TSH Reference Interval of Childbearing Age Women from Community in Urumqi

doi:10.12114/j.issn.1007-9572.2018.00.251

Abstract

Abstract: Background　Foreign studies report that pre-pregnancy serum thyroid stimulating hormone（TSH） is associated with an increased risk of adverse pregnancy outcomes，while TSH levels are affected by age，ethnicity，iodine nutrition，etc，so it is necessary to establish a reference range for women of childbearing age in different regions，provide basic data for the eugenics.Objective　To establish reference interval of TSH in women of childbearing age in a community of Urumqi.Methods　A total of 356 women between 18-45 years with complete information from 2 080 subjects in an epidemiological survey of thyroid diseases in a community of Urumqi in May 2013 were selected.Subjects were divided into Uygur and Han groups，which included 182 of Uygur，174 of Han.The basic data of body mass index（BMI），TSH，anti-thyroglobulin（TgAb），anti-thyroid peroxidase（TPOAb），urinary iodine，total cholesterol（TC），high density lipoprotein cholesterol（HDL-C），low density lipoprotein cholesterol（LDL-C），triglycerides（TG） were recorded.Results　The Uygur group had higher BMI and TgAb than Han group，and the levels of TC and HDL-C were lower than those of Han group（P<0.05）．The reference interval of TSH in Han and Uygur women of childbearing age were 0.86-6.47 μU/ml and 0.55-6.86 μU/ml.TSH level in Uygur group was lower than that in Han group（P<0.05）．Conclusion　The reference interval of TSH level in Han and Uygur groups are 0.86-6.47 μU/ml and 0.55-6.86 μU/ml，respectively.

Key words: Thyrotropin, Women, Reference value, Han nationality, Uygur nationality

摘要： 背景　国外研究报道妊娠前促甲状腺激素（TSH）升高与不良妊娠结局的风险增加有关，而TSH受年龄、种族、碘营养等因素的影响，故有必要建立不同地区的育龄期女性TSH参考范围，为育龄期女性优生优育提供基础数据。目的　探讨乌鲁木齐某社区育龄期女性血清TSH参考范围。方法　选取2013年5月在新疆乌鲁木齐某社区进行甲状腺疾病流行病学调查的2 080例受试者中资料完整的356例女性受试者为研究对象，年龄18~45岁。按照不同民族，将其分为维吾尔族组（n=182）和汉族组（n=174）。记录受试者体质指数（BMI）及TSH、甲状腺球蛋白抗体（TgAb）滴度、甲状腺过氧化物酶抗体（TPOAb）滴度、尿碘、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、三酰甘油（TG）。结果　维吾尔族组BMI、TgAb滴度高于汉族组，TC、HDL-C低于汉族组（P<0.05）。汉族组和维吾尔族组TSH参考范围分别为0.86~6.47 μU/ml和0.55~6.86 μU/ml。维吾尔族组TSH低于汉族组（P<0.05）。结论　汉族组和维吾尔族组TSH参考范围分别为0.86~6.47 μU/ml和0.55~6.86 μU/ml。

关键词: 促甲状腺激素, 妇女, 参考值, 汉族, 维吾尔族

ADILA·Alimu,GUO Yanying,WANG Xinling, et al. TSH Reference Interval of Childbearing Age Women from Community in Urumqi　[J]. Chinese General Practice, 2019, 22(9): 1043-1046. DOI: 10.12114/j.issn.1007-9572.2018.00.251.
阿地拉·阿里木,郭艳英,王新玲等. 乌鲁木齐社区育龄期女性血清促甲状腺激素参考范围的建立[J]. 中国全科医学, 2019, 22(9): 1043-1046. DOI: 10.12114/j.issn.1007-9572.2018.00.251.

