关键词: 循证实践, 混合方法, 循证医学方法学, 循证中医药, 指南, 中医药标准化

Abstract: The development of Traditional Chinese Medicine（TCM）clinical practice guidelines is a key measure to achieve the standardization of TCM. The TCM guidelines greatly contribute to the guidance of clinical practice，but the phenomenon of inadequate use of them exists，which may be related to the contents of the guidelines. As there is a small number of high-quality TCM clinical studies，guidelines developed based on evidence-based medical data derived from them，namely，guidelines mainly based on quantitative research results，have showed limitations in their recommendations. In contrast，the evidence（quantitative and qualitative research results）from mixed methods studies may be more practical，which may better benefit the development of TCM guidelines. This paper preliminarily discussed the idea and function of mixed method research in the process of guidelines formulation，and took the Clinical practice guide in the treatment of influenza by TCM as an example. This paper discussed the problems encountered in the guideline formulation led by quantitative research and the specific application of mixed method research in the guideline formulation. It was found that mixed method research can make up for the lack of relying solely on quantitative or qualitative research results，and may become one of the main methods for future guideline formulation，but there are still certain limitations and further research is needed.

Key words: Evidence-based practice, Mixed method, Evidence-based medicine methodology, Evidence-based traditional Chinese medicine, Guideline, Standardization of traditional Chinese medicine