经颅低水平激光：一种治疗抑郁症的新方法

doi:10.12114/j.issn.1007-9572.2022.0688

中国全科医学 ›› 2023, Vol. 26 ›› Issue (27): 3335-3341.DOI: 10.12114/j.issn.1007-9572.2022.0688

所属专题：精神卫生最新文章合集

• 综述与专论 • 下一篇

经颅低水平激光：一种治疗抑郁症的新方法

梁雪梅¹, 王睿²^,^*(), 赵玉环¹, 徐天娇², 王伟³, 孙伟东¹

1．161006　黑龙江省齐齐哈尔市，齐齐哈尔医学院附属第四医院精神科
2．161006　黑龙江省齐齐哈尔市，齐齐哈尔医药科学研究所博士后科研工作站
3．157000　黑龙江省牡丹江市，牡丹江医学院马克思主义学院教研科

收稿日期:2022-08-24 修回日期:2022-11-06 出版日期:2023-09-20 发布日期:2022-11-21
通讯作者: 王睿
作者贡献：梁雪梅负责提出概念、文章框架构思与撰写；王睿负责文章质量控制与审校，对文章负责；赵玉环负责技术与材料支持；徐天娇负责资料收集与整理；王伟、孙伟东负责文章修订。
基金资助:
齐齐哈尔医学科学院临床科研基金项目(QMSI2020L-05); 黑龙江省自然科学基金面上项目(H2015068)

Transcranial Low-level Laser Therapy: a Novel Treatment for Depression

LIANG Xuemei¹, WANG Rui²^,^*(), ZHAO Yuhuan¹, XU Tianjiao², WANG Wei³, SUN Weidong¹

1. Department of Psychiatry, the Fourth Affiliated Hospital of Qiqihar Medical University, Qiqihar 161006, China
2. Postdoctoral Research Station, Qiqihar Institute of Medical and Pharmaceutical Sciences, Qiqihar 161006, China
3. Department of Teaching and Research, School of Marxism, Mudanjiang Medical University, Mudanjiang 157000, China

Received:2022-08-24 Revised:2022-11-06 Published:2023-09-20 Online:2022-11-21
Contact: WANG Rui

分享到

摘要/Abstract

摘要： 抑郁症作为全球第二大疾病，其病因及发病机制尚未完全明确，现多采用药物治疗、心理治疗和物理治疗等方法，但因药物治疗不良反应大、易复发，心理治疗存在对临床医生专业水平要求较高和物理治疗设备昂贵、定向障碍等缺陷，致使其治疗面临瓶颈。经颅低水平激光在科研实验及临床抗抑郁治疗中均被证明具有疗效。尽管该治疗方法分子及细胞机制尚未确切，但其以非侵入性方式通过颅骨，不对生物体产生损伤，具有光生物学调节效应，对神经元具有保护作用，可以作为一种创新的非药物疗法，为抗抑郁治疗提供新方向。

关键词: 抑郁症, 低强度光疗法, 低水平激光, 线粒体, 神经递质, 神经可塑性, 神经炎症, 综述, 治疗

Abstract:

As the second most serious disease worldwide, the etiology and pathogenesis of depression have not been clearly defined. Depression treatment faces a bottleneck, due to limitations of common therapies, such as side effects associated with drug therapy and high risk of recurrence after drug therapy, high requirements for clinicians to perform psychotherapy, and high cost of modalities and disorientation in physical therapy. Transcranial low-level laser, a new therapy has recently proven to be effective in scientific research and clinical antidepressant treatment, utilizes low-level laser non-invasively passing through the skull without causing damage to regulate biological tissues and protect neurons. Even though the molecular and cellular mechanisms underlying the therapy for depression are not yet clear, this non-drug therapy could be highly promising for depression treatment.

Key words: Depressive disorder, Low-level light therapy, Low-level laser, Mitochondrial, Neurotransmitter, Neuronal plasticity, Neruroinflammation, Review, Therapy

梁雪梅,王睿,赵玉环,等. 经颅低水平激光：一种治疗抑郁症的新方法[J]. 中国全科医学, 2023, 26(27): 3335-3341. DOI: 10.12114/j.issn.1007-9572.2022.0688.
LIANG Xuemei,WANG Rui,ZHAO Yuhuan, et al. Transcranial Low-level Laser Therapy: a Novel Treatment for Depression[J]. Chinese General Practice, 2023, 26(27): 3335-3341. DOI: 10.12114/j.issn.1007-9572.2022.0688.

