Abstract: Background　The incidence of benign prostatic hyperplasia（BPH） or fatty liver disease（FLD） in male university teachers is high，and both diseases are often accompanied.At present，the pathogenesis of the two diseases and the causes of their concomitant diseases are not clear yet.Objective　To explore the prevalence rate of BPH with FLD and its influencing factors among male university teachers，providing a basis for the formulation of targeted prevention and control strategies.Methods　The enrolled 2 136 male university teachers were sampled from individuals undergoing physical examination in the physical examination center of a university hospital in Guangzhou between January 2016 and January 2017，including 500 with BHP（BHP group） and 311 with BHP and FLD （combination group）．Clinical data of these two groups were analyzed comparatively.Influencing factors of BHP combined with FLD were analyzed by using multivariate Logistic regression.Results　Totaled 811 cases（38.0%） were found with BHP，311 of whom （38.4%） were identified with FLD.Those with BHP and FLD demonstrated significantly increased mean levels of BMI，urine protein，fasting blood glucose（FBG），urine specific gravity（USG），uric acid（UA），low-density lipoprotein，triacylglycerol（TG），diastolic blood pressure compared with those with BHP （P<0.05）．Multivariate Logistic regression analysis showed that increased BMI〔OR=1.447（1.306，1.603），P<0.001〕，FBG〔OR=1.694 （1.365，2.103），P<0.001〕，UA〔OR=1.003（1.000，1.006），P<0.05〕and TG〔OR=1.590 （1.186，2.132），P<0.05〕were risk factors for BHP combined with FLD，while increased high-density lipoprotein was the protective factor for BHP combined with FLD〔OR=0.389（0.162，0.931），P<0.05〕.Conclusion　The prevalence rate of BHP combined with FLD is higher than that of BHP among male university teachers.BMI，FBG，TG，UA and high-density lipoprotein are the influencing factors of BHP combined with FLD.

Key words: Prostatic hyperplasia, benign；Fatty liver；Root cause analysis；University teacher

摘要： 背景　高校男教师良性前列腺增生（BHP）和脂肪肝的发病率较高，且两种疾病常伴随出现。目前两种疾病的发病机制及相伴发病的原因尚未明确。目的　了解高校男教师BHP合并脂肪肝的患病情况及其影响因素，为有针对性地制定防治策略提供依据。方法　收集2016年1月—2017年1月在广州某高校校医院体检中心进行体检的2 136例男性教师为研究对象，其中500例单纯BHP者为BHP组，311例BHP合并脂肪肝者为合并组，对比分析两组临床资料。BHP合并脂肪肝的影响因素采用多因素Logistic回归分析。结果　高校男教师BHP的患病率为38.0%（811/2136），其BHP合并脂肪肝的患病率为38.4%（311/811）。合并组BMI、尿蛋白、空腹血糖、尿比重、尿酸、低密度脂蛋白胆固醇、三酰甘油、舒张压水平较BHP组明显升高（P<0.05）。多因素Logistic分析显示，体质指数（BMI）〔OR=1.447（1.306，1.603），P<0.001〕、空腹血糖〔OR=1.694（1.365，2.103），P<0.001〕、尿酸〔OR=1.003（1.000，1.006），P<0.05〕、三酰甘油〔OR=1.590（1.186，2.132），P<0.05〕是高校男教师患BHP合并脂肪肝的危险因素，高密度脂蛋白胆固醇是高校男教师患BHP合并脂肪肝的保护因素〔OR=0.389（0.162，0.931），P<0.05〕。结论　高校男教师BHP合并脂肪肝的患病率较单纯BHP患病率高，BMI、空腹血糖、三酰甘油、尿酸、高密度脂蛋白胆固醇是高校男教师患BHP合并脂肪肝的影响因素。

关键词: 前列腺增生, 良性；脂肪肝；影响因素分析；大学教师