References

［1］CHEN S，ZHOU X，ZHU H，et al．Preconception TSH and pregnancy outcomes：a population-based cohort study in 184 611 women［J］．Clini Endocrinol（Oxf），2017，86（6）：816-824.DOI：10.1111/cen.13329.
［2］OROUJI JOKAR T，FOURMAN L T，LEE H，et al．Higher TSH levels within the normal range are associated with unexplained infertility［J］．J Clin Endocrinol Metab，2018，103（2）：632-639.DOI：10.1210/jc.2017-02120.
［3］BALOCH Z，CARAYON P，CONTEDEVOLX B，et al．Laboratory medicine practice guidelines.Laboratory support for the diagnosis and monitoring of thyroid disease［J］．Thyroid，2003，13（1）：3-126.DOI：10.1089/105072503321086962.
［4］郭艳英，阿地拉?阿里木，辛亮，等．新疆维吾尔自治区乌鲁木齐市维吾尔族和汉族育龄期妇女碘营养状况调查分析［J］．中华妇幼临床医学杂志（电子版），2017，13（4）：466-469.DOI：10.3877/cma.j.issn.1673-5250.2017.04.017.
GUO Y Y，ADILA A L M，XIN L，et al．Investigation and analysis of iodine nutritional status in Han and Uygur nationalities in childbearing age women in Urumqi，Xinjiang Uygur Autonomous Region［J］．Chinese Journal of Obstetrics & Gynecology and Pediatrics（Electronic Edition），2017，13（4）：466-469.DOI：10.3877/cma.j.issn.1673-5250.2017.04.017.
［5］SURKS M I，BOUCAI L.Age- and race-based serum thyrotropin reference limits［J］．J Clin Endocrinol Metab，2010，95（2）：496-502.DOI：10.1210/jc.2009-1845.
［6］WS/T 107-2006尿中碘的砷铈催化分光光度测定方法［S］．北京：人民卫生出版社，2006.
［7］张菲，彭伟，林彦琳，等．妊娠前半期妇女血清TSH水平与妊娠结局的相关性研究［J］．中华内分泌代谢杂志，2017，33（1）：52-55.DOI：10.3760/cma.j.issn.1000-6699.2017.01.009.
ZHANG F，PENG W，LIN Y L，et al．Relationship between TSH and pregnancy outcomes during the first half of pregnancy in women［J］．Chin J Endocrinol Metab，2017，33（1）：52-55.DOI：10.3760/cma.j.issn.1000-6699.2017.01.009.
［8］EHRENKRANZ J，BACH P R，SNOW G L，et al．Circadian and circannual rhythms in thyroid hormones：determining the TSH and free T4 reference intervals based upon time of day，age，and sex［J］．Thyroid，2015，25（8）：954-961.DOI：10.1089/thy.2014.0589.
［9］李晨嫣，滕卫平.年龄及种族特异性的血清促甲状腺激素参考范围［J］．中华内分泌代谢杂志，2010，26（6）：504-506.DOI：10.3760/cma.j.issn.1000-6699.2010.06.020.
LI C Y，TENG W P.Age-and race-based serum thyrotropin reference limits［J］．Chinese Journal of Endocrinology and Metabolism，2010，26（6）：504-506.DOI：10.3760/cma.j.issn.1000-6699.2010.06.020.
［10］KUTLUTURK F，YILDIRIM B，OZTURK B，et al．The reference intervals of thyroid stimulating hormone in healthy individuals with normal levels of serum free thyroxine and without sonographic pathologies［J］．Endocr Res，2013，39（2）：56-60.DOI：10.3109/07435800.2013.824896.