参考文献 65

[1]	HERRMAN H, KIELING C, MCGORRY P, et al. Reducing the global burden of depression：a Lancet-World Psychiatric Association Commission[J]. Lancet，2019，393(10189):e42-43. DOI：10.1016/S0140-6736(18)32408-5.
[2]	GBD2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories，1990-2019：a systematic analysis for the Global Burden of Disease Study 2019[J]. Lancet，2020，396(10258):1204-1222. DOI：10.1016/S0140-6736(20)30925-9.
[3]	MILLER L, CAMPO J V. Depression in adolescents[J]. N Engl J Med，2021，385(5):445-449. DOI：10.1056/NEJMra2033475.
[4]	MCCARRON R M, SHAPIRO B, RAWLES J, et al. Depression[J]. Ann Intern Med，2021，174(5):ITC65-ITC80. DOI：10.7326/AITC202105180.
[5]	LU J, XU X F, HUANG Y Q, et al. Prevalence of depressive disorders and treatment in China：a cross-sectional epidemiological study[J]. Lancet Psychiatry，2021，8(11):981-990. DOI：10.1016/S2215-0366(21)00251-0.
[6]	GONDA X, DOME P, NEILL J C, et al. Novel antidepressant drugs：beyond monoamine targets[J]. CNS Spectr，2021:1-10. DOI：10.1017/S1092852921000791.
[7]	KOSTYUNINA A, ABDULLAEV B, NARKULOVA K. Antidepressants efficiency in patients with depression and depression related to Parkinson's disease[J]. Park Relat Disord，2018，46:e49. DOI：10.1016/j.parkreldis.2017.11.167.
[8]	杨潇，董再全，王瑜，等. 抑郁症病因学和治疗学的研究进展[J]. 中国科学（生命科学），2022，52(11):1678-1691.
[9]	DE BARROS D D, DOS SANTOS BARROS CATÃO J S, FERREIRA A C D, et al. Correction to：low-level laser therapy is effective in controlling postoperative pain in lower third molar extractions：a systematic review and meta-analysis[J]. Lasers Med Sci，2022，37(5):2379. DOI：10.1007/s10103-022-03591-3.
[10]	MUSSTTAF R A, JENKINS D F L, JHA A N. Assessing the impact of low level laser therapy（LLLT） on biological systems：a review[J]. Int J Radiat Biol，2019，95(2):120-143. DOI：10.1080/09553002.2019.1524944.
[11]	MOHAMMED H S, KHADRAWY Y A. Antidepressant and antioxidant effects of transcranial irradiation with 830-nm low-power laser in an animal model of depression[J]. Lasers Med Sci，2022，37(3):1615-1623. DOI：10.1007/s10103-021-03410-1.
[12]	SALEHPOUR F, CASSANO P, ROUHI N, et al. Penetration profiles of visible and near-infrared lasers and light-emitting diode light through the head tissues in animal and human species：a review of literature[J]. Photobiomodul Photomed Laser Surg，2019，37(10):581-595. DOI：10.1089/photob.2019.4676.
[13]	PENBERTHY W T, VORWALLER C E. Utilization of the 1064 nm wavelength in photobiomodulation：a systematic review and meta-analysis[J]. J Lasers Med Sci，2021，12(1):e86. DOI：10.34172/jlms.2021.86.
[14]	HAMBLIN M R. Mechanisms and mitochondrial redox signaling in photobiomodulation[J]. Photochem Photobiol，2018，94(2):199-212. DOI：10.1111/php.12864.
[15]	SALEHPOUR F, BERMAN M H, SADIGH-ETEGHAD S. Photobiomodulation as a brain-boosting strategy in aging[M]//Assessments，Treatments and Modeling in Aging and Neurological Disease. Amsterdam：Elsevier，2021：389-402.
[16]	HENNESSY M, HAMBLIN M R. Photobiomodulation and the brain：a new paradigm[J]. J Opt，2017，19(1):013003. DOI：10.1088/2040-8986/19/1/013003.
[17]	ROJAS J C, GONZALEZ-LIMA F. Neurological and psychological applications of transcranial lasers and LEDs[J]. Biochem Pharmacol，2013，86(4):447-457. DOI：10.1016/j.bcp.2013.06.012.
[18]	HAMBLIN M R. Photobiomodulation for traumatic brain injury and stroke[J]. J Neurosci Res，2018，96(4):731-743. DOI：10.1002/jnr.24190.
[19]	PURUSHOTHUMAN S, JOHNSTONE D M, NANDASENA C, et al. Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models[J]. Alzheimers Res Ther，2014，6(1):2. DOI：10.1186/alzrt232.
