Diagnostic Value of Cystatin C and Uric Acid for Early Renal Impairment in Kazakh Patients with H-type Hypertension

doi:10.12114/j.issn.1007-9572.2018.00.035

Abstract

Abstract: Background　Cystatin C （CysC） and uric acid （UA） are closely related to renal impairment in patients with hypertension，and have become a hot research topic in recent years.Objective　To investigate the value of CysC and UA in diagnosis of early renal impairment in Kazakh patients with H-type hypertension.Methods　A total of 318 Kazakh patients with H-type hypertension who participated in the epidemiological investigation in Xinjiang between May 2014 and August 2015 were selected randomly.According to their eGFR levels，the patients were divided into a renal function impairment group〔n=174，eGFR<90 ml?min-1?（1.73 m2）-1〕 and a normal renal function group 〔n=144，eGFR≥90 ml?min-1?（1.73 m2）-1〕.Baseline data were compared between the two groups，and the correlations among CysC，UA and eGFR were analyzed.Factors influencing early renal impairment in Kazakh patients with H-type hypertension，as well as the value of CysC and UA in diagnosis of the condition，were investigated.Results　The indicators age，systolic blood pressure（SBP），diastolic blood pressure（DBP），triglyceride（TG），low density lipoprotein cholesterol（LDL-C），blood urea nitrogen（BUN），creatinine（Cr），homocysteine（Hcy），CysC and UA were higher in the renal function impairment group than in the normal renal function group（P<0.05）.CysC and UA were negatively correlated with eGFR（r=-0.791 and -0.671，P<0.05）.Multivariate Logistic regression showed that LDL-C，CysC，and UA were influencing factors for early renal impairment in Kazakh patients with H-type hypertension（P<0.05）.The areas under the ROC curve（AUC） of CysC and UA in the diagnosis of early renal impairment in these patients were 0.967〔95%CI（0.946，0.989）〕 and 0.875〔95%CI（0.837，0.913）〕.Conclusion　CysC and UA are correlated with early renal impairment in Kazakh patients with H-type hypertension and are a favorable indicator for the diagnosis of early renal impairment.

Key words: Hypertension, Kidney injury, Kazakh, Cystatin C, Uric acid, Glomerular filtration rate

摘要： 背景　胱抑素C（CysC）、尿酸（UA）与高血压患者的肾损害密切相关，已成为近年来研究的热点。目的　探讨CysC、UA对哈萨克族H型高血压患者初期肾损害的诊断价值。方法　随机抽取2014年5月—2015年8月参与新疆地区流行病学调查的哈萨克族H型高血压患者318例为研究对象，依据估算肾小球滤过率（eGFR）将患者分为肾损害组〔n=174，eGFR<90 ml?min-1?（1.73 m2）-1〕、肾功能正常组〔n=144，eGFR≥90 ml?min-1?（1.73 m2）-1〕。比较两组患者的基线资料；分析CysC、UA与eGFR的相关性，哈萨克族H型高血压患者初期肾损害的影响因素以及CysC、UA诊断哈萨克族H型高血压患者初期肾损害的价值。结果　肾损害组患者年龄、收缩压（SBP）、舒张压（DBP）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、血尿素氮（BUN）、肌酐（Cr）、同型半胱氨酸（Hcy）、CysC、UA高于肾功能正常组（P<0.05）。CysC、UA与eGFR呈负相关（r值分别为-0.791、-0.671，P<0.05）。多因素Logistic回归分析结果显示，LDL-C、CysC、UA是哈萨克族H型高血压患者初期肾损害的影响因素（P<0.05）。CysC、UA诊断哈萨克族H型高血压患者初期肾损害的受试者工作特征曲线（ROC）曲线下面积（AUC）分别为0.967〔95%CI（0.946，0.989）〕、0.875〔95%CI（0.837，0.913）〕。结论　哈萨克H 型高血压患者 CysC、UA与初期肾损害有相关性，并对其有一定的诊断价值，可作为诊断初期肾损害的重要指标。

关键词: 高血压, 肾损害, 哈萨克族, 胱抑素C, 尿酸, 肾小球滤过率

LI Ruru,CHEN Shaoze,LIU Jingjing, et al. Diagnostic Value of Cystatin C and Uric Acid for Early Renal Impairment in Kazakh Patients with H-type Hypertension[J]. Chinese General Practice, 2019, 22(6): 664-667. DOI: 10.12114/j.issn.1007-9572.2018.00.035.
李茹茹,陈少泽,刘晶晶等. 胱抑素C和尿酸对哈萨克族H型高血压患者初期肾损害的诊断价值研究[J]. 中国全科医学, 2019, 22(6): 664-667. DOI: 10.12114/j.issn.1007-9572.2018.00.035.

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