关键词: 贫血, 睡眠障碍, 穴位贴敷法, 静电敷贴, 体征和症状

Abstract: Background　Sleep disorder has become a common health issue in chronic anemia patients，and its induced impaired sleep quality may increase the level of anxiety and decrease the recovery of anemia symptoms.Drug therapy can improve sleep quality，but has a series of side effects.So nonpharmacological interventions for improving sleep quality has obtained increasing attentions from medical professionals.However，there is no enough clinical evidence that demonstrates whether the use of electrostatic acupoint plaster （EAP） cranial electrotherapy stimulation（CES） can improve the quality of sleep and efficacy of anemia treatment in this population.Objective　To explore the effect of EAP CES therapy on the sleep quality and symptom distress of chronic anemia patients.Methods　A total of 96 chronic anemia patients treated in General Practice Department，the Affiliated Hospital of Hangzhou Normal University were enrolled from November 2018 to January 2019，and were randomized into intervention group and control group with 48 cases in each.Both groups received routine therapy，the intervention group received EAP CES treatment for 8 weeks additionally.The sleep quality and symptom distress of the two groups were compared by the results measured by the improved Pittsburg Sleep Quality Index （PSQI） before and after the intervention.Results　There were no significant differences in the pre-intervention global and each component scores of the improved PSQI between the two groups （P>0.05）.After the intervention，no significant changes were found in the average global and component scores of the improved PSQI in the control group（P>0.05），but in the intervention group，except the average score of cough or snore loudly almost remained the same（P>0.05），obvious declines were found in the average global score of improved PSQI，and the average scores of bed time，hours of sleep per night，wake up easy and early，frequent urination，feel too cold and hot，had bad dreams，take medicine to help sleep，daytime sleepiness，and daytime energy deficiency（P<0.05）.In comparison with the control group，the intervention group showed lower post-intervention average global score of improved PSQI，and lower average scores of bed time，hours of sleep per night，wake up easy and early，frequent urination，feel too cold and hot，had bad dreams，take medicine to help sleep，daytime sleepiness，and daytime energy deficiency（P<0.05），but similar average score of cough or snore loudly（P>0.05）.There was no significant intergroup difference in the incidence of anemia symptoms before intervention （P>0.05），but the intervention group showed lower incidence of daytime sleepiness，fatigue，dizziness，palpitation，shortness of breath and anorexia after intervention （P<0.05）.Conclusion　EAP CES treatment may help to effectively improve sleep quality and anemia symptoms in patients with chronic anemia.

Key words: Anemia, Sleep disorders, Acupoint sticking therapy, Cranial electrotherapy stimulation, Signs and symptoms