[20]	O'DONNELL C M, BARRETT D W, FINK L H, et al. Transcranial infrared laser stimulation improves cognition in older bipolar patients：proof of concept study[J]. J Geriatr Psychiatry Neurol，2022，35(3):321-332. DOI：10.1177/0891988720988906.
[21]	SALEHPOUR F, MAHMOUDI J, KAMARI F, et al. Brain photobiomodulation therapy：a narrative review[J]. Mol Neurobiol，2018，55(8):6601-6636. DOI：10.1007/s12035-017-0852-4.
[22]	SALEHPOUR F, RASTA S H, MOHADDES G, et al. Therapeutic effects of 10-HzPulsed wave lasers in rat depression model：a comparison between near-infrared and red wavelengths[J]. Lasers Surg Med，2016，48(7):695-705. DOI：10.1002/lsm.22542.
[23]	SALEHPOUR F, FARAJDOKHT F, CASSANO P, et al. Near-infrared photobiomodulation combined with coenzyme Q₁₀ for depression in a mouse model of restraint stress：reduction in oxidative stress，neuroinflammation，and apoptosis[J]. Brain Res Bull，2019，144:213-222. DOI：10.1016/j.brainresbull.2018.10.010.
[24]	MOHAMMED H S. Transcranial low-level infrared laser irradiation ameliorates depression induced by reserpine in rats[J]. Lasers Med Sci，2016，31(8):1651-1656. DOI：10.1007/s10103-016-2033-5.
[25]	XU Z Q, GUO X B, YANG Y, et al. Low-level laser irradiation improves depression-like behaviors in mice[J]. Mol Neurobiol，2017，54(6):4551-4559. DOI：10.1007/s12035-016-9983-2.
[26]	ESHAGHI E, SADIGH-ETEGHAD S, MOHADDES G, et al. Transcranial photobiomodulation prevents anxiety and depression via changing serotonin and nitric oxide levels in brain of depression model mice：a study of three different doses of 810 nm laser[J]. Lasers Surg Med，2019，51(7):634-642. DOI：10.1002/lsm.23082.
[27]	RODRIGUES J H, MARQUES M M, BIASOTTO-GONZALEZ D A, et al. Evaluation of pain，jaw movements，and psychosocial factors in elderly individuals with temporomandibular disorder under laser phototherapy[J]. Lasers Med Sci，2015，30(3):953-959. DOI：10.1007/s10103-013-1514-z.
[28]	BLANCO N J, SAUCEDO C L, GONZALEZ-LIMA F. Transcranial infrared laser stimulation improves rule-based，but not information-integration，category learning in humans[J]. Neurobiol Learn Mem，2017，139:69-75. DOI：10.1016/j.nlm.2016.12.016.
[29]	ESHAGHI E, SADIGH-ETEGHAD S, MOHADDES G, et al. Transcranial photobiomodulation prevents anxiety and depression via changing serotonin and nitric oxide levels in brain of depression model mice：a study of three different doses of 810 nm laser[J]. Lasers Surg Med，2019，51(7):634-642. DOI：10.1002/lsm.23082.
[30]	CASSANO P, PETRIE S R, HAMBLIN M R, et al. Review of transcranial photobiomodulation for major depressive disorder：targeting brain metabolism，inflammation，oxidative stress，and neurogenesis[J]. Neurophotonics，2016，3(3):031404. DOI：10.1117/1.NPh.3.3.031404.
[31]	ELSAYED M M, RAKHA M, ELSHEIMY H A, et al. Effect of laser biostimulation and a low-calorie diet vs. a low-calorie diet alone on insulin resistance，inflammatory biomarkers，and depression among obese postmenopausal women：a randomized controlled trial[J]. Eur Rev Med Pharmacol Sci，2022，26(9):3269-3277. DOI：10.26355/eurrev_202205_28745.
[32]	KERPPERS F K, DOS SANTOS K M M G, CORDEIRO M E R, et al. Study of transcranial photobiomodulation at 945-nm wavelength：anxiety and depression[J]. Lasers Med Sci，2020，35(9):1945-1954. DOI：10.1007/s10103-020-02983-7.
[33]	SALEHPOUR F, MAJDI A, PAZHUHI M, et al. Transcranial photobiomodulation improves cognitive performance in young healthy adults：a systematic review and meta-analysis[J]. Photobiomodul Photomed Laser Surg，2019，37(10):635-643. DOI：10.1089/photob.2019.4673.
