Abstract: Background　Male late-onset hypogonadism （LOH）is a clinical and biochemical syndrome associated with aging.It will severely affect the quality of life and bring adverse effects on multiple organs .At present，there is no unified diagnostic criteria at home and abroad，and the incidence of LOH varies in different regions.Objective　To investigate the prevalence of LOH and identify age-specific cut-off point for the determination of LOH among community-dwelling middle-aged and older males in Chengdu.Methods　By use of stratified sampling，we selected 800 males aged 30-70 from the fixed populations living in Chengdu Banknote Printing Company Community in Chengdu's Wenjiang District during May to August 2017，and 709 of them including 231（32.6％） aged 30-39，168（23.7％） aged 40-49，178（25.1％） aged 50-59，and 132（18.6％） aged 60-69 were finally enrolled according to the exclusion criteria.The Androgen Deficiency in Aging Males（ADAM） questionnaire was used to screen LOH.Serum total testosterone was measured to identify LOH.Chi-square test was used to compare the prevalence of LOH among different age groups.Spearman rank correlation analysis was used to explorethe relationship between age and the prevalence of LOH.ROC curve analysis was performed to determine the age-specific cut-off point for the determination of high risk population of LOH．Results　The prevalence of LOH in all participants assessed by ADAM score，serum TT level，and ADAM score combined with serum TT level was 67.1%，19.0%，17.9%，respectively.The prevalence of LOH assessed by ADAM score，serum TT level，and ADAM score combined with serum TT level differed significantly between the four age groups（P<0.05）.The prevalence of LOH in all participants assessed by ADAM score，or ADAM score combined with serum TT level increased with age（rs=0.238，0.231，P<0.05）．The optimal age-specific cut-off points for the identification of LOH by ADAM score，serum TT level，and ADAM score combined with serum TT level were 42.5，50.5，53.5，respectively.Conclusion　The prevalence of LOH in community-dwelling middle-aged and older males in Chengdu is high，and it correlates with age.The age-specific cut-off point  of LOH is 40-55 years old，but it needs to be further verified.

Key words: Hypogonadism, Age factors, Androgen deficiency in the aging male score, Serum total testosterone

摘要： 背景　男性迟发性性腺功能减退症（LOH）是一种与男性年龄增长相关的临床和生物化学综合征，严重影响患者的生活质量，并给多器官功能带来不良影响。目前国内外均没有较为统一的诊断标准，不同地区LOH发病率也存在一定差异。目的　了解成都市社区中老年男性LOH的患病情况，并研究其LOH高危年龄切点。方法　2017年5—8月采用分层抽样的方法在成都市温江区成都印钞公司社区固定人群中选取30~70岁的中老年男性800例，按照排除标准筛选出709例进行中老年男性雄激素缺乏（ADAM）量表调查，同时测定其血清总睾酮（TT）。采用χ2检验比较不同年龄段中老年男性筛查阳性率，Spearman秩相关分析研究中老年男性筛查阳性情况与年龄之间的关系，受试者工作特征曲线（ROC曲线）确定LOH高危中老年男性年龄切点。结果　709例研究对象中30~39岁231例（32.6％），40~49岁168例（23.7％），50~59岁178例（25.1％），60~69岁132例（18.6％）。ADAM量表、血清TT、ADAM量表联合血清TT筛查阳性率分别为67.1％、19.0%、17.9%。不同年龄段中老年男性ADAM量表、血清TT、ADAM量表联合血清TT筛查阳性率比较，差异有统计学意义（P<0.05）。ADAM量表、ADAM量表联合血清TT筛查阳性情况与年龄相关（rs=0.238、0.231，P<0.05）。ADAM量表、血清TT、ADAM量表联合血清TT筛查LOH的年龄切点分别为42.5、50.5、53.5岁。结论　成都市社区中老年男性LOH患病率较高，且与年龄有一定的相关性，其LOH年龄切点范围为40~55岁。

关键词: 性腺功能减退症, 年龄因素, 中老年男性雄激素缺乏调查量表, 血清总睾酮