自体富血小板浓缩物在妇科领域中的应用研究进展

doi:10.12114/j.issn.1007-9572.2023.0213

中国全科医学 ›› 2023, Vol. 26 ›› Issue (35): 4472-4476.DOI: 10.12114/j.issn.1007-9572.2023.0213

自体富血小板浓缩物在妇科领域中的应用研究进展

王小雪¹, 毛乐乐¹, 王子君¹, 杨慕坤¹, 白文佩¹^,^*(), 刁翯²^,³

1．100038　北京市，北京大学第九临床医学院　北京世纪坛医院妇产科
2．300199　天津市中心妇产科医院中医科
3．300199　天津市人类发育与生殖调控重点实验室

收稿日期:2023-04-07 修回日期:2023-05-16 出版日期:2023-12-15 发布日期:2023-05-25
通讯作者: 白文佩
作者贡献：王小雪、白文佩负责研究命题的提出；王小雪负责论文撰写；毛乐乐负责文献收集、筛选；王子君、杨慕坤、刁翯负责论文修订；白文佩负责最终版本修订，文章的质量控制及审校，对论文负责。
基金资助:
国家自然科学基金青年科学基金项目(82004409); 北京市医院管理中心临床医学发展专项经费资助(ZYLX202112); 首都医科大学附属北京世纪坛医院青年基金(2021-q21)

Advances in the Application of Autologous Platelet Concentrate in the Field of Gynecology

WANG Xiaoxue¹, MAO Lele¹, WANG Zijun¹, YANG Mukun¹, BAI Wenpei¹^,^*(), DIAO He²^,³

1. Department of Obstetrics and Gynecology, Peking University Ninth School of Clinical Medicine/Beijing Shijitan Hospital, Beijing 100038, China
2. Department of Traditional Chinese Medicine, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300199, China
3. Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin 300199, China

Received:2023-04-07 Revised:2023-05-16 Published:2023-12-15 Online:2023-05-25
Contact: BAI Wenpei

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摘要/Abstract

摘要： 自体富血小板浓缩物是通过抽取人体或动物血液经过离心获得的血小板浓缩物，主要包括第一代血小板浓缩物富血小板血浆（PRP）及第二代血小板浓缩物富血小板纤维蛋白（PRF）。因其促进伤口愈合及组织修复的作用，被广泛运用于口腔种植、骨缺损修复、烧伤整形等领域。近年来，自体富血小板浓缩物开始运用于改善卵巢功能、促进子宫内膜增生修复、治疗宫颈及外阴相关病变，并取得了显著疗效，但目前缺乏对PRP、PRF在妇科领域研究成果的有效整合。本文系统、全面地梳理了自体富血小板浓缩物的制备、生物学特性以及在妇科多种疾病中的应用，以期能为临床医生提供妇科相关疾病新的治疗思路，并为自体富血小板浓缩物研究应用的深入开展提供借鉴。

关键词: 妇科疾病, 富血小板血浆, 富血小板纤维蛋白, 自体富血小板浓缩物, 子宫内膜增生, 卵巢疾病, 综述

Abstract:

Autologous platelet concentrate (APC) is a platelet concentrate obtained by centrifugation of human or animal blood, mainly includes first-generation platelet concentrate platelet-rich plasma (PRP) and second-generation platelet concentrate platelet-rich fibrin (PRF), which is widely applied in varies fields such as dental implants, bone defect repairing and burn plastic surgery because of its role in wound healing and tissue repair. In recent years, autologous platelet concentrate has been applied to improve ovarian function, promote the repair of endometrial hyperplasia, treat cervical and vulvo-related lesions, and has achieved significant efficacy. However, there is a lack of effective integration of PRP and PRF research results in the field of gynecology. This paper systematically and comprehensively review the preparation, biological properties and applications in various gynecological diseases, in order to provide clinicians with new treatment ideas for gynecological diseases and reference for the further application of APC.

Key words: Gynecologic diseases, Platelet-rich plasma, Platelet-rich fibrin, Autologous platelet concentrates, Endometrial hyperplasia, Ovarian diseases, Review

王小雪,毛乐乐,王子君,等. 自体富血小板浓缩物在妇科领域中的应用研究进展[J]. 中国全科医学, 2023, 26(35): 4472-4476. DOI: 10.12114/j.issn.1007-9572.2023.0213.
WANG Xiaoxue,MAO Lele,WANG Zijun, et al. Advances in the Application of Autologous Platelet Concentrate in the Field of Gynecology[J]. Chinese General Practice, 2023, 26(35): 4472-4476. DOI: 10.12114/j.issn.1007-9572.2023.0213.

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自体富血小板浓缩物在妇科领域中的应用研究进展

Advances in the Application of Autologous Platelet Concentrate in the Field of Gynecology

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