[34]	ZORZO C, ARIAS J L, MÉNDEZ M. Hippocampus and cortex are involved in the retrieval of a spatial memory under full and partial cue availability[J]. Behav Brain Res，2021，405:113204. DOI：10.1016/j.bbr.2021.113204.
[35]	BANSAL Y, KUHAD A. Mitochondrial dysfunction in depression[J]. Curr Neuropharmacol，2016，14(6):610-618. DOI：10.2174/1570159x14666160229114755.
[36]	KARABATSIAKIS A, BÖCK C, SALINAS-MANRIQUE J, et al. Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression[J]. Transl Psychiatry，2014，4:e397. DOI：10.1038/tp.2014.44.
[37]	DE FREITAS L F, HAMBLIN M R. Proposed mechanisms of photobiomodulation or low-level light therapy[J]. IEEE J Sel Top Quantum Electron，2016，22(3):7000417. DOI：10.1109/JSTQE.2016.2561201.
[38]	KOLAR D, KLETECKOVA L, BROZKA H, et al. Mini-review：brain energy metabolism and its role in animal models of depression，bipolar disorder，schizophrenia and autism[J]. Neurosci Lett，2021，760:136003. DOI：10.1016/j.neulet.2021.136003.
[39]	SALEHPOUR F, AHMADIAN N, RASTA S H, et al. Transcranial low-level laser therapy improves brain mitochondrial function and cognitive impairment in D-galactose-induced aging mice[J]. Neurobiol Aging，2017，58:140-150. DOI：10.1016/j.neurobiolaging.2017.06.025.
[40]	LIN Y B, DAI X M, ZHANG J, et al. Metformin alleviates the depression-like behaviors of elderly apoE4 mice via improving glucose metabolism and mitochondrial biogenesis[J]. Behav Brain Res，2022，423:113772. DOI：10.1016/j.bbr.2022.113772.
[41]	HAO Y, TONG Y P, GUO Y H, et al. Metformin attenuates the metabolic disturbance and depression-like behaviors induced by corticosterone and mediates the glucose metabolism pathway[J]. Pharmacopsychiatry，2021，54(3):131-141. DOI：10.1055/a-1351-0566.
[42]	WANG X L, DMOCHOWSKI J P, ZENG L, et al. Transcranial photobiomodulation with 1064-nm laser modulates brain electroencephalogram rhythms[J]. Neurophotonics，2019，6(2):025013. DOI：10.1117/1.NPh.6.2.025013.
[43]	LEE E S, YOUN H, HYUNG W S W, et al. The effects of cerebral amyloidopathy on regional glucose metabolism in older adults with depression and mild cognitive impairment while performing memory tasks[J]. Eur J Neurosci，2021，54(7):6663-6672. DOI：10.1111/ejn.15461.
[44]	MINTZOPOULOS D, GILLIS T E, TEDFORD C E, et al. Effects of near-infrared light on cerebral bioenergetics measured with phosphorus magnetic resonance spectroscopy[J]. Photomed Laser Surg，2017，35(8):395-400. DOI：10.1089/pho.2016.4238.
[45]	SALEHPOUR F, RASTA S H. The potential of transcranial photobiomodulation therapy for treatment of major depressive disorder[J]. Rev Neurosci，2017，28(4):441-453. DOI：10.1515/revneuro-2016-0087.
[46]	郭晓波. 低强度激光治疗改善小鼠抑郁样行为的研究[D]. 苏州：苏州大学，2015.
[47]	FUDIN N A, KHADARTSEV A A, MOSKVIN S V. Transcranial electrostimulation and serotonin laser phoresis in the Athletes experiencing a combined effect of fatigue and psycho-emotional stress[J]. Vopr Kurortol Fizioter Lech Fiz Kult，2019，96(1):37-42. DOI：10.17116/kurort20199601137.
[48]	MALHI G S, MANN J J. Depression[J]. Lancet，2018，392(10161):2299-2312. DOI：10.1016/S0140-6736(18)31948-2.
[49]	MEYNAGHIZADEH-ZARGAR R, SADIGH-ETEGHAD S, MOHADDES G, et al. Effects of transcranial photobiomodulation and methylene blue on biochemical and behavioral profiles in mice stress model[J]. Lasers Med Sci，2020，35(3):573-584. DOI：10.1007/s10103-019-02851-z.
