Abstract: Background　Foreign studies report that pre-pregnancy serum thyroid stimulating hormone（TSH） is associated with an increased risk of adverse pregnancy outcomes，while TSH levels are affected by age，ethnicity，iodine nutrition，etc，so it is necessary to establish a reference range for women of childbearing age in different regions，provide basic data for the eugenics.Objective　To establish reference interval of TSH in women of childbearing age in a community of Urumqi.Methods　A total of 356 women between 18-45 years with complete information from 2 080 subjects in an epidemiological survey of thyroid diseases in a community of Urumqi in May 2013 were selected.Subjects were divided into Uygur and Han groups，which included 182 of Uygur，174 of Han.The basic data of body mass index（BMI），TSH，anti-thyroglobulin（TgAb），anti-thyroid peroxidase（TPOAb），urinary iodine，total cholesterol（TC），high density lipoprotein cholesterol（HDL-C），low density lipoprotein cholesterol（LDL-C），triglycerides（TG） were recorded.Results　The Uygur group had higher BMI and TgAb than Han group，and the levels of TC and HDL-C were lower than those of Han group（P<0.05）．The reference interval of TSH in Han and Uygur women of childbearing age were 0.86-6.47 μU/ml and 0.55-6.86 μU/ml.TSH level in Uygur group was lower than that in Han group（P<0.05）．Conclusion　The reference interval of TSH level in Han and Uygur groups are 0.86-6.47 μU/ml and 0.55-6.86 μU/ml，respectively.

Key words: Thyrotropin, Women, Reference value, Han nationality, Uygur nationality

摘要： 背景　国外研究报道妊娠前促甲状腺激素（TSH）升高与不良妊娠结局的风险增加有关，而TSH受年龄、种族、碘营养等因素的影响，故有必要建立不同地区的育龄期女性TSH参考范围，为育龄期女性优生优育提供基础数据。目的　探讨乌鲁木齐某社区育龄期女性血清TSH参考范围。方法　选取2013年5月在新疆乌鲁木齐某社区进行甲状腺疾病流行病学调查的2 080例受试者中资料完整的356例女性受试者为研究对象，年龄18~45岁。按照不同民族，将其分为维吾尔族组（n=182）和汉族组（n=174）。记录受试者体质指数（BMI）及TSH、甲状腺球蛋白抗体（TgAb）滴度、甲状腺过氧化物酶抗体（TPOAb）滴度、尿碘、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、三酰甘油（TG）。结果　维吾尔族组BMI、TgAb滴度高于汉族组，TC、HDL-C低于汉族组（P<0.05）。汉族组和维吾尔族组TSH参考范围分别为0.86~6.47 μU/ml和0.55~6.86 μU/ml。维吾尔族组TSH低于汉族组（P<0.05）。结论　汉族组和维吾尔族组TSH参考范围分别为0.86~6.47 μU/ml和0.55~6.86 μU/ml。

关键词: 促甲状腺激素, 妇女, 参考值, 汉族, 维吾尔族