从脂肪组织的内分泌功能角度探讨其在慢性阻塞性肺疾病中的作用机制研究

doi:10.12114/j.issn.1007-9572.2022.0541

中国全科医学 ›› 2023, Vol. 26 ›› Issue (06): 754-759.DOI: 10.12114/j.issn.1007-9572.2022.0541

从脂肪组织的内分泌功能角度探讨其在慢性阻塞性肺疾病中的作用机制研究

王益德, 李争^*(), 李风森

830000　新疆乌鲁木齐市，新疆医科大学第四临床医学院

收稿日期:2022-06-15 修回日期:2022-09-05 出版日期:2023-02-20 发布日期:2022-10-27
通讯作者: 李争
王益德，李争，李风森.从脂肪组织的内分泌功能角度探讨其在慢性阻塞性肺疾病中的作用机制研究[J].中国全科医学，2023，26（6）：754-759. [www.chinagp.net]
作者贡献：李争、李风森负责文章的可行性分析、质量控制及审校、监督管理，对文章整体负责；王益德提出文章思路，文献/资料检索与收集、论文撰写与修订。
基金资助:
国家自然科学基金资助项目(82060803)

Role of Endocrine Function of Adipose Tissue in the Development of Chronic Obstructive Pulmonary Disease: a Review of Recent Advances

WANG Yide, LI Zheng^*(), LI Fengsen

The Fourth Clinical Medical College, Xinjiang Medical University, Urumqi 830000, China

Received:2022-06-15 Revised:2022-09-05 Published:2023-02-20 Online:2022-10-27
Contact: LI Zheng
About author:
WANG Y D, LI Z, LI F S. Role of endocrine function of adipose tissue in the development of chronic obstructive pulmonary disease: a review of recent advances[J]. Chinese General Practice, 2023, 26 (6) : 754-759.

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摘要/Abstract

摘要： 脂肪组织除了通过其力学特征或机械功能对周边组织器官产生影响以外，还可以凭借非物理性的内分泌功能通过脂肪因子输出信号方式有效地建立起与呼吸系统等远程器官的互作信息网络，进而参与多种肥胖相关疾病的发生与发展。作为内分泌领域的突破性进展之一，脂肪组织的内分泌功能受到生命科学领域的关注。近年来，多项流行病调查研究揭示了肥胖是造成慢性阻塞性肺疾病（COPD）等呼吸系统疾病肺功能损害重要的危险因素。基于此，本文将分别梳理脂联素、瘦素、内脂素等脂肪因子在COPD中的作用机制，从脂肪组织内分泌功能角度为COPD的防治研究提供新思路。

关键词: 肺疾病, 慢性阻塞性, 肥胖, 脂肪组织, 内分泌功能, 机制研究

Abstract:

In addition to affecting adjacent tissues and organs through its mechanical characteristics or mechanical functions, adipose tissue participates in the development of a variety of obesity-related diseases by effectively establishing an interaction information network with organs of the respiratory system and other remote organs through signaling pathways of adipokines secreted by adipocytes. As a breakthrough in the field of endocrinology, the endocrine function of adipose tissue has attracted increasing attention in life sciences. A number of recent epidemiological studies have revealed that obesity is an important risk factor for chronic obstructive pulmonary disease and other respiratory impairments. We reviewed recent advances in the role of adiponectin, leptin, endolipin and other adipocytokines in the development of COPD, providing new ideas for the prevention and treatment of COPD from the perspective of endocrine function of adipose tissue.

Key words: Pulmonary disease, chronic obstructive, Obesity, Adipose tissue, Endocrine function, Mechanism research

王益德,李争,李风森. 从脂肪组织的内分泌功能角度探讨其在慢性阻塞性肺疾病中的作用机制研究[J]. 中国全科医学, 2023, 26(06): 754-759. DOI: 10.12114/j.issn.1007-9572.2022.0541.
WANG Yide,LI Zheng,LI Fengsen. Role of Endocrine Function of Adipose Tissue in the Development of Chronic Obstructive Pulmonary Disease: a Review of Recent Advances[J]. Chinese General Practice, 2023, 26(06): 754-759. DOI: 10.12114/j.issn.1007-9572.2022.0541.

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从脂肪组织的内分泌功能角度探讨其在慢性阻塞性肺疾病中的作用机制研究

Role of Endocrine Function of Adipose Tissue in the Development of Chronic Obstructive Pulmonary Disease: a Review of Recent Advances

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