［11］LI C，GUAN H，TENG X，et al．An epidemiological study of the serum thyrotropin reference range and factors that influence serum thyrotropin levels in iodine sufficient areas of China［J］．Endocr J，2011，58（11）：995-1002.
［12］HOLLOWELL J G，STAEHLING N W，FLANDERS W D，et al．Serum TSH，T（4），and thyroid antibodies in the United States population （1988 to 1994）：National Health and Nutrition Examination Survey （NHANESⅢ）［J］．J Clin Endocrinol Metab，2002，87（2）：489.DOI：10.1210/jcem.87.2.8182.
［13］杨慎华，梅洵，钱思兰.高龄老年人血清促甲状腺激素水平的变化及相关因素分析［J］．南昌大学学报（医学版），2013，53（12）：84-86.
YANG S H，MEI X，QIAN S L．Changes of serum thyroid stimulating hormone levels and related factors in elderly patients［J］．Journal of Nanchang University（Medical Sciences），2013，53（12）：84-86.
［14］李晨嫣，关海霞，滕晓春，等．碘充足地区血清TSH正常值范围及其影响因素的流行病学研究［J］．中华内分泌代谢杂志，2011，27（6）：458-462.DOI：10.3760/cma.j.issn.1000-6699.2011.06.003.
LI C Y，GUAN H X，TENG X C，et al．The reference range of serum thyrotropin in iodine-sufficient areas：an epidemiological study［J］．Chinese Journal of Endocrinology and Metabolism，2011，27（6）：458-462.DOI：10.3760/cma.j.issn.1000-6699.2011.06.003.
［15］王新玲，木尼拉?阿不都乃依木，陈翔，等．乌鲁木齐地区正常人群血清TSH参考区间的建立［J］．标记免疫分析与临床，2015，22（9）：839-841.DOI：10.11748/bjmy.issn.1006-1703.2015.09.004.
WANG X L，MUNILA A B D N Y M，CHEN X，et al．Research on TSH reference interval of normal population in Urumqi area［J］．Labeled Immunoassays and Clinical Medicine，2015，22（9）：839-841.DOI：10.11748/bjmy.issn.1006-1703.2015.09.004.
［16］GUAN H，SHAN Z，TENG X，et al．Influence of iodine on the reference interval of TSH and the optimal interval of TSH：results of a follow-up study in areas with different iodine intakes［J］．Clin Endocrinol（Oxf），2008，69（1）：136-141.DOI：10.1111/j.1365-2265.2007.03150x.
［17］BOUCAI L，HOLLOWELL J G，SURKS M I.An approach for development of age-，gender-，and ethnicity-specific thyrotropin reference limits［J］．Thyroid，2011，21（1）：5-11.DOI：10.1089/thy.2010.0092.
［18］SRIPHRAPRADANG C，PAVARANGKOON S，JONGJAROENPRASERT W，et al．Reference ranges of serum TSH，FT4 and thyroid autoantibodies in the Thai population：the national health examination survey［J］．Clin Endocrinol（Oxf），2014，80（5）：751-756.DOI：10.1111/cen.12371.
［19］李晨嫣，滕卫平，单忠艳，等．碘充足地区血清TSH正常值范围及其影响因素的流行病学研究［C］．南京：中华医学会全国内分泌学学术会议，2009.
［20］VAN DE VEN A C，NETEA-MAIER R T，DE VEGT F，et al．Associations between thyroid function and mortality：the influence of age［J］．Eur J Endocrinol，2014，171（2）：183-191.DOI：10.1530/EJE-13-1070.

