Role of Gut Microbiome and Intermittent Fasting in the Treatment of Obesity

doi:10.12114/j.issn.1007-9572.2019.00.452

Abstract

Abstract: Obesity and obesity-related metabolic diseases have become killers threatening human health.Recent studies have shown that obesity has a close relationship with gut microbiome，gut microbiome imbalance and lower intestinal barrier function of host can cause abnormal lipid metabolism，which triggers obesity and obesity-induced metabolic disorders.Diet is the main factor affecting gut microbiome，and unreasonable dietary structure leads to gut microbiome imbalance.A number of studies have shown that intermittent fasting can reshape gut microbiome and significantly alleviate metabolic syndrome such as obesity，which is of great significance to human health.This article elaborates the role of gut microbiome and intermittent fasting in the treatment of obesity，and points out that the combination of gut microbiome and intermittent fasting may promote clinical application of obesity research achievements.

Key words: Enterobacteriaceae, Fasting, Obesity, Caloric restriction

摘要： 肥胖及其相关代谢性疾病已经成为威胁人类健康的杀手，近年来的研究表明，肥胖与肠道菌群有着密切的关系，肠道菌群失调及宿主肠屏障功能降低会引起脂代谢异常，进而触发肥胖并引发代谢损伤。饮食是影响肠道菌群的主要因素，不合理的膳食结构会导致肠道菌群失调。多项研究表明，通过间歇性禁食来重塑肠道菌群，可显著改善肥胖等代谢综合征，对人类健康具有重要意义。本文阐述了肠道菌群在间歇性禁食治疗肥胖中的作用，并提出了在肥胖的研究中，或可通过肠道菌群与间歇性禁食二者结合研究来促进临床转化的观点。

关键词: 肠杆菌科, 禁食, 肥胖症, 热量限制

WANG Junyu,ZHANG Anren. Role of Gut Microbiome and Intermittent Fasting in the Treatment of Obesity　[J]. Chinese General Practice, 2019, 22(27): 3308-3311. DOI: 10.12114/j.issn.1007-9572.2019.00.452.
汪俊宇,张安仁. 肠道菌群在间歇性禁食治疗肥胖中的作用研究[J]. 中国全科医学, 2019, 22(27): 3308-3311. DOI: 10.12114/j.issn.1007-9572.2019.00.452.

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