Popularization of medical knowledge plays an important role in promoting effective communication and understanding between doctors and patients. Based on the shortcomings of the model of popularization of traditional medical knowledge, such as unidirectional dissemination, insufficient depth of information and difficulty in understanding, this paper explores the types and advantages of innovative models of popularization of medical knowledge by searching the literature. Currently, the main models of community-based popularization of medical knowledge include traditional media (TV, radio, newspapers), lectures, special report, books, brochures, etc., which are limited in terms of the effectiveness of information dissemination, lack of interaction and personalization, as well as continuity and traceability. In this paper, an in-depth discussion was conducted on the innovative model of popularizing the knowledge of critical care medicine in the community, and many new models of popularizing knowledge, including cartoons, animation, virtual reality, augmented reality, and Internet platforms were proposed, and useful community practice was carried out. The results of the practice showed that the number of reading hits and the satisfaction with popularizing science were significantly increased under the innovative models of popularization of knowledge. The innovative model of popularization of knowledge can improve the efficiency of medical knowledge popularization, enhance patient participation, bridge the gap of medical knowledge, and provide customized health management solutions, which is of a significant advantage, however, it also has limitations such as higher dependence on technology and equipment, and the model of popularization of knowledge still needs to be continuously innovated and explored.