[50]	VAN RENSBURG D J, LINDEQUE Z, HARVEY B H, et al. Reviewing the mitochondrial dysfunction paradigm in rodent models as platforms for neuropsychiatric disease research[J]. Mitochondrion，2022，64:82-102. DOI：10.1016/j.mito.2022.03.002.
[51]	ZHANG J W, SUN J K, ZHENG Q, et al. Low-level laser therapy 810-nm up-regulates macrophage secretion of neurotrophic factors via PKA-CREB and promotes neuronal axon regeneration in vitro[J]. J Cell Mol Med，2020，24(1):476-487. DOI：10.1111/jcmm.14756.
[52]	HUANG Y Y, NAGATA K, TEDFORD C E, et al. Low-level laser therapy （LLLT） reduces oxidative stress in primary cortical neurons in vitro[J]. J Biophotonics，2013，6(10):829-838. DOI：10.1002/jbio.201200157.
[53]	XUAN W J, HUANG L Y, VATANSEVER F, et al. Transcranial low-level laser therapy increases memory，learning，neuroprogenitor cells，BDNF and synaptogenesis in mice with traumatic brain injury[C]//SPIE BiOS. Proc SPIE 9309，Mechanisms for Low-Light Therapy X，San Francisco，California，USA. 2015，9309：92-101.
[54]	YAN X D, LIU J F, ZHANG Z P, et al. Low-level laser irradiation modulates brain-derived neurotrophic factor mRNA transcription through calcium-dependent activation of the ERK/CREB pathway[J]. Lasers Med Sci，2017，32(1):169-180. DOI：10.1007/s10103-016-2099-0.
[55]	YIN K, ZHU R J, WANG S H, et al. Low-level laser effect on proliferation，migration，and antiapoptosis of mesenchymal stem cells[J]. Stem Cells Dev，2017，26(10):762-775. DOI：10.1089/scd.2016.0332.
[56]	YANG L D, TUCKER D, DONG Y, et al. Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells[J]. Exp Neurol，2018，299(Pt A):86-96. DOI：10.1016/j.expneurol.2017.10.013.
[57]	CALDIERARO M A, LAUFER-SILVA T, CASSANO P. Dosimetry and clinical efficacy of transcranial photobiomodulation for major depression disorder：could they guide dosimetry for Alzheimer's disease? [J]. J Alzheimers Dis，2021，83(4):1453-1469. DOI：10.3233/JAD-210586.
[58]	LIANG J G, LIU L, XING D. Photobiomodulation by low-power laser irradiation attenuates Aβ-induced cell apoptosis through the Akt/GSK3β/β-catenin pathway[J]. Free Radic Biol Med，2012，53(7):1459-1467. DOI：10.1016/j.freeradbiomed.2012.08.003.
[59]	GAL'ECKI P, TALAROWSKA M. Inflammatory theory of depression[J]. Psychiatr Pol，2018，52(3):437-447. DOI：10.12740/PP/76863.
[60]	YANG L D, WU C Y, TUCKER L, et al. Photobiomodulation therapy attenuates anxious-depressive-like behavior in the TgF344 rat model[J]. J Alzheimers Dis，2021，83(4):1415-1429. DOI：10.3233/JAD-201616.
[61]	RAMEZANI F, NESHASTEH-RIZ A, GHADAKSAZ A, et al. Mechanistic aspects of photobiomodulation therapy in the nervous system[J]. Lasers Med Sci，2022，37(1):11-18. DOI：10.1007/s10103-021-03277-2.
[62]	HAMBLIN M R. Mechanisms and applications of the anti-inflammatory effects of photobiomodulation[J]. AIMS Biophys，2017，4(3):337-361. DOI：10.3934/biophy.2017.3.337.
[63]	SALEHPOUR F, GHOLIPOUR-KHALILI S, FARAJDOKHT F, et al. Therapeutic potential of intranasal photobiomodulation therapy for neurological and neuropsychiatric disorders：a narrative review[J]. Rev Neurosci，2020，31(3):269-286. DOI：10.1515/revneuro-2019-0063.
[64]	PEREZ GARCIA G, PEREZ G M, OTERO-PAGAN A, et al. Transcranial laser therapy does not improve cognitive and post-traumatic stress disorder-related behavioral traits in rats exposed to repetitive low-level blast injury[J]. Neurotrauma Rep，2021，2(1):548-563. DOI：10.1089/neur.2021.0005.
[65]	SALEHPOUR F, KHADEMI M, HAMBLIN M R. Photobiomodulation therapy for dementia：a systematic review of pre-clinical and clinical studies[J]. J Alzheimers Dis，2021，83(4):1431-1452. DOI：10.3233/JAD-210029.

