关键词: 抑郁症, 脂类代谢, 机制, α- 突触核蛋白, 多不饱和脂肪酸

Abstract: Lipid metabolism is a key physiological process in the body, and its disruption is closely linked to the onset and development of depression. Nevertheless, a systematic collation of these associations is currently inadequate. This article comprehensively explores the changes in lipid metabolism in patients with depression and elaborates on disorders in which disorders of lipid metabolism are co-morbidly associated with depression, such as overweight, obesity, and type II diabetes mellitus. In addition, the article summarises five intrinsic mechanisms by which abnormalities in lipid metabolism are associated with the development of depression: overexpression of SNCA genes and abnormal accumulation of α-Syn, iron death, dysbiosis of intestinal flora, impaired mitochondrial mass control system, and chronic stress. Finally, this paper suggests future research directions aimed at providing a new perspective and research basis for the early diagnosis and treatment of depression.

Key words: Depression, Lipid metabolism, Mechanism, Alpha-synuclein, Polyunsaturated fatty acids