[1]	YUAN Xianxian, WANG Jia, ZHANG Kexin, YANG Ruihua, ZHENG Wei, LI Guanghui. Association between Blood Lipid Levels and Macrosomia in Pregnant Women with Different Pre-pregnancy Body Mass Index [J]. Chinese General Practice, 2023, 26(24): 2973-2979.
[2]	CAO Ziyao, QIAN Cheng, XIE Guohua, CHANG Qingsong, WU Donghui. Analysis on the Correlation of Passive Suicidal Ideation with Thyroid Stimulating Hormone and Prolactin among Elderly Schizophrenia Inpatients [J]. Chinese General Practice, 2023, 26(23): 2894-2898.
[3]	GAO Baokai, HU Zhaoyan, WANG Wenlong, CHEN Kexin, QIAO Hui. Changes and Equity of Health Service Utilization in Married Women of Childbearing Age in Rural Mountainous Areas of Southern Ningxia after 10 Years of the New Healthcare Reform [J]. Chinese General Practice, 2023, 26(22): 2748-2755.
[4]	Chao ZHANG, Yan LONG, Xina FU. Reference Range for Thyroid Function during Twin Pregnancies [J]. Chinese General Practice, 2022, 25(27): 3404-3408.
[5]	Lei MO, Ping ZHONG. Study on the Relationship between Intestinal Microflora Differences and the Incidence of Preeclampsia in Pregnant Women in the Early and Middle Stages of Pregnancy [J]. Chinese General Practice, 2022, 25(20): 2489-2492.
[6]	Qianqian ZHAO, Yanli ZHOU, Chaoqun XIAO, Wenting LIU, Zhongyi FAN, Yu CHEN. Advances in Screening for Postpartum Hypomanic Symptoms and Their Relationship with Postpartum Depression and Bipolar Disorder [J]. Chinese General Practice, 2022, 25(20): 2547-2550.
[7]	Yu LIU, Yan WEI, Ping YANG. Comparative Analysis of Cervical Cancer Screening Results in 2019 and 2020 in Shihezi Urban Areas, Xinjiang [J]. Chinese General Practice, 2022, 25(18): 2223-2230.
[8]	Jingjing ZHAO, Yuhong LI, Min YU, Fangfang YANG, Qiaozhi YU, Xiaoyue WANG, Sisi BU, Peipei LIAO. Maternal Physical Activity in the Third Trimester and Delayed Onset of Lactogenesis [J]. Chinese General Practice, 2022, 25(18): 2268-2274.
[9]	Moufang JI, Ruobing LI, Kejing WEI, Fanhua ZENG. Influence of Physical Exercise Interventions during Pregnancy on Natural Childbirth: a Meta-analysis [J]. Chinese General Practice, 2022, 25(15): 1897-1905.
[10]	Jiehong KANG, Xiangyun CHANG, Yurong ZHU, Tao BA, Yuan SUN. Association of Cyclic RNAs with the Risk of Type 2 Diabetes Mellitus in Han Chinese [J]. Chinese General Practice, 2022, 25(15): 1863-1868.
[11]	MAO Xiaoyan, ZHOU Yan, LIU Li, YIN Runxiu, YANG Chunhui, CUI Tingting, FANG Chunlian, JIANG Hongchao, TIAN Xin. Ethnic-specific Clinical Features in Children with Non-M3 Acute Myeloid Leukaemia from Yunnan Province [J]. Chinese General Practice, 2022, 25(08): 979-983.
[12]	SUN Lei，LI Mei. TSH Suppression Therapy May Affect Bone Health，How to Manage Differentiated Thyroid Cancer Scientifically？ [J]. Chinese General Practice, 2021, 24(8): 941-946.
[13]	ZHANG Dengyan，ZHU Qingshuang. Recent Developments in Postpartum Blood Glucose Screening among Patients with Gestational Diabetes Mellitus　 [J]. Chinese General Practice, 2021, 24(24): 3087-3095.
[14]	JIANG Xuelong，CHEN Dongmei，WANG Qin，ZHANG Qinglong，LI Jianping，SHI Juan，LI Min，HE Zhongming，HAN Fang，CHEN Yan. Hypertension and Diabetes Incidence in Community-dwelling Han and Uygur Chinese People with Obstructive Sleep Apnea：a 7-year Telephone Follow-up Study　 [J]. Chinese General Practice, 2021, 24(23): 2902-2906.
[15]	Chinese Medical Doctor Association（CMDA）'s General Practitioners Sub-association，the Primary Care Branch of Beijing Institute of Obstetrics & Gynecology.Expert recommendations on community-based manag. Expert Recommendations on Community-based Management of Women with Abnormal Cervical Cancer Screening Test Results　 [J]. Chinese General Practice, 2021, 24(17): 2117-2121.