Abstract: Background　Lung cancer and diabetes mellitus（DM） are common diseases with age-related increases in incidence.Moreover，clinical coexistence of the two is becoming more common.DM may have an impact on the occurrence and development of lung cancer.Objective　To investigate the effect of DM on the progression-free survival（PFS） in patients with lung cancer.Methods　The clinical information of 189 inpatients with lung cancer with DM（DM group） and 198 inpatients with lung cancer without DM（control group），who were recruited from Department of Respiratory Medicine and Thoracic Surgery，Changhai Hospital，the Second Military Medical University between December 1，2006 and December 31，2016 was collected.Inter-subgroup comparisons were performed in those aged < 65 years and in those aged ≥65 years.The survival curves of patients with different characteristics were drawn and analyzed.And the influencing factors of PFS were analyzed by Cox regression model.Results　Compared with those without DM，lung cancer patients with DM showed much higher proportions of males and older people，higher prevalence of smoking history and commodities （P<0.05）．Moreover，they demonstrated significantly longer mean PFS〔11.0 months，95%CI（8.7，13.3）vs 9.0 months，95%CI（7.8，10.1）〕 （χ2=4.197，P=0.040）.In lung cancer patients aged <65 years，those with DM were found with significantly higher proportions of males，prevalence of smoking history and commodities compared with those without （P<0.05）．Furthermore，they presented longer mean PFS〔11.0 months，95%CI（8.5，13.5） vs 7.0 months，95%CI（6.9，9.1）〕 （χ2=7.257，P=0.007）.In lung cancer patients aged ≥65 years，the mean PFS in those with DM was equal to or greater than that of those without〔11.0 months，95%CI（6.5，15.5） vs 12.0 months，95%CI（6.0，18.0）〕（χ2=0.058，P=0.809）.Cox regression model analysis showed that age，lung cancer staging and treatment regimen were the influencing factors of PFS in lung cancer patients （P<0.05）；lung cancer staging and DM were the influencing factors of PFS in lung cancer patients aged <65 years （P<0.05）；lung cancer staging and treatment regimen were the influencing factors of PFS in lung cancer patients ≥65 years （P<0.05）．Conclusion　For lung cancer patients，especially those aged <65 years，the prevalence of DM was associated with prolonged PFS.

Key words: Diabetes mellitus, Lung neoplasms, Disease-free survival

摘要： 背景　肺癌与糖尿病（DM）均是随年龄增长发病率增高的常见病，临床上二病共存的现象越来越常见，DM可能对肺癌的发生、发展产生影响。目的　探讨DM对肺癌患者无进展生存期（PFS）的影响。方法　收集2006-12-01至2016-12-31于第二军医大学附属长海医院呼吸内科及胸外科住院治疗的肺癌合并DM患者189例（DM组）及肺癌不合并DM患者198例（对照组）的临床资料。按照年龄<65岁和≥65岁进行亚组分析。绘制不同特征患者PFS生存曲线，采用Cox回归模型分析分析肺癌患者PFS的影响因素。结果　DM组男性、≥65岁、有吸烟史、有其他合并症患者比例高于对照组（P<0.05）。<65岁DM亚组的男性、有吸烟史、有其他合并症患者的比例高于<65岁对照亚组（P<0.05）。DM组患者中位PFS〔11.0个月，95%CI（8.7，13.3）个月〕长于对照组〔9.0个月，95%CI（7.8，10.1）个月〕（χ2=4.197，P=0.040）。<65岁DM亚组患者PFS〔11.0个月，95%CI（8.5，13.5）个月〕长于<65岁对照亚组〔7.0个月，95%CI（6.9，9.1）个月〕（χ2=7.257，P=0.007）。≥65岁DM亚组患者中位PFS〔11.0个月，95%CI（6.5，15.5）个月〕与≥65岁对照亚组中位PFS〔12.0个月，95%CI（6.0，18.0）个月〕比较，差异无统计学意义（χ2=0.058，P=0.809）。Cox回归模型分析结果显示，年龄、分期、治疗方案是肺癌患者PFS的影响因素（P<0.05），DM与分期是<65岁肺癌患者PFS的影响因素（P<0.05），分期与治疗方案是≥65岁肺癌患者PFS的影响因素（P<0.05）。结论　合并DM是肺癌患者PFS的影响因素，尤其对于<65岁肺癌患者PFS有益。

关键词: 糖尿病, 肺肿瘤, 无病生存