差、肌酐、脂蛋白a是并发肺部感染与否的影响因素（OR值分别为2.316、2.258、0.998、0.987、1.106、1.029、1.003、1.056，P<0.05）。结论　首发缺血性脑卒中的血液检测值对并发肺部感染有预测作用，其中血小板计数、血红蛋白水平升高者并发肺部感染的风险降低，中性粒细胞、红细胞分布宽度标准差、肌酐、脂蛋白a升高者并发肺部感染风险加大。

关键词: 卒中, 缺血性脑卒中, 肺部感染, 影响因素分析