关键词: 多潘立酮片, 门诊医疗, 药物疗法, 知识库

Abstract: Background　Domperidone is a gastrointestinal prokinetic drug that has been on the National Essential Drugs List since 2012. In 2012—2014，reports from Canada，the United States and the United Kingdom put forward that domperidone may be associated with increased risk of sudden cardiac death and sudden ventricular arrhythmia，especially in those older than 60 years and those using domperidone greater than 30 mg as a total daily dose. In view of this，in September 2016，the former China Food and Drug Administration issued the Notice on the Revision of the Instructions for Use of Domperidone Preparations，requiring the revision of the package insert for domperidone preparations. Since then，domperidone manufacturers have revised the contents of "adverse reactions，contraindications，precautions，usage and dosage"，and the updated package insert includes relevant warnings and risk warnings. Objective　To explore outpatient use of domperidone tablets in the treatment of various diseases，to provide a reference for safe and appropriate use of medicines in clinical practice. Methods　A total of 515 patients with a diagnosis of single illness who were prescribed Domperidone Tablets at Wujing Community Health Center，Minhang District of Shanghai，between March and August 2019，were selected. Data concerning gender，age，clinical diagnosis，and usage and dosage were collected. A drug use management system using the intelligent knowledge base was developed in accordance with the characteristics of drug use in community hospitals. Results　The 515 patients consisted of 197（38.3%） men and 318（61.7%） women，ranging in age from 26 to 98（mean 72.0±12.4） years，and those aged 60 or over accounted for the largest proportion〔86.0%（443/515）〕. The diagnoses involved 19 illnesses，with dyspepsia，peptic ulcer，chronic gastritis，and gastroesophageal reflux disease as the 4 top-ranked，accounting for 81.4%（419/515） of all diagnoses. The daily dose of all patients conformed with the package insert information. Conclusion　Current outpatient use of domperidone tablets is appropriate generally. With the help of knowledge base，information technology can be used to "escort" patients with medication.

Key words: Domperidone tablet, Ambulatory care, Drug therapy, Knowledge base