中国全科医学 ›› 2022, Vol. 25 ›› Issue (35): 4375-4380.DOI: 10.12114/j.issn.1007-9572.2022.0584

所属专题: 共病最新文章合集

• 专题研究·共病问题 • 上一篇    下一篇

骨质疏松症与腰椎间盘突出症共病调查及影响因素分析

韩涛1, 孙凯1, 孙传睿1, 章轶立2, 谢雁鸣3, 申浩4, 王旭1, 齐保玉1, 朱立国1,*(), 魏戌1,*()   

  1. 1100102 北京市,中国中医科学院望京医院
    2210023 江苏省南京市,南京中医药大学中医学院·中西医结合学院
    3100700 北京市,中国中医科学院中医临床基础医学研究所
    4100072 北京市丰台区长辛店镇社区卫生服务中心
  • 收稿日期:2022-07-11 修回日期:2022-08-26 出版日期:2022-12-15 发布日期:2022-09-29
  • 通讯作者: 朱立国, 魏戌
  • 韩涛、孙凯为共同第一作者 韩涛,孙凯,孙传睿,等.骨质疏松症与腰椎间盘突出症共病调查及影响因素分析[J].中国全科医学,2022,25(35):4375-4380.[www.chinagp.net]
    作者贡献:韩涛、孙凯负责数据分析,论文撰写与修改;朱立国、魏戌对文章进行审核,监督管理,对文章整体负责;孙传睿、章轶立、申浩、王旭、齐保玉负责数据整理与校对;谢雁鸣、朱立国负责研究的设计与可行性分析。
  • 基金资助:
    国家重点研发计划(2021YFC1712800); 国家中医药传承创新团队项目(ZYYCXTD-C-202003); 中国中医科学院科技创新工程(CI2021A02013); 中国中医科学院优秀青年人才(创新类)培养专项(ZZ13-YQ-039)

Prevalence and Associated Factors of Lumbar Disc Herniation in Osteoporosis: a Cross-sectional Survey

HAN Tao1, SUN Kai1, SUN Chuanrui1, ZHANG Yili2, XIE Yanming3, SHEN Hao4, WANG Xu1, QI Baoyu1, ZHU Liguo1,*(), WEI Xu1,*()   

  1. 1Wangjing Hospital of CACMS, Beijing 100102, China
    2School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
    3Institute of Basic Research In Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
    4Fengtai Changxindian Community Health Center, Beijing 100072, China
  • Received:2022-07-11 Revised:2022-08-26 Published:2022-12-15 Online:2022-09-29
  • Contact: ZHU Liguo, WEI Xu
  • About author:
    HAN T, SUN K, SUN C R, et al. Prevalence and associated factors of lumbar disc herniation in osteoporosis: a cross-sectional survey[J]. Chinese General Practice, 2022, 25 (35) : 4375-4380. HAN Tao and SUN Kai are co-first authors

摘要: 背景 骨质疏松症(OP)和腰椎间盘突出症(LDH)是骨科临床中十分常见的两种疾病,二者关系密切,常合并发病。随着社会老龄化的不断加剧,其给中老年人带来了严重的困扰。 目的 基于北京市社区中老年人群横断面调查研究,分析OP与LDH的共病发生情况及相关影响因素,为临床有效防治该类疾病提供参考。 方法 2017年11月至2018年7月选取北京市朝阳区和丰台区10个社区的1 540例社区居民为研究对象,有完整的信息记录和骨量筛查数据,现场采集居民的一般资料、骨折史、跌倒史、遗传病史、骨密度、EuroQol健康指数等数据,筛选符合OP诊断的患者,以其是否并发LDH分为并发LDH组与未并发LDH组。采用多因素Logistic回归分析探讨OP并发LDH的影响因素。 结果 共纳入521例OP患者,其中是否并发LDH信息记录缺失1例;并发LDH组80例,未并发LDH组440例。多因素Logistic回归分析结果显示,将年龄、体质指数(BMI)作为校正因素,跌倒史〔OR=1.96,95%CI(1.02,3.78),P=0.044〕、骨折史〔OR=1.80,95%CI(1.04,3.12),P=0.035〕以及疼痛/不舒适〔OR=2.43,95%CI(1.41,4.18),P=0.001〕可能是OP并发LDH的影响因素。 结论 OP和LDH共病情况普遍存在,跌倒、骨折以及疼痛/不舒适可能是OP并发LDH的影响因素。

关键词: 骨质疏松症, 骨质疏松, 腰椎间盘突出症, 横断面研究, 共病, 影响因素分析

Abstract:

Background

Osteoporosis (OP) and lumbar disc herniation (LDH) are two common orthopedic diseases encountered clinically, which are closely related and often coexisted, causing great suffering to middle-aged and elderly people along with the accelerated process of population aging.

Objective

To perform a cross-sectional survey on the prevalence and associated factors of LDH in OP in community-dwelling middle-aged and elderly people in Beijing, providing a reference for clinical prevention and treatment of this disease.

Methods

From November 2017 to July 2018, 1 540 residents with complete demographics and bone mass measurement data who lived in 10 communities in Chaoyang District and Fengtai District of Beijing were selected. A survey was conducted with the residents for understanding their data collected on-site, including demographics, fracture history, fall history, history of hereditary disease, bone mineral density, EuroQol Health Utility score, then those with OP were further selected and divided into two groups by the prevalence of LDH. Multivariate Logistic regression analysis was used to explore the influencing factors of LDH in OP.

Results

A total of 521 cases of OP attended the survey, except for one with missing information of LDH, the other 520 cases (80 with LDH, and 440 without LDH) were included for final analysis. Multivariate Logistic regression analysis indicated that after controlling for age and BMI, falls〔OR=1.96, 95%CI (1.02, 3.78) , P=0.044〕, fracture〔OR=1.80, 95%CI (1.04, 3.12) , P=0.035〕and pain/discomfort〔OR=2.43, 95%CI (1.41, 4.18) , P=0.001〕were independently associated with LDH in OP.

Conclusion

The coexistence of LDH and OP was common in this population. Falls, fractures, and pain/discomfort may be influencing factors of LDH in OP.

Key words: Osteoporosis, Osteoporosis, Lumbar disc herniation, Cross-sectional studies, Comorbidity, Root cause analysis