Chinese General Practice ›› 2019, Vol. 22 ›› Issue (9): 1074-1077.DOI: 10.12114/j.issn.1007-9572.2018.00.289

Special Issue: 女性健康最新文章合集

• Monographic Research • Previous Articles     Next Articles

Clinical Effectiveness of Shuganziyin Granules Combined with Auricular-plaster Therapy for Simple Premature Thelarche in Girls with Ganyuyinxu Syndrome 

  

  1. Department of Pediatrics,Shanghai Jiading Hospital of Traditional Chinese Medicine,Shanghai 201800,China
    *Corresponding author:WANG Chunrong,Attending physician;E-mail:wangchunrongdddd@163.com
  • Published:2019-03-20 Online:2019-03-20

疏肝滋阴方配合耳穴贴压治疗肝郁阴虚型女童单纯性乳房早发育临床疗效观察

  

  1. 201800上海市嘉定区中医医院儿科
    *通信作者:王春荣,主治医师; E-mail:wangchunrongdddd@163.com
  • 基金资助:
    基金项目:2017年度中医特色诊疗技术提升项目(zyjx-2017052);中医薄弱领域专科建设项目(BRZK2016013)

Abstract: Background At present,there are no targeted drugs for simple premature thelarche(SPT) in girls in Western medicine.Both at home and abroad,regular follow-up and dietary guidance are used as intervention means,lacking of targeted treatment measures.In traditional Chinese medicine,individualized treatment should be emphasized.Objective To explore the effectiveness of Shuganziyin granules combined with auricular-plaster therapy for SPT in girls with Ganyuyinxu syndrome.Methods Thirty-eight participants with SPT were recruited from Department of Pediatrics,Shanghai Jiading Hospital of Traditional Chinese Medicine from May 2016 to November 2017.They were randomized into the treatment group(21 cases) and control group(17 cases),receiving Shuganziyin granules combined with auricular-plaster therapy,Zhibaidihuang pills combined with Xiaoyao pills via the oral route,respectively.The scores of Tanner stage of breast development in girls and TCM-based Ganyuyinxu syndrome pattern differentiation scale scores before and after treatment,and clinical response were compared between the two groups.Results Two groups showed similar scores of Tanner stage of breast development in girls and TCM-based Ganyuyinxu syndrome pattern differentiation scale before treatment(P>0.05).After treatment,although the scores of Tanner stage of breast development in girls were still similar in both groups(P>0.05),TCM-based Ganyuyinxu syndrome pattern differentiation scale scores decreased significantly in the treatment group(P<0.05).The treatment group demonstrated much better clinical response compared with the control group(P<0.05).Conclusion Auricular-plaster therapy is simple and convenient to use.Moreover,it has no side effects and the adherence to it is high in girls.Shuganziyin granules combined with auricular-plaster therapy is effective for SPT in girls with Ganyuyinxu syndrome by reducing the concomitant symptoms.

Key words: Growth and development;Breast;Puberty, precocious;Auriculotherapy

摘要: 背景 目前西医对女童单纯性乳房早发育没有针对性药物,国内外均是以定期检查随访以及饮食生活指导作为干预手段,缺乏针对性治疗措施。而中医辨证论治,重视个体化治疗。目的 观察疏肝滋阴方配合耳穴贴压治疗肝郁阴虚型女童单纯性乳房早发育的临床疗效。方法 选取上海市嘉定区中医医院儿科2016年5月—2017年11月门诊符合研究标准的38例单纯性乳房早发育患儿,将患儿随机分为治疗组21例和对照组17例。治疗组采用疏肝滋阴方配合耳穴贴压治疗,对照组采用知柏地黄丸联合逍遥丸口服。观察并比较两组治疗前后乳房发育分期、中医证候量化评分及临床疗效。结果 治疗前两组乳房发育分期、中医证候量化评分比较,差异无统计学意义(P>0.05)。治疗后两组乳房发育分期评分比较,差异无统计学意义(P>0.05);治疗后治疗组中医证候量化评分低于对照组(P<0.05)。治疗组临床疗效优于对照组(P<0.05)。结论 疏肝滋阴方配合耳穴贴压是治疗肝郁阴虚型女童单纯性乳房早发育的有效方法,可减轻伴随症状,且耳穴贴压具有无创伤、简便易行、患儿依从性强等优势。

关键词: 生长和发育;乳房;青春期, 早熟;耳穴疗法