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中国全科医学

所属专题： 呼吸疾病文章合辑

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慢性阻塞性肺疾病急性加重期患者报告结局测评工具研究现状

李春阳1，2，王佳佳1，2*，卫梦雨1，2，李建生1，2   

  1. 1.450046 河南省郑州市，河南中医药大学，呼吸疾病中医药防治省部共建协同创新中心 / 河南省中医药防治呼吸病重点实验室；2.450000 河南省郑州市，河南中医药大学第一附属医院呼吸科
  • 收稿日期:2023-06-07 修回日期:2023-09-04
  • 通讯作者: 王佳佳，副教授 / 研究生导师
  • 基金资助:
    国家自然科学基金项目（81830116，82004500）；中医药传承与创新“百千万”人才工程—岐黄工程首席科学家（国中医药人教函［2020］219 号）；河南省中医药科学研究专项课题（2023ZY2039）；河南省特色骨干学科中医学学科建设项目（STG-ZYXKY-2020006）

Research Status of Patient-reported Outcome Measurements for Acute Exacerbation of Chronic Obstructive Pulmonary Disease

LI Chunyang1，2，WANG Jiajia1，2*，WEI Mengyu1，2，LI Jiansheng1，2   

  1. 1.Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P.R/Henan University of Chinese Medicine，Zhengzhou 450046，China；2.Department of Respiratory Diseases，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
  • Received:2023-06-07 Revised:2023-09-04
  • Contact: WANG Jiajia，Lecturer/Master supervisor

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摘要： 慢性阻塞性肺疾病（COPD）是常见呼吸系统疾病之一，其急性加重作为一种急性事件，严重影响COPD 患者生存质量。本研究检索 PubMed、中国知网、万方数据知识服务平台、维普网和中国生物医学文献数据库，经纳排标准共筛出 69 篇代表性文献，发现目前国内外应用于 COPD 急性加重期患者报告结局的测评工具共 23 个，除EXACT-PRO 外均直接采用稳定期患者报告结局测评工具，可分为普适性、疾病特异性及症状特异性测评工具，主要涉及症状、生理领域、社会领域、心理情绪、日常活动等领域。建议未来 COPD 急性加重期患者生存质量研究重点关注以下几方面：（1）加强特异性测评工具研究；（2）重视经典测量理论、项目反应理论及概化理论联合应用；（3）重视测评工具最小临床重要差值研究；（4）合理选择测评工具。

关键词: 肺疾病, 慢性阻塞性；量表；患者报告结局；呼吸道疾病；测评工具；综述

Abstract: Chronic obstructive pulmonary disease （COPD）is one of the common respiratory diseases，and the acute exacerbation of COPD is an acute event that severely reduces the quality of life in patients with COPD. We searched PubMed，CNKI，Wanfang Data Knowledge Service platform，Vip.com and Chinese Biomedical Literature，sifted out 69 representative literatures according to the inclusion and exclusion criteria，and found that there were 23 Patient-reported Outcome（PRO）assessment tools used in patients with acute exacerbation of COPD. Except for the EXACT PRO，all of them directly use PRO assessment tools of stable patients. These assessment tools are divided into general，disease-specific and symptom-specific assessment tools，mainly involving symptoms，physiological field，social field，psychological emotion，daily activities and other fields. The number of items is from one to 100，and the response scale is mostly in the form of Likert，and its development and assessment are based on classical test theory . It is suggested that future studies on quality of life of patients with acute exacerbation of COPD should focus on the following points：strengthening the research on specific assessment tools；attaching importance to the combined application of classical test theory，item response theory and generalizability theory；paying attentionto the study of the minimal clinically important difference of assessment tools；selecting assessment tools appropriately.

Key words: Pulmonary disease, chronic obstructive；Scale；Patient-reported outcome；Respiratory tract diseases；Assessment tools；Review

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