经颅低水平激光：一种治疗抑郁症的新方法

Transcranial Low-level Laser Therapy: a Novel Treatment for Depression

RichHTML

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 65

相关文章 15

编辑推荐

Metrics

留言

[1]	南子晴, 蔺莉. 妊娠期尿潴留的诊治进展[J]. 中国全科医学, 2023, 26(36): 4608-4612.
[2]	张迪, 李鸿鹏, 马江, 聂谦, 孙剑峰, 吴志鹏, 张宏才, 赵珏. 眼针带针运动对经皮冠状动脉介入术治疗患者术后心率变异性及预后的影响研究[J]. 中国全科医学, 2023, 26(36): 4535-4544.
[3]	刘炳蔚, 王静, 乔雪, 牟思霖, 时光喜, 李静蔚. 雌激素受体阳性乳腺癌患者内分泌治疗期高脂血症的临床特征及中药用药分析：基于真实世界研究[J]. 中国全科医学, 2023, 26(36): 4558-4564.
[4]	中华医学会心身医学分会进食障碍协作学组, 中华医学会精神医学分会进食障碍研究协作组, 陈妍, 陈涵, 刘兰英, 孔庆梅, 乔慧芬, 张岚, 李雪霓, 匡桂芳, 张大荣, 栗克清, 王振, 陈珏. 中国神经性贪食诊疗专家共识[J]. 中国全科医学, 2023, 26(36): 4487-4497.
[5]	慢性阻塞性肺疾病中西医结合管理专家共识写作组. 慢性阻塞性肺疾病中西医结合管理专家共识（2023版）[J]. 中国全科医学, 2023, 26(35): 4359-4371.
[6]	柳浦青, 陈静文, 寿张轩. 基于Beers标准评价住院老年非瓣膜性心房颤动患者直接口服抗凝药物的潜在不适当用药研究[J]. 中国全科医学, 2023, 26(35): 4388-4393.
[7]	王小雪, 毛乐乐, 王子君, 杨慕坤, 白文佩, 刁翯. 自体富血小板浓缩物在妇科领域中的应用研究进展[J]. 中国全科医学, 2023, 26(35): 4472-4476.
[8]	刘欣怡, 刘占东. 慢性疲劳综合征相关焦虑及抑郁的研究进展[J]. 中国全科医学, 2023, 26(35): 4477-4482.
[9]	刘颖宏, 杨晓娟. Takayasu动脉炎妊娠期间临床管理的研究进展[J]. 中国全科医学, 2023, 26(35): 4483-4486.
[10]	姚裕忠, 马晓骏, 宋懽, 钟瑜. 基于"全专精准管理"的糖尿病"1358模式"对社区糖尿病患者的管理效果研究[J]. 中国全科医学, 2023, 26(34): 4308-4314.
[11]	李殿江, 潘恩春, 孙中明, 文进博, 王苗苗, 武鸣, 沈冲. 社区2型糖尿病患者临床惰性现状及其影响因素分析[J]. 中国全科医学, 2023, 26(34): 4296-4301.
[12]	林恺, 姚弥, 陈章, 纪欣鑫, 林润琪, 陈永松, Sim MOIRA. 2型糖尿病治疗负担的概念框架及应对方式：基于视频记录分析[J]. 中国全科医学, 2023, 26(34): 4302-4307.
[13]	王旭, 魏戌, 朱立国, 冯天笑, 王志鹏, 师彬. 医工结合的中医手法治疗脊柱退行性疾病疗效机制研究：思路与前景[J]. 中国全科医学, 2023, 26(33): 4118-4124.
[14]	辛功恺, 丛欣, 袁磊, 程悦彤, 倪翠萍, 张巍巍, 張平平, 刘宇. 失智症老年人综合评估工具的研究进展[J]. 中国全科医学, 2023, 26(33): 4103-4109.
[15]	周俞余, 高川, 崔埔安, 王亚平, 何仲. 更年期综合征患者绝经激素治疗中医患共同决策质量的影响因素研究[J]. 中国全科医学, 2023, 26(33): 4181-4186.